DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lrp1 and Lrp4

DIOPT Version :9

Sequence 1:XP_036011543.1 Gene:Lrp1 / 16971 MGIID:96828 Length:4562 Species:Mus musculus
Sequence 2:NP_727914.1 Gene:Lrp4 / 32552 FlyBaseID:FBgn0030706 Length:2009 Species:Drosophila melanogaster


Alignment Length:2006 Identity:640/2006 - (31%)
Similarity:957/2006 - (47%) Gaps:331/2006 - (16%)


- Green bases have known domain annotations that are detailed below.


Mouse   641 KTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPK---DSRRGRLERAWMDGSHRDIFVTSKTVLWP 702
            ||.::....|   ..:.|.|....| ||.:..:   |:|.|.||..  :.|..|           
  Fly    26 KTAVKRNAPH---YGIHPTNALGRW-DWNKHKQLHSDARIGHLEAG--NESRED----------- 73

Mouse   703 NGLSLDIP--AGRLYWVDAF--YDRIETILLNGTDRKIVYEGPELNHAFGLCHHGNYLFWTEYRS 763
             .||.::.  ..:|:.|..:  |.:      |..|.:.|             ||..        .
  Fly    74 -QLSEELSKFGEKLFPVSNYPPYQQ------NNEDSQEV-------------HHSG--------E 110

Mouse   764 GSVYRLERGVAGAPPTVTLL----RSERPPIFEIRMYDAQQQQVGTNKCRVNNGGCSSLCLATPG 824
            |.::.:|..|    |:.|.:    .|...|.|         :.:|..:.|....|          
  Fly   111 GRLHTMESSV----PSKTRISGGTNSNDTPKF---------RNIGAQRGRTEIAG---------- 152

Mouse   825 SRQCACAEDQVLDTDGVTCLANPSYVPPPQ------------------CQPGE--FACANNRCIQ 869
                      :.:||.::......::..|.                  .||||  ..|.|:.   
  Fly   153 ----------IRETDRISSRGRDGFIGGPSNKQKPFRVNLAVLVQDDPSQPGETYSNCQNSN--- 204

Mouse   870 ERWKCDGDNDCLDNSDEAPAL---CHQ---HT-CPSDRFKCENNRCIPNRWLCDGDNDCGNSEDE 927
                 :.|.:|....|..|.|   |.:   |. ||      ...|||...||||||:|||:..||
  Fly   205 -----ESDENCNPEEDAVPNLQRDCEKTGIHVMCP------RTFRCISKYWLCDGDDDCGDYSDE 258

Mouse   928 SNATCSART-CPPNQFSCASGRCIPISWTCDLDDDCGDRSDESASCAYPTCFPLTQFTCNNGRCI 991
            ::  |.||| |..:||.|.:|.|||.:|.||.::||.|.|||: .|...||.. ..||||:|.||
  Fly   259 TH--CGARTNCTDDQFECLNGFCIPRTWVCDGENDCKDFSDET-HCNRTTCTD-EHFTCNDGYCI 319

Mouse   992 NINWRCDNEKDCGDGSDEKTCPEPADNDCGDNSDEAGCSHSCSSTQFKCN---------SGRCIP 1047
            ::.:|||.|.||.|.|||..|              |...:||...:|||.         ||:||.
  Fly   320 SLAFRCDGEHDCNDNSDELKC--------------AAVINSCPEGEFKCRGGLGGAGGPSGQCIL 370

Mouse  1048 EHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHSDEFQCRLDGLCIPLRWRCDGDTDCMDSSDE 1112
            ..:.|||||||||:|||  .||..:    |..|.|:|::| .||.|||.||:||.:.||....||
  Fly   371 NRFRCDGDNDCGDWSDE--ENCPQK----PSLCTSNEYKC-ADGTCIPKRWKCDKEQDCDGGEDE 428

