DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lrp6 and yl

DIOPT Version :9

Sequence 1:NP_032540.2 Gene:Lrp6 / 16974 MGIID:1298218 Length:1613 Species:Mus musculus
Sequence 2:NP_996433.1 Gene:yl / 32367 FlyBaseID:FBgn0004649 Length:1984 Species:Drosophila melanogaster


Alignment Length:1110 Identity:313/1110 - (28%)
Similarity:467/1110 - (42%) Gaps:193/1110 - (17%)


- Green bases have known domain annotations that are detailed below.


Mouse   592 CAEDNGGCSHLCLYRPQGLRCACPIGFELISDMKTC--IV-----PEAFLLFSRRADIRRISLET 649
            |.|.:..||..|.....|.||.|..|:.|..|.:||  :|     .:..||::.:..|..:.|..
  Fly   352 CKEQDDLCSQGCENTSGGYRCVCDAGYLLDKDNRTCRAVVYGSKEQQPLLLYTTQMTIMGMHLRE 416

Mouse   650 NN--NNVAIPLTGVKEASALDFDVTDNRIYWTDI--SLKTISRAFMNGSALEHVVEFGLDYPEGM 710
            :|  |:|......:.:...:.:|  .:.||||:|  ..::|.:|..:||..|.::..|||.||.:
  Fly   417 DNVRNHVYQVAGNLSKVIGVAYD--GSHIYWTNIQNEAESIVKANGDGSNAEILLTSGLDAPEDL 479

Mouse   711 AVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDR 775
            |||||.:|:|::|.....|.|...||.:..|||.:|:..||:||:.|.:|.|:||:||.||.|.|
  Fly   480 AVDWLTQNIYFSDNIMRHIAVCSNDGLNCAVLVTQDVHQPRSLAVWPQKGLMFWTDWGEKPMIGR 544

Mouse   776 AAMDGSERTTLV-PNVGRANGLTIDYAKRRLYWTDLDTNLIESSDMLGLNREVIADD-LPHPFGL 838
            |:||||....:| .|:...||:.:|..::|:||.|.....:::....|..|..:.|. |.||:||
  Fly   545 ASMDGSRSRPIVSDNIEWPNGIALDMHQQRIYWVDAKLGSVQTVRPDGTGRRTVLDGMLKHPYGL 609

Mouse   839 TQYQDYIYWTDWSRRSIERANKTSG-------QNRTIIQGHLDYVMDILVFHSSRQAGWNECASS 896
            ..::|.:||:||:.:|:...:|.||       ::|||...|        ::|.::|.. :.....
  Fly   610 AIFEDQLYWSDWATKSVHACHKFSGKDHRILAKDRTIYAVH--------IYHPAKQPN-SPHGCE 665

Mouse   897 NGHCSHLC-LAVP-VGGFVCGCPAHYSLNADNRTCSAPT----------TFLLFSQKSAINRMVI 949
            |..||||| ||.| :||..|.||....|..|:|.|....          ..||..:.:|..|   
  Fly   666 NATCSHLCLLAEPEIGGHSCACPDGMRLAPDHRRCMLMEKRQRLFIGLGQVLLEIEHTAFGR--- 727

Mouse   950 DEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNSIRKAHEDGGQGFNVVANSVANQNLEI 1014
             .|.|....||.    .:..:.|:.::..|...|:.|..|.:...:..:...:|.:::.|.:.  
  Fly   728 -HQVSKSYTLPC----LINEMVYNRINGSLIIADNDQRLILEFQPESHESNVLVRSNLGNVSA-- 785

Mouse  1015 QPYDLSIDIYSRYIYWTCEATNVIDVTRLDGRSVGVV--LKGEQDRPRAIVVNPEKGYMYFTNLQ 1077
                |:.|..||.:||......||:|..|..|...::  ..| |:.|..:.|.|.:||:|.....
  Fly   786 ----LAFDHLSRNLYWADTERAVIEVLSLQTRHRALIRFFPG-QEVPIGLTVMPAEGYLYVVLKA 845

Mouse  1078 ERSPKIERAALDGTEREV-LFFSGL-SKPIALALDSKLGKLFWADSDLRRIESSDLSGANRIVLE 1140
            :|...|::..|.|...:| :|...| ...|.|..|.:...:||:||||.||..|:....:..:..
  Fly   846 KRHSHIDKIPLSGKGEQVHVFEDDLGDDDIKLVTDYETQTIFWSDSDLGRISYSNYRVPHSQIFR 910

Mouse  1141 DSNILQPVGLTVFEN---W-------LYWIDKQQQMIEK-IDMTGREGRTKVQ--ARIAQLSDIH 1192
             ..:.:|..|.:..:   |       :||..|......| ||:..::....:.  ..:|..:.|.
  Fly   911 -GKLRRPYSLAMVHHDLFWNELGTPRIYWTHKSNMGPRKVIDIMEKDDPAAIMPYVPVATPNGIP 974

Mouse  1193 AVKELNLQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQ-DELSCGEPPTCSPQQFTC 1256
            ......:.: ..|||.|.||||||||:.:|...:.|.||...|... ...:|.|...|   :|.|
  Fly   975 LAASSPVGQ-ESHPCQQQNGGCSHICVGEGPYHSICLCPAGFVYRDAGNRTCVEALDC---EFRC 1035

Mouse  1257 FTGDIDCIPVAWRCDGFTECEDHSDELNCP---------VCSESQFQCASG-QCIDGALRCNGDA 1311
            .:|  :|:.:..||:|..:|.|:|||:||.         :||.:||.|.|| ||:|...||:...
  Fly  1036 HSG--ECLTMNHRCNGRRDCVDNSDEMNCDEEHRRKPKVLCSPNQFACHSGEQCVDKERRCDNRK 1098

