DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lrp6 and Lrp4

DIOPT Version :9

Sequence 1:NP_032540.2 Gene:Lrp6 / 16974 MGIID:1298218 Length:1613 Species:Mus musculus
Sequence 2:NP_727914.1 Gene:Lrp4 / 32552 FlyBaseID:FBgn0030706 Length:2009 Species:Drosophila melanogaster


Alignment Length:1273 Identity:508/1273 - (39%)
Similarity:755/1273 - (59%) Gaps:55/1273 - (4%)


- Green bases have known domain annotations that are detailed below.


Mouse     2 GAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFGHGLIY 66
            |.:||..|..  |..|..|..||.|||.|:|.|..:|.:.:|  :|.||.:|.|:||....||::
  Fly   594 GYILRPDLRS--CKALGGAMTLLVANRWDIRRVTLSNNRYSA--IVKGLHNAIALDFHHRKGLMF 654

Mouse    67 WSDVSEEAIKRTEFNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKV 131
            |||||.:.||....|.|. |::|:..||.||.|:|.||:.:.|:||||.|.|:||||..|:||.|
  Fly   655 WSDVSTDVIKMVYMNGTR-VRDVIKWGLESPGGIAVDWIHDLLFWTDSGTRRVEVSNFQGNLRTV 718

Mouse   132 LFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFVIINTEIYWPNGLTLDYQERKL 196
            :...:||:||||.:.|.....:|:|||..||||||.|||:.|.|||:..:.|||||.:|:...|:
  Fly   719 IASYDLDKPRAIVVHPGEALAFWSDWGPNPKIERAYMDGTQRKVIISKGVTWPNGLAIDFPNSKI 783

Mouse   197 YWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDTLYWTDWNTHSILACNKYTGEGLREI 261
            ||||||.:.|..|||||::|..::...|||||||||||||:|||||||.::.|.:|.||:..|.:
  Fly   784 YWADAKQHAIECSNLDGSDRNKILSTHLPHPFALTLFEDTMYWTDWNTKTVSAADKITGKEFRAV 848

Mouse   262 HSNIFSPMDIHAFSQQRQPNATNPCGID----NGGCSHLCLMSPVKPFYQCACPTGVKLLENGKT 322
            |.|...||||||:...|||...:.|..|    .||||||||  |.|...:|.||.|:.|.|:|||
  Fly   849 HENFHFPMDIHAYHPARQPEYADRCQKDRRGLRGGCSHLCL--PNKTSRRCGCPIGLSLKEDGKT 911

Mouse   323 CKDGATELLLLARRTDLR----RISLDTPDFTDIVLQLEDIRHAIAIDYDPVEGYIYWTDDEVRA 383
            ||..|.:|:|:|||.|:|    |.:...|:..|:::.|::::||:|:|:.....:|||||.|...
  Fly   912 CKSTADKLVLVARRKDIRLRHLRDNQADPNDVDMIVPLDNLKHAVALDWCSDTDFIYWTDVERST 976

Mouse   384 IRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEP 448
            |.::.::||..|.||.:.:..|.|:|:||:...|||||..|:||||...||.||.:||.|.|.:|
  Fly   977 INKAHLNGSYQQRVVHSNLVSPVGLALDWITDKLYWTDPSTNRIEVATTNGKMRTLLIWEKLYKP 1041

Mouse   449 RAIVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGTIYWGDAKTDK 513
            |.||::|:.|:|:|:|||:.|.||||.:||.:||.:.:..|.:|||||:||::..||:.|..|..
  Fly  1042 RDIVVNPIEGFMFWSDWGDDPMIERANMDGHERVTITSKKLIYPNGLAIDYEKSKIYFVDGGTKT 1106

Mouse   514 IEVMNTDGTGRRVLVEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRSA-EREVIIDQLPDLMG 577
            :|.||.||:||:|:: :.:.|.||..:....|:||||..:|:...:|.:. :..|||....|||.
  Fly  1107 LENMNFDGSGRQVIL-NGLGHPFGLDVNEGRVFWTDWDTKSVMSANKLTGKDTNVIIANSTDLMD 1170

Mouse   578 LKATSVHRIIGSNPCAEDNGGCSHLCLYRPQGLRCACPIGFELISDMKTCIV-PEAFLLFSRRAD 641
            ::.....|....|.|.:.|||||||||..|....|||.:|.:|..|..||.. |..::||:.|.|
  Fly  1171 IRVFHRTRRRIFNACDKLNGGCSHLCLLNPTSYTCACTVGVQLKEDRHTCSEGPTQYILFAHRID 1235

