DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrrn3 and Toll-6

DIOPT Version :9

Sequence 1:	NP_001258637.1	Gene:	Lrrn3 / 16981	MGIID:	106036	Length:	707	Species:	Mus musculus
Sequence 2:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster

Alignment Length:	766	Identity:	142/766 - (18%)
Similarity:	285/766 - (37%)	Gaps:	224/766 - (29%)

- Green bases have known domain annotations that are detailed below.

Mouse     1 MKDTPLQVHVLLGLAITTLVQA----IDKKVDCPQLCTCEIRPWFTPRSIYMEASTV-------- 53
            :::..|:.|.:|..|:...::|    :.::::...|.:..|  |..|.:|:...|.:
  Fly   172 LRNLTLRTHNILWPALNFEIEADAFSVTRRLERLDLSSNNI--WSLPDNIFCTLSELSALNMSEN 234

Mouse    54 ---DCNDLGLLNFPARLPADTQILLLQTNNIAR--IEHSTDFPVNLTGLDLSQNNLSSVTNINVQ 113
               |.|:||..: .::.|.:.......|...|:  ...||...::|..||:|.|:...:......
  Fly   235 RLQDVNELGFRD-RSKEPTNGSTESTSTTESAKKSSSSSTSCSLDLEYLDVSHNDFVVLPANGFG 298

Mouse   114 KMSQLLSVYLEENKLTELPEKCLYGLSNL-------------------------QELYVNHNLLS 153
            .:.:|..:.:..|.::.:.:|.|.||.||                         ||:|:.:|.:|
  Fly   299 TLRRLRVLSVNNNGISMIADKALSGLKNLQILNLSSNKIVALPTELFAEQAKIIQEVYLQNNSIS 363

Mouse   154 TISP--------------------------GAFIGLHNLLRLHLNSNRLQMINSQWFDALPNLEI 192
            .::|                          ..|:||..|:.|:|:.|:|..:..:.|..|..|:|
  Fly   364 VLNPQLFSNLDQLQALDLSMNQITSTWIDKNTFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQI 428

Mouse   193 LMLGDNPIIRIKDMNFQPLVKLRSLVIAG----------------INLTEIPDDALAGL------ 235
            |.|..|.:..|....|.|:..|.:|:::.                ::|..:.::||.|:
  Fly   429 LNLRHNQLENIAADTFAPMNNLHTLLLSHNKLKYLDAYALNGLYVLSLLSLDNNALIGVHPDAFR 493

Mouse   236 --ENLESISFYDNRLSKVPQVALQKAVNLKFLDLNKNPINRIRRGDFSNMLHLKELG-INNMPEL 297
              ..|:.::...|:|..|| :||:...:|:.:||.:|.|..:....|..:.:|..|. |.|..|.
  Fly   494 NCSALQDLNLNGNQLKTVP-LALRNMRHLRTVDLGENMITVMEDSAFKGLGNLYGLRLIGNYLEN 557

Mouse   298 VSIDSLAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNTNALSALYHGTIESLPNLKE 362
            :::.:..  :||:|:.:....| |::.:.|.||.....::::.|:.|.|:.: :|...::|:|..
  Fly   558 ITMHTFR--DLPNLQILNLARN-RIAVVEPGAFEMTSSIQAVRLDGNELNDI-NGLFSNMPSLLW 618

Mouse   363 ISIHSNPI------RCDCVIRWINMNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMMEICLP 421
            ::|..|.:      .....::|::::|.  |.....:.|.:| .|.:.|.: .|.|..:..
  Fly   619 LNISDNRLESFDYGHVPSTLQWLDLHKN--RLSSLSNRFGLD-SELKLQTL-DVSFNQLQR---- 675

Mouse   422 LIAPESFPSDLDVEADSYVSLHCRATAEPQPEIYWITPSGKKLLPNTMREKFYVHSEGTLEIRGI 486
             |.|.|.|:.:::   .:::.:...|.:|..                     ::|.
  Fly   676 -IGPSSIPNSIEL---LFLNDNLITTVDPDT---------------------FMHK--------- 706

Mouse   487 TPKEGGLYTCIATNLVGADLKSIMIKVGGSVPQDNNGSLNIKIRDIRANSVLVSW--KASSKILK 549
                        |||...||.:..|..                .||::..:|..|  :|..:...
  Fly   707 ------------TNLTRVDLYANQITT----------------LDIKSLRILPVWEHRALPEFYI 743

Mouse   550 SSVKWTAFVKTEDSHAAQSARIPFDVKVYNLTHLKPSTEYKICIDIPTVYQKSRKQCVNVTTKSL 614
            ....:|.           ...|.:..|:.::|    |.:|...:|:.|:|.|............:
  Fly   744 GGNPFTC-----------DCNIDWLQKINHIT----SRQYPRIMDLETIYCKLLNNRERAYIPLI 793

