DRSC/TRiP Functional Genomics Resources

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Protein Alignment DHX36 and bgcn

DIOPT Version :10

Sequence 1:NP_065916.2 Gene:DHX36 / 170506 HGNCID:14410 Length:1008 Species:Homo sapiens
Sequence 2:NP_523832.2 Gene:bgcn / 47873 FlyBaseID:FBgn0004581 Length:1215 Species:Drosophila melanogaster


Alignment Length:1022 Identity:227/1022 - (22%)
Similarity:403/1022 - (39%) Gaps:237/1022 - (23%)


- Green bases have known domain annotations that are detailed below.


Human   153 KMFRIRNRSYIDRDSEY------------LLQENEPDGTLDQKLLEDLQKKK---NDLRYIEMQ- 201
            |:::...|.|::.....            ||......|..|.:|..||...|   :||..:.:. 
  Fly    62 KVYKQACRHYLEEPKTLVLSSGATLNMFTLLSRKSLMGKEDLELYADLVSMKANASDLPSLHLPL 126

Human   202 ----------------HFREKLPSYGMQKELVNLIDNHQVTVISGETGCGKTTQVTQFILDNYIE 250
                            :|......:.:..|::..:...:|.|.:......|:..:...|||:.  
  Fly   127 PAIRPPNLRFWTEAQLNFLTAFLGHSLSDEILQSLYASRVIVYNAALCWDKSVFLPLVILDDC-- 189

Human   251 RGKGSACRIVCTQPRRISAISVAERVAAERAESCGSGNSTGYQIRLQSRLPRKQGSILYCTTGII 315
            |.|.|..:|:|.:.:.|.|...::|.|....|..  |.:.|.|:...|.: .....|:|.|....
  Fly   190 RNKKSNVKIMCIERQAILATYNSQRTANFFGEQL--GETVGIQLPYFSAV-SSSTFIIYSTAQYF 251

Human   316 LQWLQSDPYLSSVSHIVLDEIHERNLQSDVLMTVVKDLLNFRSDLKVILMSATLNAEKFSEYFG- 379
            |:.|.|..: .::||:|::::|..:..:|:|::.::..|:...:|:|:|:|...|.:||:::|| 
  Fly   252 LRSLTSQQF-RNISHLVVNDVHLHDPYTDILLSEIRMALSSHQNLRVVLLSQMGNPKKFTDFFGE 315

Human   380 --NCPMIHIPGFTFPVVEYLLE--------------DVIEKIRYVPEQKEHRSQFKRGFMQGHVN 428
              ...||..|... |.|.||.|              |:.::|   ||          .|...:..
  Fly   316 GLQLNMIKQPEVA-PRVSYLNELHSCIALAGIHKGPDIYKEI---PE----------AFRANNPR 366

Human   429 RQEKEEKEAIYKERWPD------------------------------------------------ 445
            .::.::....|.|...|                                                
  Fly   367 NEQMDKCLQAYGELGTDAALRPFLYAVNYDLAPVNYRHSLTGKTAVHFASELNKANHLRLLLFMG 431

Human   446 ---YVRELRRRYSAS---------TVD----------VIEMMEDDKVDLNLIVALI-------RY 481
               |:.:|.::.:.|         .:|          |::..:.|.||.:||:.::       .|
  Fly   432 ADPYIVDLFQQNAISLAAMNGNHECIDVLNSYSLHGYVVKSAKPDFVDYDLIIDIMYLLRTKPEY 496

Human   482 IVLEEEDGAILVFLPGWDNISTLHDLLMSQVMFKS----DKFLIIP------LHSLMPTVNQTQV 536
            ...|...|.||:.||.:.:|..|:.:::|..:..|    ..||:..      |.:|:...::|. 
  Fly   497 SPGEYSPGNILIILPTYYHIVKLNYMILSHCLTGSLQECSIFLLYDNMRNDYLQALVNASDETV- 560

Human   537 FKRTPPGVRKIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQR-- 599
                     |:|:||:|.|:........|.||........:||.:.......|||:|....:|  
  Fly   561 ---------KVVLATDIIESLCLKVPFKYQIDTACRLNNVYDTTSCSGDDRFEWVAKDALLRREL 616

Human   600 --KGRAGRVQPGHCYHLYNGLRASLLDDYQLPEILRTPLEELCLQIKILRLGG-IAYFLSRLMDP 661
              :...|.||   |:.|.:......|.:...|.:....|:::||.:|:|.... |:.:|...:.|
  Fly   617 ILQPNKGDVQ---CFRLISKEAYEELSETSQPSLQTMQLDKICLAVKLLSPNTIISEYLGITISP 678

Human   662 PSNEAVLLSIRH----LMELNALDKQEELTPLGVHLARLPVEPHIGKMILFGALFCCLDPVLTIA 722
            |.    |:::.|    |.:::.||..|::|.||..|..:||...:|:|::||.|..||||:|||.
  Fly   679 PP----LINVHHAVQFLKKIDVLDDAEDVTWLGCRLMDIPVSCQLGRMLIFGILLRCLDPILTIV 739

