DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cacna1c and para

DIOPT Version :9

Sequence 1:XP_021330579.1 Gene:cacna1c / 170581 ZFINID:ZDB-GENE-020129-1 Length:2202 Species:Danio rerio
Sequence 2:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster


Alignment Length:2305 Identity:538/2305 - (23%)
Similarity:897/2305 - (38%) Gaps:678/2305 - (29%)


- Green bases have known domain annotations that are detailed below.


Zfish    12 KHERLEE------EVEVRFKGKLVSERELGYTHVRPGGSNYSSPSLAPVPSLNEDEHVGGGGGVL 70
            :||:.:|      |.||...|:...::|:.|.                    :|||..|      
  Fly    34 EHEKQKELERKRAEGEVPQYGRKKKQKEIRYD--------------------DEDEDEG------ 72

Zfish    71 GLAPEHIPT--PGAPLSWQAAIDAARQAKLMGT-----TGAPISTASSTQRKRQHYTKPKKQAST 128
               |:..||  .|.|:          ..:|.|:     ...|:............:....|....
  Fly    73 ---PQPDPTLEQGVPI----------PVRLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDI 124

Zfish   129 ASTRPPRALLCLTLKNPIRRACINIVEWKPFEIIILMTIFANCVALAVYIPFPEDDSNATNSNLE 193
            ......:|:..|...|||||..|.|:....|.:.|:.||..||:.:.:          .|...:|
  Fly   125 FRFSASKAMWMLDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTPTVE 179

Zfish   194 RVEYLFLIIFTVEAFLKVIAYGLLCHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKGDGGTSMG 258
            ..|.:|..|:|.|:.:||:|.|.:..|..|||:.||.|||:::.:...:.          |..:|
  Fly   180 STEVIFTGIYTFESAVKVMARGFILCPFTYLRDAWNWLDFVVIALAYVTM----------GIDLG 234

Zfish   259 GKAAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELF 323
            ..|      |||.|||||.|:.|:.||.|:.::.::|:::..|..:.:|.:|.:.::|::||:::
  Fly   235 NLA------ALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 293

Zfish   324 MGKMHRTCF--FYKDGHKGHIAEEK--------------------PAPCAPSSAHGRHCSPPNIT 366
            ||.:.:.|.  |..||..|::.:|.                    |. |...|..|: |....: 
  Fly   294 MGVLTQKCIKKFPLDGSWGNLTDENWDYHNRNSSNWYSEDEGISFPL-CGNISGAGQ-CDDDYV- 355

Zfish   367 QCMMGW-EGPNDGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPW--VYFVSLVIFG 428
             |:.|: ..||.|.|:||:|.:|.|:.|:.:|.:.|.|:...:..|.|   ||  ::|:.::..|
  Fly   356 -CLQGFGPNPNYGYTSFDSFGWAFLSAFRLMTQDFWEDLYQLVLRAAG---PWHMLFFIVIIFLG 416

Zfish   429 SFFVLNLVLGVLSGEFSKEREKAKAR--GDFQKLREKQQ--------LEEDLKGYLDWITQ---A 480
            ||:::||:|.:::..:.:.::||:..  .:.:.:||.::        |||...........   |
  Fly   417 SFYLVNLILAIVAMSYDELQKKAEEEEAAEEEAIREAEEAAAAKAAKLEERANAQAQAAADAAAA 481

Zfish   481 ED--IDPE----------------NDDEGLDDDKPR----------------------------- 498
            |:  :.||                ..::|.||:...                             
  Fly   482 EEAALHPEMAKSPTYSCISYELFVGGEKGNDDNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQA 546

Zfish   499 ---------NLSMPAS------------------------------------------------- 505
                     :||:|.|                                                 
  Fly   547 TKVRKVSTTSLSLPGSPFNIRRGSRSSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYAD 611

Zfish   506 ----------ENESV-------------------------------------------------- 510
                      ||.::                                                  
  Fly   612 DSNAVTPMSEENGAIIVPVYYGNLGSRHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLR 676

Zfish   511 --NTDNAPAGDME-GETC-----------------CTRMANRI---------------------- 533
              ||.|...|... |.||                 ||..|.:|                      
  Fly   677 NRNTRNQSVGATNGGTTCLDTNHKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDV 741

Zfish   534 ---------SKSKFSRYSRR------------------------------------WNRLCRRKC 553
                     :..:.||.|.|                                    |:  |   |
  Fly   742 MVLNDIIEQAAGRHSRASDRGVSVYYFPTEDDDEDGPTFKDKALEVILKGIDVFCVWD--C---C 801