Mouse  1312 NCQDKSDEKNCEVL-----CLIDQFRCANGQCVGKHKKCDHSVDCSDRSDELDCYPTEEPAPQAT 1371
            :|.|.|||::||..     |.:.|..|.||:||.....||.:.||.|.||||.|..|....|   
  Fly  1099 DCHDHSDEQHCEKFDKSKKCHVHQHGCDNGKCVDSSLVCDGTNDCGDNSDELLCEATSRCEP--- 1160

Mouse  1372 NTVGSVIGVIVTIFVSGTIYFICQRMLCPRMKGDGETMTNDYVVHSPASVPLGYVPHPSSLSGSL 1436
                       .:|..|:...|.....|     ||....:|           |...|...:..|.
  Fly  1161 -----------GMFQCGSGSCIAGSWEC-----DGRIDCSD-----------GSDEHDKCVHRSC 1198

Mouse  1437 -PGMSR---GKSMISSLSIMG-GSSGPPYDRAHV-TGASSSSSSSTKGTYFPAILNPPPSPATER 1495
             |.|.|   |:.:..||...| ...|...|..:. |.:|:.:.|..:..|               
  Fly  1199 PPDMQRCLLGQCLDRSLVCDGHNDCGDKSDELNCGTDSSTMNISCAEDQY--------------- 1248

Mouse  1496 SHYTMEFGYSSN----SPSTHRSYSYRPYSYRHFAPPTTPCST--------DVCDSDYAPSRRMT 1548
                   ..:||    .|||.|...            ||.|..        ||| |.|....|..
  Fly  1249 -------QCTSNLKICLPSTVRCNG------------TTECPRGEDEADCGDVC-SIYEFKCRSG 1293

Mouse  1549 SVATAKGYTSDVNYDSEPVPPPPTPRSQYLSAE-----ENYESCPPSPYTERSYSHHLYPPPPSP 1608
            .....:.:..|...|.       ...|..||.|     .|.....|...:.||...||:......
  Fly  1294 RECIRREFRCDGQKDC-------GDGSDELSCELEKGHHNQSQIQPWSTSSRSCRPHLFDCQDGE 1351

Mouse  1609 CTDSS 1613
            |.|.|
  Fly  1352 CVDLS 1356

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lrp6NP_032540.2 Beta-propeller 1 20..275
NHL 55..272 CDD:302697
NHL repeat 55..93 CDD:271320
LY 89..127 CDD:214531
NHL repeat 97..132 CDD:271320
NHL repeat 140..176 CDD:271320
Ldl_recept_b 150..190 CDD:278487
LY 175..216 CDD:214531
NHL repeat 181..217 CDD:271320
NHL repeat 226..253 CDD:271320
LDL-receptor class B 5 236..277
FXa_inhibition 286..323 CDD:291342
Beta-propeller 2 328..589
LY 353..393 CDD:214531
LY 397..437 CDD:214531
LY 438..481 CDD:214531
LY 483..524 CDD:214531
LY 525..558 CDD:214531
FXa_inhibition 592..627 CDD:291342 12/34 (35%)
Beta-propeller 3 631..890 91/271 (34%)
LY 656..694 CDD:214531 8/39 (21%)
LY 697..739 CDD:214531 18/41 (44%)
LY 740..783 CDD:214531 24/42 (57%)
LY 783..825 CDD:214531 10/42 (24%)
LY 827..866 CDD:214531 15/46 (33%)
FXa_inhibition 893..929 CDD:291342 17/37 (46%)
Beta-propeller 4 933..1202 64/295 (22%)
LY 958..998 CDD:214531 7/39 (18%)
LY 1050..1093 CDD:214531 12/44 (27%)
LY 1094..1136 CDD:214531 15/43 (35%)
FXa_inhibition 1207..1243 CDD:291342 15/36 (42%)
LDLa 1249..1285 CDD:238060 13/35 (37%)
LDLa 1288..1322 CDD:238060 17/34 (50%)
LDLa 1326..1360 CDD:238060 16/33 (48%)
PPPSP motif A 1487..1493 0/5 (0%)
PPPSP motif B 1527..1534 3/6 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1556..1613 14/61 (23%)
PPPSP motif C 1568..1575 0/6 (0%)
PPPSP motif D 1588..1593 1/4 (25%)
PPPSP motif E 1603..1610 0/6 (0%)
ylNP_996433.1 LDLa 90..124 CDD:238060
LDLa 131..166 CDD:238060
LDLa 184..216 CDD:238060
LDLa 227..262 CDD:238060
LDLa 271..302 CDD:238060
FXa_inhibition 352..387 CDD:291342 12/34 (35%)
Ldl_recept_b 442..482 CDD:278487 16/39 (41%)
LY 466..508 CDD:214531 18/41 (44%)
Ldl_recept_b 529..569 CDD:278487 19/39 (49%)
LY 553..595 CDD:214531 10/41 (24%)
LY 596..637 CDD:214531 15/40 (38%)
FXa_inhibition 669..700 CDD:291342 16/30 (53%)
LY 774..815 CDD:214531 13/46 (28%)
LDLa 1032..1062 CDD:238060 12/31 (39%)
LDLa 1074..1109 CDD:238060 17/34 (50%)
LDLa 1118..1152 CDD:238060 16/33 (48%)
LDLa 1157..1189 CDD:197566 9/61 (15%)
LDLa 1198..1232 CDD:238060 9/33 (27%)
LDLa 1243..1279 CDD:238060 10/69 (14%)
LDLa 1283..1318 CDD:238060 8/42 (19%)
LDLa 1340..1371 CDD:197566 5/17 (29%)
FXa_inhibition 1388..1416 CDD:291342
EGF_CA 1418..1452 CDD:214542
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.710

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