DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACTL10 and act-4

DIOPT Version :9

Sequence 1:	NP_001019846.1	Gene:	ACTL10 / 170487	HGNCID:	16127	Length:	245	Species:	Homo sapiens
Sequence 2:	NP_508841.1	Gene:	act-4 / 180767	WormBaseID:	WBGene00000066	Length:	376	Species:	Caenorhabditis elegans

Alignment Length:	243	Identity:	81/243 - (33%)
Similarity:	140/243 - (57%)	Gaps:	7/243 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     1 MASTALLALCSTGAFSGLAVEAGAGVCHATPIYAGHSWHQATFRLNVAGSTLSRYLRDLLVAANP 65
            :|..|:|:|.::|..:|:.:::|.||.|..|||.|::...|..||::||..|:.||..:|.....
Worm   135 VAIQAVLSLYASGRTTGVVLDSGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGY 199

Human    66 DLLQQALPRKAITHLKKRSCYVSLDFEGDLRDPARHH--PASFSVGNGCCVCLSSERFRCPEPIF 128
            .....| .|:.:..:|::.|||:||||.::...|...  ..|:.:.:|..:.:.:|||||||.:|
Worm   200 SFTTTA-EREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITVGNERFRCPEALF 263

Human   129 QPGLLGQAEQGLPALAFRALQKMPKTLRTRLADTVVLAGGSTLFPGFAERLDKELEAQCRRHGYA 193
            ||..||....|:...::.::.|....:|..|....||:||:|::||.|:|:.||:.|...    :
Worm   264 QPSFLGMESAGIHETSYNSIMKCDIDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAP----S 324

Human   194 ALRPHLVAKHGRGMAVWTGGSMVASLHSFQRRWITRAMYQECGSRLLY 241
            .::..::|...|..:||.|||::|||.:||:.||::..|.|.|..:::
Worm   325 TMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVH 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACTL10	NP_001019846.1	NBD_sugar-kinase_HSP70_actin	<2..237	CDD:327376	80/236 (34%)
act-4	NP_508841.1	PTZ00281	1..376	CDD:173506	81/243 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D649708at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11937
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020