DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BHLHA15 and bigmax

DIOPT Version :9

Sequence 1:	NP_803238.1	Gene:	BHLHA15 / 168620	HGNCID:	22265	Length:	189	Species:	Homo sapiens
Sequence 2:	NP_651556.2	Gene:	bigmax / 43293	FlyBaseID:	FBgn0039509	Length:	254	Species:	Drosophila melanogaster

Alignment Length:	159	Identity:	35/159 - (22%)
Similarity:	58/159 - (36%)	Gaps:	51/159 - (32%)

- Green bases have known domain annotations that are detailed below.

Human    25 TPDGSLPNPGPEPAKGLRSRPARAAARAPGEGRRRRPGPSGPGGRRDSSI---QRRLESN-ERER 85
            ||:.|..|...:...|    .||.:|.|                  :|::   :||.|:: :.|:
  Fly    39 TPNSSAHNSDDDDDSG----DARHSAAA------------------NSTLSYKERRREAHTQAEQ 81

Human    86 QRMHKLNNAFQALREVIPHVRADK----KLSKIETLTLAKNYIKSLTATILTMSSSRLPGLEGPG 146
            :|...:...:.:|:|::|..:.:.    ||||...|..:..||..|....|..        |..|
  Fly    82 KRRDAIKKGYDSLQELVPRCQPNDSSGYKLSKALILQKSIEYIGYLNQQKLKQ--------EDEG 138

Human   147 PKL-------------YQHYQQQQQVAGG 162
            ..|             |::..|.||...|
  Fly   139 SALQKEVTALRIIKNGYENMLQHQQANPG 167

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BHLHA15	NP_803238.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..85		13/63 (21%)
		HLH	81..127	CDD:197674	12/50 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	167..189
bigmax	NP_651556.2	HLH	69..130	CDD:238036	16/60 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910