DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kirrel and DIP-alpha

DIOPT Version :9

Sequence 1:	XP_011238330.1	Gene:	Kirrel / 170643	MGIID:	1891396	Length:	805	Species:	Mus musculus
Sequence 2:	NP_001259218.1	Gene:	DIP-alpha / 31322	FlyBaseID:	FBgn0052791	Length:	554	Species:	Drosophila melanogaster

Alignment Length:	348	Identity:	84/348 - (24%)
Similarity:	138/348 - (39%)	Gaps:	60/348 - (17%)

- Green bases have known domain annotations that are detailed below.

Mouse    34 LVVAYLIFVTLALALPGTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGI-VQWTK-DGLALGMGQ 96
            :::..|:.|:|..|:...|..|.:..::.:|..|:.|...|.:.:..|. |.|.| |..|:   |
  Fly    23 MLIHLLLIVSLLEAIGAFQPEFVESISNVSVAVGRDATFTCHVRHLGGYRVGWLKADTKAI---Q 84

Mouse    97 GLKA-----WPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEETR 156
            .:..     .||. .|...|...:||.|......|...|.||.....::|:...|.|:|||:...
  Fly    85 AIHENVITHNPRV-TVSHLDQNTWNLHIKAVSEEDRGGYMCQLNTDPMKSQIGFLDVVIPPDFIS 148

Mouse   157 IDGGPVILLQAGTPYNLTCRAFNAKPAATIIWFR-DGTQ---QEGAVTST-------ELLKDGKR 210
            .|....:::..|:...||||| ...|...:.|.| ||.:   ::...|.|       |:||..|
  Fly   149 EDTSSDVIVPEGSSVRLTCRA-RGYPEPIVTWRREDGNEIVLKDNVGTKTLAPSFRGEVLKLSK- 211

Mouse   211 ETTISQLLIEPTDLDIGRVFTCRSMNEAIPNGKETSIELDVHHPPTVTLSIEPQTVLEGERVIFT 275
               ||:       .::|. :.|.:.| .:|......|.|.:|..|.:.:..:......|..|...
  Fly   212 ---ISR-------NEMGS-YLCIASN-GVPPSVSKRISLSIHFHPVIQVPNQLVGAPLGTDVQIE 264

Mouse   276 CQATANPEILGYRWAK---------GGFLIEDAHESRYETNVDY---SFFTEPVS---CEVYNKV 325
            |...|:|:.:.| |.|         |.:.::::.:|.|||.:..   .|..:.|.   |...|.:
  Fly   265 CHVEASPKSINY-WIKDTGEMIVTSGKYHVQESSQSMYETKMSMIVRKFQKDDVGSYRCIAKNSL 328

Mouse   326 GSTNVSTLVNVHFAPRIVVYPKP 348
            |..:.|.        |:...|.|
  Fly   329 GEVDSSI--------RLYEIPGP 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kirrel	XP_011238330.1	Ig	54..148	CDD:386229	25/100 (25%)
		Ig2_KIRREL3-like	170..251	CDD:143236	24/91 (26%)
		Ig	255..336	CDD:386229	20/95 (21%)
		Ig_3	340..421	CDD:372822	3/9 (33%)
		Ig5_KIRREL3	439..536	CDD:143306
DIP-alpha	NP_001259218.1	IG_like	49..129	CDD:214653	22/83 (27%)
		Ig	51..131	CDD:299845	22/83 (27%)
		I-set	144..240	CDD:254352	27/109 (25%)
		IGc2	159..228	CDD:197706	22/82 (27%)
		Ig	244..337	CDD:299845	20/101 (20%)
		I-set	244..337	CDD:254352	20/101 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900