DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Llgl1 and l(2)gl

DIOPT Version :9

Sequence 1:	NP_001152877.1	Gene:	Llgl1 / 16897	MGIID:	102682	Length:	1062	Species:	Mus musculus
Sequence 2:	NP_001245801.1	Gene:	l(2)gl / 33156	FlyBaseID:	FBgn0002121	Length:	1161	Species:	Drosophila melanogaster

Alignment Length:	1132	Identity:	416/1132 - (36%)
Similarity:	625/1132 - (55%)	Gaps:	163/1132 - (14%)

- Green bases have known domain annotations that are detailed below.

Mouse     1 MMKFRFRRQGADP--QREKLKQELFAFHKTVEHGFPNQPSALAFDPELRIMAIGTRSGAVKIYGA 63
            |:|| .|.:|..|  .|.:|:::|||:.||.:||||::|||||:||.|::|||||::||:|::|.
  Fly     1 MLKF-IRGKGQQPSADRHRLQKDLFAYRKTAQHGFPHKPSALAYDPVLKLMAIGTQTGALKVFGQ 64

Mouse    64 PGVEFTGLH---RDAAT---VTQMHFLPGQGRLLTLLDDSSLHLWEIIHHNGCAHLEEGLSFHPP 122
            ||||..|.|   .::|:   |..:.::.|.||:|:|...:.|.|||.:          |.:..|.
  Fly    65 PGVELYGQHTLLNNSASELNVQLLEWVYGTGRILSLTAANQLILWEPV----------GATLLPI 119

Mouse   123 SRPSFDN-----ASFPASLTRVTVVLLVAGNTAALGTESGSIFFLDVATLALLEGQTLSPDVVLR 182
            ....||.     :|...||::         :...:|||.|:|:.||:.|..:.| ..:..||||.
  Fly   120 KTLPFDGKLKKVSSLCCSLSK---------DLLWIGTEGGNIYQLDLHTFTIKE-PVIYHDVVLE 174

Mouse   183 SVPDDYRCGKALGPVESLQGHLQDPSKILIGYSRGLLVIWSQATQSVDNVFL--GNQQLESLCWG 245
            .||..|:...  |.:||::.....|||:|:.|:|||.|:|...:.||...::  |:.|...|...
  Fly   175 QVPPAYKLNP--GAIESIRQLPNSPSKLLVAYNRGLCVLWDFESASVQRAYIAPGHGQSVGLTVN 237

Mouse   246 RDGSSIISSHSDGSYAIWSTDTGSPPTLQPTVVTTPYGPFPCKAINKILWRSCESGDHFIIFSGG 310
            .:||.....|:|||||.||.|...||:   .|...||||.|||:||: |::.....:..|:||||
  Fly   238 FEGSEFTWYHADGSYATWSIDNPEPPS---NVNYVPYGPDPCKSINR-LYKGKRRSNDVIVFSGG 298

Mouse   311 MPRASYGDRHCVSVLRAE-TLVTLDFTSRVIDFFTVHSTQPEDECDNPQALAVLLEEELVVLDLQ 374
            |||::|||.:||||..:: ..|.|||||:|||||...    |:..|..:.|.|||||||...||.
  Fly   299 MPRSAYGDHNCVSVHASDGHKVCLDFTSKVIDFFVTF----ENNRDVAEVLVVLLEEELCAYDLT 359

Mouse   375 TPGWPAVPAPYLAPLHSSAITCSAHVANVPSKLWARIVSAGEQQSPQPASSALSWPITGGR---N 436
            .|...|:.||||..:|:||:||:...:.|...::..|:.||::|...  .|.:|||||||.   |
  Fly   360 DPNICAIKAPYLHSVHASAVTCNYLASEVVQSVYESILRAGDEQDID--YSNISWPITGGTLPDN 422

Mouse   437 LAQEPSQRG-----LLLTGHEDGTVRFWDASGVALRPLYKLSTAGLFQTDCEH-----ADSLAQA 491
            |.:...:..     :||||||||:|:|||.:||.|:|:|...|:.:|.::.:.     ||..|:.
  Fly   423 LEESVEEDATKLYEILLTGHEDGSVKFWDCTGVLLKPIYNFKTSSIFGSESDFRDDAAADMSAEQ 487

Mouse   492 VEDDWPPFRKVGCFDPYSDDPRLGIQKVALCKYTAQMVVAGTAGQVLVLELSEVPAEHAVSVANV 556
            |::..|||||.|.||||||||||.::|:|.|..|.|::|.|||||:::.:..::|.:.::...::
  Fly   488 VDEGEPPFRKSGLFDPYSDDPRLAVKKIAFCPKTGQLIVGGTAGQIVIADFIDLPEKVSLKYISM 552

Mouse   557 DLLQDREGFTWKGHERLNPHTGLLPWPA------GFQPRMLIQCLPPAAVTAVTLHAEWSLVAFG 615
            :|:.||:||.||||::||..:.||...|      |.....::|.||||::|.:.|.|.|.||:.|
  Fly   553 NLVSDRDGFVWKGHDQLNVRSNLLDGEAIPTTERGVNISGVLQVLPPASITCMALEASWGLVSGG 617

