Protein Alignment PKD1L1 and brv3

DIOPT Version :9

• Sequence 1: XP_016867287.1
• Gene: PKD1L1 / 168507
• HGNCID: 18053
• Length: 2920
• Species: Homo sapiens
• Sequence 2: NP_001284831.1
• Gene: brv3 / 31246
• FlyBaseID: FBgn0040333
• Length: 750
• Species: Drosophila melanogaster
• Alignment Length: 683
• Identity: 138/683 - (20%)
• Similarity: 241/683 - (35%)
• Gaps: 185/683 - (27%)

Human  2192 WSSAVWAICGTASLAC----SLGTGFLAYRFGQEQCVQWLHLLSLSVVCCIF---ITQPLMVCLM 2249
            |  |::||.....:.|    ::..||      |.:.|::..:|...|:..||   |..|:...::
  Fly     8 W--AMFAITVGIIIGCMICIAVFAGF------QHEDVKFKTMLVSIVIVLIFQFLIGDPIKFVIL 64

Human  2250 ALGFA-WKRRADNHFFTESLCEATRDLDSELAERSWTRLPFSSSCSIPDCAGEVEKVLAARQQAR 2313
            ::..| |..|    .:....|:.. ::|.:...|.:.
  Fly    65 SIDRALWPPR----IYIPPRCDKD-EMDEKEERRDFL---------------------------- 96

Human  2314 HLRWAHPPSKAQLRGTRQRMRRESRTR-AALRD----ISMDILM----LLLLLCVIYGRFSQDEY 2369
                     |.:|...|..:...||.| ..|.|    |:.|:.:    .|.|:|::.....|..|
  Fly    97 ---------KQRLINKRANLMLTSRYRNYKLNDQYKMIAHDLFIYGPYFLCLMCLVLVTRDQTLY 152

Human  2370 SLNQAIRKEFTRNARNCLGGLRNI---ADWWDWSLTTLLDGLYPGGTPSARVPGAQPG-ALGGKC 2430
            ...:.|...|..|..: ..||:.:   ...:|:..:||:.......|.|     ..|| |...:.
  Fly   153 HNTRIITDLFMYNHTD-YTGLQEVYFLNQLFDFIESTLVLAFNSNSTES-----GSPGWAHAEQS 211

Human  2431 YLIGSSVIRQLKVF-PRHLCKPPR------------PFSAL---------IEDSIPTCSPEVG-- 2471
            .|:|...:|||:|. |:....||:            |:..|         .|..||.   ::|
  Fly   212 VLLGVMRLRQLRVSNPQVGLGPPKFSDTYYMPDWQLPYRKLHYSDKYWRIYEPWIPI---KMGFE 273

Human  2472 ------------GPENPYLIDPENQNVTLNGPGGCGTREDCVLSLGRTRTEAHTALSRLRASMWI 2524
                        |..|.|   ||     |.|         .|..|.|:...:...:..|..:.|:
  Fly   274 FLDALLMNFDHVGSLNSY---PE-----LAG---------YVSLLARSAANSMKVIDYLSENHWL 321

Human  2525 DRSTRAVSVHFTLYNPPTQLFTSVSLRVEILPTGSLVPSSLVESFSIFRSDSALQYHLMLPQLVF 2589
            ..:|.||.:.|||||....||:..:||||..|.|.:||...|:|..:..:...:.|..:|..|::
  Fly   322 TLNTSAVFIDFTLYNVDVNLFSICTLRVEKTPFGGIVPDVQVDSAKLLENVDQMPYTGLLALLIY 386

Human  2590 LALSLIHLCVQLYRMMDKGVLSYWRKPR------NWLELSVVGVSLTYYAVSGHLVTLAGDVTNQ 2648
            : |..|.....|       .:..|.:|.      |.|:|.:..|::....:.....:|...:..:
  Fly   387 V-LVFIQFAQTL-------AVKLWYEPHLLKSVWNKLDLFIFMVNVLVVVLVVLRESLVASMMKK 443

Human  2649 FHRGLCRAFMDLTLMASWNQRARWLRGILLFLFTLKCVYLPGIQNTMASCSSMMRHSLPSIFVA- 2712
            ........|:|....:..:|......|.|:.:.||:..       .:...:|:.:....::::|
  Fly   444 VEGASKMEFIDFRRPSRMHQLTTITIGFLICITTLRLW-------RVLQFASVFKLFTRTLYLAW 501

Human  2713 GLVGALMLAALSHLHRFLLSMWVLPPGTFTDAFPGLLFHFPRRSQKDCLLGLSKSDQRAMACY-F 2776
            ..|.:..:|.:..|..|..:: |...|.::..|..|:     :|...|:            || |
  Fly   502 SAVASTAIAIVIFLIGFCFAV-VTINGNYSSNFNKLV-----KSMVMCM------------CYSF 548

Human  2777 GILLIVSAT-----------LCFGMLRGFLMTL 2798
            |....|..:           ||:|:|...::.|
  Fly   549 GFSAQVKPSELFHGGKWLGILCYGVLAFVIIVL 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PKD1L1	XP_016867287.1	None
brv3	NP_001284831.1	PKD_channel	170..595	CDD:285288	99/470 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S9099
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276906at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.770