Mouse  1113 KSCE--GVTH--VCDPNVKFGCKDSARCISKAWVCDGDSDCEDNSDEENCEALAC-----RPPSH 1168
            ..|.  |..|  .|..: :|.| ::.|||.|.|:|||..||....||..|. |.|     ..|:.
  Fly   429 NDCGSLGSEHPLTCGSD-EFTC-NNGRCILKTWLCDGYPDCAAGEDEVECH-LQCDLGQFLCPTK 490

Mouse  1169 PCANNTSVCLPPDKLCDGKDDCGDGSDEGELCD---QCSLNNGGCSHNCSVAPGEGIVCSCPLGM 1230
            ....|..:|:....:|||.::|..|.||.: |.   :|| ....|...|.........|:|.||.
  Fly   491 QNLTNLKICVHQKHICDGHNECPAGEDEAD-CPKERKCS-EPSPCEQLCIETTAGSNECACRLGY 553

Mouse  1231 ELGSDNHTCQIQSYCAKHLK---CSQKCDQNKFSVKCSCYEGWVLEPDGESCRSLDPFKPFIIFS 1292
            .:..:...|.....| ::|.   |||||.....|.||||..|::|.||..||::|......:: :
  Fly   554 VMDKNKVNCTDIDEC-QYLTSPVCSQKCHNTMGSFKCSCETGYILRPDLRSCKALGGAMTLLV-A 616

Mouse  1293 NRHEIRRIDLHKGDYSVLVPGLRNTIALDFHLSQSALYWTDVVEDKIYRGKLL-DNGALTSFEVV 1356
            ||.:|||:.|....||.:|.||.|.||||||..:..::|:||..|.|   |:: .||  |....|
  Fly   617 NRWDIRRVTLSNNRYSAIVKGLHNAIALDFHHRKGLMFWSDVSTDVI---KMVYMNG--TRVRDV 676

Mouse  1357 IQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFW 1421
            |::||.:|.|:|||||...::|.:|...::||:...|.|||.:.:.|::.||||.:.|.:.:.||
  Fly   677 IKWGLESPGGIAVDWIHDLLFWTDSGTRRVEVSNFQGNLRTVIASYDLDKPRAIVVHPGEALAFW 741

Mouse  1422 TDWDASLPRIEAASMSGAGRRTIHRETGSGG--WPNGLTVDYLEKRILWIDARSDAIYSARYDGS 1484
            :||..: |:||.|.|.|..|:.|.    |.|  |||||.:|:...:|.|.||:..||..:..|||
  Fly   742 SDWGPN-PKIERAYMDGTQRKVII----SKGVTWPNGLAIDFPNSKIYWADAKQHAIECSNLDGS 801

Mouse  1485 GHMEVLRGHEFLSHPFAVTLYGGEVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQVYHPS 1549
            ...::|..|  |.||||:||:...:|||||.|.|::.|:|.||.....|......|.|:..|||:
  Fly   802 DRNKILSTH--LPHPFALTLFEDTMYWTDWNTKTVSAADKITGKEFRAVHENFHFPMDIHAYHPA 864

Mouse  1550 RQPMAPNPCEAN--GGRGPCSHLCLINYNRTVSCACPHLMKLHKDNTTCYE-FKKFLLYARQMEI 1611
            |||...:.|:.:  |.||.||||||.| ..:..|.||..:.|.:|..||.. ..|.:|.||:.:|
  Fly   865 RQPEYADRCQKDRRGLRGGCSHLCLPN-KTSRRCGCPIGLSLKEDGKTCKSTADKLVLVARRKDI 928

Mouse  1612 R------------GVDLDAPYYNYIISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFING 1664
            |            .||:..|..|         :.:...||:.:....:||:||....|.:|.:||
  Fly   929 RLRHLRDNQADPNDVDMIVPLDN---------LKHAVALDWCSDTDFIYWTDVERSTINKAHLNG 984

