DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lhcgr and Lgr4

DIOPT Version :9

Sequence 1:	NP_038610.1	Gene:	Lhcgr / 16867	MGIID:	96783	Length:	700	Species:	Mus musculus
Sequence 2:	NP_001285192.1	Gene:	Lgr4 / 5740505	FlyBaseID:	FBgn0085440	Length:	809	Species:	Drosophila melanogaster

Alignment Length:	799	Identity:	174/799 - (21%)
Similarity:	304/799 - (38%)	Gaps:	189/799 - (23%)

- Green bases have known domain annotations that are detailed below.

Mouse     6 PALRQLLVLAMLVLKQSQLHSPELSGSRCP-------EPCDCAP-----DGALRCPGPRAGLARL 58
            |....:.:|.::...:|.:..|: :..:||       ....|.|     ||::.|
  Fly    62 PVREVISLLGIIDGAESDILVPD-ADDKCPGGYFHCNTTAQCVPQRANCDGSVDC---------- 115

Mouse    59 SLTYLPVKVIPSQAFRGLNEVVKIEISQSDSLERIEANAFDNLLNLSEILIQNTK-------NLL 116
                       ..|...:|.|.:::....|.|.|.:.....:.|.:.|.|..|..       :.:
  Fly   116 -----------DDASDEVNCVNEVDAKYWDHLYRKQPFGRHDNLRIGECLWPNENFSCPCRGDEI 169

Mouse   117 YIEPGAFTNLP-RL-------------KYLSICNTGIRTLPDVSKISSSEFNFILEICDNLYITT 167
            .......|::| ||             .:.:|..|....||||..:       :|:.|.   |..
  Fly   170 LCRFQQLTDIPERLPQHDLATLDLTGNNFETIHETFFSELPDVDSL-------VLKFCS---IRE 224

Mouse   168 IPGNAFQGM-NNESITLKLYGNGFEEVQSHAF-NGTTLISLELKENIYLEKMHSGTFQGATGPSI 230
            |..:||..: :|...||.:..|....:..|.| .|..|..|.|..| :|..:....|
  Fly   225 IASHAFDRLADNPLRTLYMDDNKLPHLPEHFFPEGNQLSILILARN-HLHHLKRSDF-------- 280

Mouse   231 LDVSSTKLQALPSHG-------------LESIQTLIATSSYSLKTLPSREKFTSLLVATL----- 277
              ::..|||.|...|             |.:::.|....::..:..|.|...|.|.:.||
  Fly   281 --LNLQKLQELDLRGNRIGNFEAEVFARLPNLEVLYLNENHLKRLDPDRFPRTLLNLHTLSLAYN 343

Mouse   278 --------TYP--------------SHC-----CAFRNL------PKKEQNF---SFSIFENFSK 306
                    |:|              ||.     |...||      ..:.:.|   :|:..:|.|
  Fly   344 QIEDIAANTFPFPRLRYLFLAGNRLSHIRDETFCNLSNLQGLHLNENRIEGFDLEAFACLKNLS- 407

Mouse   307 QCESTVREANN-ETLYSAIFEENELSGWDYDY----DFCSP--KTLQCTPEPDAFNPCEDIMGYA 364
               |.:...|. :||.|.:.:  .|:..||.|    ..||.  ....|.|..|..:....::...
  Fly   408 ---SLLLTGNRFQTLDSRVLK--NLTSLDYIYFSWFHLCSAAMNVRVCDPHGDGISSKLHLLDNQ 467

Mouse   365 FLRVLIWLINILAIFGNLTVLFVLLTSRYKLTVPRFL-MCNLSFADFCMGLYLLLIASVDSQTKG 428
            .||..:|::..:|:.|||.||......:.:..|...| :.:|:.:||.||:||.|||..|...:|
  Fly   468 ILRGSVWVMASIAVVGNLLVLLGRYFYKSRSNVEHSLYLRHLAASDFLMGIYLTLIACADISFRG 532

