DRSC/TRiP Functional Genomics Resources

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Protein Alignment PKD1L1 and pkd1b

DIOPT Version :10

Sequence 1:XP_016867287.1 Gene:PKD1L1 / 168507 HGNCID:18053 Length:2920 Species:Homo sapiens
Sequence 2:XP_021335980.1 Gene:pkd1b / 565697 ZFINID:ZDB-GENE-100707-2 Length:4007 Species:Danio rerio


Alignment Length:2848 Identity:583/2848 - (20%)
Similarity:964/2848 - (33%) Gaps:825/2848 - (28%)


- Green bases have known domain annotations that are detailed below.


Human   324 SGSEILYP---PTQHPPV---AILARNSDNFMNPVLNCSLEVEARAP--PNLGFRVH-------- 372
            ||..|:.|   .|:..||   ||||..:|...:..|:|.     ..|  .::.|.:|        
Zfish  1314 SGLSIVSPVKTVTKGKPVNISAILASGTDIKYSWFLDCE-----HCPVISDVPFILHAFKICGVV 1373

Human   373 ---------MASGEALCLMMDFGDSSGVEMRLHNMSEAMAVTAYHQYSKGIFF------HLLHFQ 422
                     ..|.||..|:....:.|.|:.:::..|....|.:.|..   :.|      ::||::
Zfish  1374 KIRVSASNVFGSEEATKLLTIEENISKVDFQINGQSRPFFVKSNHLL---MLFGSAGPGNVLHWE 1435

Human   423 LDMSTYKEAE---TQNTTLNVYLCQSENSCLEDSDPSNLGYELISAFVTKGVYMLKAVIYNEFHG 484
            ..::.:....   |.|.|::.....:.:..|..:..:::.::.:|..:|                
Zfish  1436 WVLTLHNRTVVVLTDNQTVSYSFVDAADHRLSLNASNDISWQTVSYTIT---------------- 1484

Human   485 TEVELGPYYVEIGHEAVSAFMNSSSVHEDEVLVFADSQVNQKSTVVIHHFPSIPSYNVSFISQTQ 549
                     |:...:.:|...:||.|.||:.:.|..| |::.|.|.:    |:...|.|:  ...
Zfish  1485 ---------VQDAIQGLSLTSSSSVVCEDDSVTFLTS-VSKGSEVSV----SLEFVNASY--SVD 1533

Human   550 VGDSQAWHSM---------TVWYKMQSVSVYTNGTVFATDTDITF----TAVTKETIPLEFE--- 598
            :|.....:|:         |...|:.|.:......|.....|:..    :||.:.:..:.|:   
Zfish  1534 IGRDFTTYSLAVGNHLVRATAKNKVSSQTATATVRVVERIRDLRLIGCCSAVLEASKNISFQASA 1598

Human   599 -------WYF---GEDPPVRTTSRSIKKRLSIPQW----YRVMVKASNRM--SSVVSEPHVIRVQ 647
                   |.|   |..     :||.|.:.:....:    ..|.|:|.|..  .|:.|...:.:..
Zfish  1599 FSQANYHWTFLLNGVQ-----SSREIGQHVHFTPFANGSLSVTVEAENGFCSQSLTSTATIQKHL 1658

Human   648 KKIVANRLTSPSSALVNASVAFECWINFGTDVAYLWDFGD---GTVSLGSSSSSHVYSREGEFTV 709
            ||:..  |||...|.::..|.|....:.|:|:.::|||||   |.:....:...|.|:..|||.|
Zfish  1659 KKVTL--LTSHDGAFIDYPVTFVAITDGGSDLKFIWDFGDASEGLLVTDYNKQVHKYNVAGEFLV 1721

Human   710 EVLAFNNVSASTLRQQLFIVCEPCQPPLVKNMGPGKVQIWRSQPVRLGVTFEAAVFCD--ISQGL 772
            :|.||||:|..:::..:.:....|..|.:..: ..:..:.:|:|    ..|||.|..:  ::...
Zfish  1722 KVTAFNNISEVSVQIAIEVQNLVCTQPHIYTV-KEEYNVLKSRP----SFFEARVDFNGCVTHKA 1781

