DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lpl and CG6295

DIOPT Version :9

Sequence 1:	NP_032535.2	Gene:	Lpl / 16956	MGIID:	96820	Length:	474	Species:	Mus musculus
Sequence 2:	NP_651521.1	Gene:	CG6295 / 43247	FlyBaseID:	FBgn0039471	Length:	338	Species:	Drosophila melanogaster

Alignment Length:	295	Identity:	92/295 - (31%)
Similarity:	131/295 - (44%)	Gaps:	53/295 - (17%)

- Green bases have known domain annotations that are detailed below.

Mouse    57 IPGLADSVSNCHFNHSSKTFVVIHGWTVT-------GMYESWVPKLVAALYKREPDSNVIVVDWL 114
            |...:.|:|..|||.:..|...||||:.:       |:.::|.         ...|.|:|.|||.
  Fly    80 IKATSASISGSHFNPNHPTRFTIHGWSSSKDEFINYGVRDAWF---------THGDMNMIAVDWG 135

Mouse   115 YRAQQHYPVSAGYTKLVGNDVARFINWMEEEFNYPLDNVHLLGYSLGAHAAGVAG-SLTNKKVNR 178
            ......|..|......||..||..||:|.......|||..::|:|||||.:|.|| ::.|.:::.
  Fly   136 RARSVDYASSVLAVPGVGEQVATLINFMRSNHGLNLDNTMVIGHSLGAHVSGYAGKNVKNGQLHT 200

Mouse   179 ITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGC 243
            |.|||||.|.|.|.....|||..||.:|:.:.|     .|.::|..||:|....|||||..||||
  Fly   201 IIGLDPALPLFSYDSPNKRLSSTDAYYVESIQT-----NGGTLGFLKPIGKGAFYPNGGKSQPGC 260

Mouse   244 NIGEAIRVIAERGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCNSKEAFEKGLCLSCRKN 308
            .               ||....|:|.||:..:.:|:  .||.....||..   :|:.:...|..:
  Fly   261 G---------------VDLTGSCAHSRSVIYYAESV--TENNFPTMRCGD---YEEAVAKECGSS 305

Mouse   309 RCNNLGYEINKVRAKRSSKM-----YLKTRSQMPY 338
                  |...::.|..::.|     |:..||..||
  Fly   306 ------YSSVRMGATTNAYMVAGDYYVPVRSDAPY 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lpl	NP_032535.2	Interaction with GPIHBP1. /evidence=ECO:0000250\|UniProtKB:P06858	32..53
		lipo_lipase	33..472	CDD:132274	92/295 (31%)
		Pancreat_lipase_like	37..334	CDD:238363	88/289 (30%)
		Essential for determining substrate specificity. /evidence=ECO:0000250\|UniProtKB:P06858	243..266		3/22 (14%)
		PLAT_LPL	341..465	CDD:238856
		Important for interaction with lipoprotein particles. /evidence=ECO:0000250\|UniProtKB:P06858	417..421
		Important for heparin binding. /evidence=ECO:0000250\|UniProtKB:P06858	430..434
		Interaction with GPIHBP1. /evidence=ECO:0000250\|UniProtKB:P06858	443..467
CG6295	NP_651521.1	Pancreat_lipase_like	64..330	CDD:238363	88/289 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11610
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010