DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lifr and Dscam1

DIOPT Version :9

Sequence 1:NP_001345522.1 Gene:Lifr / 16880 MGIID:96788 Length:1092 Species:Mus musculus
Sequence 2:NP_001246162.1 Gene:Dscam1 / 35652 FlyBaseID:FBgn0033159 Length:2038 Species:Drosophila melanogaster


Alignment Length:1112 Identity:219/1112 - (19%)
Similarity:363/1112 - (32%) Gaps:318/1112 - (28%)


- Green bases have known domain annotations that are detailed below.


Mouse   115 GFQSKFTLNEKDVSLIPET-----PEILDL--SADFFTS------SLLLKWN------DRGSALP 160
            |:.::.:| |..|.::|:.     .:::::  |.|.|..      .:.:.|:      |.|....
  Fly   607 GYSARGSL-EVQV
MVLPQIVPFAYEDLINMGDSIDLFCQIQKGDRPIKVHWSFERSAGDYGFDQV 670

Mouse   161 HPSNATWEIKVLQNPRTEPVALVLLNTMLSGKDTVQHWN------WTSDLPLQCATHSVSIRWHI 219
            .|...|..|    :.:|..:::...:...:|:||....|      ::.||     |.:|..||.:
  Fly   671 QPQMRTNRI----SEKTSMISIPSASPAHTGRDTCIASNKAGTTTYSVDL-----TVNVPPRWIL 726

Mouse   220 DSPHFSGYKEWSDWSPLKNISWIRNTETNVFPQDKVVLAGSNMTICCMS-----PTKVLSGQIGN 279
            :                              |.||....||:..:.|.:     |.......:|:
  Fly   727 E------------------------------PTDKAFAQGSDAKVECKADGFPKPQVTWKKAVGD 761

Mouse   280 T------LRPLIHLYGQTVAIHILNIPVSENSGTNIIFITDDDVYG--------TVVFAGYPPDV 330
            |      |:...::..:...:|:.||     ..||..:...:.:.|        .::....||:.
  Fly   762 TPGEYKDLKKSDNIRVEEGTLHVDNI-----QKTNEGYYLCEAINGIGSGLSAVIMISVQAPPEF 821

Mouse   331 PQK-------------LSCETHDLKEIICSWNPGRITGLVGPRN-TEYTLFESISGKSAVFHRIE 381
            .:|             |.||....|.|...||...:.  :.|:| ..||:.|.|..         
  Fly   822 TEKLRNQTARRGEPAVLQCEAKGEKPIGILWNMNNMR--LDPKNDNRYTIREEILS--------- 875

Mouse   382 GLTNETYRLGVQMHPGQEIHNFTLTGRNPLGQAQSAVVINVTERVAPHDPTSLKVKDINSTVVTF 446
              |.....|.::.....:...||....|..|...::  ||:..:..|..|.:|||.|.:...|..
  Fly   876 --TGVMSSLSIKRTERSDSALFTCVATNAFGSDDAS--INMIVQEVPEMPYALKVLDKSGRSVQL 936

Mouse   447 SWYLP--GNFTKINLLCQIEICKANSKKEVRNATIRGAEDSTYHVAVDKLNPYTAYTFRVRCSSK 509
            ||..|  ||......:.:.:..:| |..|:....:.|   .|....|.||:|.|.|..|:...:.
  Fly   937 SWAQPYDGNSPLDRYIIEFKRSRA-SWSEIDRVIVPG---HTTEAQVQKLSPATTYNIRIVAENA 997

Mouse   510 TFWKWSRWSDEKRHLTTEATPSKGPDTWREWSSDGKNLIVYWKPLPINEANGKILSYNVSCSL-N 573
            .  ..|:.|:....:|.|..||..|...:....:...:.|.|||.|..|.||:||.|.|...| |
  Fly   998 I--GTSQSSEAVTIITAEEAPSGKPQNIKVEPVNQTTMRVTWKPPPRTEWNGEILGYYVGYKLSN 1060

Mouse   574 EETQSVLEIFD------PQHRAEIQLSK--NDYIISVVARNSAGSSPPSKIASMEIPNDDITVEQ 630
            ..:..|.|..:      .:|..|:|..:  ..|.:.:.|.|..|:.|.|:      .....|.|.
  Fly  1061 TNSSYVFETINFITEEGKEHNLELQNLRVYTQYSVVIQAFNKIGAGPLSE------EEKQFTAEG 1119

Mouse   631 AVGLGNRIFLTWRHDPNMTCDYVIKWCNSSRSEPCLLDWRKVPSNSTETVIE--------SDQFQ 687
                      |....|:.|.      |.:..|:...:.|...|..|...||:        ||::.
  Fly  1120 ----------TPSQPPSDTA------CTTLTSQTIRVGWVSPPLESANGVIKTYKVVYAPSDEWY 1168

