DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slc5a6 and CG32669

DIOPT Version :9

Sequence 1:	NP_570102.1	Gene:	Slc5a6 / 170551	RGDID:	69648	Length:	634	Species:	Rattus norvegicus
Sequence 2:	NP_727460.1	Gene:	CG32669 / 326229	FlyBaseID:	FBgn0052669	Length:	604	Species:	Drosophila melanogaster

Alignment Length:	576	Identity:	223/576 - (38%)
Similarity:	327/576 - (56%)	Gaps:	53/576 - (9%)

- Green bases have known domain annotations that are detailed below.

  Rat    20 ISTFSVVDYVVFGLLLVLSLVIGLYHACRGWGRHTVGELLMADRKMGCLPVALSLLATFQSAVAI 84
            ::|....||.:..::|::|:.||:|:...|..:.|..|.|:|||.|...|||.||:|:|.|||.|
  Fly     1 MATLGAWDYTILAVVLIISVAIGIYYRFVGGKQSTTTEYLLADRSMNVAPVAFSLMASFMSAVTI 65

  Rat    85 LGGPAEIYRFGTQYWFLGCSYFLGLLIPAHIFIPVFYRLHLTSAYEYLELRFNKAVRICGTVTFI 149
            ||...|.|::||.:..:..||.|...:.|::.|||||||...|.||||||||..|.|:..:::|.
  Fly    66 LGVSMENYQYGTMFVVINLSYVLSTPVAAYLIIPVFYRLKTASVYEYLELRFGYATRLAASLSFS 130

  Rat   150 FQMVVYMGVALYAPSLALNAVTGFDLWLSVLALGIVCNIYTALGGLKAVIWTDVFQTLIMFLGQL 214
            .|||:|||:.:|||:|||.||||.....|::.:|:||..|..|||:|||:.||::|:|:||....
  Fly   131 LQMVLYMGIVVYAPALALEAVTGLSQVFSIVIVGVVCTFYATLGGMKAVLITDIYQSLLMFAAVF 195

  Rat   215 VVIIVGAAKVGGLGHVWAVASQHGLISGIELDPDPFVRHTFWTLAFGGVFMMLSLYGVNQAQVQR 279
            .|||....|.|.|..:|.||.::|.|:......||..|||::|...||....|::|||||.||||
  Fly   196 SVIICAWVKAGSLEVIWRVAQENGRINLTNFSVDPTERHTWFTQILGGCATYLAIYGVNQTQVQR 260

  Rat   280 YLSSHSEKAAVLSCYAVFPCQQVALCM----SCLIGLVMFAYYKKYSMSPQQEQAAPDQLVLYFV 340
            .::..|..||..:.:...|    .||:    :|..||.::.||:......:....:.||::..||
  Fly   261 LMAVKSLSAARAALWWCLP----ILCLLSLSTCFSGLCIYWYYRDCDPLLEGRVNSRDQVMPLFV 321

  Rat   341 MDLLKDMPGLPGLFVACLFSGSLSTISSAFNSLATVTMEDLIQPWFP-----QLTETRAIMLSRS 400
            :|.:.:..||.||||:.:|..|||||||..:|||.||:||.::|...     .||:.:.:..|:.
  Fly   322 VDTMGEYTGLAGLFVSGIFCASLSTISSIISSLAAVTLEDYLKPLVSCCAKRTLTDRQTLWYSKL 386

  Rat   401 LAFAYGLVCLGMAYVSSHLGSVLQAALSIFGMVGGPLLGLFCLGMFFPCANPLGAIVGLLTGLTM 465
            |:..:|.:|:|||:::..:|.:|||||||||::||||||||.|||:...||..|||.|||..|..
  Fly   387 LSLFFGALCIGMAFMAGSIGGLLQAALSIFGIIGGPLLGLFTLGMYVTKANEKGAIGGLLISLAF 451

  Rat   466 AFWIGIGS----IVSRMSSAAASPPLNGSSS---FLPSNLTVATVTTLMPSTLSKPTGLQQFYSL 523
            .||||.|.    :|| :..:.|..|::.|.:   ||.:.:.||           :.......|.:
  Fly   452 CFWIGFGQPKPPLVS-LDMSTAGCPVDRSFARDIFLKTVIAVA-----------EEEHYFYLYRI 504

  Rat   524 SYLWYSAHNSTTVIAVGLIVSLLTGGMRGRSLNPGTIYPVLPKLLALLPLSCQKRL 579
            ||:||:        |:|.:::...|.:             |..|.|||.....:|:
  Fly   505 SYMWYA--------ALGFLITFFGGWL-------------LSWLFALLKWDNNRRI 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc5a6	NP_570102.1	SLC5-6-like_sbd	23..548	CDD:382020	215/540 (40%)
CG32669	NP_727460.1	SLC5sbd_NIS-SMVT	7..527	CDD:271383	217/556 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354567
Domainoid	1	1.000	371	1.000	Domainoid score	I866
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	433	1.000	Inparanoid score	I1652
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D327628at2759
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	1	1.000	-	-		mtm9146
orthoMCL	1	0.900	-	-		OOG6_101204
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.900