Zfish   554 RAAVKSNVFYWLVIF----------LVFLNTLTIASEHHQQPEWLTNVQDIANKVLLALFTGEML 608
            ...:|...:..|::|          .:.:||:.:|.:||...:.:..|....|....|.|..|..
  Fly   802 WVWLKFQEWVSLIVFDPFVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEAT 866

Zfish   609 LKMYSLGLQAYFVSLFNRFDSFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSL 673
            :|:.::..:.||...:|.||..:|...:||..|...:     |:||||..||||:||:.:.|.:|
  Fly   867 MKLMAMSPKYYFQEGWNIFDFIIVALSLLELGLEGVQ-----GLSVLRSFRLLRVFKLAKSWPTL 926

Zfish   674 SNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETR-------RSTFDNFPQSLL 731
            :.|::.:..::.::.:|..:|.:.|.||:::||||||..::..:.|       |..|.:|..|.:
  Fly   927 NLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYHDHKDRFPDGDLPRWNFTDFMHSFM 991

Zfish   732 TVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCI-YFIILFICGNYILLNVFLAIAVDNLADAES 795
            .||::|.|| |...|:|.:       :.|.:.|| :|:...:.||.::||:|||:.:.|.. :.|
  Fly   992 IVFRVLCGE-WIESMWDCM-------YVGDVSCIPFFLATVVIGNLVVLNLFLALLLSNFG-SSS 1047

Zfish   796 LTSAQKEEEEEKERK---KLARTASPEKR---------------QNSEKPPLE------------ 830
            |::...:.:..|..:   ::.|..|..||               |.|::|..|            
  Fly  1048 LSAPTADNDTNKIAEAFNRIGRFKSWVKRNIADCFKLIRNKLTNQISDQPSGERTNQISWIWSEG 1112

Zfish   831 --------------------DE-------KK--EEKIELKSITSDG-----------ETPTATK- 854
                                ||       ||  :|:.:|:....||           ..|..:| 
  Fly  1113 KGVCRCISAEHGDNELELGHDEILADGLIKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKY 1177

Zfish   855 ---------INIDEYTGEDN-----------------EEKNPYPVNDFPAGEDDEEEPEMPVGPR 893
                     .:|:.|....|                 |||......|....|:.:||.|...||.
  Fly  1178 LNNATDDDTASINSYGSHKNRPFKDESHKGSAETMEGEEKRDASKEDLGLDEELDEEGECEEGPL 1242

Zfish   894 PRPL------SDI--QLKEKAVPMPQAKAFFIFSPSN---------KFRVLCHKIVNHNIFTNLI 941
            ...:      .||  :......|....|.|.|.:..:         ..|:...:::.:..|...:
  Fly  1243 DGDIIIHAHDEDILDEYPADCCPDSYYKKFPILAGDDDSPFWQGWGNLRLKTFQLIENKYFETAV 1307

Zfish   942 LFFILLSSISLAAED------PVKNDSFRNQILGYADYVFTGIFTIEIILKMTAYGAFLHKGSFC 1000
            :..||:||::||.||      |:..|     ||.|.|.:||.||.:|:::|..|.|..:    :.
  Fly  1308 ITMILMSSLALALEDVHLPQRPILQD-----ILYYMDRIFTVIFFLEMLIKWLALGFKV----YF 1363

Zfish  1001 RNYFNILDLVVVSVSLI---SSGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIR 1062
            .|.:..||.|:|.||||   :|.:.:..|...|.:|.||.||||||::|.:|::.||..:..||.
  Fly  1364 TNAWCWLDFVIVMVSLINFVASLVGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIP 1428

Zfish  1063 TIGNIVIVTSLLQFMFACIGVQLFKGKFFYCTDTSKQTQAECRGAYILYK-DGNVGKPEKAQRSW 1126
            :|.|:::|..:...:||.:|||||.||:|.|.|.:        |..:.:: ..|....|....:|
  Fly  1429 SIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCEDMN--------GTKLSHEIIPNRNACESENYTW 1485

Zfish  1127 ENSDFNFDDVLQGMMALFAVSTFEGWPGLLYRAIDSHAEDVGPIYNYRVVISIFFIIYIIIIAFF 1191
            .||..|||.|....:.||.|:||:||..::..||||...|..||....:.:.::|:.:||..:||
  Fly  1486 VNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFF 1550

Zfish  1192 MMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEY----------ALKARPLRRYIPKNPYQYK 1246
            .:|:|:|.:|..|.||.::...:.|:...:.|...|          .|||.|..|:.|    |..
  Fly  1551 TLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRP----QAI 1611