Mouse   642 IRRISLETNN-NNVAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLD 705
            ||:|||:.:: .:|.:||..:..|.|||.|.....|||:|.....|..:..:|..::.:|...|:
  Fly  1236 IRQISLDFDHLIDVVLPLPPISNAVALDVDRKTGYIYWSDTIENVIMSSSPDGLHVQKIVGDSLE 1300

Mouse   706 YPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGK 770
            .|:|:.||.:|:.:||||.|.:.|||:.|||.:|.|:.:|||:|||.||||...|.::||:||..
  Fly  1301 NPDGLVVDSIGRTIYWADAGRHTIEVASLDGSNRHVIAYKDLESPRGLALDYEAGLLFWTDWGHY 1365

Mouse   771 PKIDRAAMDGSERTTLV-PNVGRANGLTIDYAKRRLYWTDLDTNLIESSDMLGLNREVIADDLPH 834
            .||:|:.:||:||:.:| .|:|..|||::|...:|:||.|.....|:|.|..|..|::|...|.|
  Fly  1366 RKIERSHLDGNERSRIVTANLGWPNGLSLDLKSKRIYWVDARLKTIDSCDYTGNQRKLIMSSLHH 1430

Mouse   835 PFGLTQYQDYIYWTDWSRRSI---ERANKTSGQNRTIIQGHLDYVMDI-LVFHSSRQAGW-NECA 894
            |:.|....|.||||||..:::   ||.|.::  .|.||. ::|.:||| :::.:..|:.. |.|.
  Fly  1431 PYALALSDDNIYWTDWKSKALHMTERRNISA--KRDIIT-NIDGLMDIKIIYQNQNQSTMKNACG 1492

Mouse   895 SSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRT-C-SAPTTFLLFSQKSAINRMVIDEQQSPDI 957
            ::||:||||||..| .|:.|.||....|..::.| | :.|..:||.:.:|.|..:.::.....|:
  Fly  1493 NNNGNCSHLCLRNP-SGYSCQCPIGLRLRQNSTTQCQNLPEDYLLIALRSGIGMISLNSGDFMDV 1556

Mouse   958 ILPIHSLRNVRAIDYDPLDKQLYWIDSRQNSIRKAHEDGGQGFNVVANSVANQNLEIQPYDLSID 1022
            :|||:.:.....:||......|::.|...:.||:.:.     .|:..:.|......:.|..:::|
  Fly  1557 VLPINGVHGAVVLDYHYRKNLLFFADVNLDVIRRVNL-----LNLTESKVIVGTDVLTPNGIAVD 1616

Mouse  1023 IYSRYIYWTCEATNVIDVTRLDGRSVGVVLKGEQDRPRAIVVNPEKGYMYFTNLQERSP-KIERA 1086
            ..:..:||:.....:|:|:||||.....:::.....||:::|:|:|.|:::::..  || ||||:
  Fly  1617 WIADNLYWSDTDRKLIEVSRLDGSCRKRIVEDNLGDPRSLIVHPKKAYLFWSDWS--SPAKIERS 1679

Mouse  1087 ALDGTEREVLFFSGLSKPIALALDSKLGKLFWADSDLRRIESSDLSGANRIVLEDSNIL----QP 1147
            .|||:.|.|:..||:..|..|.:|....:|.|||:....|...|.:|..|     ..|:    .|
  Fly  1680 YLDGSNRTVIITSGIGFPTGLTIDFTNRRLLWADALEDNIGQVDFNGKRR-----QTIVPYAPHP 1739

Mouse  1148 VGLTVFEN---WLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQHPCAQ 1209
            .|||:|||   |..|.:|.....:|:..:|.....:|:..::...||.|| .|:.|....:.|||
  Fly  1740 FGLTLFENSIFWTDWYNKSVYRSQKLARSGYGNPFEVRDALSGALDIRAV-SLSRQPKSVNHCAQ 1803

Mouse  1210 DNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPP 1247
            |||||:|:||.:..... |:||.  |:...:::|...|
  Fly  1804 DNGGCTHLCLNRNVDYV-CACPD--VMDPKDVACSIKP 1838