Human   723 ASLSFKDPFVIPLGKE----------KIADARRKE---LAKDTRSDHLTVVNAFEGWEEA--RRR 772
            :|||..||..||..::          .|.::.:||   |:.:..|||...|..::.|:..  .|.
  Fly   740 SSLSTADPLGIPFTEDIDNLWDRFTIYIQNSIKKERTYLSDNQFSDHFIFVRLYKEWQNRMHNRT 804

Human   773 GFRYEKDYCWEY-FLSSNTLQMLHNMKGQFAEHLLGAGFVSSRNPKDPESNIN--SDNEKIIKAV 834
            ...|.||   || |:.:..::.|.:::.:....|..|..:.||. |...:|:|  |.|..::||.
  Fly   805 PPLYLKD---EYEFMLNGLMEQLTSIRSEIVSSLRAANLIHSRG-KLSMNNLNQMSCNWHMVKAA 865

Human   835 ICAGLYPKVAKIRLNLGKKRKMVKVYTKTDGLVAVHPKSV--------NVEQTDFHYNWLIYHLK 891
            :..|:||.:..:..   :|..:...::   |.|::||.:|        |:....|...|::.:  
  Fly   866 LTGGMYPNIYAVDT---RKSSLKSAFS---GNVSMHPNTVLRDFLEPLNISAQSFRTPWIVCN-- 922

Human   892 MRTSSIYLYDCTEVSPYCLLFFGG----------DISIQKDNDQETIAVDEWIVFQSPARIAHLV 946
             |..|..:| .|.|.|..:..|.|          |..:...:....:.:||||........|.:|
  Fly   923 -RQKSHIVY-ATLVVPLAVAMFSGHPRIRLSPICDSEMSLTDRNVNVFIDEWIWMVMSKATAEMV 985

Human   947 KELRKELDILLQEKIESPHPVD-WNDTKSRDCAVLSAIIDLIKTQEK 992
            ...|.....:..:.::....:| |.    |||..:|....|..|..|
  Fly   986 MRTRYYFFKMYHDLLKHCSELDMWR----RDCEPVSQYTVLTDTLSK 1028

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DHX36NP_065916.2 Necessary for nuclear and nucleolar caps localizations. /evidence=ECO:0000269|PubMed:18279852 1..200 13/61 (21%)
Required for the pre-miR-134 transport. /evidence=ECO:0000250|UniProtKB:D4A2Z8 1..104
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..58
Required for recruitment to cytoplasmic stress granules. /evidence=ECO:0000269|PubMed:18854321 1..51
Required for G4-DNA-and G4-RNA-binding. /evidence=ECO:0000269|PubMed:21149580, ECO:0000269|PubMed:21846770, ECO:0000269|PubMed:24151078 53..105
DSM (DHX36-specific motif). /evidence=ECO:0000269|PubMed:20472641, ECO:0000269|PubMed:22238380, ECO:0000269|PubMed:24369427, ECO:0000269|PubMed:26195789, ECO:0000269|PubMed:26649896 53..75
RecA-like domain 1. /evidence=ECO:0000250|UniProtKB:Q05B79 106..386 59/267 (22%)
DEXHc_DHX36 207..386 CDD:350739 45/181 (25%)
HrpA 215..>776 CDD:441249 158/688 (23%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 265..317 12/51 (24%)
DEAH box. /evidence=ECO:0000255|PROSITE-ProRule:PRU00541 334..337 0/2 (0%)
RecA-like domain 2. /evidence=ECO:0000250|UniProtKB:Q05B79 387..628 62/345 (18%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 498..557 15/68 (22%)
Nuclear localization signal. /evidence=ECO:0000303|PubMed:14731398 517..528 3/16 (19%)
WH domain. /evidence=ECO:0000250|UniProtKB:Q05B79 629..698 20/73 (27%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 638..697 18/63 (29%)
OB_NTP_bind 831..917 CDD:400182 22/103 (21%)
OB-fold-like subdomains. /evidence=ECO:0000250|UniProtKB:Q05B79 841..905 14/71 (20%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 849..860 1/10 (10%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 870..900 8/37 (22%)
bgcnNP_523832.2 DEAD-like_helicase_N 155..314 CDD:475120 41/164 (25%)
ANKYR <398..>460 CDD:440430 4/61 (7%)
ANK repeat 406..438 CDD:293786 1/31 (3%)
P-loop containing Nucleoside Triphosphate Hydrolases 465..>594 CDD:476819 31/138 (22%)
HA2 687..789 CDD:461295 36/101 (36%)
OB_NTP_bind 862..945 CDD:400182 21/92 (23%)
Blue background indicates that the domain is not in the aligned region.

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