DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PKD1L1 and pkd1b

DIOPT Version :9

Sequence 1:XP_016867287.1 Gene:PKD1L1 / 168507 HGNCID:18053 Length:2920 Species:Homo sapiens
Sequence 2:XP_021335980.1 Gene:pkd1b / 565697 ZFINID:ZDB-GENE-100707-2 Length:4007 Species:Danio rerio


Alignment Length:2848 Identity:583/2848 - (20%)
Similarity:964/2848 - (33%) Gaps:825/2848 - (28%)


- Green bases have known domain annotations that are detailed below.


Human   324 SGSEILYP---PTQHPPV---AILARNSDNFMNPVLNCSLEVEARAP--PNLGFRVH-------- 372
            ||..|:.|   .|:..||   ||||..:|...:..|:|.     ..|  .::.|.:|        
Zfish  1314 SGLSIVSPVKTVTKGKPVNISAILASGTDIKYSWFLDCE-----HCPVISDVPFILHAFKICGVV 1373

Human   373 ---------MASGEALCLMMDFGDSSGVEMRLHNMSEAMAVTAYHQYSKGIFF------HLLHFQ 422
                     ..|.||..|:....:.|.|:.:::..|....|.:.|..   :.|      ::||::
Zfish  1374 KIRVSASNVFGSEEATKLLTIEENISKVDFQINGQSRPFFVKSNHLL---MLFGSAGPGNVLHWE 1435

Human   423 LDMSTYKEAE---TQNTTLNVYLCQSENSCLEDSDPSNLGYELISAFVTKGVYMLKAVIYNEFHG 484
            ..::.:....   |.|.|::.....:.:..|..:..:::.::.:|..:|                
Zfish  1436 WVLTLHNRTVVVLTDNQTVSYSFVDAADHRLSLNASNDISWQTVSYTIT---------------- 1484

Human   485 TEVELGPYYVEIGHEAVSAFMNSSSVHEDEVLVFADSQVNQKSTVVIHHFPSIPSYNVSFISQTQ 549
                     |:...:.:|...:||.|.||:.:.|..| |::.|.|.:    |:...|.|:  ...
Zfish  1485 ---------VQDAIQGLSLTSSSSVVCEDDSVTFLTS-VSKGSEVSV----SLEFVNASY--SVD 1533

Human   550 VGDSQAWHSM---------TVWYKMQSVSVYTNGTVFATDTDITF----TAVTKETIPLEFE--- 598
            :|.....:|:         |...|:.|.:......|.....|:..    :||.:.:..:.|:   
Zfish  1534 IGRDFTTYSLAVGNHLVRATAKNKVSSQTATATVRVVERIRDLRLIGCCSAVLEASKNISFQASA 1598

Human   599 -------WYF---GEDPPVRTTSRSIKKRLSIPQW----YRVMVKASNRM--SSVVSEPHVIRVQ 647
                   |.|   |..     :||.|.:.:....:    ..|.|:|.|..  .|:.|...:.:..
Zfish  1599 FSQANYHWTFLLNGVQ-----SSREIGQHVHFTPFANGSLSVTVEAENGFCSQSLTSTATIQKHL 1658

Human   648 KKIVANRLTSPSSALVNASVAFECWINFGTDVAYLWDFGD---GTVSLGSSSSSHVYSREGEFTV 709
            ||:..  |||...|.::..|.|....:.|:|:.::|||||   |.:....:...|.|:..|||.|
Zfish  1659 KKVTL--LTSHDGAFIDYPVTFVAITDGGSDLKFIWDFGDASEGLLVTDYNKQVHKYNVAGEFLV 1721

Human   710 EVLAFNNVSASTLRQQLFIVCEPCQPPLVKNMGPGKVQIWRSQPVRLGVTFEAAVFCD--ISQGL 772
            :|.||||:|..:::..:.:....|..|.:..: ..:..:.:|:|    ..|||.|..:  ::...
Zfish  1722 KVTAFNNISEVSVQIAIEVQNLVCTQPHIYTV-KEEYNVLKSRP----SFFEARVDFNGCVTHKA 1781

