Protein Alignment QSOX2 and Qsox3

DIOPT Version :10

• Sequence 1: NP_859052.3
• Gene: QSOX2 / 169714
• HGNCID: 30249
• Length: 698
• Species: Homo sapiens
• Sequence 2: NP_650997.1
• Gene: Qsox3 / 42582
• FlyBaseID: FBgn0038918
• Length: 562
• Species: Drosophila melanogaster
• Alignment Length: 533
• Identity: 152/533 - (28%)
• Similarity: 254/533 - (47%)
• Gaps: 67/533 - (12%)

Human    60 EDAVWVLDSGSVRGATANSSAAWLVQFYSSWCGHCIGYAPTWRALAGDVRDWASAIRVAALDCME 124
            ||.:.|:...|::...|..:...||||.:|:||:|..:|.|:|.:|.|::.|...:|:.|:||..
  Fly    39 EDNIHVVVGASLKKILAEPAMGKLVQFLNSYCGNCRRFAHTFRKMAVDLQKWNRVLRIYAVDCAR 103

Human   125 EKNQAVCHDYDIHFYPTFRYFKAFTKEFTTGENFKGPDREL---RTVRQTMIDFLQNHTEGSRPP 186
            .:|..:|.|:.|...||.||:.:   :|....:..|.|.|.   ..:...:|:.|..:.......
  Fly   104 LENVKLCRDFRITLTPTIRYYPS---KFQRIRHGIGTDIETTIPSEIADQLIESLSENDYSESKG 165

Human   187 ACPRLDPIQP----SDVLSLLDNRGSHYVAIVFESNSSYLGREVILDLIPYESIVVTRALDGDKA 247
            ..|..|||:|    :|:....||:.: |:.:|...:   :|.|.||:::||..:.|....|.:
  Fly   166 VKPIFDPIEPGNKLNDIYEQFDNKVT-YILLVHPVD---MGIETILNMLPYPDVGVRIIKDAE-- 224

Human   248 FLEKLGVSSVPSCYLIYPNGSHGLINVVKPLRAFFSSYLKSLPDVRKK----SLPL--PEKPH-- 304
            ...:.|:.  |...::......|...::||.....|:|::|:..:..:    |:|.  |.:|.
  Fly   225 MFAQFGLK--PCKQMVALLNRSGKAQLIKPAGKSSSAYVESVAGLLHQNGHTSMPTLPPAEPEYI 287

Human   305 -KEENSEIVVWREFDKSK-LYTVDLESGLHYLLRVELAAHKSLAGAELKTLKDFVTVLAKLF--- 364
             .|.....:|....:.:| |:..|||..::..|.||:.....::|.:.|.|:..:    :||
  Fly   288 LSEGYDAFIVDYVLNSTKVLFQADLEQAIYQFLHVEIPKTAFISGFKFKALRHII----RLFRRF 348

Human   365 -----PGRPPVKKLLEMLQEWLASLPLDRIPYNAVLDLVNN-KMRISGIFLTNHIKWVGCQGSRS 423
                 .||..:..|:..|.|      :..|......|:|:: :.|:..||...  ::|||.||..
  Fly   349 NVLNRDGRRMLNSLVNHLFE------VTEITGEEFRDVVDDLQTRLDPIFAEQ--QYVGCLGSTP 405

Human   424 ELRGYPCSLWKLFHTLTVEAS---THPDALVGTGFEDDPQAVLQTMRRYVHTFFGCKECGEHFEE 485
            ..|.:.||||.|||..||.|:   .:|.:.|..|        |..:.::   |:.||:...:|.:
  Fly   406 HTRRFSCSLWTLFHYFTVLAAQMKVYPPSSVTIG--------LYGLAKF---FYDCKDGSMYFVK 459

Human   486 MAKE-SMDSVKTPDQAILWLWKKHNMVNGRLAGHLSEDPRFPKLQWPTPDLCPACHEEIKGLASW 549
            :||. ::..|:|.|:.|||||:.||.||.:|||..|.||||||:|:|....||.|:..   ...:
  Fly   460 LAKRMNIAKVRTHDEEILWLWEAHNEVNEKLAGDASGDPRFPKVQFPERKHCPDCYTH---SGEF 521

Human   550 DEGHVLTFLKQHY 562
            |...||.:||:.|
  Fly   522 DRDEVLKYLKRVY 534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
QSOX2	NP_859052.3	PDI_a_QSOX	61..174	CDD:239290	34/115 (30%)
		QSOX_Trx1	185..292	CDD:465653	26/110 (24%)
		FAD_SOX	318..421	CDD:465728	27/112 (24%)
		Evr1_Alr	430..531	CDD:461423	43/104 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	570..624
Qsox3	NP_650997.1	PDI_a_QSOX	40..153	CDD:239290	34/115 (30%)
		FAD_SOX	302..403	CDD:465728	27/112 (24%)
		Evr1_Alr	412..506	CDD:461423	43/104 (41%)