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lrp6NP_032540.2 Beta-propeller 1 20..275 131/254 (52%)
NHL 55..272 CDD:302697 113/216 (52%)
NHL repeat 55..93 CDD:271320 16/37 (43%)
LY 89..127 CDD:214531 20/37 (54%)
NHL repeat 97..132 CDD:271320 19/34 (56%)
NHL repeat 140..176 CDD:271320 19/35 (54%)
Ldl_recept_b 150..190 CDD:278487 22/39 (56%)
LY 175..216 CDD:214531 22/40 (55%)
NHL repeat 181..217 CDD:271320 19/35 (54%)
NHL repeat 226..253 CDD:271320 19/26 (73%)
LDL-receptor class B 5 236..277 21/40 (53%)
FXa_inhibition 286..323 CDD:291342 20/40 (50%)
Beta-propeller 2 328..589 107/265 (40%)
LY 353..393 CDD:214531 13/39 (33%)
LY 397..437 CDD:214531 19/39 (49%)
LY 438..481 CDD:214531 22/42 (52%)
LY 483..524 CDD:214531 17/40 (43%)
LY 525..558 CDD:214531 10/32 (31%)
FXa_inhibition 592..627 CDD:291342 17/34 (50%)
Beta-propeller 3 631..890 104/264 (39%)
LY 656..694 CDD:214531 12/37 (32%)
LY 697..739 CDD:214531 18/41 (44%)
LY 740..783 CDD:214531 21/42 (50%)
LY 783..825 CDD:214531 16/42 (38%)
LY 827..866 CDD:214531 15/41 (37%)
FXa_inhibition 893..929 CDD:291342 16/36 (44%)
Beta-propeller 4 933..1202 76/276 (28%)
LY 958..998 CDD:214531 9/39 (23%)
LY 1050..1093 CDD:214531 15/43 (35%)
LY 1094..1136 CDD:214531 13/41 (32%)
FXa_inhibition 1207..1243 CDD:291342 15/35 (43%)
LDLa 1249..1285 CDD:238060
LDLa 1288..1322 CDD:238060
LDLa 1326..1360 CDD:238060
PPPSP motif A 1487..1493
PPPSP motif B 1527..1534
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1556..1613
PPPSP motif C 1568..1575
PPPSP motif D 1588..1593
PPPSP motif E 1603..1610
Lrp4NP_727914.1 LDLa 267..301 CDD:238060
LDLa 306..340 CDD:238060
LDLa 347..390 CDD:238060
LDLa 397..431 CDD:238060
LDLa 442..476 CDD:238060
LDLa 480..521 CDD:238060
FXa_inhibition 576..604 CDD:291342 4/11 (36%)
LY 634..671 CDD:214531 17/36 (47%)
NHL <656..793 CDD:302697 70/137 (51%)
LY 680..714 CDD:214531 19/33 (58%)
NHL repeat 681..722 CDD:271320 22/40 (55%)
NHL repeat 726..760 CDD:271320 18/33 (55%)
LY 761..803 CDD:214531 22/41 (54%)
NHL repeat 769..793 CDD:271320 13/23 (57%)
FXa_inhibition 882..912 CDD:291342 18/31 (58%)
LY 946..985 CDD:214531 12/38 (32%)
NHL <967..1142 CDD:302697 81/175 (46%)
LY 988..1030 CDD:214531 20/41 (49%)
NHL repeat 998..1037 CDD:271320 21/38 (55%)
NHL repeat 1038..1080 CDD:271320 21/41 (51%)
NHL repeat 1084..1119 CDD:271320 18/34 (53%)
FXa_inhibition 1185..1220 CDD:291342 17/34 (50%)
NHL 1260..>1445 CDD:302697 77/184 (42%)
NHL repeat 1260..1296 CDD:271320 10/35 (29%)
NHL repeat 1302..1337 CDD:271320 17/34 (50%)
NHL repeat 1345..1383 CDD:271320 18/37 (49%)
FXa_inhibition <1499..1525 CDD:291342 11/26 (42%)
LY 1600..1640 CDD:214531 10/39 (26%)
LY 1643..1686 CDD:214531 15/44 (34%)
LY 1688..1729 CDD:214531 13/40 (33%)
FXa_inhibition 1801..>1825 CDD:291342 13/24 (54%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 66 1.000 Domainoid score I9901
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D121310at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
65.720

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