DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lrp5 and arr

DIOPT Version :9

Sequence 1:NP_032539.2 Gene:Lrp5 / 16973 MGIID:1278315 Length:1614 Species:Mus musculus
Sequence 2:NP_524737.2 Gene:arr / 44279 FlyBaseID:FBgn0000119 Length:1678 Species:Drosophila melanogaster


Alignment Length:1662 Identity:709/1662 - (42%)
Similarity:993/1662 - (59%) Gaps:139/1662 - (8%)


- Green bases have known domain annotations that are detailed below.


Mouse    27 PAAA---SP-LLLFANRRDVRLVD----AGGVKLESTIVASGLEDAAAVDFQFSKGAVYWTDVSE 83
            ||:|   :| .|||..|.|:::.:    .||.:::  ::...|.:|.|:||.::|..|.|||...
  Fly    78 PASAFVNTPATLLFTTRHDIQVANITRPTGGPQID--VIVRDLAEAMAIDFYYAKNLVCWTDSGR 140

Mouse    84 EAIKQTYLNQTG------AAAQNIVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRK 142
            |.|:....|.:.      |..|.::.:||..|:|||.||...|:||||.|.||||||.|:|..:|
  Fly   141 EIIECAQTNSSALQPLLRAPKQTVISTGLDKPEGLAMDWYTDKIYWTDGEKNRIEVATLDGRYQK 205

Mouse   143 VLFWQDLDQPRAIALDPAHGYMYWTDWGEAPRIERAGMDGS--TRKIIVDSDIYWPNGLTIDLEE 205
            ||||.|||||||:|:.||...:.||||||.|:||||.|||.  :|..:|...::|||||.:||:.
  Fly   206 VLFWTDLDQPRAVAVVPARKLLIWTDWGEYPKIERASMDGDPLSRMTLVKEHVFWPNGLAVDLKN 270

Mouse   206 QKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKWTGEQR 270
            :.:||.|.|..||....||||.|:.:| .:|.:||:||...|.|||||||..|::|.:..|.| .
  Fly   271 ELIYWTDGKHHFIDVMRLDGSSRRTIV-NNLKYPFSLTFYDDRLYWTDWQRGSLNALDLQTRE-L 333

Mouse   271 KEILSALYSPMDIQVLSQERQPPFHTPCEEDNGGCSHLCLLSPREPFYSCACPTGVQLQDNGKTC 335
            ||::....:|..::......||....||..:||.|||||||:.....:||||||||:| .:..||
  Fly   334 KELIDTPKAPNSVRAWDPSLQPYEDNPCAHNNGNCSHLCLLATNSQGFSCACPTGVKL-ISANTC 397

Mouse   336 KTGAEEVLLLARRTDLRRISLDTPDFTDIVLQVGDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAY 400
            ..|::|::.:.:||.:.:||||:||:|...|.:|.:::||||||||:|.::||:|.|...|:||:
  Fly   398 ANGSQEMMFIVQRTQISKISLDSPDYTIFPLPLGKVKYAIAIDYDPVEEHIYWSDVETYTIKRAH 462

Mouse   401 LDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIVL 465
            .||:|....|.:|:..|||:|:||:|||||||||.||||||.||:||:||:|:.|.|:|||||.:
  Fly   463 ADGTGVTDFVTSEVRHPDGLALDWLARNLYWTDTVTDRIEVCRLDGTARKVLIYEHLEEPRAIAV 527

Mouse   466 HPVMGLMYWTDWGE-NPKIECANLDGRDRHVLVNTSLGWPNGLALDLQEGKLYWGDAKTDKIEVI 529
            .|.:|.|:|:||.| .||:|.|:|||.:|.|||:.:||||||:|||::...:||.|.|||||||.
  Fly   528 APSLGWMFWSDWNERKPKVERASLDGSERVVLVSENLGWPNGIALDIEAKAIYWCDGKTDKIEVA 592

