DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lrp5 and yl

DIOPT Version :9

Sequence 1:NP_032539.2 Gene:Lrp5 / 16973 MGIID:1278315 Length:1614 Species:Mus musculus
Sequence 2:NP_996433.1 Gene:yl / 32367 FlyBaseID:FBgn0004649 Length:1984 Species:Drosophila melanogaster


Alignment Length:1205 Identity:282/1205 - (23%)
Similarity:449/1205 - (37%) Gaps:363/1205 - (30%)


- Green bases have known domain annotations that are detailed below.


Mouse   298 CEEDNGGCSHLCLLSPREPFYSCACPTGVQLQDNGKTCKT---GAEE---VLLLARRTDLRRISL 356
            |:|.:..||..|  ......|.|.|..|..|..:.:||:.   |::|   :||...:..:..:.|
  Fly   352 CKEQDDLCSQGC--ENTSGGYRCVCDAGYLLDKDNRTCRAVVYGSKEQQPLLLYTTQMTIMGMHL 414

Mouse   357 DTPDFTDIVLQV-GDIRHAIAIDYDPLEGYVYWTD--DEVRAIRRAYLDGSGAQTLVNTEINDPD 418
            ...:..:.|.|| |::...|.:.||  ..::|||:  :|..:|.:|..|||.|:.|:.:.::.|:
  Fly   415 REDNVRNHVYQVAGNLSKVIGVAYD--GSHIYWTNIQNEAESIVKANGDGSNAEILLTSGLDAPE 477

Mouse   419 GIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIVLHPVMGLMYWTDWGENPKI 483
            .:||||:.:|:|::|.....|.|...:|.:..:||::|:.:||::.:.|..|||:||||||.|.|
  Fly   478 DLAVDWLTQNIYFSDNIMRHIAVCSNDGLNCAVLVTQDVHQPRSLAVWPQKGLMFWTDWGEKPMI 542

Mouse   484 ECANLDGRDRHVLVNTSLGWPNGLALDLQEGKLYWGDAKTDKIEVINIDGTKRKTLLEDKLPHIF 548
            ..|::||.....:|:.::.||||:|||:.:.::||.|||...::.:..|||.|:|:|:..|.|.:
  Fly   543 GRASMDGSRSRPIVSDNIEWPNGIALDMHQQRIYWVDAKLGSVQTVRPDGTGRRTVLDGMLKHPY 607

Mouse   549 GFTLLGDFIYWTDWQRRSIERVHKVKASRDVIIDQLPDLMGLKAVNVAKVVGTNPCADGNGGCSH 613
            |..:..|.:||:||..:|:...||.......|:.:...:..:...:.|| ...:|....|..|||
  Fly   608 GLAIFEDQLYWSDWATKSVHACHKFSGKDHRILAKDRTIYAVHIYHPAK-QPNSPHGCENATCSH 671

Mouse   614 LCFFT-PR--ATKCGCPIGLELLSDMKTCIIPE----AFLVFTSRATIHRISLETNNNDVAIPLT 671
            ||... |.  ...|.||.|:.|..|.:.|::.|    .|:      .:.::.||           
  Fly   672 LCLLAEPEIGGHSCACPDGMRLAPDHRRCMLMEKRQRLFI------GLGQVLLE----------- 719

Mouse   672 GVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSV------EHVIEF-------------GLD 717
             ::..:.....||.::.....::....:|  :|||.:      ..::||             .|.
  Fly   720 -IEHTAFGRHQVSKSYTLPCLINEMVYNR--INGSLIIADNDQRLILEFQPESHESNVLVRSNLG 781

Mouse   718 YPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVL-VWRDLDNPRSLALDPTKGYIYWT---- 777
            ....:|.|.:.:|||||||....|||..|..:.|.:: .:...:.|..|.:.|.:||:|..    
  Fly   782 NVSALAFDHLSRNLYWADTERAVIEVLSLQTRHRALIRFFPGQEVPIGLTVMPAEGYLYVVLKAK 846

Mouse   778 --------EWGGKPRIVRAFMD--GTNCMTLVDKVGRANDLTIDYADQRLYWTDLDTNMIESSNM 832
                    ...||...|..|.|  |.:.:.||          .||..|.::|:|.|...|..||.
  Fly   847 RHSHIDKIPLSGKGEQVHVFEDDLGDDDIKLV----------TDYETQTIFWSDSDLGRISYSNY 901

Mouse   833 LGQERMVIADDLPYPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMD------- 890
            ......:....|..|:.|......::|.:.....|....|::...|.:|.     :|:       
  Fly   902 RVPHSQIFRGKLRRPYSLAMVHHDLFWNELGTPRIYWTHKSNMGPRKVID-----IMEKDDPAAI 961

Mouse   891 ------------ILVFHSSRQDGLNDCVHSNGQCGQLCLAIPGGHR-CGCASHYTL-DPSSRNCS 941
                        .|...|......:.|...||.|..:|:.....|. |.|.:.:.. |..:|.| 
  Fly   962 MPYVPVATPNGIPLAASSPVGQESHPCQQQNGGCSHICVGEGPYHSICLCPAGFVYRDAGNRTC- 1025

Mouse   942 PPSTFLLFSQKFAISRMIPDDQLSPDLVLPL----HGLRNVKAINYDPLDKFIYWVDGRQNIKRA 1002
                         :..:..:.:......|.:    :|.|:.              ||....:...
  Fly  1026 -------------VEALDCEFRCHSGECLTMNHRCNGRRDC--------------VDNSDEMNCD 1063

Mouse  1003 KDDGTQPSMLTSPSQSLSPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLDGDAMGVVLRGDRDK 1067
            ::...:|.:|.||:|                     :.|.:                   |::  
  Fly  1064 EEHRRKPKVLCSPNQ---------------------FACHS-------------------GEQ-- 1086