Mouse  1665 TGVETVVSADLPNAHGLAVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVV-QGLEQPHGLVVH 1728
            :..:.||.::|.:..|||:||::..|:||...||:  |.||..:|..:..:: :.|.:|..:||:
  Fly   985 SYQQRVVHSNLVSPVGLALDWITDKLYWTDPSTNR--IEVATTNGKMRTLLIWEKLYKPRDIVVN 1047

Mouse  1729 PLRGKLYWTD-GDN--ISMANMDGSNHTLLFSGQK-GPVGLAIDFPESKLYWISSGNHTINRCNL 1789
            |:.|.::|:| ||:  |..|||||.....:.|.:. .|.|||||:.:||:|::..|..|:...|.
  Fly  1048 PIEGFMFWSDWGDDPMIERANMDGHERVTITSKKLIYPNGLAIDYEKSKIYFVDGGTKTLENMNF 1112

Mouse  1790 DGSELEVIDTMRSQLGKATALAIMGDKLWWADQVSEKMGTCNKADGSG-SVVLRNSTTLVMHMKV 1853
            |||..:||   .:.||....|.:...:::|.|..::.:.:.||..|.. :|::.|||.| |.::|
  Fly  1113 DGSGRQVI---LNGLGHPFGLDVNEGRVFWTDWDTKSVMSANKLTGKDTNVIIANSTDL-MDIRV 1173

Mouse  1854 YDESIQLEHEGTNPCSVNNGDCSQLCL--PTSETTRSCMCTAGYSLRSGQQAC-EGVGSFLLYSV 1915
            :..:   .....|.|...||.||.|||  |||.|   |.||.|..|:..:..| ||...::|::.
  Fly  1174 FHRT---RRRIFNACDKLNGGCSHLCLLNPTSYT---CACTVGVQLKEDRHTCSEGPTQYILFAH 1232

Mouse  1916 HEGIRGIPLDPNDKSDALVPVSGTSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTWREDVVTN 1980
            ...||.|.||.:...|.::|:...|.||.:|...:...|||.|...:.|..:..|....:.:|.:
  Fly  1233 RIDIRQISLDFDHLIDVVLPLPPISNAVALDVDRKTGYIYWSDTIENVIMSSSPDGLHVQKIVGD 1297

Mouse  1981 GIGRVEGIAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEW 2045
            .:...:|:.||.|...|||.|.|...||||.|:||.|:|:..:.|:.||.:.:..|.|.||||:|
  Fly  1298 SLENPDGLVVDSIGRTIYWADAGRHTIEVASLDGSNRHVIAYKDLESPRGLALDYEAGLLFWTDW 1362

Mouse  2046 GHYPRIERSRLDGTERVVLVNVSISWPNGISVDYQGGKLYWCDARMDKIERIDLETGENREVVLS 2110
            |||.:||||.|||.||..:|..::.||||:|:|.:..::||.|||:..|:..|. ||..|::::|
  Fly  1363 GHYRKIERSHLDGNERSRIVTANLGWPNGLSLDLKSKRIYWVDARLKTIDSCDY-TGNQRKLIMS 1426

Mouse  2111 SNNMDMFSVSVFEDFIYWSD--------RTHANGSIKRGCKDNATDSVPLRTGIGVQLKDIKVFN 2167
            |.: ..:::::.:|.|||:|        ....|.|.||....|...           |.|||:..
  Fly  1427 SLH-HPYALALSDDNIYWTDWKSKALHMTERRNISAKRDIITNIDG-----------LMDIKIIY 1479

Mouse  2168 RDRQKGT--NVCAVANGGCQQLCLYRGGGQRACACAHGMLAEDGAS--CREY-AGYLLYSERTIL 2227
            :::.:.|  |.|...||.|..|||....|. :|.|..|:.....::  |:.. ..|||.:.|:.:
  Fly  1480 QNQNQSTMKNACGNNNGNCSHLCLRNPSGY-SCQCPIGLRLRQNSTTQCQNLPEDYLLIALRSGI 1543