Mouse   530 NIDGTKRKTLLEDKLPHIFGFTLLGDFIYWTDWQRRSIERVHKVKA-SRDVIIDQLPDLMGLKAV 593
            |:||:.|:.::.|.|.|:||.::|.|::||||||||||:|.||:.. :|.|::||.|||||||..
  Fly   593 NMDGSGRRVVISDNLKHLFGLSILDDYLYWTDWQRRSIDRAHKITGNNRIVVVDQYPDLMGLKVT 657

Mouse   594 NVAKVVGTNPCADGNGGCSHLCFFTPRATKCGCPIGLELLSDMKTCIIPEAFLVFTSRATIHRIS 658
            .:.:|.|.|.||..||||||||...||...|.|.|..||.:|.:||::|.|||:|:.:..|.|||
  Fly   658 RLREVRGQNACAVRNGGCSHLCLNRPRDYVCRCAIDYELANDKRTCVVPAAFLLFSRQEHIGRIS 722

Mouse   659 L---ETNNNDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVIEFGLDYPE 720
            :   |.|:||..||...|::|.|||..|:...|||||...|.|.|||:|||.|:.:::.||..|:
  Fly   723 IEYNEGNHNDERIPFKDVRDAHALDVSVAERRIYWTDQKSKCIFRAFLNGSYVQRIVDSGLIGPD 787

Mouse   721 GMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRI 785
            |:||||:..|:||:|....|||||||||..|:||:|:.::.||||.|:|.:||:|||| .....|
  Fly   788 GIAVDWLANNIYWSDAEARRIEVARLDGSSRRVLLWKGVEEPRSLVLEPRRGYMYWTE-SPTDSI 851

Mouse   786 VRAFMDGTNCMTLVDKVGRANDLTIDYADQRLYW-TDLDTNMIESSNMLGQERMV-IADDLPYPF 848
            .||.|||::..|:|.....|..||.|...:|||| |......|||::..|::|.: :..|:..|:
  Fly   852 RRAAMDGSDLQTIVAGANHAAGLTFDQETRRLYWATQSRPAKIESADWDGKKRQILVGSDMDEPY 916

Mouse   849 GLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCVHSNGQCG 913
            .::.|.||:||:|||...|||..||:|:||:|:...:.::..:|||:..||.|:|.|..:||.|.
  Fly   917 AVSLYQDYVYWSDWNTGDIERVHKTTGQNRSLVHSGMTYITSLLVFNDKRQTGVNPCKVNNGGCS 981

Mouse   914 QLCLAIPG--GHRCGCASHYTLDPSSRNCSPPSTFLLFSQKFAISRMIPDDQLSPDLVLPLHGLR 976
            .||||.||  |..|.|.:||.|.....:|.||..:::|||:....|::|:....|::.||:.| :
  Fly   982 HLCLAQPGRRGMTCACPTHYQLAKDGVSCIPPRNYIIFSQRNCFGRLLPNTTDCPNIPLPVSG-K 1045

Mouse   977 NVKAINYDPLDKFIYWVDGR-QNIKRAKDDGTQPSMLTSPSQSLSPDRQPHDLSIDIYSRTLFWT 1040
            |::|::|||:...|||::|| .:|||:..:||:.|:|.:..       ||.||:|||..|.||||
  Fly  1046 NIRAVDYDPITHHIYWIEGRSHSIKRSLANGTKVSLLANSG-------QPFDLAIDIIGRLLFWT 1103

Mouse  1041 CEATNTINVHRLDGDAMGVVLRGDRDKPRAIAVNAERGYMYFTNMQDHAAKIERASLDGTEREVL 1105
            |..:|:|||....|:::||:..||.:|||.|||:|.:..:::|::..|.| |.||.:||.|| |.
  Fly  1104 CSQSNSINVTSFLGESVGVIDTGDSEKPRNIAVHAMKRLLFWTDVGSHQA-IIRARVDGNER-VE 1166

Mouse  1106 FTTGLIRPVALVVDNALGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPVGLTVLGRHLYWID 1170
            ....|....||.:|.....:::  |..|||::.|::|.|:.||...:|.|.:.:..||..:||:|
  Fly  1167 LAYKLEGVTALALDQQSDMIYY--AHGKRIDAIDINGKNKKTLVSMHISQVINIAALGGFVYWLD 1229