Mouse   616 TSHGFGLFDYQRKSPVLARCTLHPNDSLAMEGPLSRVKSLKKSLRQSFRRIRKSRVSGKKRTPAA 680
            |:||..|||::...||..||||:|||.......|||.||.|||||:|||::||.|
  Fly   618 TAHGLVLFDFKNFVPVFHRCTLNPNDLTGAGEQLSRRKSFKKSLRESFRKLRKGR---------- 672

Mouse   681 SSKLQEANAQLAEQTCPHDLEMTPVQRRIEPRSADDSLSGVVRCLYFADTFLRDATHHGPTMWAG 745
            |::..::|      ..|..||..||:|:||.|.|||.|..:||||.||.|::.:.....||:|:.
  Fly   673 STRTNQSN------QVPTTLEARPVERQIEARCADDGLGSMVRCLLFAKTYVTNVNITSPTLWSA 731

Mouse   746 TNSGSVFAYALEVPAA--------TAGGEKRPE--QAVEAVLGKEVQLMHRAPVVAIAVLDGRGR 800
            ||:.:|..:.|.:|.|        :|.|...|.  :.:.|.|.||:||.||||||.|::.|..|.
  Fly   732 TNASTVSVFLLHLPPAQTAATAVPSASGNAPPHMPRRISAQLAKEIQLKHRAPVVGISIFDQAGS 796

Mouse   801 PLPEPYEASRDLAQAPDMQGGHAVLIASEEQFKVFTLPKVSAKTKFKLTAHEGCRVRKVALATFA 865
            |:.:       |....:....|.||||||||||||:||::....|:||||:||.|:|::...:|:
  Fly   797 PVDQ-------LNAGENGSPPHRVLIASEEQFKVFSLPQLKPINKYKLTANEGARIRRIHFGSFS 854

Mouse   866 SVMSED-------------------------------------YAETCLACLTNLGDVHVFSVPG 893
            ..:|.:                                     |.||.|.||||:||:.|.|||.
  Fly   855 CRISPETLQSMHGCSPTKSTRSHGDGEADPNISGSLAVSRGDVYNETALICLTNMGDIMVLSVPE 919

Mouse   894 LRPQVHYSCIRKEDISGIASCVFTRHGQGFYLISPSEFERFSLSARNITEPLCSLDISWPQNATQ 958
            |:.|::.:.:|:|||:|::|..||..|:..|::|.||.:|.:|:...:.:|...:.:. |....:
  Fly   920 LKRQLNAAAVRREDINGVSSLCFTNSGEALYMMSSSELQRIALATSRVVQPTGVVPVE-PLENEE 983

Mouse   959 PRLQESPKLSQANGTRDIILAPE-------------SCEGSPSSAHSKRADTMEPPEAALSPVSI 1010
            ..|:|    :.|...::.....|             |....|:..:..|....:     ::.|:|
  Fly   984 SVLEE----NDAENNKETYACDEVVNTYEIKNPSGISICTRPAEENVGRNSVQQ-----VNGVNI 1039

Mouse  1011 DSA--ASGDTMLDTTGDVTVEYVKDFL 1035
            .::  .:.:|:..:.||:||:.|:|.|
  Fly  1040 SNSPNQANETISSSIGDITVDSVRDHL 1066

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Llgl1	NP_001152877.1	WD40 repeat	38..73	CDD:293791	22/37 (59%)
		WD 1	38..71		20/32 (63%)
		WD 2	78..119		11/40 (28%)
		WD40 repeat	116..174	CDD:293791	16/62 (26%)
		WD 3	139..175		9/35 (26%)
		WD40 repeat	182..234	CDD:293791	18/51 (35%)
		WD40	<195..>310	CDD:225201	45/116 (39%)
		WD 4	199..233		13/33 (39%)
		WD40 repeat	239..282	CDD:293791	15/42 (36%)
		WD 5	239..271		12/31 (39%)
		LLGL	279..378	CDD:285555	49/99 (49%)
		WD 6	289..331		18/42 (43%)
		WD 7	339..373		15/33 (45%)
		WD 8	395..473		34/85 (40%)
		WD 9	517..592		27/80 (34%)
		WD 10	601..662		32/60 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	667..688		4/20 (20%)
		WD 11	722..782		23/69 (33%)
		WD 12	791..843		20/51 (39%)
		WD 13	848..901		25/89 (28%)
		WD 14	915..938		9/22 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	980..1002		4/34 (12%)
l(2)gl	NP_001245801.1	WD40 repeat	39..78	CDD:293791	22/38 (58%)
		WD40 repeat	84..126	CDD:293791	13/51 (25%)
		WD40 repeat	131..174	CDD:293791	15/52 (29%)
		WD40 repeat	188..224	CDD:293791	14/35 (40%)
		LLGL	268..>338	CDD:285555	37/74 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848764
Domainoid	1	1.000	340	1.000	Domainoid score	I1089
eggNOG	1	0.900	-	-		E1_KOG1983
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31220
Inparanoid	1	1.050	672	1.000	Inparanoid score	I731
Isobase	1	0.950	-	0.928771	Normalized mean entropy	S6106
OMA	1	1.010	-	-		QHG48039
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000702
OrthoInspector	1	1.000	-	-		otm42628
orthoMCL	1	0.900	-	-		OOG6_104800
Panther	1	1.100	-	-	O	PTHR10241
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4628
SonicParanoid	1	1.000	-	-		X453
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740