Mouse  2228 KSIHLS--DERNLNAPVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNIQQIN--D 2288
            ..|.|:  |..::..|:      ..:...:.|.:.||       .|.:||:|::...|:::|  :
  Fly  1544 GMISLNSGDFMDVVLPI------NGVHGAVVLDYHYR-------KNLLFFADVNLDVIRRVNLLN 1595

Mouse  2289 DGSGRTTIVENVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTR-PGAFERETVITMSGDDHP 2352
            ....:..:..:|.:..|:|.....|.|||     |...|..::.:| .|:..:..|....||  |
  Fly  1596 LTESKVIVGTDVLTPNGIAVDWIADNLYW-----SDTDRKLIEVSRLDGSCRKRIVEDNLGD--P 1653

Mouse  2353 RAFVLDECQNLMFWTNWNELHPS-IMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATL 2416
            |:.::...:..:||::|:.  |: |.|:.|.|:|...:|...|..|.||.||....:|.::||..
  Fly  1654 RSLIVHPKKAYLFWSDWSS--PAKIERSYLDGSNRTVIITSGIGFPTGLTIDFTNRRLLWADALE 1716

Mouse  2417 DKIERCEYDGSHRYVILKSEPVHPFGLAVYGEHIFWTDWVRRAVQRANKYVGSD----------- 2470
            |.|.:.:::|..|..|:...| |||||.::...||||||..::|.|:.|...|.           
  Fly  1717 DNIGQVDFNGKRRQTIVPYAP-HPFGLTLFENSIFWTDWYNKSVYRSQKLARSGYGNPFEVRDAL 1780

Mouse  2471 ---MKLLRVDIPQQPMGIIAVANDTNSCELSPCRINNGGCQDLCLLTHQGHVNCSC 2523
               :.:..|.:.:||..:            :.|..:||||..|||..:..:| |:|
  Fly  1781 SGALDIRAVSLSRQPKSV------------NHCAQDNGGCTHLCLNRNVDYV-CAC 1823

