DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment DHX36 and mle

DIOPT Version :10

Sequence 1:NP_065916.2 Gene:DHX36 / 170506 HGNCID:14410 Length:1008 Species:Homo sapiens
Sequence 2:NP_476641.1 Gene:mle / 35523 FlyBaseID:FBgn0002774 Length:1293 Species:Drosophila melanogaster


Alignment Length:1083 Identity:354/1083 - (32%)
Similarity:559/1083 - (51%) Gaps:166/1083 - (15%)


- Green bases have known domain annotations that are detailed below.


Human    17 SSGGGYGGGPAGGHGGNRGSGGGG-------GGGGGGRGGRGRHPGHLKGREIGMWYA-----KK 69
            :..|..||||..|..|...:||.|       |..|....|....|.:..|.:.|..|:     ::
  Fly    81 ADAGASGGGPRTGLEGAGMAGGSGQQKRVFDGQSGPQDLGEAYRPLNHDGGDGGNRYSVIDRIQE 145

Human    70 QGQKNKEAERQERAVVH----MDERREE-QIVQLLNSVQ---------AKNDKESEAQISWFAP- 119
            |...|:.......|.:|    ::..:|. .|.:..|:::         .::.:...|::|.:.| 
  Fly   146 QRDMNEAEAFDVNAAIHGNWTIENAKERLNIYKQTNNIRDDYKYTPVGPEHARSFLAELSIYVPA 210

Human   120 -------EDHGYGTEVSTKNTPCS------------------ENKLDIQEK--------KLINQE 151
                   .:.|...:.::|:...|                  :.|.|.|.|        .|||:.
  Fly   211 LNRTVTARESGSNKKSASKSCALSLVRQLFHLNVIEPFSGTLKKKKDEQLKPYPVKLSPNLINKI 275

Human   152 KKMFR-----------------------IRNRSYID---RDSEYLLQE----------------- 173
            .::.:                       |.|.|.||   :|.|...:.                 
  Fly   276 DEVIKGLDLPVVNPRNIKIELDGPPIPLIVNLSRIDSSQQDGEKRQESSVIPWAPPQANWNTWHA 340

Human   174 -NEPDGTLDQKLLEDL---------QKKKNDLRYIEMQHFREKLPSYGMQKELVNLIDNHQVTVI 228
             |..:|.|....::||         .:::||..|.:...||||||...|:.|::..|:::.|.:|
  Fly   341 CNIDEGELATTSIDDLSMDYERSLRDRRQNDNEYRQFLEFREKLPIAAMRSEILTAINDNPVVII 405

Human   229 SGETGCGKTTQVTQFILDNYIERGKGSACRIVCTQPRRISAISVAERVAAERAESCGSGNSTGYQ 293
            .|.||||||||:.|:|||:||..|:|....|..||||||||||||||||.||.|..  |::.||.
  Fly   406 RGNTGCGKTTQIAQYILDDYICSGQGGYANIYVTQPRRISAISVAERVARERCEQL--GDTVGYS 468

Human   294 IRLQSRLPRKQGSILYCTTGIILQWLQSDPYLSSVSHIVLDEIHERNLQSDVLMTVVKDLLNFRS 358
            :|.:|..||..|:||:||.|::|:.|::.  |..||||::||||||::.||.|:.:::|:::...
  Fly   469 VRFESVFPRPYGAILFCTVGVLLRKLEAG--LRGVSHIIVDEIHERDVNSDFLLVILRDMVDTYP 531

Human   359 DLKVILMSATLNAEKFSEYFGNCPMIHIPGFTFPVVEYLLEDVIEKIRYVPEQKEHRSQFKRGFM 423
            ||.|||||||::..|||:|||.||::.:||..|||.::.|||:|:...:||..:..|        
  Fly   532 DLHVILMSATIDTTKFSKYFGICPVLEVPGRAFPVQQFFLEDIIQMTDFVPSAESRR-------- 588

Human   424 QGHVNRQEKEEKEAIYKERWPD----YVRELRRRYSASTVDVIEMMEDDKVDLNLIVALIRYIVL 484
                .|:|.|::|.:..|...:    |.:....:||..|.:.:.|:.:..|...|:.||:.:|..
  Fly   589 ----KRKEVEDEEQLLSEDKDEAEINYNKVCEDKYSQKTRNAMAMLSESDVSFELLEALLMHIKS 649

Human   485 EEEDGAILVFLPGWDNISTLHDLLMSQVMF-KSDKFLIIPLHSLMPTVNQTQVFKRTPPGVRKIV 548
            :...||||||||||:.|..|...|.:..:| .:.::.|:|.||.:|...|.:||:..|.||.||:
  Fly   650 KNIPGAILVFLPGWNLIFALMKFLQNTNIFGDTSQYQILPCHSQIPRDEQRKVFEPVPEGVTKII 714

Human   549 IATNIAETSITIDDVVYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRKGRAGRVQPGHCYH 613
            ::||||||||||||:|:|||..|.:...|.:.||:::.:..|.||.|.:|||||||||:||.|:.
  Fly   715 LSTNIAETSITIDDIVFVIDICKARMKLFTSHNNLTSYATVWASKTNLEQRKGRAGRVRPGFCFT 779