Zfish  1247 VWYVVNSTYFEYLMFTLILLNTICLAMQHHGQSQSFNKAMNILNMLFTGLFTVEMILKLIAFKPR 1311
            |:.:|....|:.::...|.||...:.:..:..|.::|..::.||.:|..:|:.|.:||:.|.:..
  Fly  1612 VFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALRYH 1676

Zfish  1312 GYFSDPWNVFDFLIVIGSIIDVILSEINPADPSSSPPSSVVRPMGLQNTEDNARISITFFRLFRV 1376
             ||.:|||:||.::||.||:.::||:|                      .:...:|.|..|:.||
  Fly  1677 -YFIEPWNLFDVVVVILSILGLVLSDI----------------------IEKYFVSPTLLRVVRV 1718

Zfish  1377 M---RLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALRDNSQINR 1438
            .   |:::|:...:||||||:....|..||..:.||:.::.||:|:.||..|  :.:::.|.||.
  Fly  1719 AKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF--MHVKEKSGIND 1781

Zfish  1439 NNNFQTFPQAVLLLFRCATGEAWQEIMLACSPNRPCEKGSEINHSSEDCGSHFAIFYFVSFYMLC 1503
            ..||:||.|:::|||:.:|...|..::.|......|:..........:|||......|:..|::.
  Fly  1782 VYNFKTFGQSMILLFQMSTSAGWDGVLDAIINEEACDPPDNDKGYPGNCGSATVGITFLLSYLVI 1846

Zfish  1504 AFLI-INLFVAVIMDNFDYLTRD-WSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQP 1566
            :||| ||:::|||::|:...|.| ...|.....|.:..||.::|||....|::..:...|..::|
  Fly  1847 SFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEP 1911

Zfish  1567 PLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLF-ALVRTALRIKTEGN-LEQANE--ELRA 1627
            ||...|  |::.   :::||::|: ..|.:|:...:. ||.:.....|  || :|:..|  |:.|
  Fly  1912 PLQIHK--PNKY---KIISMDIPI-CRGDLMYCVDILDALTKDFFARK--GNPIEETGEIGEIAA 1968

Zfish  1628 ---------IVKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVAKI 1683
                     :...:|::.                    :.|...|||..:||.|.|.|.|  ...
  Fly  1969 RPDTEGYEPVSSTLWRQR--------------------EEYCARLIQHAWRKHKARGEGG--GSF 2011

Zfish  1684 PPKTALSLQAGLRTLHDMGPEIRRAISGDLTVEEELERAMKETVCAASEDDIFRVKRSGGLFGNH 1748
            .|.|... ..|.....|..|:  .|..||               ..|..|........|....:.
  Fly  2012 EPDTDHG-DGGDPDAGDPAPD--EATDGD---------------APAGGDGSVNGTAEGAADADE 2058

Zfish  1749 VNYYHQSDGHVSFPQSFTTQRPLHISKSGSPGEAESPSHQKLV----DSTFTPSSYSSSGSNANI 1809
            .|.....:...:...:.........:.:|||| |.|...|..|    |...|             
  Fly  2059 SNVNSPGEDAAAAAAAAAAAAAAGTTTAGSPG-AGSAGRQTAVLVESDGFVT------------- 2109

Zfish  1810 NNANNTAIGHRYPKPTVSTVD--GQTGPPL 1837
            .|.:...|..|.|..|..|.|  .:..|||
  Fly  2110 KNGHKVVIHSRSPSITSRTADVXARPRPPL 2139

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacna1cXP_021330579.1 Ion_trans 156..452 CDD:306908 89/320 (28%)
Ion_trans 559..798 CDD:306908 74/256 (29%)
Ion_trans 934..1211 CDD:306908 101/286 (35%)
Ion_trans 1253..1527 CDD:306908 83/278 (30%)
GPHH 1528..1598 CDD:318993 18/69 (26%)
Ca_chan_IQ 1600..1671 CDD:312334 15/83 (18%)
CAC1F_C 1694..2129 CDD:318975 30/150 (20%)
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 84/303 (28%)
Na_trans_cytopl 515..648 CDD:288761 6/132 (5%)
Ion_trans 835..1028 CDD:278921 60/205 (29%)
Na_trans_assoc 1054..1296 CDD:284034 39/241 (16%)
Ion_trans 1318..1571 CDD:278921 96/269 (36%)
Na_channel_gate 1561..1613 CDD:240441 13/55 (24%)
Ion_trans 1636..1871 CDD:278921 79/259 (31%)
GPHH 1880..1930 CDD:293510 15/54 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.940

Return to query results.
Submit another query.