Protein Alignment QSOX2 and Qsox1

DIOPT Version :10

• Sequence 1: NP_859052.3
• Gene: QSOX2 / 169714
• HGNCID: 30249
• Length: 698
• Species: Homo sapiens
• Sequence 2: NP_610852.1
• Gene: Qsox1 / 36464
• FlyBaseID: FBgn0033814
• Length: 637
• Species: Drosophila melanogaster
• Alignment Length: 733
• Identity: 198/733 - (27%)
• Similarity: 321/733 - (43%)
• Gaps: 157/733 - (21%)

Human     1 MAAAGAAVARSPGIGAGPALRARRSPPPRAARLPRLLVLLAAAAVGPGAGGAARLYRAGEDAV-- 63
            :|:||..:.|.      .||..::|||.                 .|..|    ||..|:..:
  Fly    17 IASAGVPLPRY------EALLKQQSPPS-----------------DPTLG----LYDDGDKVIRL 54

Human    64 -------WVLDSGSVRGATANSSAAWLVQFYSSWCGHCIGYAPTWRALAGDVRDWASAIRVAALD 121
                   .|||..  |||        ||:||:::||||..:|||::::|..:..|:..:.|||:|
  Fly    55 SVDNFNATVLDQN--RGA--------LVEFYNTYCGHCRRFAPTYKSVAEHLLPWSEVLIVAAID 109

Human   122 CMEEKNQAVCHDYDIHFYPTFRY----FKAFTKEFTTGENFKGPDR-ELRTVRQTMIDFLQNHTE 181
            |..|:|..:|.:|::..|||.||    |:...:.:  |::....|: |:|.:...|: ..:|.|.
  Fly   110 CAAEENNGICRNYEVMGYPTLRYLGPGFQPGPQHY--GQSLHTQDKNEIREILAGMV-AAENLTS 171

Human   182 GSRPPACPRLDPIQPSDVLSLLD---NRGSHYVAIVFESNSSYLGREVILDLIPYESIVVTRALD 243
            .......|....:..:|..|.|.   :..:.|||:|.|..::.||.||.|.:..:.::.|.|.:|
  Fly   172 SHNNSYWPNFHYLTENDSASSLFEGLSSATEYVAVVHEPENTTLGVEVALFMTQWPAVRVRRVID 236

Human   244 GDKAFLEKLGVSSVPSCYLIYPNGSHGLINVVKPLRAFFSSYLKSLPDV--RKKSLPLPEKPHK- 305
            ...|...|:..:::|...:    ...|.|....|......||.|.|.||  :|...|.|.|.|:
  Fly   237 PAVAAKFKIDPTNLPLSLV----DRKGEITAYAPESTNGESYAKKLWDVLGKKNITPRPVKVHQP 297

Human   306 --------EENSEIVVWREFDKSKLYTVDLESGLHYLLRVELAAHKSLAGAELKTLKDFVTVLAK 362
                    :..:|::.....:|..:|..|||..:..:|..|::....::|.:|..|:.|:.||.:
  Fly   298 SATPASKIKGQNELIDEVHRNKHFVYQADLEQAIRTVLHNEVSKVGEISGEKLLALQRFLAVLQR 362

Human   363 LFPGRPPVKKLLEMLQEWLASLPLDRIPYNAV-LDLVNNKMRISGIFLTNHIKWVGCQGSRSELR 426
            ..|......:|:..|::::......|:..:.. .:|...:..:|.::.:||  :|||.||...||
  Fly   363 YNPLGANGHQLVSKLKDYVVQFNDQRLTGSQFEEELKRLEAHLSPVYSSNH--FVGCVGSSPRLR 425

Human   427 GYPCSLWKLFHTLTVEASTHPDALVGTGFEDDPQAVLQTMRRYVHTFFGCKECGEHFEEMA-KES 490
            |:.||||.|||.:||:|:.:.:.       .||..|||.|..|:..||||.||.|||:.|| :..
  Fly   426 GFSCSLWTLFHFMTVQAANNEET-------QDPLEVLQAMHGYIKNFFGCTECSEHFQAMASRRK 483

Human   491 MDSVKTPDQAILWLWKKHNMVNGRLAGHLSEDPRFPKLQWPTPDLCPACHE---------EIKGL 546
            :.||...::|:||||..||.||.||||..:|||.|||.|:|.|:.|..|:.         ||:
  Fly   484 IWSVPNKEEAVLWLWAAHNEVNQRLAGDATEDPEFPKKQFPAPESCNECYRTPVSKSENLEIE-- 546

Human   547 ASWDEGHVLTFLKQHYGRDNLLDTYSADQGDSSEGGTLARGEEEEKRLTPPEVSHGDRDTQSVRP 611
              |::..||.|||..: ....:..|               |.:.|
  Fly   547 --WNKDAVLGFLKNIH-NPQFVSRY---------------GVQRE-------------------- 573

Human   612 PGALGPRPALPESLHHSLDGKLQSLDGPGAHKEVGGAAPFLGVDFSSLDMSLCVVLYVASSLFLM 676
                       |.||.:.|...|.       :::...       |:.:||.:.::||....:.::
  Fly   574 -----------ELLHPTADKMRQK-------RQISSV-------FTDMDMRMGMLLYAFCIVMMV 613

Human   677 VMYFFFRVRSRRWKVKHH 694
            :.:..|..:..|.|...|
  Fly   614 LAFKLFAFKGYRKKPYGH 631

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
QSOX2	NP_859052.3	PDI_a_QSOX	61..174	CDD:239290	39/126 (31%)
		QSOX_Trx1	185..292	CDD:465653	27/109 (25%)
		FAD_SOX	318..421	CDD:465728	24/103 (23%)
		Evr1_Alr	430..531	CDD:461423	50/101 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	570..624		3/53 (6%)
Qsox1	NP_610852.1	PDI_a_QSOX	49..162	CDD:239290	38/124 (31%)
		FAD_SOX	322..420	CDD:465728	23/99 (23%)
		Evr1_Alr	429..524	CDD:461423	50/101 (50%)