Human   614 LYNGLRASLLDDYQLPEILRTPLEELCLQIKILRLGGIAYFLSRLMDPPSNEAVLLSIRHLMELN 678
            |.:..|...|:|...||:.||||.|:.|.||:||||.|.:|||:.::||..:||:.:...|.|:.
  Fly   780 LCSRARFQALEDNLTPEMFRTPLHEMALTIKLLRLGSIHHFLSKALEPPPVDAVIEAEVLLREMR 844

Human   679 ALDKQEELTPLGVHLARLPVEPHIGKMILFGALFCCLDPVLTIAASLS--FKDPFVIPLGKEKIA 741
            .||..:||||||..|||||:||.:|||::.||:|.|.| ::.|.||.|  |.:.|.:.:|:.::|
  Fly   845 CLDANDELTPLGRLLARLPIEPRLGKMMVLGAVFGCAD-LMAIMASYSSTFSEVFSLDIGQRRLA 908

Human   742 DARRKELAKDTRSDHLTVVNAFEGWEEARRRGFRYEKDYC-WEYFLSSNTLQMLHNMKGQFAEHL 805
            : .:|.|:....|||:.::.|.:.|...::||...|..:| |: .|..:|:.::.:.|.|..:.|
  Fly   909 N-HQKALSGTKCSDHVAMIVASQMWRREKQRGEHMEARFCDWK-GLQMSTMNVIWDAKQQLLDLL 971

Human   806 LGAGFVSSRNPK------DPESNINSDNE--KIIKAVICAGLYPKVAKIRLNLGKKRKMVKVYTK 862
            ..|||     |:      :.:..|:.|:.  .:..|::|.||||.:...:    :|||::...:|
  Fly   972 QQAGF-----PEECMISHEVDERIDGDDPVLDVSLALLCLGLYPNICVHK----EKRKVLTTESK 1027

Human   863 TDGLVAVHPKSVNVEQ--TDFHYNWLIYHLKMRTSSIYLYDCTEVSPYCLLFFGG-DISIQKDND 924
            .   ..:|..|||...  ..|.|.:.::..|:||.::.....:.|||..::.||. .|.:..:| 
  Fly  1028 A---ALLHKTSVNCSNLAVTFPYPFFVFGEKIRTRAVSCKQLSMVSPLQVILFGSRKIDLAANN- 1088

Human   925 QETIAVDEWIVFQSPARIAHLVKELRKELDILLQEKIESPHPV 967
              .:.||.|:.|.....:|..:..|:..|:.|:....::|..:
  Fly  1089 --IVRVDNWLNFDIEPELAAKIGALKPALEDLITVACDNPSDI 1129

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DHX36NP_065916.2 Necessary for nuclear and nucleolar caps localizations. /evidence=ECO:0000269|PubMed:18279852 1..200 52/295 (18%)
Required for the pre-miR-134 transport. /evidence=ECO:0000250|UniProtKB:D4A2Z8 1..104 24/112 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..58 14/47 (30%)
Required for recruitment to cytoplasmic stress granules. /evidence=ECO:0000269|PubMed:18854321 1..51 13/40 (33%)
Required for G4-DNA-and G4-RNA-binding. /evidence=ECO:0000269|PubMed:21149580, ECO:0000269|PubMed:21846770, ECO:0000269|PubMed:24151078 53..105 11/70 (16%)
DSM (DHX36-specific motif). /evidence=ECO:0000269|PubMed:20472641, ECO:0000269|PubMed:22238380, ECO:0000269|PubMed:24369427, ECO:0000269|PubMed:26195789, ECO:0000269|PubMed:26649896 53..75 5/26 (19%)
RecA-like domain 1. /evidence=ECO:0000250|UniProtKB:Q05B79 106..386 123/366 (34%)
DEXHc_DHX36 207..386 CDD:350739 91/178 (51%)
HrpA 215..>776 CDD:441249 246/567 (43%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 265..317 29/51 (57%)
DEAH box. /evidence=ECO:0000255|PROSITE-ProRule:PRU00541 334..337 2/2 (100%)
RecA-like domain 2. /evidence=ECO:0000250|UniProtKB:Q05B79 387..628 94/245 (38%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 498..557 23/59 (39%)
Nuclear localization signal. /evidence=ECO:0000303|PubMed:14731398 517..528 4/10 (40%)
WH domain. /evidence=ECO:0000250|UniProtKB:Q05B79 629..698 36/68 (53%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 638..697 29/58 (50%)
OB_NTP_bind 831..917 CDD:400182 24/88 (27%)
OB-fold-like subdomains. /evidence=ECO:0000250|UniProtKB:Q05B79 841..905 14/65 (22%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 849..860 3/10 (30%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 870..900 9/31 (29%)
mleNP_476641.1 DSRM_DHX9_rpt1 2..70 CDD:380683
DSRM_DHX9_rpt2 167..241 CDD:380684 9/73 (12%)
DEXHc_DHX9 326..559 CDD:350730 103/236 (44%)
HrpA 378..>889 CDD:441249 237/527 (45%)
OB_NTP_bind 1002..1079 CDD:400182 23/83 (28%)
Blue background indicates that the domain is not in the aligned region.

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