DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ltbp2 and frac

DIOPT Version :9

Sequence 1:	NP_001357672.1	Gene:	Ltbp2 / 16997	MGIID:	99502	Length:	1809	Species:	Mus musculus
Sequence 2:	NP_001137905.1	Gene:	frac / 38850	FlyBaseID:	FBgn0035798	Length:	1618	Species:	Drosophila melanogaster

Alignment Length:	1289	Identity:	338/1289 - (26%)
Similarity:	460/1289 - (35%)	Gaps:	462/1289 - (35%)

- Green bases have known domain annotations that are detailed below.

Mouse   768 ETLP---------DKGDSRAVQITTSAPHLPARVPGDATGRPAPSL--------------PGQGI 809
            ||:|         |:.|...|......|..|..|...|..:|.|.:              ....:
  Fly   136 ETVPNDYVENSDIDEDDDEEVSEREPPPPPPPPVVDGADSKPEPQIVIEINDDHANEVVESEPAL 200

Mouse   810 PESPAEEQVIPS---------SDVL--------VTHSPPDFDPCFAGASNICGP--GTCVSL--- 852
            .|:..|.:|:.:         :|||        ||:.|  ::|.|  ..|.||.  |.|..:
  Fly   201 AETETENEVLENETPLKAEVQTDVLNSSNASVKVTNDP--YEPTF--LDNNCGEDNGGCAHICKR 261

Mouse   853 ---PNG----YRCVCSPGYQLHPSQDY--CTDDNECMRNPCEGRGR----CVNSVGSYSCLCYPG 904
               |:.    .:|.|..||.|.|: ||  |.|.:||:    |..|.    |.|..|.|.|.|..|
  Fly   262 LLYPDENQPINKCDCREGYTLDPN-DYASCLDIDECL----ESNGGCSEICENLPGEYKCSCQEG 321

Mouse   905 YTLVTLRDTQECQDIDECEQPGVCSG--GRCSNTEGSYHC------------------------- 942
            |.|.  ...:.|.||:||..|.:.|.  |.|.|..|||.|
  Fly   322 YYLD--ESGKSCVDINECANPELSSNCQGACENLPGSYRCVEPLEENPEITEVVENPIEKTNEVP 384

Mouse   943 -----------ECDRGYIMVRKG-HCQDINECRHPG--------TCPDGRCVNSPGSYTCLACEE 987
                       .|:.|:.:...| .|||||||...|        .|.. :|.|:.||:.| .|.|
  Fly   385 VNVSESQPAGKTCNSGFQLSADGTDCQDINECEVDGPEDLDNNAVCQQ-KCENTIGSFRC-TCVE 447

Mouse   988 GY---VGQSG----SCVDV-NECLTPGICTHGRCINM-EGSFRCSCEPGYEVTPDKKGCRDVDE- 1042
            ||   ..|..    ||.|: |..|....|.| .|.:: |||:||.|..|||::.|:..|. |.|
  Fly   448 GYHLLEDQRSCALDSCTDLENPQLNRTRCAH-ECQDLPEGSYRCVCPKGYELSEDQHSCL-VQES 510

Mouse  1043 -CASR---ASCPTGLCLNTEG--SFTCSACQSGYWVNEDGTACEDLDECAFPGVCPTGVCTNTVG 1101
             |::.   ..|..|.||.:|.  ||:| .|.:||  ..:..:|:|:||||......:..|.||.|
  Fly   511 PCSTEKGVEKCSPGTCLASEDNTSFSC-ICPTGY--RSEAFSCQDIDECAEDTHLCSHTCQNTPG 572

Mouse  1102 SFSCK--------------------------------------DCDRGYRPNPLGNRCEDVDECE 1128
            .:.|:                                      .|..|:|.:..|..|||||||.
  Fly   573 GYQCQCPEGLNLVEEYTCLAENLCEVNNNGCEQICLTARGGVCACREGFRLSADGKSCEDVDECL 637