Mouse   688 PGVRYNF--------YLYGC---TNQGYQLLRSIIG-----------YVEELAPIVAPNFTVEDT 730
            ...:.::        .|:|.   ||...|:|.:..|           ..|...| .||.    |.
  Fly  1169 DETKRHYKKTASSDTVLHGLKKYTNYTMQVLATTAGGDGVRSVPIHCQTEPDVP-EAPT----DV 1228

Mouse   731 SA-----DSILVKWDDIPVEELRGFLRGYLFYFQ-KGERDTPKTRSLEPHHSDIKLKNITDISQK 789
            .|     .:|||.|.  |..:..|.:..|..|.: :|.....||:.: ||:            |.
  Fly  1229 KALVMGNAAILVSWR--PPAQPNGIITQYTVYSKAEGAETETKTQKV-PHY------------QM 1278

Mouse   790 TLRIADLQGKTSYHLVLRAYTHGGLGPEKSMFVVTKENSVGLIIAILIPVAVAVIVGVVTSILCY 854
            :....:|:....|...:.|.|..|.|.:....|....:.|        |..:|......|:    
  Fly  1279 SFEATELEKNKPYEFWVTASTTIGEGQQSKSIVAMPSDQV--------PAKIASFDDTFTA---- 1331

Mouse   855 RKREWIKETFYPD---------IPNPE---NCKALQFQKSVCEGSNALKTLEMNPCTPNNVEVLE 907
                    ||..|         .|.||   ..|.::|..:                  :.:.||.
  Fly  1332 --------TFKEDAKMPCLAVGAPQPEITWKIKGVEFSAN------------------DRMRVLP 1370

Mouse   908 SRSIVPKI---EDTEIISPVAERPGERSEVDPENHVVVSYCPPIIEEEITNPAADEVGGASQVVY 969
            ..|::.|.   :|....|..||....:..:   .|.::...||      .:|........:..:.
  Fly  1371 DGSLLIKSVNRQDAGDYSCHAENSIAKDSI---THKLIVLAPP------QSPHVTLSATTTDALT 1426

Mouse   970 IDVQSMYQPQAKAEEEQDVDPV--VVAGYKPQM-RLPISPAVEDTAAEDEEGKTAGYRPQANVNT 1031
            :.::         ..|.|..|:  ....|||:. ....|....|:...:.||...|.|.|.....
  Fly  1427 VKLK---------PHEGDTAPLHGYTLHYKPEFGEWETSEVSVDSQKHNIEGLLCGSRYQVYATG 1482

Mouse  1032 WNLVS-------------------PDSPRSTDSNNEVVSF--------GSPCSINSRQFLIPPKD 1069
            :|.:.                   |:.||..:.::..||.        |.|.|    .|::..|.
  Fly  1483 FNNIGAGEASDILNTRTKGQKPKLPEKPRFIEVSSNSVSLHFKAWKDGGCPMS----HFVVESKK 1543

Mouse  1070 EDSPKSN 1076
            .|..:.|
  Fly  1544 RDQIEWN 1550

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LifrNP_001345522.1 LIFR_N 50..124 CDD:375634 2/8 (25%)
LIFR_D2 126..239 CDD:375455 22/137 (16%)
FN3 428..525 CDD:238020 26/98 (27%)
WSXWS motif 514..518 1/3 (33%)
FN3 547..613 CDD:389787 23/74 (31%)
FN3 724..816 CDD:238020 21/97 (22%)
Box 1 motif 864..872 3/16 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1009..1092 19/95 (20%)
Dscam1NP_001246162.1 Ig 38..130 CDD:299845
IG 57..133 CDD:214652
IG_like 267..343 CDD:214653
Ig 269..340 CDD:143165
IG_like 353..425 CDD:214653
IGc2 361..413 CDD:197706
I-set 433..527 CDD:254352
IGc2 446..517 CDD:197706
I-set 533..618 CDD:254352 3/11 (27%)
IGc2 544..607 CDD:197706 219/1112 (20%)
Ig 641..714 CDD:143165 12/76 (16%)
IGc2 735..804 CDD:197706 13/73 (18%)
I-set 819..914 CDD:254352 23/109 (21%)
Ig 833..921 CDD:299845 22/102 (22%)
FN3 918..1011 CDD:238020 26/98 (27%)
FN3 1018..1116 CDD:238020 26/103 (25%)
FN3 1124..1217 CDD:238020 18/98 (18%)
FN3 1222..1312 CDD:238020 25/109 (23%)
Ig 1339..1406 CDD:299845 14/87 (16%)
FN3 1409..1499 CDD:238020 17/104 (16%)
FN3 1504..1584 CDD:238020 12/51 (24%)
Dscam_C 1890..2008 CDD:289151
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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