DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BHLHA15 and dimm

DIOPT Version :9

Sequence 1:	NP_803238.1	Gene:	BHLHA15 / 168620	HGNCID:	22265	Length:	189	Species:	Homo sapiens
Sequence 2:	NP_001260674.1	Gene:	dimm / 35404	FlyBaseID:	FBgn0023091	Length:	390	Species:	Drosophila melanogaster

Alignment Length:	139	Identity:	62/139 - (44%)
Similarity:	76/139 - (54%)	Gaps:	18/139 - (12%)

- Green bases have known domain annotations that are detailed below.

Human    19 ATPGEGTPDG-SLPNPGPE-------------PAKGLRSRPARAAARAPGEGRRRRPGPSGPGGR 69
            :|...|.|.| ||...||.             |:....:..:..::.|.|...|||.|......|
  Fly    90 STTNTGHPSGCSLGGQGPSGRGRVQQASSGACPSTIAPNSTSSNSSNANGNASRRRKGALNAKER 154

Human    70 RDSSIQRRLESNERERQRMHKLNNAFQALREVIPHVRADKKLSKIETLTLAKNYIKSLTATILTM 134
            .    .||||||||||.|||.||:|||:||||||||..:::||||||||||||||.:||..||:.
  Fly   155 N----MRRLESNERERMRMHSLNDAFQSLREVIPHVEMERRLSKIETLTLAKNYIINLTHIILSK 215

Human   135 SSSRLPGLE 143
            .:.....||
  Fly   216 RNEEAAALE 224

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BHLHA15	NP_803238.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..85		24/79 (30%)
		HLH	81..127	CDD:197674	35/45 (78%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	167..189
dimm	NP_001260674.1	HLH	154..208	CDD:238036	41/57 (72%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147275
Domainoid	1	1.000	85	1.000	Domainoid score	I8218
eggNOG	1	0.900	-	-		E1_KOG3898
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005380
OrthoInspector	1	1.000	-	-		oto91414
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19290
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4537
SonicParanoid	1	1.000	-	-		X6113
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.870