Human   773 SYTWNLMDSEGLP----VSLPAAVDTHRQTLILPSHTLEYGNYTALAKVQIEGSVVYSNYCVGLE 833
            ||.|.:......|    |:|..:||.....|.||.|||:.|||......:::|:.:..|..:.|.
Zfish  1782 SYIWEIFRGPDCPGMNKVNLNHSVDVTTPLLSLPKHTLKVGNYCLTFTARLKGTPLQQNKTIKLN 1846

Human   834 VRAQAPVSVISEGTHLFFSRTTSSPIVLRGTQSFDPDDPGATLRYHWECATAGSPAHPCFDSSTA 898
            |.....:.||..|:...:|  ....:.|..|:|||||                         |..
Zfish  1847 VVHSRLIPVIKGGSLRLWS--CLCDLTLDATESFDPD-------------------------SEK 1884

Human   899 HQLDAAAPTVSFEAQWLSDSYDQFLVMLRVSS-GGRNSSETRVFLSP----YPDSAFRF------ 952
            :.:|.      |:.||.....:...:.|.:|: .|..|..:.:.:.|    .||..:||      
Zfish  1885 NDIDL------FKFQWSYTIENTTALSLAISTLHGHISGNSSMLILPRSVLLPDRVYRFTLTLFK 1943

Human   953 ---------------------VHISWVSFKDTF--VNWNDELSLQAMCEDCSEIPNLSYSWDLFL 994
                                 |.:..||..:..  :|.||.:||...|..|.:  .:.|.|    
Zfish  1944 SGRQPASISQSVRVYNATLLTVTVKCVSCNNQLFHMNHNDHVSLAGYCSSCQD--TIQYRW---- 2002

Human   995 VNATEKNRIEVPFCRVVGLLGSLGLGAISESSQLNLLPTEPGTADPDATTTPFSREPSPVTLGQP 1059
               |.:|:                                                         
Zfish  2003 ---TAENQ--------------------------------------------------------- 2007

Human  1060 ATSAPRGTPTEPMTGVYWIPPAGDSAVLGEAPEEGSLDLEPGPQSKGSLMTGRSERSQPTHSPDP 1124
                                 .|::..|.|.                :.:||...|.        
Zfish  2008 ---------------------RGEALTLNEV----------------TTLTGSLRRE-------- 2027

Human  1125 HLSDFEAYYSDIQEAIPSGGRQPAKDTSFPGSGPSLSAEESPGDGDNLVDPSLSAGRAEPVLMID 1189
                                                                             
Zfish  2028 ----------------------------------------------------------------- 2027

Human  1190 WPKALLGRAVFQGYSSSGITEQTVTIKPYSLSSGETYVLQVSVAS-KHGLLGKAQLYLTVNPAPR 1253
                                   :.|||..|..|:.|...::|:. ..||.|.|.:.|..|..|.
Zfish  2028 -----------------------IVIKPGVLMEGQEYTFTLNVSDPASGLWGSASITLVSNHPPY 2069

Human  1254 DMACQVQPHHGLE-AHTVFSVFCMSGKPDFHYE-----FSYQIGNTSKH-------TLYHGRDTQ 1305
            ...|.:.|...|. ..|..|..| ||..|...:     ||.|:......       |||.|..:.
Zfish  2070 GGFCTLSPDDSLYFLETKVSYSC-SGWMDDDGDSAQLIFSLQVAQCEDFGPLCPLITLYRGTQST 2133

Human  1306 YYFVLPAG--EHLDNYKVM-VSTEITDGKGSKVQPCTVVVTVLPRYHGNDCLGEDLYNSSLKNLS 1367
            ...::|.|  ..::|..|: |...|.|..|:.|......:||||   .:.|....|...|.....
Zfish  2134 LSSLVPLGIKNTVENASVIHVLVHIEDSMGATVVAVKKKLTVLP---CDQCTVTWLKKRSQSEFW 2195

