DRSC/TRiP Functional Genomics Resources

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Protein Alignment DHX36 and CG32533

DIOPT Version :10

Sequence 1:NP_065916.2 Gene:DHX36 / 170506 HGNCID:14410 Length:1008 Species:Homo sapiens
Sequence 2:NP_728244.1 Gene:CG32533 / 32933 FlyBaseID:FBgn0052533 Length:1139 Species:Drosophila melanogaster


Alignment Length:1051 Identity:282/1051 - (26%)
Similarity:446/1051 - (42%) Gaps:246/1051 - (23%)


- Green bases have known domain annotations that are detailed below.


Human    80 QERAVVHMDERREEQI-----------VQLLNSVQAKNDK------ESEAQISWFAPEDHGYGTE 127
            :::|..|...||..||           .:|:..:|||:.:      |:||....|..:   |...
  Fly     5 KKKADEHASSRRRTQINLIEFSFLDHKAELVGLLQAKSRQVGRSLVENEADFWKFVGK---YEAM 66

Human   128 VSTKNTPCSENKLDIQEKKLINQEKKMFRIRNRS---YIDRDSEYLLQE--NEPDGTLDQKLLE- 186
            :.:...|       :...:|...|....:..:||   .:..|::.||||  ::........||. 
  Fly    67 MRSTGQP-------VLPPRLAEAELSSMQPYHRSKHLALRLDADELLQEARDQMQSQFRHILLVY 124

Human   187 -DLQKKKNDLRYIEMQHFREKLPSYGMQKELVNLIDNHQVTVISGETGCGKTTQVTQFILDNYIE 250
             |.::.:...|..:::..:..||....:|:|...:|..:|.:::|:|||||:|||.|::.|    
  Fly   125 LDFRQTEKFQRIRKLRQTQRNLPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYD---- 185

Human   251 RGKGSACRIVCTQPRRISAISVAERVAAERAESCGSGNSTGYQIRLQSRLPRKQGSILYCTTGII 315
            .|..|   |.||||||::.:|:.:|||.|..:..||  ...:|||.: |...|..:||:.|.|::
  Fly   186 FGYRS---IACTQPRRLACVSLCKRVAHELLDDYGS--RVAFQIRFE-RSRTKLTNILFITEGLL 244

Human   316 LQWLQSDPYLSSVSHIVLDEIHERNLQSDVLMTVVKDLLNFRSDLKVILMSATLNAEKFSEYFG- 379
            |:.|.....|.....::|||||||||..|.|:.|.|.||..|..||:||||||:|.|.|..||| 
  Fly   245 LRQLAVAANLDQYDALILDEIHERNLFGDFLLGVTKCLLRARPQLKLILMSATINVELFHGYFGE 309

Human   380 -NCPMIHIPGFTFPVVEYLLEDVIEKIRYVP----EQKEHRSQFKRGFMQGHVNRQEKEEKEAIY 439
             ...::.:||..||:          |:||:|    |.|..::..||.                  
  Fly   310 EGARLVQVPGRLFPI----------KLRYLPPPALELKAGQATSKRS------------------ 346

Human   440 KERWPDYVRELRRRYSASTVDVIEMMEDDKVDLNLIVALIRYIVLEEEDGAILVFLPGWDNIST- 503
                     :..|...|..|.|:.:::.            :|..  .|.|.:|:|:.|.:.|.: 
  Fly   347 ---------QRNRIDPAPFVQVLSLIDQ------------QYPT--SERGDVLIFVSGVNEIESV 388

Human   504 ---LHDLLMSQVMFKSDKFLIIPLHSLMPTVNQTQVFKRTPPGVRKIVIATNIAETSITIDDVVY 565
               :|:....|.     .:|::||||.....:|::||...|.|:||.:::|||||||:|:|.|.:
  Fly   389 VEAVHEYATEQT-----HWLVLPLHSGQAIADQSKVFDYAPEGMRKCIVSTNIAETSLTVDGVRF 448

Human   566 VIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRKGRAGRVQPGHCYHLYNGLRASLLDDYQLPE 630
            |:|.||:||.:||.......:...||||::|.||||||||..||.|:.||...:.:..:.|..||
  Fly   449 VVDSGKVKEMNFDATCKGQRLKEFWVSKSSADQRKGRAGRTGPGVCFRLYTAEQYNAFEAYPTPE 513

Human   631 ILRTPLEELCLQIKILRLGGIAYFLSRLMDPPSNEAVLLSIRHLMELNALDKQEELTPLGVHLAR 695
            |.|.||:.:.||:..:.|..:..|  ..::.|..|.:..:|..|.:..||..:|::||||..||.
  Fly   514 IYRVPLDTMLLQMVSMGLPDVRAF--PFIEAPETERIEQTILALKQHCALSVEEKITPLGRSLAN 576

