DRSC/TRiP Functional Genomics Resources

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Protein Alignment DHX36 and CG8915

DIOPT Version :10

Sequence 1:NP_065916.2 Gene:DHX36 / 170506 HGNCID:14410 Length:1008 Species:Homo sapiens
Sequence 2:NP_573208.1 Gene:CG8915 / 32715 FlyBaseID:FBgn0030833 Length:976 Species:Drosophila melanogaster


Alignment Length:964 Identity:295/964 - (30%)
Similarity:474/964 - (49%) Gaps:135/964 - (14%)


- Green bases have known domain annotations that are detailed below.


Human    42 GGGGGRGGRGRHPGHLKGREIGMWYAKKQGQKNKEAERQERAVVHMDERREEQIV-QLLNSVQAK 105
            ||..|.|.:...||                 ||.:|:..:: :...||:...|:| ..|.|.:.:
  Fly    37 GGPKGTGKQKTRPG-----------------KNAKADAGDK-LKSEDEKMLRQLVDDFLQSCEPE 83

Human   106 ND-----KESEAQISWFA-----------PEDHGYGTEVSTKNTPCSE---------NKLDI--- 142
            ..     |...:.:...|           ||::    .|...:.|.|:         .||||   
  Fly    84 KQLPGLTKAQRSHVHRLAQHRGLKTVSKGPEEN----RVLFISRPQSDGQQQYILCNTKLDICPP 144

Human   143 -----------QEKKLINQEKKMFRIRNRSYIDRDSEYLLQENEPDGTLDQKLLEDLQKKKNDLR 196
                       .|::|:|....: :...:.|.|    ..|..|  .|.:.|:|:...|..:|.  
  Fly   145 LLDVLGQMAGNVERRLMNSVGDL-KCNKQQYKD----IRLPSN--FGLVGQRLIPPPQSNRNR-- 200

Human   197 YIEMQHFREKLPSYGMQKELVNLIDNHQVTVISGETGCGKTTQVTQFILDNYIERGKGSACRIVC 261
              .:||.|..||.|..::.::|::...||.:|.|.||.||:||:.|:||:...|.  .:..|||.
  Fly   201 --NIQHERRSLPIYKQRESILNVLQRDQVLIIKGATGSGKSTQLPQYILEWAAEH--RAPVRIVV 261

Human   262 TQPRRISAISVAERVAAERAESCGSGNSTGYQIRLQSRLPRKQGSILYCTT-GIILQWLQSD--P 323
            :|||||:||||:||::.||.|:  .|.:.||.||:..:.  ...::|..|| |.:|:.|..|  .
  Fly   262 SQPRRIAAISVSERISKERGEA--PGTTVGYNIRMNRQC--SSNTVLMLTTSGCLLRALAMDKKS 322

Human   324 YLSSVSHIVLDEIHERNLQSDVLMTVVKDLLNFRSDLKVILMSATLNAEKFSEYFGNCPMIHIPG 388
            :..:.:|:::||.|||:|.:|.|:...|..|.....|:::|||||::.|..|.|||...::.:.|
  Fly   323 FFKNTTHLIIDEAHERDLDTDFLLLATKLELQKNPHLRLVLMSATMDLEALSNYFGGGTVMDVEG 387

Human   389 FTFPVVEYLLEDVIEKIRYVPEQKEHRSQFKRGFMQGHVNRQEKEEKEAIYKERWPDYVRELRRR 453
            .:|.|..|.|||::.|..|:..:.|.       |:.....::...|..|.|              
  Fly   388 RSFEVSIYHLEDILSKTGYMHPRMEK-------FLGKPTGKETPSELLAAY-------------- 431

Human   454 YSASTVDVIEMMEDDKVDLNLIVALIRYIVLEEEDGAILVFLPGWDNISTLHDLLMSQVMFKSDK 518
            |..:|:     :..| :|.:|||:|:..::.:.:.||::|:|||:.::::|...|.|.:  ..::
  Fly   432 YGGNTI-----VHPD-IDNDLIVSLLELLLRQGDAGAVIVYLPGYSDMTSLLARLESSL--PREQ 488

Human   519 FLIIPLHSLMPTVNQTQVFKRTPPGVR-KIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQNN 582
            ..||.|||.:....|.:|| ||.|||| ||:::|||.:|||||.|::||||.|..|...:|:..:
  Fly   489 ITIILLHSQVDNSEQRKVF-RTYPGVRLKIILSTNIGQTSITIPDLLYVIDTGLAKMKTYDSTID 552

Human   583 ISTMSAEWVSKANAKQRKGRAGRVQPGHCYHLYNGLRASLLDDYQLPEILRTPLEELCLQIKILR 647
            .|.::..|:|:|:||||.||||||..|:||.||:..|.:.::.|.:|||:|..|:|:||..|:..
  Fly   553 ASQLTLTWISQADAKQRAGRAGRVCHGNCYRLYDNDRMARMNLYTIPEIMRRTLDEICLLTKLAA 617

