DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lhx6 and ey

DIOPT Version :9

Sequence 1:	NP_032526.2	Gene:	Lhx6 / 16874	MGIID:	1306803	Length:	392	Species:	Mus musculus
Sequence 2:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster

Alignment Length:	365	Identity:	78/365 - (21%)
Similarity:	121/365 - (33%)	Gaps:	132/365 - (36%)

- Green bases have known domain annotations that are detailed below.

Mouse     7 SAAPALPEGCRLPAEGGPTTDQVMAQPGSGCKATTRCLEGTAP---------PAMAQSDAEALAG 62
            |...|:.|..||      ...|..|.||....|....|.|.:|         |.:...:.:||..
  Fly   296 SEQEAIYEKLRL------LNTQHAAGPGPLEPARAAPLVGQSPNHLGTRSSHPQLVHGNHQALQQ 354

Mouse    63 ALDKD------EGRASPCTPSTPSVCSPPSAAS-----SVPSAGKNICSSCGLEILDRYLLKVNN 116
            ...:.      .|...|.:.|...:.|.|:.||     |.||...::.....:|.|
  Fly   355 HQQQSWPPRHYSGSWYPTSLSEIPISSAPNIASVTAYASGPSLAHSLSPPNDIESL--------- 410

Mouse   117 LIWHVRCLECSVCRTSLRQQNSCYIKNKEIYCKMDYFSRFGTKCARCGRQIYASDWVRRARGNAY 181
                          .|:..|.:|.:..::|:.|.:.          .|.|   ||
  Fly   411 --------------ASIGHQRNCPVATEDIHLKKEL----------DGHQ---SD---------- 438

Mouse   182 HLACFACFSCKRQLSTGEEFGLVEEKVLCRIHYDTMIENLKRAAENGNGLTLEGA--VPSEQDSQ 244
                        :..:||                         .||.||    ||  :.:.:|.|
  Fly   439 ------------ETGSGE-------------------------GENSNG----GASNIGNTEDDQ 462

Mouse   245 -----PKPAKRARTSFTAEQLQVMQAQFAQDNNPDAQTLQKLADMTGLSRRVIQVWFQNCRA--- 301
                 .:..:|.|||||.:|:..::.:|.:.:.||....::||...||....|||||.|.||
  Fly   463 ARLILKRKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARERLAGKIGLPEARIQVWFSNRRAKWR 527

Mouse   302 -----RHKKHTPQHPVPPSGAPPTRLPSALSDDIHYSPFS 336
                 |:::.||.    .:||..|...::.:..:..||.|
  Fly   528 REEKLRNQRRTPN----STGASATSSSTSATASLTDSPNS 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lhx6	NP_032526.2	LIM1_Lhx6	99..152	CDD:188766	7/52 (13%)
		LIM2_Lhx6	160..214	CDD:188768	6/53 (11%)
		Homeobox	252..304	CDD:278475	22/59 (37%)
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	21/51 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940