DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lmnb2 and LamC

DIOPT Version :9

Sequence 1:	NP_034852.3	Gene:	Lmnb2 / 16907	MGIID:	96796	Length:	615	Species:	Mus musculus
Sequence 2:	NP_001260974.1	Gene:	LamC / 36615	FlyBaseID:	FBgn0010397	Length:	640	Species:	Drosophila melanogaster

Alignment Length:	584	Identity:	218/584 - (37%)
Similarity:	332/584 - (56%)	Gaps:	58/584 - (9%)

- Green bases have known domain annotations that are detailed below.

Mouse    15 AATSAM---ASLPPHAGPATPLSPTRLSRLQEKEELRELNDRLAHYIDRVRALELENDRLLLRIS 76
            |:||..   ||.....|..:|.||||.||.||||||:.||||||.||||:|.||.||.||...::
  Fly    15 ASTSTPVGGASTSSRVGATSPTSPTRTSRQQEKEELQHLNDRLACYIDRMRNLENENSRLTQELN 79

Mouse    77 EKEEVTTREVSGIKTLYESELADARRVLDETARERARLQIEIGKVQAELEEARKSAKKREGELTV 141
            ..::...||.|.:|.:||.|||.||::|||||:|:|:|:|:|.::..|.::.:....|:..|.||
  Fly    80 LAQDTVNRETSNLKAVYEKELAAARKLLDETAKEKAKLEIDIKRLWEENDDLKPRLDKKTKEATV 144

Mouse   142 AQGRVKDLESLFHRSEAELATALSDKQGLETEVAE-------LRAQLAKAEDGHAVAKKQLEKET 199
            |:...:..|:.::....:...:|:|::..|.:..|       ||.||   :|    .:||||.||
  Fly   145 AENNARLYENRYNEVNGKYNQSLADRKKFEDQAKELALENERLRRQL---DD----LRKQLEAET 202

Mouse   200 LMRVDLENRCQSLQEELAFSKSVFEEEVRETRRRHERRLVEVDSSRQQEYDFKMAQALEDLRSQH 264
            |.||||||:.|||:|||||...|..:|:.|||.|.:..:.|:|....::|:.|:.|:|::||.|:
  Fly   203 LARVDLENQNQSLREELAFKDQVHTQELTETRSRRQIEISEIDGRLSRQYEAKLQQSLQELRDQY 267

Mouse   265 DEQVRLYRVELEQTYQAKLDNAKLLSDQNDKAAHAAREELKEARMRVESLSYQLLGLQKQASAAE 329
            :.|:|:.|.|:|..|..::.|.|..:::..:.:..|.||::..|.:::.|:.:|..|:...:...
  Fly   268 EGQMRINREEIELLYDNEIQNLKAAANRAAQGSALATEEVRLMRTKIDGLNAKLQNLEDTNAGLN 332

Mouse   330 NHIHELEEALAGERDKFRKMLDAKEQEMTEVRDAMQQQLAEYQELLDIKLALDMEISAYRKLLEG 394
            ..|.|||..|..||.:..:.:.:.|.|:..:||.|..||.|||.|:|||::||:||:||.|||.|
  Fly   333 ARIRELENLLDTERQRHNQYIASLEAELQRMRDEMAHQLQEYQGLMDIKVSLDLEIAAYDKLLCG 397

Mouse   395 EEERLKLS----PSPSSRITI--SRATSSSSSSSG-----------VGMSVGQGRGKRRRL---E 439
            ||.||.:.    |:..|.|:.  |..|:|:||.||           .|:| |....||||.   |
  Fly   398 EERRLNIESPGRPTTDSGISSNGSHLTASASSRSGRVTPSGRRSATPGIS-GSSAVKRRRTVIDE 461

Mouse   440 TEDTSGSPSRASRVSSGSRLAQQTV---ATGVVNIDEVDPEGRFVRLKNSSDKDQSLGNWRIKRQ 501
            :||.:              |::.:|   |.|.:.|.|.|.||||::|.|...::.:|..|::.|
  Fly   462 SEDRT--------------LSEYSVNAAAKGDLEIIEADVEGRFIKLHNKGTEEINLTGWQLTR- 511

Mouse   502 VLEGEDIAYKFTPKYVLRAGQTVTVWAAGAGATHSPPSTLVWKSQTNWGPGESFRTALVSADGE 565
            :...|::|:||:....:..|.:||:|:..||..|.||:.||.|.:  |....|.|:.|.:||.|
  Fly   512 IAGDEELAFKFSRGSKVLGGASVTIWSVDAGTAHDPPNNLVMKKK--WPVANSMRSVLANADKE 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lmnb2	NP_034852.3	Filament	42..398	CDD:306535	144/362 (40%)
Lmnb2	NP_034852.3	LTD	465..569	CDD:307195	37/101 (37%)
LamC	NP_001260974.1	Filament	45..401	CDD:278467	144/362 (40%)
		ATP-synt_B	<67..>142	CDD:304375	29/74 (39%)
		MreC	<178..>224	CDD:302802	27/52 (52%)
		LTD	473..574	CDD:279300	37/104 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	270	1.000	Domainoid score	I1818
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7818
Inparanoid	1	1.050	391	1.000	Inparanoid score	I1969
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48052
OrthoDB	1	1.010	-	-		D204815at33208
OrthoFinder	1	1.000	-	-		FOG0001052
OrthoInspector	1	1.000	-	-		mtm8905
orthoMCL	1	0.900	-	-		OOG6_103212
Panther	1	1.100	-	-	O	PTHR45721
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2618
SonicParanoid	1	1.000	-	-		X632
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	14.010