Human   773 SYTWNLMDSEGLP----VSLPAAVDTHRQTLILPSHTLEYGNYTALAKVQIEGSVVYSNYCVGLE 833
            ||.|.:......|    |:|..:||.....|.||.|||:.|||......:::|:.:..|..:.|.
Zfish  1782 SYIWEIFRGPDCPGMNKVNLNHSVDVTTPLLSLPKHTLKVGNYCLTFTARLKGTPLQQNKTIKLN 1846

Human   834 VRAQAPVSVISEGTHLFFSRTTSSPIVLRGTQSFDPDDPGATLRYHWECATAGSPAHPCFDSSTA 898
            |.....:.||..|:...:|  ....:.|..|:|||||                         |..
Zfish  1847 VVHSRLIPVIKGGSLRLWS--CLCDLTLDATESFDPD-------------------------SEK 1884

Human   899 HQLDAAAPTVSFEAQWLSDSYDQFLVMLRVSS-GGRNSSETRVFLSP----YPDSAFRF------ 952
            :.:|.      |:.||.....:...:.|.:|: .|..|..:.:.:.|    .||..:||      
Zfish  1885 NDIDL------FKFQWSYTIENTTALSLAISTLHGHISGNSSMLILPRSVLLPDRVYRFTLTLFK 1943

Human   953 ---------------------VHISWVSFKDTF--VNWNDELSLQAMCEDCSEIPNLSYSWDLFL 994
                                 |.:..||..:..  :|.||.:||...|..|.:  .:.|.|    
Zfish  1944 SGRQPASISQSVRVYNATLLTVTVKCVSCNNQLFHMNHNDHVSLAGYCSSCQD--TIQYRW---- 2002

Human   995 VNATEKNRIEVPFCRVVGLLGSLGLGAISESSQLNLLPTEPGTADPDATTTPFSREPSPVTLGQP 1059
               |.:|:                                                         
Zfish  2003 ---TAENQ--------------------------------------------------------- 2007

Human  1060 ATSAPRGTPTEPMTGVYWIPPAGDSAVLGEAPEEGSLDLEPGPQSKGSLMTGRSERSQPTHSPDP 1124
                                 .|::..|.|.                :.:||...|.        
Zfish  2008 ---------------------RGEALTLNEV----------------TTLTGSLRRE-------- 2027

Human  1125 HLSDFEAYYSDIQEAIPSGGRQPAKDTSFPGSGPSLSAEESPGDGDNLVDPSLSAGRAEPVLMID 1189
                                                                             
Zfish  2028 ----------------------------------------------------------------- 2027

Human  1190 WPKALLGRAVFQGYSSSGITEQTVTIKPYSLSSGETYVLQVSVAS-KHGLLGKAQLYLTVNPAPR 1253
                                   :.|||..|..|:.|...::|:. ..||.|.|.:.|..|..|.
Zfish  2028 -----------------------IVIKPGVLMEGQEYTFTLNVSDPASGLWGSASITLVSNHPPY 2069

Human  1254 DMACQVQPHHGLE-AHTVFSVFCMSGKPDFHYE-----FSYQIGNTSKH-------TLYHGRDTQ 1305
            ...|.:.|...|. ..|..|..| ||..|...:     ||.|:......       |||.|..:.
Zfish  2070 GGFCTLSPDDSLYFLETKVSYSC-SGWMDDDGDSAQLIFSLQVAQCEDFGPLCPLITLYRGTQST 2133

Human  1306 YYFVLPAG--EHLDNYKVM-VSTEITDGKGSKVQPCTVVVTVLPRYHGNDCLGEDLYNSSLKNLS 1367
            ...::|.|  ..::|..|: |...|.|..|:.|......:||||   .:.|....|...|.....
Zfish  2134 LSSLVPLGIKNTVENASVIHVLVHIEDSMGATVVAVKKKLTVLP---CDQCTVTWLKKRSQSEFW 2195

