DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kirrel and kirre

DIOPT Version :9

Sequence 1:	XP_011238330.1	Gene:	Kirrel / 170643	MGIID:	1891396	Length:	805	Species:	Mus musculus
Sequence 2:	NP_001245505.1	Gene:	kirre / 31292	FlyBaseID:	FBgn0028369	Length:	956	Species:	Drosophila melanogaster

Alignment Length:	817	Identity:	227/817 - (27%)
Similarity:	333/817 - (40%)	Gaps:	159/817 - (19%)

- Green bases have known domain annotations that are detailed below.

Mouse    55 FSQEPADQTVVAGQRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEI 119
            |:.||.|||.|.|.|..|||.::...|.:|||||...||..:.|..:.||.:|||.:.|.::|:|
  Fly    84 FAMEPQDQTAVVGSRVTLPCRVMEKVGALQWTKDDFGLGQHRNLSGFERYSMVGSDEEGDFSLDI 148

Mouse   120 TDAELSDDASYECQA-----TEAALRSRRAKLTVLIPPEETRIDGGPVILLQAGTPYNLTCRAFN 179
            ....|.|||.|:||.     .|..:|||.||||||:|||..:|..|..::........|.|.:..
  Fly   149 YPLMLDDDAKYQCQVGPGPQGEQGIRSRFAKLTVLVPPEAPKITQGDYLVTTEDREIELECVSQG 213

Mouse   180 AKPAATIIWFRDG---TQQEGAVTSTELLKDGKRETTISQLLIEPTDLDIGRVFTCRSMNEAIPN 241
            .||||.|.|. ||   ...:|.....|.|.|.:|.|..|.|.:.|........|||::.|.|...
  Fly   214 GKPAAEITWI-DGLGNVLTKGIEYVKEPLADSRRITARSILKLAPKKEHHNTTFTCQAQNTADRT 277

Mouse   242 GKETSIELDVHHPPTVTLSI-----EPQTVLEGERVIFTCQATANPEILGYRWAKGGFLIEDAHE 301
            .:...:.|:|.:.|.|.:|:     ....:.||..||.:|||.|||..|.|||    |:.::...
  Fly   278 YRSAKLLLEVKYAPKVIVSVVGGALAGGKIPEGAEVILSCQADANPHELSYRW----FINDELMT 338

Mouse   302 SRYET-----NVDYSFFTEPVSCEVYNKVGSTNVSTLVNVHFAPRIVVYPKPTTTDIGSDVTLTC 361
            ..:.|     ||...:....|.|||.|.||.:..|..:::.|.|.....|.....|:|:.|::.|
  Fly   339 GDFTTKMIIHNVSRQYHDAIVKCEVVNAVGKSEQSKKLDISFGPVFRQRPVSVEADLGATVSMRC 403

Mouse   362 VWVGNPPLTLTWTKKDSNMGPRLPGSPPEANLSAQVLSNSNQLLLKSVTQADAGTYTCRAIV--- 423
            ...|||...:.|..::|:                ||:..:.:|.|| |:...||.|.|:|:|
  Fly   404 DVAGNPEPEIEWISENSD----------------QVVGVAAELKLK-VSSETAGRYFCKAVVNGF 451

Mouse   424 PRIGVAEREVPLYVNGPPIISSEAVQFAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLER 488
            |.||.   |..|||...|||:|..|||...|...|::|...|.|..:.|.|:::...:.:.:.:.
  Fly   452 PEIGA---EATLYVKRAPIITSHKVQFGGVGGRVKIDCLAFSIPKAEHILWSFEGKIINMSSADP 513

Mouse   489 --YTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQ-LEEREVLPV-GIIAGA 549
              |..|..:...||.:.|.|.:.....| ..||||..||:|..:.:|. |.|...:|| .::.|:
  Fly   514 DIYIFEEHHLPEGVRAALIIRDSKATHF-GKYNCTVMNSYGGDSLVITLLREPGNIPVLLVVMGS 577

Mouse   550 TIGAGILVVFSFAALVFFLYRRRKGSRK----DVTLR------KL-DIKVETVNREPLTMHSDRE 603
            .....|:::.   .::..:||:|:..:|    ||...      || ::|.|..::.....:|:..
  Fly   578 MFCVAIILMI---VMIIIVYRKRRSRKKPMPADVIPEASRGGDKLNELKSELRSKAYDVEYSEAG 639

Mouse   604 DDTASISTATRVMKAIYSSFKDDVDLK----------------------------QDLRCDTIDT 640
            .|..:|:.....|        .||.:|                            :......:..
  Fly   640 GDGLAINLTQSPM--------PDVQMKGATLGVPLAGPVKFDERFSGDFGGDRYNRQCHIKNLKN 696

Mouse   641 REE--YEMKDPTNGYYNVRAHEDRPSSRAVLYA-DYRAPGPTRFDGRPSSRLSHSSGYAQLNT-- 700
            ::|  |:.....|||    ||...       || ||..||     |..::.:..|.|..:|..
  Fly   697 QQETAYKGSPQANGY----AHYFE-------YALDYSPPG-----GEGAAVVVGSGGVGKLKNGG 745

Mouse   701 -------YSRAPASDYGTEPTPSGPSAP-----------------------GGTDTTSQLSYEN- 734
                   :|.|...:.|......|.|.|                       .|.|:.....|.|
  Fly   746 MNSATLPHSAAATVNGGGAGNGGGASLPRNQRHEIQQSQQSNGFLGQPLLQNGIDSRFSAIYGNP 810

Mouse   735 YEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTPYEA 771
            |.:.||...|......|.......|||      ||.|
  Fly   811 YLRTNSSLLPPLPPPSTANPAATPAPP------PYHA 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kirrel	XP_011238330.1	Ig	54..148	CDD:386229	43/97 (44%)
		Ig2_KIRREL3-like	170..251	CDD:143236	25/83 (30%)
		Ig	255..336	CDD:386229	29/90 (32%)
		Ig_3	340..421	CDD:372822	21/80 (26%)
		Ig5_KIRREL3	439..536	CDD:143306	29/99 (29%)
kirre	NP_001245505.1	Ig	87..183	CDD:299845	43/95 (45%)
		IG_like	88..182	CDD:214653	41/93 (44%)
		C2-set_2	189..279	CDD:285423	26/90 (29%)
		Ig_2	307..379	CDD:290606	26/75 (35%)
		I-set	382..462	CDD:254352	28/99 (28%)
		IGc2	396..446	CDD:197706	18/66 (27%)
		Ig	466..561	CDD:299845	29/95 (31%)
		IG_like	478..561	CDD:214653	22/83 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838621
Domainoid	1	1.000	87	1.000	Domainoid score	I7972
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	259	1.000	Inparanoid score	I3111
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001084
OrthoInspector	1	1.000	-	-		mtm8709
orthoMCL	1	0.900	-	-		OOG6_103358
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3009
SonicParanoid	1	1.000	-	-		X1593
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.680