Mouse  1129 GPQSSCRGGECKNTEGSYQCLCHQGFQL-----VNGTMCEDVNECVGEEH-CAPHGECLNSLGSF 1187
            .....|: ..|:|..|||.|:|..|::|     :.| .|.|::||....| |:....|.|..||:
  Fly   638 VNNGGCQ-QVCRNLPGSYGCICAAGYELLKLDGIRG-YCFDIDECSQRTHGCSDQMLCENLNGSY 700

Mouse  1188 FCLCAPGFA--------------------SAE--GGTRCQDVDECAATDPCPGGHCVNTEGSFSC 1230
            .|||.||:|                    |:|  ....|.|:|||:..:......|.|..|.|.|
  Fly   701 TCLCPPGYALGLDNHIVTSLNSSFITDSTSSETPSAHTCLDIDECSLANGNCSHFCQNEPGGFQC 765

Mouse  1231 LCETGFQPSPDSGECLDIDECEDREDPVCGAWRCENSPGSYRCILDCQPGFYVAPNG-DCIDIDE 1294
            .|..|:..|.|...|.|||||.| .:..| :..|.|.||.:.|.  |:.||.:.|:| .|.||||
  Fly   766 ACPLGYALSEDMRTCQDIDECLD-SNGQC-SQLCLNQPGGFACA--CETGFELTPDGFGCADIDE 826

Mouse  1295 CANDTVCGN-HGFCDNTDGSFRCLCDQGFETSPSGWECVDVNECE-LMMAVCGDALCENVEGSFL 1357
            |:.|  .|| ...|.|..|:..|.|::|:|.:.....|:||:||. |:...|... |.|..|:|.
  Fly   827 CSQD--YGNCSDICINLLGTHACACERGYELAKDKLSCLDVDECAGLLSGGCSHE-CINKAGTFE 888

Mouse  1358 CLCASDLEEYDAEEGHCRPRVAGAQRIPEVRTEDQAPSLIRMECYSEHNGGPPCSQILGQNSTQA 1422
            |.|                                                 |...||..:
  Fly   889 CGC-------------------------------------------------PLGYILNDD---- 900

Mouse  1423 ECCCTQGARWGKACAP----CPSEDSVEFSQLCPSGQGYIPVEGAWTFGQTMYTDADECVLFGPA 1483
                      |::|:|    ||....       .|..|..|:|  ...|.|:.:| |:||.....
  Fly   901 ----------GRSCSPALVGCPPGTQ-------RSADGCAPIE--CNPGYTLGSD-DKCVDIDEC 945

Mouse  1484 LCQNG----RCLNIVPGYICLCNPGYHYDASSRKCQDHNEC-QD-LACENGECVNTEGSFHCLCN 1542
            ..|||    ||.|....:.|.|.|||..|:..:.|||.:|| || .:|..|.|:|..|.|.|
  Fly   946 QKQNGGCSHRCSNTEGSFKCSCPPGYELDSDQKTCQDIDECDQDKTSCITGTCINEIGGFRC--- 1007

Mouse  1543 PPLTLDLSGQRCVNSTSSTEDFPDHDIHMDICWKKVTNDVCSQPLRGHHTTYTECCCQDGEAWSQ 1607
                                :||...:..:|
  Fly  1008 --------------------EFPKFPVLPEI---------------------------------- 1018

Mouse  1608 QCALCPPRSSEVYAQLCNVARIEAERGAGIHFRPGY-EYGPGLDDLPENLYGPDGAPFYNYLGPE 1671
                 |..||     |....:||.:       .|.| ::....:::|||   |.....::|
  Fly  1019 -----PTASS-----LPESPKIELK-------TPKYPDFTELSNEIPEN---PKKPAEFDY---- 1059

