Protein Alignment SLC30A8 and ZnT86D

DIOPT Version :10

• Sequence 1: NP_776250.2
• Gene: SLC30A8 / 169026
• HGNCID: 20303
• Length: 369
• Species: Homo sapiens
• Sequence 2: NP_650049.1
• Gene: ZnT86D / 41342
• FlyBaseID: FBgn0037875
• Length: 366
• Species: Drosophila melanogaster
• Alignment Length: 325
• Identity: 68/325 - (20%)
• Similarity: 142/325 - (43%)
• Gaps: 62/325 - (19%)

Human    84 FMIAEVVGGHIAGSLAVVTDAAHLLIDLTSFLLSLFSLWLSSKPPSKRLTFGWHRAEILGALLSI 148
            |...|:..|.:..||.:::|:.|:..|.|..|..|.:..::....:.:.::|:.|||:|...::.
  Fly    46 FAFVELFYGIVTNSLGLISDSFHMFFDCTGLLAGLAASVITKWKANDKFSYGYVRAEVLAGFVNS 110

Human   149 LCIWVVTGVLVYLACERLLYPDYQIQATVMIIVSSCAVAANIVLTVVL----------------- 196
            |.:..:...::....|||:.|. :::...:.:||...:..|:|.....
  Fly   111 LFLLFIAFFILSEGVERLIEPP-EVKHERLFVVSVLGLLVNLVGIYAFNHGGHGHSHGGHGHSHG 174

Human   197 ------------------HQRCL--------------GHNHKEVQANAS--VRAAFVHALGDLFQ 227
                              ||...              ||:|.::..:.|  :|..|:|.|.|...
  Fly   175 GGHGHGHSHGHTDAGNHNHQAITLDNGHGHSHDHDSHGHSHGDMSGSNSQIMRGVFLHILADTLG 239

Human   228 SISVLISALIIYFKPEYKIADPICTFIFSILVLASTITILKDFSILLMEGVPKSLNYS--GVKEL 290
            |:.|:|||::::.. .:.||||||:...::|:..|.::::|:..::||:..|..|:.|  ...:.
  Fly   240 SVGVIISAVLMHMF-GWMIADPICSIFIALLIALSVLSLIKESIMILMQRQPADLDRSLPQCYQK 303

Human   291 ILAVDGVLSVHSLHIWSLTMNQVILSAHVATAASRDSQVV---RREIAKALSKSFTMHSLTIQME 352
            :..:.||.:|...|.|:|..:..:.:..:..:.:.|.:.|   .|.|.:|:.    :..:.||::
  Fly   304 VTGLAGVYAVQEPHFWTLCSDVYVGALKLEVSKNVDPKYVVTHTRMIFEAVG----VKQIYIQLD 364

Human   353  352
              Fly   365  364

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC30A8	NP_776250.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	31..52
		CzcD	50..358	CDD:440843	68/325 (21%)
		HCH Motif, seals regulatory zinc-binding pocket. /evidence=ECO:0000269|PubMed:32723473	52..54
ZnT86D	NP_650049.1	CzcD	45..365	CDD:440843	68/325 (21%)