Human  1368 TLQLMGSYTEIRNYITVITRILSRLSK------EDK---------TASCNQWSRIQD-ALISSVC 1416
            .|...|:..:|..|...:|..|::|:.      |||         ..:....|.:|| |||||..
Zfish  2196 ALIQQGNPQDIMQYSFALTSQLNQLTSISAQELEDKIHIRTRVIQVLASLPVSSLQDVALISSAL 2260

Human  1417 RLAFVDQEEMIGSVLMLRDLVSFSNKLGFMSAVL-----ILKYTRALLAQGQFSGPFVIDKGVRL 1476
            ..:.|...|:..|              |..:.||     ::|..|....:|..:   ..|.|  .
Zfish  2261 AQSTVVPSEVQCS--------------GCYAKVLQVTKKMIKVIREQTGEGNIN---PTDTG--R 2306

Human  1477 ELIGLISRVWEVSEQENSKEEVYRHEEGITVISDL--LLGCLSLNHVSTGQMEFRTLLHYNLQSS 1539
            .::.::|.......::.|..:...|...::.:..:  |:..|.|:.:..|...|..:      ..
Zfish  2307 NILTVLSNTMTADLRQRSTPDTSEHIRAVSALGQVFELMRSLMLSRMRGGTALFLAI------PK 2365

Human  1540 VQSLG----------------SVQVHLPGDLAGHSPAGAETQSPCYISQLILFKKNPY-PGSQAP 1587
            :.::|                ..|.|:|..|:  |....|.|....|...:..::||: ||::.|
Zfish  2366 ISAVGIQGDPTEDLRCKDVLTHCQFHIPPALS--SQLKEEKQEVLQILLQMENEENPFIPGAEPP 2428

Human  1588 GQIGGVVGLNLYTCSSRRPINRQWLRKPVMVEFGEEDGLDNRRNKTTFVLLRDKVNLH-----QF 1647
              |..::....:......||:...|.....::..........::::   ||...:.|.     .|
Zfish  2429 --ISTMLAAMEFATPQGNPISIANLTLDSAIQVTLHKQAQEMKDES---LLWKNITLKHNGSVNF 2488

Human  1648 T--ELSENPQESLQIEIEFSKPVTRAFPVMLLVRFSEKPTPSDFLVKQIYFWDESIVQIYIPAAS 1710
            |  .:...|...|.:.:.||.....|.....||..|....|.|....:|:..:   :.|::.|.:
Zfish  2489 TVKAMDAEPHTGLYVALNFSLIPGSAEKASGLVWISINDQPVDLQSGRIHHQE---LTIFLSAQT 2550

Human  1711 QKDASVGYLS-LLDADYDRKPPNRYLAK-----------AVNYTVH---FQWIRCLFWDKRE--W 1758
            .....:.:|: ||:..          ||           .|:.||.   |. :.|.|:|.:|  |
Zfish  2551 PLLQHIIFLTPLLNGS----------AKELFVKVNSSIGGVDVTVSVCVFS-VLCRFFDVKELRW 2604

Human  1759 KSERFSPQPGTSPEKVNCSYHRLAAFALLRRKLKASFEVSDISKLQSHPENLL---PSI------ 1814
            .|:..||...:||...:|....|..|.               :.|..|||.||   ||.      
Zfish  2605 SSDGLSPLSTSSPHSAHCLTQHLTMFG---------------ASLFIHPEALLLLPPSEEPVRNV 2654

Human  1815 ---FIMGSVILYGFLVA-KSRQVDHHEKKKAGYIFLQEASLPGHQLYAVVIDTGFRAPARLTSKV 1875
               .|.|.::|...||. .:.::||.|..:..::.|  ....|...|.|::.||::..:..|:.|
Zfish  2655 VVGIICGVLLLIHLLVGLMAHKLDHLENLRLCWVPL--CGQKGRYQYRVLVKTGWKRGSGTTAHV 2717