Human  1368 TLQLMGSYTEIRNYITVITRILSRLSK------EDK---------TASCNQWSRIQD-ALISSVC 1416
            .|...|:..:|..|...:|..|::|:.      |||         ..:....|.:|| |||||..
Zfish  2196 ALIQQGNPQDIMQYSFALTSQLNQLTSISAQELEDKIHIRTRVIQVLASLPVSSLQDVALISSAL 2260

Human  1417 RLAFVDQEEMIGSVLMLRDLVSFSNKLGFMSAVL-----ILKYTRALLAQGQFSGPFVIDKGVRL 1476
            ..:.|...|:..|              |..:.||     ::|..|....:|..:   ..|.|  .
Zfish  2261 AQSTVVPSEVQCS--------------GCYAKVLQVTKKMIKVIREQTGEGNIN---PTDTG--R 2306

Human  1477 ELIGLISRVWEVSEQENSKEEVYRHEEGITVISDL--LLGCLSLNHVSTGQMEFRTLLHYNLQSS 1539
            .::.::|.......::.|..:...|...::.:..:  |:..|.|:.:..|...|..:      ..
Zfish  2307 NILTVLSNTMTADLRQRSTPDTSEHIRAVSALGQVFELMRSLMLSRMRGGTALFLAI------PK 2365

Human  1540 VQSLG----------------SVQVHLPGDLAGHSPAGAETQSPCYISQLILFKKNPY-PGSQAP 1587
            :.::|                ..|.|:|..|:  |....|.|....|...:..::||: ||::.|
Zfish  2366 ISAVGIQGDPTEDLRCKDVLTHCQFHIPPALS--SQLKEEKQEVLQILLQMENEENPFIPGAEPP 2428

Human  1588 GQIGGVVGLNLYTCSSRRPINRQWLRKPVMVEFGEEDGLDNRRNKTTFVLLRDKVNLH-----QF 1647
              |..::....:......||:...|.....::..........::::   ||...:.|.     .|
Zfish  2429 --ISTMLAAMEFATPQGNPISIANLTLDSAIQVTLHKQAQEMKDES---LLWKNITLKHNGSVNF 2488

Human  1648 T--ELSENPQESLQIEIEFSKPVTRAFPVMLLVRFSEKPTPSDFLVKQIYFWDESIVQIYIPAAS 1710
            |  .:...|...|.:.:.||.....|.....||..|....|.|....:|:..:   :.|::.|.:
Zfish  2489 TVKAMDAEPHTGLYVALNFSLIPGSAEKASGLVWISINDQPVDLQSGRIHHQE---LTIFLSAQT 2550

Human  1711 QKDASVGYLS-LLDADYDRKPPNRYLAK-----------AVNYTVH---FQWIRCLFWDKRE--W 1758
            .....:.:|: ||:..          ||           .|:.||.   |. :.|.|:|.:|  |
Zfish  2551 PLLQHIIFLTPLLNGS----------AKELFVKVNSSIGGVDVTVSVCVFS-VLCRFFDVKELRW 2604

Human  1759 KSERFSPQPGTSPEKVNCSYHRLAAFALLRRKLKASFEVSDISKLQSHPENLL---PSI------ 1814
            .|:..||...:||...:|....|..|.               :.|..|||.||   ||.      
Zfish  2605 SSDGLSPLSTSSPHSAHCLTQHLTMFG---------------ASLFIHPEALLLLPPSEEPVRNV 2654

Human  1815 ---FIMGSVILYGFLVA-KSRQVDHHEKKKAGYIFLQEASLPGHQLYAVVIDTGFRAPARLTSKV 1875
               .|.|.::|...||. .:.::||.|..:..::.|  ....|...|.|::.||::..:..|:.|
Zfish  2655 VVGIICGVLLLIHLLVGLMAHKLDHLENLRLCWVPL--CGQKGRYQYRVLVKTGWKRGSGTTAHV 2717