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lrp1XP_036011543.1 LDLa 27..60 CDD:197566
LDLa 72..105 CDD:197566
FXa_inhibition 120..149 CDD:405372
FXa_inhibition 159..189 CDD:405372
LY 276..315 CDD:214531
LY 317..359 CDD:214531
LY 362..402 CDD:214531
FXa_inhibition 487..520 CDD:405372
LY 552..594 CDD:214531
LY 595..634 CDD:214531
LY 641..690 CDD:214531 14/51 (27%)
LY <701..734 CDD:214531 6/36 (17%)
FXa_inhibition 808..843 CDD:405372 4/34 (12%)
LDLa 854..886 CDD:197566 8/51 (16%)
LDLa 896..929 CDD:238060 16/32 (50%)
LDLa 936..968 CDD:197566 16/32 (50%)
LDLa 979..1012 CDD:238060 17/32 (53%)
LDLa 1033..1066 CDD:238060 20/41 (49%)
LDLa 1080..1115 CDD:238060 17/34 (50%)
LDLa 1122..1158 CDD:238060 15/35 (43%)
LDLa 1163..1196 CDD:238060 9/37 (24%)
FXa_inhibition 1203..1239 CDD:405372 8/35 (23%)
LY 1354..1394 CDD:214531 15/39 (38%)
LY 1398..1441 CDD:214531 16/42 (38%)
LY 1442..1486 CDD:214531 18/45 (40%)
LY 1631..1667 CDD:214531 10/35 (29%)
LY 1668..1711 CDD:214531 17/42 (40%)
LY 1715..1752 CDD:214531 16/40 (40%)
LY 1752..1793 CDD:214531 15/41 (37%)
FXa_inhibition 1868..1904 CDD:405372 17/37 (46%)
LY 1934..1974 CDD:214531 11/39 (28%)
LY 1977..2017 CDD:214531 17/39 (44%)
LY 2018..2061 CDD:214531 21/42 (50%)
LY 2063..2105 CDD:214531 16/41 (39%)
FXa_inhibition 2177..2212 CDD:405372 11/36 (31%)
YvrE 2271..2481 CDD:225921 63/227 (28%)
Ldl_recept_b 2362..2403 CDD:395012 14/41 (34%)
LY 2388..2429 CDD:214531 13/40 (33%)
FXa_inhibition 2500..2532 CDD:405372 11/24 (46%)
LDLa 2545..2575 CDD:238060
LDLa 2584..2618 CDD:238060
LDLa 2623..2657 CDD:238060
LDLa <2684..2706 CDD:238060
LDLa 2714..2748 CDD:238060
LDLa 2752..2783 CDD:197566
LDLa 2791..2824 CDD:197566
LDLa 2835..2867 CDD:197566
LDLa 2875..2908 CDD:197566
LDLa 2925..2957 CDD:238060
cEGF 2980..3003 CDD:403760
EGF_CA 3000..>3029 CDD:214542
LY 3067..3111 CDD:214531
LY 3112..3154 CDD:214531
LY 3156..3198 CDD:214531
LY 3200..3241 CDD:214531
LY 3242..3282 CDD:214531
FXa_inhibition 3312..3348 CDD:405372
LDLa 3352..3383 CDD:238060
LDLa 3392..3426 CDD:238060
LDLa 3431..3466 CDD:238060
LDLa 3470..3503 CDD:197566
LDLa 3511..3544 CDD:197566
LDLa 3554..3588 CDD:238060
LDLa 3593..3627 CDD:238060
LDLa 3631..3665 CDD:238060
LDLa 3671..3703 CDD:197566
LDLa 3713..3749 CDD:238060
LDLa 3764..3794 CDD:238060
LY 3973..4010 CDD:214531
Ldl_recept_b 4031..4071 CDD:395012
LY 4055..4096 CDD:214531
Lrp4NP_727914.1 LDLa 267..301 CDD:238060 17/34 (50%)
LDLa 306..340 CDD:238060 18/34 (53%)
LDLa 347..390 CDD:238060 20/44 (45%)
LDLa 397..431 CDD:238060 17/34 (50%)
LDLa 442..476 CDD:238060 15/35 (43%)
LDLa 480..521 CDD:238060 11/41 (27%)
FXa_inhibition 576..604 CDD:291342 14/27 (52%)
LY 634..671 CDD:214531 18/41 (44%)
NHL <656..793 CDD:302697 57/146 (39%)
LY 680..714 CDD:214531 13/33 (39%)
NHL repeat 681..722 CDD:271320 16/40 (40%)
NHL repeat 726..760 CDD:271320 15/34 (44%)
LY 761..803 CDD:214531 18/45 (40%)
NHL repeat 769..793 CDD:271320 10/23 (43%)
FXa_inhibition 882..912 CDD:291342 13/30 (43%)
LY 946..985 CDD:214531 11/47 (23%)
NHL <967..1142 CDD:302697 63/179 (35%)
LY 988..1030 CDD:214531 17/43 (40%)
NHL repeat 998..1037 CDD:271320 14/40 (35%)
NHL repeat 1038..1080 CDD:271320 16/41 (39%)
NHL repeat 1084..1119 CDD:271320 15/34 (44%)
FXa_inhibition 1185..1220 CDD:291342 17/37 (46%)
NHL 1260..>1445 CDD:302697 72/186 (39%)
NHL repeat 1260..1296 CDD:271320 8/35 (23%)
NHL repeat 1302..1337 CDD:271320 17/34 (50%)
NHL repeat 1345..1383 CDD:271320 21/37 (57%)
FXa_inhibition <1499..1525 CDD:291342 7/26 (27%)
LY 1600..1640 CDD:214531 10/44 (23%)
LY 1643..1686 CDD:214531 13/46 (28%)
LY 1688..1729 CDD:214531 13/40 (33%)
FXa_inhibition 1801..>1825 CDD:291342 11/24 (46%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 56 1.000 Domainoid score I10974
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 1 1.100 - - O PTHR24270
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
54.810

Return to query results.
Submit another query.