Mouse  1171 RQQQMIERVEKTTGDKRTRVQGRVTHLTGIHAVEEVSLEEFSAHPCARDNGGCSHICIAKGDGTP 1235
             .:..:||: ...|::|:....|:..:|.|.||.....:....|.|......|||||||.|:|..
  Fly  1230 -DKTGVERI-TVNGERRSAELQRLPQITDIRAVWTPDPKVLRNHTCMHSRTKCSHICIASGEGIA 1292

Mouse  1236 R----CSCPVHLVLLQNLLTCGEPPTCSPDQFACTT-----GEI--DCIPGAWRCDGFPECADQS 1289
            |    ||||.||:||::...||..|.|.||.|.|..     .::  ||||.:|||||..:|.|:|
  Fly  1293 RTRDVCSCPKHLMLLEDKENCGAFPACGPDHFTCAAPVSGISDVNKDCIPASWRCDGQKDCPDKS 1357

Mouse  1290 DEEGCPVCSASQFPCARGQCVDLRLRCDGEADCQDRSDEANCDAVC-LPNQFRCTSGQ-CVLIKQ 1352
            ||.|||.|.|.||.|..|:|:|..|.|||..:|.:..|||:|   | .|.:|:|...: |:....
  Fly  1358 DEVGCPTCRADQFSCQSGECIDKSLVCDGTTNCANGHDEADC---CKRPGEFQCPINKLCISAAL 1419

Mouse  1353 QCDSFPDCADGSDE---LMCEINKPPSDDIPAHSSAIGPVIGIILSLFVMGGVYFVCQRVMCQRY 1414
            .||.:.:||||:||   :..:....|:.|..|....||..:..|.|:     ||.:   ..|:..
  Fly  1420 LCDGWENCADGADESSDICLQRRMAPATDKRAFMILIGATMITIFSI-----VYLL---QFCRTR 1476

Mouse  1415 TGASGPFPHEYVGGAPHVPLNFIAPGGSQHGPFPGIPCSKSVMSS----------MSLVGGRGSV 1469
            .|.|...|.:.....|..|...                |||...|          ||.:..|.|:
  Fly  1477 IGKSRTEPKDDQATDPLSPSTL----------------SKSQRVSKIASVADAVRMSTLNSRNSM 1525

Mouse  1470 PLYDRNHVTGASSSSSSSTKATLYPPILNPPPSPATDPSLYNVDVFYSSGIPATARPYRPYVIRG 1534
            ..|||||:||||||:::.:....||  :||||||||                .:.||||.|.|..
  Fly  1526 NSYDRNHITGASSSTTNGSSMVAYP--INPPPSPAT----------------RSRRPYRHYKIIN 1572

Mouse  1535 MAPPTTPCSTDVC---DSDYST------SRWKSSKY-------YLDLNSDSDPYPPPPTPHSQYL 1583
            ..||.||||||:|   ||:|::      |...::|:       .|....||:||||||||.|.|.
  Fly  1573 QPPPPTPCSTDICDESDSNYTSKSNSNNSNGGATKHSSSSAAACLQYGYDSEPYPPPPTPRSHYH 1637

Mouse  1584 S-----AEDSCPPSPGTERS-YCHLFPPPPSPCTDSS 1614
            |     .|.||||||.:..| |....||||||....|
  Fly  1638 SDVRIVPESSCPPSPSSRSSTYFSPLPPPPSPVQSPS 1674