Human  1876 YIVLCGDNGLSETKELSCPEKPLFERNSRHTFILSAPAQLGLLRKIRLWHDSRGPSPGWFISHVM 1940
            .|.|   .||:::.......:..|:|||...|.:...|.||.:.|||:|||:.|..|.|::.||:
Zfish  2718 GISL---YGLNKSGSRHLQRQGAFQRNSMDDFQVETDANLGEIWKIRIWHDNTGLDPSWYLQHVI 2779

Human  1941 VKELHTGQGWFFPAQCWLSA--GRHDGRVEREL--TCLQGGLGFRKLFYCKFTEYLEDFHVWLSV 2001
            |.::.|...:||..:.|||.  .::.||||:.:  :|.|....|:::.:.:....|::.|:|:|:
Zfish  2780 VWDIQTENMFFFLVEDWLSVENEKNSGRVEKVILASCPQELHQFKRILHSQLLFGLQEHHLWISL 2844

Human  2002 YSRPSSSRYLHTPRLTVSFSLLCVYACLTAL-VAAGGQEQPHLDVSPTL----GSFRVGLLCTLL 2061
            :.||:.||:....|:|....||.:|....|: ..|.|::.....||..:    .:..||:....|
Zfish  2845 WERPTHSRFSRAQRVTCCALLLHLYLAAGAVWYGAVGRKGSSGRVSTQMVMNAETVLVGMTVAAL 2909

Human  2062 ASPGAQLLSLLFRLSKE----------APGSARVE-----PHSPLRGGAQTEAPHGPNS------ 2105
            ..|...:|..||:.:|.          :|.|..||     .|..|...:....|..|.|      
Zfish  2910 TFPFQAILKFLFQRTKSKVTLEVSAPPSPVSHTVEMDVFLSHPDLTCSSFLSLPTCPKSSIYDGP 2974

Human  2106 ----------------WGRIPDAQEPR--KQPASAILSG----SGRA---QRKAA---------- 2135
                            |.. ||.:..|  :.|:...:.|    :|..   :||.|          
Zfish  2975 SPFTNSLQSKKLDSEFWNS-PDPRNGRVDQLPSCDSIFGLPELTGTTHLLKRKKALLQLHLSTPT 3038

Human  2136 --SDNG----TACPAPKLQVHGADHSRTSLMGK------SHCCPPHTQAPSSGLEGLMPQWS--- 2185
              .|||    ::.....|:....|...|:.:..      |....|:...|:...:....:||   
Zfish  3039 SDHDNGELAKSSASEEDLRTISPDMDLTNTLSSDPEASDSGNFTPNDTIPTDTQDSFCSEWSDLS 3103

Human  2186 ---RALQPWW--SSAVWAICGTAS----------------------------------------- 2204
               ...:|.:  ||:..::...||                                         
Zfish  3104 VDTPTYEPGFHRSSSSLSVLSEASTFLPSLPPDSISTVSTTRIGVVRGVPGFYLPSWVLRMVHLL 3168

Human  2205 LACSLGT-----GFLAYRFGQEQCVQWLHLLSLSVVCCIFITQPLMVCLMALGFAWKRRADNHFF 2264
            :|..|||     |.....|.....:.||.....:|:....:.:||.:|:.||             
Zfish  3169 VAVLLGTCLAVVGLYGSSFTSSVVLMWLVSTLSAVLTSALLLEPLAICIQAL------------- 3220

Human  2265 TESLCEATRDLDSELAERSWTRLPFSSSCSIPDCAGEVEKVLAARQQARHLR-WAHPPSKAQLRG 2328
              .|....|.:|.|:.||               .|.|.|    .|:.....| ..||.....|..
Zfish  3221 --YLATVVRPVDPEVEER---------------LAQETE----VRRSEEDFRDKVHPLCGYGLLQ 3264