Mouse   429 QYYNHAIDWQTGSGCSAAGFFTVFASELSVYTLTVITLERWHTITYAVQLDQKLRLRHAIPIMLG 493
            :|..:...|:....|:.|||.:.|:.:.|...||::|.:|..::|..::.....::|..:.::|
  Fly   533 EYIKYEETWRHSGVCAFAGFLSTFSCQSSTLLLTLVTWDRLMSVTRPLKPRDTEKVRIVLRLLL- 596

Mouse   494 GWIFSTLMATLPLV-----GVSSYMKVSICLPMDVESTLSQVY---ILSILLLNAVAFVVICACY 550
            .|..|..:|..||:     |...|....:||.:.:....::.:   .|..:|:|.::.:.|...|
  Fly   597 LWGISFGLAAAPLLPNPYFGSHFYGNNGVCLSLHIHDPYAKGWEYSALLFILVNTLSLIFILFSY 661

Mouse   551 VRIYFAVQNP----ELTAPNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITVTNSKV- 610
            :|:..|:::.    ..|...::..:|.:.||::.||..|..||        ..|.|..::..::
  Fly   662 IRMLQAIRDSGGGMRSTHSGRENVVATRFAIIVTTDCACWLPI--------IVVKLAALSGCEIS 718

Mouse   611 ------LLVLFYPVNSCANPFLYAVFTKAFQRDFFLLLSRFGCCKHRAELYRRKEFSACTFNSKN 669
                  |.||..||||..||.||.:.|.||::.    |.|:  |         ....:|:..:..
  Fly   719 PDLYAWLAVLVLPVNSALNPVLYTLTTAAFKQQ----LRRY--C---------HTLPSCSLVNNE 768

Mouse   670 GFPRSSKPSQAALKLSIVH 688
            ...::....::.|.:|:.|
  Fly   769 TRSQTQTAYESGLSVSLAH 787

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lhcgr	NP_038610.1	LRR 1	52..75		1/22 (5%)
		leucine-rich repeat	55..78	CDD:275380	1/22 (5%)
		LRR_5	66..204	CDD:290045	33/160 (21%)
		leucine-rich repeat	79..103	CDD:275380	4/23 (17%)
		leucine-rich repeat	104..128	CDD:275380	5/31 (16%)
		LRR 2	126..150		9/37 (24%)
		leucine-rich repeat	129..150	CDD:275380	7/33 (21%)
		leucine-rich repeat	155..178	CDD:275380	6/23 (26%)
		LRR 3	176..200		6/25 (24%)
		leucine-rich repeat	180..202	CDD:275380	6/22 (27%)
		leucine-rich repeat	203..227	CDD:275380	6/23 (26%)
		LRR 4	225..248		6/35 (17%)
		leucine-rich repeat	228..248	CDD:275380	6/32 (19%)
		7tm_1	380..627	CDD:278431	70/266 (26%)
Lgr4	NP_001285192.1	Ldl_recept_a	87..124	CDD:278486	8/57 (14%)
		LRR_RI	<184..397	CDD:238064	46/233 (20%)
		LRR_8	188..248	CDD:290566	16/69 (23%)
		leucine-rich repeat	188..211	CDD:275380	3/22 (14%)
		leucine-rich repeat	212..235	CDD:275380	7/32 (22%)
		leucine-rich repeat	238..261	CDD:275380	6/22 (27%)
		LRR_8	261..320	CDD:290566	13/69 (19%)
		leucine-rich repeat	262..285	CDD:275380	6/33 (18%)
		LRR_4	284..325	CDD:289563	7/40 (18%)
		leucine-rich repeat	286..309	CDD:275380	5/22 (23%)
		LRR_4	308..348	CDD:289563	7/39 (18%)
		leucine-rich repeat	310..334	CDD:275380	4/23 (17%)
		leucine-rich repeat	335..357	CDD:275380	4/21 (19%)
		LRR_8	356..416	CDD:290566	11/63 (17%)
		leucine-rich repeat	358..381	CDD:275380	3/22 (14%)
		LRR_4	381..421	CDD:289563	10/43 (23%)
		leucine-rich repeat	382..405	CDD:275380	3/22 (14%)
		leucine-rich repeat	406..427	CDD:275380	6/26 (23%)
		7tm_1	483..741	CDD:278431	70/266 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810