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lrp5NP_032539.2 Beta-propeller 1 31..287 115/268 (43%)
NHL <36..>168 CDD:302697 58/141 (41%)
NHL repeat 64..103 CDD:271320 14/44 (32%)
LY 101..141 CDD:214531 22/39 (56%)
NHL repeat 106..147 CDD:271320 25/40 (63%)
Ldl_recept_b 162..202 CDD:278487 21/41 (51%)
LY 186..228 CDD:214531 18/41 (44%)
LY 229..270 CDD:214531 18/40 (45%)
LDL-receptor class B 5 247..289 15/41 (37%)
FXa_inhibition 298..335 CDD:291342 19/36 (53%)
Beta-propeller 2 340..601 141/262 (54%)
LY 365..405 CDD:214531 20/39 (51%)
LY 407..449 CDD:214531 27/41 (66%)
LY 450..493 CDD:214531 23/43 (53%)
LY 494..536 CDD:214531 25/41 (61%)
LY 537..570 CDD:214531 17/32 (53%)
FXa_inhibition 604..639 CDD:291342 18/34 (53%)
Beta-propeller 3 643..902 117/263 (44%)
NHL 684..877 CDD:302697 89/194 (46%)
LY 709..751 CDD:214531 21/41 (51%)
NHL repeat 719..755 CDD:271320 21/35 (60%)
NHL repeat 762..801 CDD:271320 20/38 (53%)
NHL repeat 807..842 CDD:271320 13/36 (36%)
NHL repeat 846..870 CDD:271320 11/23 (48%)
FXa_inhibition 905..940 CDD:291342 16/36 (44%)
Beta-propeller 4 944..1211 95/267 (36%)
LY 969..1008 CDD:214531 17/39 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1002..1025 4/22 (18%)
LY 1059..1102 CDD:214531 18/42 (43%)
LY 1103..1145 CDD:214531 11/41 (27%)
FXa_inhibition 1216..1252 CDD:291342 19/39 (49%)
LDLa 1258..1294 CDD:238060 19/42 (45%)
LDLa 1297..1331 CDD:238060 16/33 (48%)
LDLa 1335..1369 CDD:238060 13/38 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1474..1498 11/23 (48%)
PPPSP motif A 1499..1505 5/5 (100%)
PPPSP motif B 1537..1544 5/6 (83%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1567..1599 21/37 (57%)
PPPSP motif C 1573..1580 6/6 (100%)
PPPSP motif D 1590..1595 4/4 (100%)
PPPSP motif E 1604..1611 6/6 (100%)
arrNP_524737.2 LY 162..201 CDD:214531 22/38 (58%)
NHL 168..503 CDD:302697 169/337 (50%)
NHL repeat 172..237 CDD:271320 41/64 (64%)
LY 252..293 CDD:214531 18/40 (45%)
NHL repeat 261..298 CDD:271320 18/37 (49%)
NHL repeat 303..339 CDD:271320 18/36 (50%)
NHL repeat 341..419 CDD:271320 31/78 (40%)
NHL repeat 428..476 CDD:271320 22/47 (47%)
LY 472..511 CDD:214531 27/38 (71%)
NHL repeat 477..503 CDD:271320 19/25 (76%)
Ldl_recept_b 534..573 CDD:278487 23/38 (61%)
LY 558..599 CDD:214531 25/40 (63%)
LY 600..641 CDD:214531 20/40 (50%)
FXa_inhibition 668..703 CDD:291342 18/34 (53%)
LY 739..773 CDD:214531 17/33 (52%)
LY 776..818 CDD:214531 21/41 (51%)
LY 819..860 CDD:214531 21/41 (51%)
FXa_inhibition 973..1010 CDD:291342 16/36 (44%)
LY 1122..1164 CDD:214531 18/42 (43%)
FXa_inhibition 1273..1313 CDD:291342 19/39 (49%)
LDLa 1319..1362 CDD:238060 19/42 (45%)
LDLa 1365..1399 CDD:238060 16/33 (48%)
LDLa 1399..1433 CDD:197566 12/36 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 123 1.000 Domainoid score I5564
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1327 1.000 Inparanoid score I146
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG48457
OrthoDB 1 1.010 - - D121310at2759
OrthoFinder 1 1.000 - - FOG0004181
OrthoInspector 1 1.000 - - otm44191
orthoMCL 1 0.900 - - OOG6_100345
Panther 1 1.100 - - LDO PTHR46513
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4876
SonicParanoid 1 1.000 - - X3498
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1413.870

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