Human   696 LPVEPHIGKMILFGALFCCLDPVLTIAASLSFKDPFVIPLGKEKIADARRKELAKDTRSDHLTVV 760
            ||||..||||:|.|::|..::.:||:||.||.::|.......::.....|:.|..| ..|..|:|
  Fly   577 LPVELSIGKMLLMGSVFPEVEQLLTLAAMLSVQNPLTNRAHTDQRCVRERESLESD-HGDLFTLV 640

Human   761 NAFEGWEE--ARRRGFRYEKDYCWEYFLSSNTLQMLHNMKGQFAEHLLGAGFVSSRNPKDPESNI 823
            ..:..|.:  .||.|.|   .:|....:.......:..::.||...|...|.|.:   .|.:|.:
  Fly   641 RLYNVWVQLKMRRDGTR---QWCRRLGIEEQRFYEVTKLRQQFQRILESCGMVVA---SDSDSQL 699

Human   824 NS----------------------------------------DNEK------------------- 829
            .|                                        |.|:                   
  Fly   700 TSAERATRHGELRQLKAMKRRQRFEQPRQRKLLKQSAGRVAEDEEEQEEAQGDDMRDVDFRLRFD 764

Human   830 --------------------IIKAVICAGLYPKVA-KIRLNLGKKRKMVKVYTKTDGLVAVHPKS 873
                                ::|.::.:|.||::| ....|..|.......:|:....|..||.|
  Fly   765 PRQLALLERSSRLDRHSVVVLLKLLLGSGFYPQLAISDEFNYCKGGGQQFFHTRLKPFVLQHPNS 829

Human   874 --------VNVEQTDF---------------HYNWLIYHLKMRTSSIYLYDCTEV-SPYCLLFFG 914
                    :.:.::|.               .:..|.|...:.|:..||.:|..: :...||.| 
  Fly   830 QFAKHFELLKLTESDLLPKPDFYTPKLPLSKRHQLLCYQSLLETAKPYLINCIRLPAAQTLLLF- 893

Human   915 GDISIQKDNDQETIAVDEWIVFQSP-----ARIAHLVKELRKELDILLQEKI-------ESP-HP 966
             ..:|..:.....||.|.|:....|     ..:.....|||:....||.:|:       ||| |.
  Fly   894 -SFAIDTNAGITQIACDGWLGLDLPMPGSGMELLRRAIELRRRWSRLLYDKLDDLKSKQESPSHS 957

Human   967 VD------WND 971
            .|      |.|
  Fly   958 SDDRSSALWQD 968

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DHX36NP_065916.2 Necessary for nuclear and nucleolar caps localizations. /evidence=ECO:0000269|PubMed:18279852 1..200 29/143 (20%)
Required for the pre-miR-134 transport. /evidence=ECO:0000250|UniProtKB:D4A2Z8 1..104 7/34 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..58
Required for recruitment to cytoplasmic stress granules. /evidence=ECO:0000269|PubMed:18854321 1..51
Required for G4-DNA-and G4-RNA-binding. /evidence=ECO:0000269|PubMed:21149580, ECO:0000269|PubMed:21846770, ECO:0000269|PubMed:24151078 53..105 8/35 (23%)
DSM (DHX36-specific motif). /evidence=ECO:0000269|PubMed:20472641, ECO:0000269|PubMed:22238380, ECO:0000269|PubMed:24369427, ECO:0000269|PubMed:26195789, ECO:0000269|PubMed:26649896 53..75
RecA-like domain 1. /evidence=ECO:0000250|UniProtKB:Q05B79 106..386 94/294 (32%)
DEXHc_DHX36 207..386 CDD:350739 75/180 (42%)
HrpA 215..>776 CDD:441249 197/572 (34%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 265..317 18/51 (35%)
DEAH box. /evidence=ECO:0000255|PROSITE-ProRule:PRU00541 334..337 2/2 (100%)
RecA-like domain 2. /evidence=ECO:0000250|UniProtKB:Q05B79 387..628 74/248 (30%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 498..557 20/62 (32%)
Nuclear localization signal. /evidence=ECO:0000303|PubMed:14731398 517..528 5/10 (50%)
WH domain. /evidence=ECO:0000250|UniProtKB:Q05B79 629..698 24/68 (35%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 638..697 17/58 (29%)
OB_NTP_bind 831..917 CDD:400182 22/110 (20%)
OB-fold-like subdomains. /evidence=ECO:0000250|UniProtKB:Q05B79 841..905 16/87 (18%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 849..860 2/10 (20%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 870..900 8/52 (15%)
CG32533NP_728244.1 HrpA 145..>619 CDD:441249 190/541 (35%)
OB_NTP_bind 792..897 CDD:400182 21/106 (20%)
Blue background indicates that the domain is not in the aligned region.

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