DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ARX and yox1

DIOPT Version :9

Sequence 1:	NP_620689.1	Gene:	ARX / 170302	HGNCID:	18060	Length:	562	Species:	Homo sapiens
Sequence 2:	NP_595674.1	Gene:	yox1 / 2540309	PomBaseID:	SPBC21B10.13c	Length:	201	Species:	Schizosaccharomyces pombe

Alignment Length:	84	Identity:	29/84 - (34%)
Similarity:	46/84 - (54%)	Gaps:	4/84 - (4%)

- Green bases have known domain annotations that are detailed below.

Human   304 GKDGEDSVCLSAGSDSEEGLLKRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRL--D 366
            |..|:|.:..:...:.|:....:|:||.|||.....|  ||:.|.||..|.:..|:||:.:|  .
pombe    11 GNTGKDLISNNEAKNHEDEETHQKKRRRRTTDAEATL--LEQYFLKTPKPSLIERQELSKKLKSS 73

Human   367 LTEARVQVWFQNRRAKWRK 385
            :|...:|:||||:|...|:
pombe    74 MTPRELQIWFQNKRQSLRR 92

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ARX	NP_620689.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	50..81
		GCG-encoded polyalanine repeat	102..111
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	118..255
		Homeobox	332..385	CDD:395001	21/54 (39%)
		OAR	526..544	CDD:397759
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	530..543
yox1	NP_595674.1	COG5576	1..141	CDD:227863	29/84 (35%)
yox1	NP_595674.1	homeodomain	34..94	CDD:238039	25/61 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	45	1.000	Domainoid score	I4015
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5874
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940