Human  1876 YIVLCGDNGLSETKELSCPEKPLFERNSRHTFILSAPAQLGLLRKIRLWHDSRGPSPGWFISHVM 1940
            .|.|   .||:::.......:..|:|||...|.:...|.||.:.|||:|||:.|..|.|::.||:
Zfish  2718 GISL---YGLNKSGSRHLQRQGAFQRNSMDDFQVETDANLGEIWKIRIWHDNTGLDPSWYLQHVI 2779

Human  1941 VKELHTGQGWFFPAQCWLSA--GRHDGRVEREL--TCLQGGLGFRKLFYCKFTEYLEDFHVWLSV 2001
            |.::.|...:||..:.|||.  .::.||||:.:  :|.|....|:::.:.:....|::.|:|:|:
Zfish  2780 VWDIQTENMFFFLVEDWLSVENEKNSGRVEKVILASCPQELHQFKRILHSQLLFGLQEHHLWISL 2844

Human  2002 YSRPSSSRYLHTPRLTVSFSLLCVYACLTAL-VAAGGQEQPHLDVSPTL----GSFRVGLLCTLL 2061
            :.||:.||:....|:|....||.:|....|: ..|.|::.....||..:    .:..||:....|
Zfish  2845 WERPTHSRFSRAQRVTCCALLLHLYLAAGAVWYGAVGRKGSSGRVSTQMVMNAETVLVGMTVAAL 2909

Human  2062 ASPGAQLLSLLFRLSKE----------APGSARVE-----PHSPLRGGAQTEAPHGPNS------ 2105
            ..|...:|..||:.:|.          :|.|..||     .|..|...:....|..|.|      
Zfish  2910 TFPFQAILKFLFQRTKSKVTLEVSAPPSPVSHTVEMDVFLSHPDLTCSSFLSLPTCPKSSIYDGP 2974

Human  2106 ----------------WGRIPDAQEPR--KQPASAILSG----SGRA---QRKAA---------- 2135
                            |.. ||.:..|  :.|:...:.|    :|..   :||.|          
Zfish  2975 SPFTNSLQSKKLDSEFWNS-PDPRNGRVDQLPSCDSIFGLPELTGTTHLLKRKKALLQLHLSTPT 3038

Human  2136 --SDNG----TACPAPKLQVHGADHSRTSLMGK------SHCCPPHTQAPSSGLEGLMPQWS--- 2185
              .|||    ::.....|:....|...|:.:..      |....|:...|:...:....:||   
Zfish  3039 SDHDNGELAKSSASEEDLRTISPDMDLTNTLSSDPEASDSGNFTPNDTIPTDTQDSFCSEWSDLS 3103

Human  2186 ---RALQPWW--SSAVWAICGTAS----------------------------------------- 2204
               ...:|.:  ||:..::...||                                         
Zfish  3104 VDTPTYEPGFHRSSSSLSVLSEASTFLPSLPPDSISTVSTTRIGVVRGVPGFYLPSWVLRMVHLL 3168

Human  2205 LACSLGT-----GFLAYRFGQEQCVQWLHLLSLSVVCCIFITQPLMVCLMALGFAWKRRADNHFF 2264
            :|..|||     |.....|.....:.||.....:|:....:.:||.:|:.||             
Zfish  3169 VAVLLGTCLAVVGLYGSSFTSSVVLMWLVSTLSAVLTSALLLEPLAICIQAL------------- 3220

Human  2265 TESLCEATRDLDSELAERSWTRLPFSSSCSIPDCAGEVEKVLAARQQARHLR-WAHPPSKAQLRG 2328
              .|....|.:|.|:.||               .|.|.|    .|:.....| ..||.....|..
Zfish  3221 --YLATVVRPVDPEVEER---------------LAQETE----VRRSEEDFRDKVHPLCGYGLLQ 3264