Human   648 LG-GIAYFLSRLMDPPSNEAVLLSIRHLMELNALDKQEELTPLGVHLARLPVEPHIGKMILFGAL 711
            .. .|..||:..:|.|..:||:.|...|..|..||:::|:||||..:|.||:...|||.:::...
  Fly   618 PDKKIENFLALALDTPPKDAVMQSCSRLKLLGVLDERDEVTPLGHIVAELPLGVQIGKCLVYSIY 682

Human   712 FCCLDPVLTIAASLSFKDPFVIPL--GKEKIADARRKELAKDTRSDHLTVVNAFEGWEEARRRGF 774
            ..|||.::.|||..|.:||||:.:  ||:......|...|.|..||.|.|:..:|.:...:|:..
  Fly   683 LRCLDSMIIIAAYHSVRDPFVLNIERGKKSGQQISRVLFAGDGMSDSLAVIKLYEEFTNLKRKDI 747

Human   775 RYEKDYCWEYFLSSNTLQMLHNMKGQFAEHLLGAGFVSSRNPKDPESNINSDNEKIIKAVICAGL 839
               .|:|...|:..|.::|..:......:.:... |..|.......|:.|:|. .:|:..:.|||
  Fly   748 ---GDFCERNFICRNAMEMFVSAASTLRDTVYRI-FRFSEASARLASSFNNDT-NMIRLALTAGL 807

Human   840 YPKVAKIRLNLGKKRKMVKVYTKTDGLVAVHPKSV---NVEQTDFHYNWLIYHLKMRTSS--IYL 899
            |||:|  .::...|.::|   .:.|.||.|...|.   ..:|.|....|:::..|.||:.  ..|
  Fly   808 YPKLA--YMDRENKNQLV---AEGDPLVQVSRSSCLRGKKKQKDLASEWILFVEKTRTADQISSL 867

Human   900 YDCTEVSPYCLLFFGGDISIQKDNDQE-TIAVDEWIVFQSPARIA---HLVKEL 949
            ...|.||...:...||...|.:.:..| .:.:|.||..:.||...   |.|:.|
  Fly   868 EHTTLVSGLMVALAGGKRFITEAHGSEMLLCLDSWIRLKCPAEFGLQLHKVRML 921

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DHX36NP_065916.2 Necessary for nuclear and nucleolar caps localizations. /evidence=ECO:0000269|PubMed:18279852 1..200 38/197 (19%)
Required for the pre-miR-134 transport. /evidence=ECO:0000250|UniProtKB:D4A2Z8 1..104 15/62 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..58 6/15 (40%)
Required for recruitment to cytoplasmic stress granules. /evidence=ECO:0000269|PubMed:18854321 1..51 4/8 (50%)
Required for G4-DNA-and G4-RNA-binding. /evidence=ECO:0000269|PubMed:21149580, ECO:0000269|PubMed:21846770, ECO:0000269|PubMed:24151078 53..105 11/52 (21%)
DSM (DHX36-specific motif). /evidence=ECO:0000269|PubMed:20472641, ECO:0000269|PubMed:22238380, ECO:0000269|PubMed:24369427, ECO:0000269|PubMed:26195789, ECO:0000269|PubMed:26649896 53..75 3/21 (14%)
RecA-like domain 1. /evidence=ECO:0000250|UniProtKB:Q05B79 106..386 95/321 (30%)
DEXHc_DHX36 207..386 CDD:350739 69/181 (38%)
HrpA 215..>776 CDD:441249 204/567 (36%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 265..317 21/52 (40%)
DEAH box. /evidence=ECO:0000255|PROSITE-ProRule:PRU00541 334..337 2/2 (100%)
RecA-like domain 2. /evidence=ECO:0000250|UniProtKB:Q05B79 387..628 84/241 (35%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 498..557 22/59 (37%)
Nuclear localization signal. /evidence=ECO:0000303|PubMed:14731398 517..528 5/10 (50%)
WH domain. /evidence=ECO:0000250|UniProtKB:Q05B79 629..698 28/69 (41%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 638..697 22/59 (37%)
OB_NTP_bind 831..917 CDD:400182 27/90 (30%)
OB-fold-like subdomains. /evidence=ECO:0000250|UniProtKB:Q05B79 841..905 18/68 (26%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 849..860 2/10 (20%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 870..900 7/34 (21%)
CG8915NP_573208.1 R3H 67..123 CDD:460206 9/59 (15%)
HrpA 208..>702 CDD:441249 193/529 (36%)
OB_NTP_bind 799..884 CDD:400182 26/89 (29%)

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