Mouse  1068 PRAIAVNAERGYMYFTNMQDHAAKIERASLDGTEREVLFTTGLIRPVALVVDNALGKLFWVDADL 1132
                .|:.||                                                       
  Fly  1087 ----CVDKER------------------------------------------------------- 1092

Mouse  1133 KRIESCDLSGANRLTLEDANIVQPVGLTVLGRHLYWIDRQQQMIERVEKTTGDKRTRVQGRVTHL 1197
                .||    ||....|.:                   .:|..|:.:|:   |:..|.      
  Fly  1093 ----RCD----NRKDCHDHS-------------------DEQHCEKFDKS---KKCHVH------ 1121

Mouse  1198 TGIHAVEEVSLEEFSAHPCARDNGGC---SHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCS 1259
                           .|.|  |||.|   |.:|    |||..|...      .:.|.|.....|.
  Fly  1122 ---------------QHGC--DNGKCVDSSLVC----DGTNDCGDN------SDELLCEATSRCE 1159

Mouse  1260 PDQFACTTGEIDCIPGAWRCDGFPECADQSDEEGCPV---CSASQFPCARGQCVDLRLRCDGEAD 1321
            |..|.|.:|  .||.|:|.|||..:|:|.|||....|   |......|..|||:|..|.|||..|
  Fly  1160 PGMFQCGSG--SCIAGSWECDGRIDCSDGSDEHDKCVHRSCPPDMQRCLLGQCLDRSLVCDGHND 1222

Mouse  1322 CQDRSDEANCDA---------------------VCLPN--------------------------Q 1339
            |.|:|||.||..                     :|||:                          :
  Fly  1223 CGDKSDELNCGTDSSTMNISCAEDQYQCTSNLKICLPSTVRCNGTTECPRGEDEADCGDVCSIYE 1287

Mouse  1340 FRCTSG-QCVLIKQQCDSFPDCADGSDELMCEINK 1373
            |:|.|| :|:..:.:||...||.||||||.||:.|
  Fly  1288 FKCRSGRECIRREFRCDGQKDCGDGSDELSCELEK 1322

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lrp5NP_032539.2 Beta-propeller 1 31..287
NHL <36..>168 CDD:302697
NHL repeat 64..103 CDD:271320
LY 101..141 CDD:214531
NHL repeat 106..147 CDD:271320
Ldl_recept_b 162..202 CDD:278487
LY 186..228 CDD:214531
LY 229..270 CDD:214531
LDL-receptor class B 5 247..289
FXa_inhibition 298..335 CDD:291342 10/36 (28%)
Beta-propeller 2 340..601 86/266 (32%)
LY 365..405 CDD:214531 15/42 (36%)
LY 407..449 CDD:214531 12/41 (29%)
LY 450..493 CDD:214531 20/42 (48%)
LY 494..536 CDD:214531 16/41 (39%)
LY 537..570 CDD:214531 11/32 (34%)
FXa_inhibition 604..639 CDD:291342 13/37 (35%)
Beta-propeller 3 643..902 61/315 (19%)
NHL 684..877 CDD:302697 51/226 (23%)
LY 709..751 CDD:214531 16/54 (30%)
NHL repeat 719..755 CDD:271320 14/36 (39%)
NHL repeat 762..801 CDD:271320 14/52 (27%)
NHL repeat 807..842 CDD:271320 9/34 (26%)
NHL repeat 846..870 CDD:271320 4/23 (17%)
FXa_inhibition 905..940 CDD:291342 10/36 (28%)
Beta-propeller 4 944..1211 25/270 (9%)
LY 969..1008 CDD:214531 5/42 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1002..1025 5/22 (23%)
LY 1059..1102 CDD:214531 4/42 (10%)
LY 1103..1145 CDD:214531 2/41 (5%)
FXa_inhibition 1216..1252 CDD:291342 12/38 (32%)
LDLa 1258..1294 CDD:238060 17/35 (49%)
LDLa 1297..1331 CDD:238060 16/33 (48%)
LDLa 1335..1369 CDD:238060 18/60 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1474..1498
PPPSP motif A 1499..1505
PPPSP motif B 1537..1544
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1567..1599
PPPSP motif C 1573..1580
PPPSP motif D 1590..1595
PPPSP motif E 1604..1611
ylNP_996433.1 LDLa 90..124 CDD:238060
LDLa 131..166 CDD:238060
LDLa 184..216 CDD:238060
LDLa 227..262 CDD:238060
LDLa 271..302 CDD:238060
FXa_inhibition 352..387 CDD:291342 10/36 (28%)
Ldl_recept_b 442..482 CDD:278487 13/39 (33%)
LY 466..508 CDD:214531 12/41 (29%)
Ldl_recept_b 529..569 CDD:278487 20/39 (51%)
LY 553..595 CDD:214531 16/41 (39%)
LY 596..637 CDD:214531 13/40 (33%)
FXa_inhibition 669..700 CDD:291342 12/30 (40%)
LY 774..815 CDD:214531 14/40 (35%)
LDLa 1032..1062 CDD:238060 5/43 (12%)
LDLa 1074..1109 CDD:238060 14/162 (9%)
LDLa 1118..1152 CDD:238060 14/66 (21%)
LDLa 1157..1189 CDD:197566 15/33 (45%)
LDLa 1198..1232 CDD:238060 16/33 (48%)
LDLa 1243..1279 CDD:238060 3/35 (9%)
LDLa 1283..1318 CDD:238060 15/34 (44%)
LDLa 1340..1371 CDD:197566
FXa_inhibition 1388..1416 CDD:291342
EGF_CA 1418..1452 CDD:214542
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.710

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