Mouse   615 EHDGKEYGKNHTVFVACVGGLLGIIGVMCLFSCVSQEGSSEGEHSYAVNHC 665
            |.:.|.:                    :|.:.          .|.:||.||
  Fly   794 EAEPKHF--------------------LCTYK----------THCFAVCHC 814

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrrn3	NP_001258637.1	LRRNT	28..72	CDD:214470	11/54 (20%)
		LRR 1	70..91		4/22 (18%)
		leucine-rich repeat	72..93	CDD:275380	4/22 (18%)
		LRR_8	93..152	CDD:290566	17/83 (20%)
		LRR 2	93..114		5/20 (25%)
		leucine-rich repeat	94..117	CDD:275380	5/22 (23%)
		LRR 3	117..138		4/20 (20%)
		leucine-rich repeat	118..141	CDD:275380	6/22 (27%)
		LRR	139..160	CDD:197688	9/71 (13%)
		LRR 4	141..162		9/71 (13%)
		leucine-rich repeat	142..165	CDD:275380	10/73 (14%)
		LRR 5	165..186		6/20 (30%)
		leucine-rich repeat	166..189	CDD:275380	7/22 (32%)
		LRR_8	173..221	CDD:290566	14/47 (30%)
		LRR 6	189..210		7/20 (35%)
		leucine-rich repeat	190..213	CDD:275380	8/22 (36%)
		LRR_8	213..272	CDD:290566	17/82 (21%)
		LRR 7	213..234		5/36 (14%)
		leucine-rich repeat	214..237	CDD:275380	6/46 (13%)
		LRR 8	237..258		7/20 (35%)
		leucine-rich repeat	238..261	CDD:275380	7/22 (32%)
		LRR 9	261..282		6/20 (30%)
		leucine-rich repeat	262..285	CDD:275380	6/22 (27%)
		LRR 10	285..304		5/19 (26%)
		leucine-rich repeat	286..310	CDD:275380	6/24 (25%)
		LRR 11	310..332		6/21 (29%)
		LRR_8	311..370	CDD:290566	14/58 (24%)
		leucine-rich repeat	311..333	CDD:275380	6/21 (29%)
		LRR 12	335..358		4/22 (18%)
		leucine-rich repeat	336..359	CDD:275380	4/22 (18%)
		LRRCT	368..419	CDD:214507	10/56 (18%)
		I-set	429..513	CDD:254352	10/83 (12%)
		Ig	440..513	CDD:299845	9/72 (13%)
		fn3	526..593	CDD:278470	11/68 (16%)
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380
		LRR_8	171..236	CDD:290566	11/65 (17%)
		leucine-rich repeat	172..201	CDD:275380	5/28 (18%)
		leucine-rich repeat	202..278	CDD:275380	15/78 (19%)
		leucine-rich repeat	229..249	CDD:275380	4/20 (20%)
		LRR_RI	278..468	CDD:238064	39/189 (21%)
		leucine-rich repeat	279..302	CDD:275380	5/22 (23%)
		LRR_8	301..386	CDD:290566	14/84 (17%)
		leucine-rich repeat	303..326	CDD:275380	6/22 (27%)
		leucine-rich repeat	327..350	CDD:275380	1/22 (5%)
		LRR	350..729	CDD:227223	88/453 (19%)
		leucine-rich repeat	352..375	CDD:275380	6/22 (27%)
		leucine-rich repeat	376..401	CDD:275380	3/24 (13%)
		LRR_RI	<401..626	CDD:238064	55/229 (24%)
		leucine-rich repeat	402..425	CDD:275380	7/22 (32%)
		leucine-rich repeat	426..449	CDD:275380	8/22 (36%)
		leucine-rich repeat	450..473	CDD:275380	2/22 (9%)
		leucine-rich repeat	474..497	CDD:275380	4/22 (18%)
		leucine-rich repeat	498..518	CDD:275380	7/20 (35%)
		leucine-rich repeat	521..544	CDD:275380	6/22 (27%)
		leucine-rich repeat	545..566	CDD:275380	5/22 (23%)
		leucine-rich repeat	569..592	CDD:275380	6/23 (26%)
		leucine-rich repeat	593..615	CDD:275380	4/22 (18%)
		leucine-rich repeat	616..637	CDD:275380	3/20 (15%)
		leucine-rich repeat	638..662	CDD:275380	6/26 (23%)
		leucine-rich repeat	663..684	CDD:275380	7/26 (27%)
		leucine-rich repeat	685..708	CDD:275380	3/67 (4%)
		leucine-rich repeat	709..728	CDD:275380	6/34 (18%)
		LRR_8	883..943	CDD:290566
		leucine-rich repeat	885..908	CDD:275380
		leucine-rich repeat	909..932	CDD:275380
		LRR_8	932..990	CDD:290566
		leucine-rich repeat	933..956	CDD:275380
		TIR	1114..1247	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910