Mouse  1672 DTAPEPPF-SNP-----------ASQPGDNTPV-LEP---------PLQPSELQPHYLA------ 1708
               |||.| |.|           |..|....|| |.|         .|||.:|.|.:.|
  Fly  1060 ---PEPKFPSLPKWEGLPKLPPLADIPTSKAPVPLRPEVPKSLWVNQLQPRDLCPRFQAPRNGKS 1121

Mouse  1709 -----SHSEPLASFEGLQAEECGILNGCENGRCVRVREGYTCDC---FEGFQLDAAHMACVDVNE 1765
                 .|.:.|..:     ..|.|  .|.:|..::..|..:||.   :||     ....||.:|:
  Fly  1122 HCNRYRHKQKLFYY-----SRCRI--SCNSGYILQGPEIKSCDANGIWEG-----PETKCVAINQ 1174

Mouse  1766 --------CEDL----NG---PAALCAHGH------CENTEGSYRCHCSPGYVA 1798
                    |..|    ||   ||: |..|.      |       |..|:.|:|:
  Fly  1175 PRAQSPGICPALKPAQNGVILPAS-CTQGPSRFGDVC-------RLQCNAGFVS 1220

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ltbp2	NP_001357672.1	Glutenin_hmw	<72..>170	CDD:281191
		Heparin-binding. /evidence=ECO:0000250	94..115
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	103..152
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	220..305
		Heparin-binding. /evidence=ECO:0000250	226..243
		Heparin-binding. /evidence=ECO:0000250	329..339
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	492..524
		TB	547..>580	CDD:334208
		EGF_CA	606..>635	CDD:214542
		TB	667..709	CDD:334208
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	727..758
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	784..816		7/45 (16%)
		EGF_CA	875..909	CDD:238011	14/37 (38%)
		EGF_CA	918..>948	CDD:214542	14/67 (21%)
		EGF_CA	958..993	CDD:238011	16/45 (36%)
		EGF_CA	998..1029	CDD:214542	13/32 (41%)
		EGF_CA	1039..1079	CDD:311536	14/46 (30%)
		EGF_CA	1081..1121	CDD:311536	14/77 (18%)
		EGF_CA	1123..1163	CDD:214542	16/44 (36%)
		EGF_CA	1164..1205	CDD:214542	17/63 (27%)
		EGF_CA	1206..1245	CDD:311536	13/38 (34%)
		EGF_CA	1291..1324	CDD:214542	14/33 (42%)
		TB	1411..1452	CDD:334208	7/44 (16%)
		EGF_CA	1473..1506	CDD:214542	14/36 (39%)
		TB	1583..1625	CDD:334208	4/41 (10%)
		C-terminal domain. /evidence=ECO:0000250\|UniProtKB:Q14767	1627..1809		54/230 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1667..1713		20/78 (26%)
		EGF_CA	1762..>1796	CDD:214542	12/54 (22%)
frac	NP_001137905.1	FXa_inhibition	296..331	CDD:291342	12/40 (30%)
		cEGF	396..415	CDD:289433	7/18 (39%)
		FXa_inhibition	425..458	CDD:291342	11/34 (32%)
		FXa_inhibition	476..505	CDD:291342	13/29 (45%)
		vWFA	<550..586	CDD:294047	11/35 (31%)
		FXa_inhibition	596..630	CDD:291342	4/33 (12%)
		FXa_inhibition	636..>664	CDD:291342	10/28 (36%)
		EGF_CA	676..715	CDD:284955	15/38 (39%)
		FXa_inhibition	745..780	CDD:291342	10/34 (29%)
		FXa_inhibition	786..821	CDD:291342	13/38 (34%)
		FXa_inhibition	827..862	CDD:291342	11/36 (31%)
		FXa_inhibition	874..904	CDD:291342	11/93 (12%)
		FXa_inhibition	945..980	CDD:291342	12/34 (35%)
		CCP	1110..1170	CDD:153056	13/71 (18%)
		CCP	1183..1235	CDD:153056	13/46 (28%)
		DUF5011	1468..1536	CDD:295940
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D4721at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42398
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24034
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020