Human  2329 TRQRMRRESRTRAALRDISMDILMLLLLLCVIYGRFSQ--DEYSLNQAIRKEFTRNARNCLGGLR 2391
            .::..|:....||.:|...:.:|.||::|.|.|....|  |...|:.|| |....:|.....||.
Zfish  3265 AKEEARKLRTLRALMRSCLVYMLFLLVVLMVNYQEHVQMADSRRLHSAI-KHTLISASAGKPGLM 3328

Human  2392 NIADWWD---WSLTTLLDGLYPGGTPSARVPGAQPGALGGKCYLIGSSVIRQLKVFPRHLCKPPR 2453
            .::.|.:   |....|...||.  .||..:.|.                .|..||:.:..|    
Zfish  3329 KLSGWMNAEQWINEKLTSHLYE--NPSLLLTGP----------------ARLQKVYFQDFC---- 3371

Human  2454 PFSALIEDS--------IPTCSPEVGGPENPYLIDPENQNVTLNGPGG-----------CGTRED 2499
              |..|.|.        :||.  .|....|     |..|..|.:....           |...:.
Zfish  3372 --SQGIRDQFQSGRLSLMPTA--HVSSHAN-----PGQQTSTAHSKNTPALSTWQKRALCAFSQT 3427

Human  2500 CVLSLGRTRTEAHTALSRLRASMWIDRSTRAVSVHFTLYNPPTQLFTSVSLRVEILPTGSLVPSS 2564
            ..|.||.........||.|:...|:...|:||.:.||.|:..|.:...||:.::...||.::...
Zfish  3428 EELVLGNNTEYTRQILSDLQKEKWMTTGTKAVLIEFTQYHKQTSILAPVSILLDQTQTGRILAFI 3492

Human  2565 LVESFSIFRSDSALQYHLMLPQLVFLALSLIHLCVQLYRMMDKGVLSYWRKPRNWLE-----LSV 2624
            .::.|.| ...|....|:.| .:|.|..:|..|..:: |.:.:....|.|:...|.:     |::
Zfish  3493 SIQPFHI-SPLSGPDLHVTL-TVVLLLFALCFLSTEV-RALIRKPSQYLRQAWCWFQTLLALLAL 3554

Human  2625 VGVSLTYYAVSGHLVTLAGDVTNQFHRGLCRAFMDLTLMASWNQRARWLRGILLFLFTLKCV-YL 2688
            ....|..|.:....|.::.      :|.:..:|.|....|:..:::..|..|||.|..||.| .|
Zfish  3555 AAAVLRLYFLYTTTVCISR------YRSIPSSFADFHSAATVARKSNQLSAILLTLLALKMVGIL 3613

Human  2689 PGIQNTMASCSSMMRHSLPSIF--VAGLVGALMLAAL--SHLHRFLLSMWVLPPGTFTDAFPGLL 2749
            ..::..:     :|...:..:|  :.|:|..|:|..|  ||:...|.|..|....|...|...||
Zfish  3614 QFVRRWL-----VMGRVIWQVFPQICGVVFLLLLLLLLFSHIGMMLFSGSVEGFRTLGQASSSLL 3673

Human  2750 FHFPRRSQKDCLL----GLSKSDQR-----AMACY--FGILLIVSATLCFGML 2791
                      |||    ||.:..:.     .:.|.  .||...|...||..:|
Zfish  3674 ----------CLLRGRTGLQRLCEHHPVVGPLYCLSAVGIGFWVLGRLCAAVL 3716

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PKD1L1XP_016867287.1 None
pkd1bXP_021335980.1 PCC 25..2314 CDD:188093 249/1306 (19%)
GPS 2590..2636 CDD:321989 15/61 (25%)
PLAT_polycystin 2697..2815 CDD:238850 40/120 (33%)
PKD_channel 3302..3720 CDD:332708 108/471 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 44 1.000 Domainoid score I37150
eggNOG 1 0.900 - - E1_KOG3599
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
NCBI 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1276906at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.820

Return to query results.
Submit another query.