Human  2329 TRQRMRRESRTRAALRDISMDILMLLLLLCVIYGRFSQ--DEYSLNQAIRKEFTRNARNCLGGLR 2391
            .::..|:....||.:|...:.:|.||::|.|.|....|  |...|:.|| |....:|.....||.
Zfish  3265 AKEEARKLRTLRALMRSCLVYMLFLLVVLMVNYQEHVQMADSRRLHSAI-KHTLISASAGKPGLM 3328

Human  2392 NIADWWD---WSLTTLLDGLYPGGTPSARVPGAQPGALGGKCYLIGSSVIRQLKVFPRHLCKPPR 2453
            .::.|.:   |....|...||.  .||..:.|.                .|..||:.:..|    
Zfish  3329 KLSGWMNAEQWINEKLTSHLYE--NPSLLLTGP----------------ARLQKVYFQDFC---- 3371

Human  2454 PFSALIEDS--------IPTCSPEVGGPENPYLIDPENQNVTLNGPGG-----------CGTRED 2499
              |..|.|.        :||.  .|....|     |..|..|.:....           |...:.
Zfish  3372 --SQGIRDQFQSGRLSLMPTA--HVSSHAN-----PGQQTSTAHSKNTPALSTWQKRALCAFSQT 3427

Human  2500 CVLSLGRTRTEAHTALSRLRASMWIDRSTRAVSVHFTLYNPPTQLFTSVSLRVEILPTGSLVPSS 2564
            ..|.||.........||.|:...|:...|:||.:.||.|:..|.:...||:.::...||.::...
Zfish  3428 EELVLGNNTEYTRQILSDLQKEKWMTTGTKAVLIEFTQYHKQTSILAPVSILLDQTQTGRILAFI 3492

Human  2565 LVESFSIFRSDSALQYHLMLPQLVFLALSLIHLCVQLYRMMDKGVLSYWRKPRNWLE-----LSV 2624
            .::.|.| ...|....|:.| .:|.|..:|..|..:: |.:.:....|.|:...|.:     |::
Zfish  3493 SIQPFHI-SPLSGPDLHVTL-TVVLLLFALCFLSTEV-RALIRKPSQYLRQAWCWFQTLLALLAL 3554

Human  2625 VGVSLTYYAVSGHLVTLAGDVTNQFHRGLCRAFMDLTLMASWNQRARWLRGILLFLFTLKCV-YL 2688
            ....|..|.:....|.::.      :|.:..:|.|....|:..:::..|..|||.|..||.| .|
Zfish  3555 AAAVLRLYFLYTTTVCISR------YRSIPSSFADFHSAATVARKSNQLSAILLTLLALKMVGIL 3613

Human  2689 PGIQNTMASCSSMMRHSLPSIF--VAGLVGALMLAAL--SHLHRFLLSMWVLPPGTFTDAFPGLL 2749
            ..::..:     :|...:..:|  :.|:|..|:|..|  ||:...|.|..|....|...|...||
Zfish  3614 QFVRRWL-----VMGRVIWQVFPQICGVVFLLLLLLLLFSHIGMMLFSGSVEGFRTLGQASSSLL 3673

Human  2750 FHFPRRSQKDCLL----GLSKSDQR-----AMACY--FGILLIVSATLCFGML 2791
                      |||    ||.:..:.     .:.|.  .||...|...||..:|
Zfish  3674 ----------CLLRGRTGLQRLCEHHPVVGPLYCLSAVGIGFWVLGRLCAAVL 3716

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PKD1L1XP_016867287.1 PCC <519..892 CDD:188093 97/413 (23%)
REJ 798..>990 CDD:366875 49/225 (22%)
REJ <1199..1343 CDD:366875 39/160 (24%)
PLAT_polycystin 1855..1973 CDD:238850 40/121 (33%)
Polycystin_dom 2395..2570 CDD:466668 41/196 (21%)
pkd1bXP_021335980.1 PCC 25..2314 CDD:188093 249/1306 (19%)
GPS 2590..2636 CDD:470616 15/61 (25%)
PLAT_polycystin 2697..2815 CDD:238850 40/120 (33%)
PKD_channel 3513..3720 CDD:462341 53/226 (23%)

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