Protein Alignment PKD1L1 and Pkd1l1

DIOPT Version :9

• Sequence 1: XP_016867287.1
• Gene: PKD1L1 / 168507
• HGNCID: 18053
• Length: 2920
• Species: Homo sapiens
• Sequence 2: XP_038948500.1
• Gene: Pkd1l1 / 289796
• RGDID: 1564724
• Length: 2586
• Species: Rattus norvegicus
• Alignment Length: 2777
• Identity: 1576/2777 - (56%)
• Similarity: 1884/2777 - (67%)
• Gaps: 319/2777 - (11%)

Human   210 PRFHHRRLCATGTADSTFSALL--------QLQGTTSAAAPCSLKMEASCC-VLRLLCCAEDVAT 265
            ||.:||  .||..||:..:|::        .||| .|:|||||||.||.|| ..||||..||.|.
  Rat    24 PREYHR--LATSKADNEANAVIDVPDAPCVDLQG-VSSAAPCSLKKEAFCCNGTRLLCSGEDSAN 85

Human   266 GLLPGTVTMETPTKVARPTQTSSQRVPLWPISHFPTSPRSSHGLPPGIPRTPSFTASQSGSEILY 330
            .||    :...|                                ||||.:|.:.:||....|...
  Rat    86 TLL----SFSDP--------------------------------PPGISQTRNLSASWYHPESSC 114

Human   331 PPTQHPPVAILARNSDNFMNPVLNCSLEVEARAPPNLGFRVHMASGEALCLMMDFGDSSGVEMRL 395
            |.||||..|:||...:|..:....|..|.:|:|||.||.|||.||..||||::||||:.|.||:|
  Rat   115 PLTQHPLGAVLATQPENAGHFATCCFPETDAKAPPALGIRVHAASRTALCLLLDFGDNHGAEMKL 179

Human   396 HNMSEAMAVTAYHQYSKGIFFHLLHFQLDMSTYKEAETQNTTLNVYLCQSENSCLEDSDPSNLGY 460
            ..::.|..:|.|:||.
  Rat   180 STVTGAATMTGYYQYR------------------------------------------------- 195

Human   461 ELISAFVTKGVYMLKAVIYNEFHGTEVELGPYYVEIGHEAVSAFMNSSSVHEDEVLVFADSQVNQ 525
                   |:|||.||.|: ::.||.:.||||||::|||..||.||||||:|.:|.|.||:|...|
  Rat   196 -------TEGVYKLKVVV-SDCHGADEELGPYYMDIGHGNVSVFMNSSSIHNNESLAFANSLPQQ 252

Human   526 KSTVVIHHFPSIPSYNVSFISQTQVGDSQAWHSMTVWYKMQSVSVYTNGTVFATDTDITFTAVTK 590
            :.|||:|.|.|:.||||||:|||:||.||||..:||.|.||||||||||||||.||:|||.|||:
  Rat   253 EGTVVVHCFSSVSSYNVSFMSQTRVGSSQAWSGVTVGYTMQSVSVYTNGTVFAADTNITFVAVTE 317

Human   591 ETIPLEFEWYFGEDPPVRTTSRSIKKRLSIPQWYRVMVKASNRMSSVVSEPHVIRVQKKIVANRL 655
            ||:||||.|||||:|||.||||||::||||||||||||||::||.|||||||:|||||:|:||||
  Rat   318 ETVPLEFTWYFGENPPVTTTSRSIRRRLSIPQWYRVMVKATSRMGSVVSEPHLIRVQKRILANRL 382

Human   656 TSPSSALVNASVAFECWINFGTDVAYLWDFGDGTVSLGSSSSSHVYSREGEFTVEVLAFNNVSAS 720
            .|.:||||||:|:|||.:||||||||||:||||::.||||||.|||.||||||||||||||:|::
  Rat   383 VSTASALVNANVSFECRLNFGTDVAYLWNFGDGSIELGSSSSGHVYDREGEFTVEVLAFNNISSA 447

Human   721 TLRQQLFIVCEPCQPPLVKNMGPGKVQIWRSQPVRLGVTFEAAVFCDISQGLSYTWNLMDSEGLP 785
            |||:|:|||.||||||.||||||.|||||||||:|||||||||:.|:|||||||||:.:.:|...
  Rat   448 TLRKQIFIVQEPCQPPPVKNMGPAKVQIWRSQPLRLGVTFEAAIICNISQGLSYTWSFVGAEATA 512

Human   786 VSLPAAVDTHRQTLILPSHTLEYGNYTALAKVQIEGSVVYSNYCVGLEVRAQAPVSVISEGTHLF 850
            |:|||||:|||||::|||:|||.|||||:|||||:||:||||||||:||||:|||||||||||:|
  Rat   513 VTLPAAVNTHRQTIMLPSYTLECGNYTAVAKVQIKGSMVYSNYCVGVEVRARAPVSVISEGTHIF 577

Human   851 FSRTTSSPIVLRGTQSFDPDDPGATLRYHWECATAGSPAHPCFDSSTAHQLDAAAPTVSFEAQWL 915
            .|:.||:.|:|.|:||:|||:|||.|||||.|..|.||..||||.||::|:|..||.:||.|:||
  Rat   578 LSKATSTSIILSGSQSYDPDNPGAALRYHWTCTAASSPIWPCFDDSTSYQMDTQAPAISFPAKWL 642

Human   916 SDSYDQFLVMLRVSSGGRNSSETRVFLSPYPDSAFRFVHISWVSFKDTFVNWNDELSLQAMCEDC 980
            |:..|||||.|.|||.|||||:...|||..||.||||:|:|||:|:|..||||:|:||:|:||||
  Rat   643 SECCDQFLVTLTVSSSGRNSSQALTFLSTRPDLAFRFIHVSWVNFRDISVNWNEEVSLRAVCEDC 707

Human   981 SEIPNLSYSWDLFLVNATEKNRIEVPFCRVVGLLGSLGLGAISESSQLNLLPTEPGTADPDATTT 1045
            .::.:|:||||||||||||||.:|...|..:.|:|.:
  Rat   708 GDVSDLTYSWDLFLVNATEKNAVEGKSCYSILLIGKV---------------------------- 744

Human  1046 PFSREPSPVTLGQPATSAPRGTPTEPMTGVYWIPPAGDSAVLGEAPEEGSLDLEPGPQSKGSLMT 1110
                 ..||        |..|.|.|                     :.|||...|...::.:||.
  Rat   745 -----HGPV--------AGSGEPME---------------------DYGSLSPAPSSLAEEALMM 775

Human  1111 GRSERSQPTHSPDPHLSDFEAYYSDIQEAIPSGGRQPAKDTSFPGSGPSLSAEESPGDGDNLVDP 1175
            ...|.|.|..|..   :.|:...::.|||                 |.|||||||...||||:.|
  Rat   776 SDPEGSWPFPSSS---TAFDGISANFQEA-----------------GSSLSAEESASYGDNLLGP 820

Human  1176 SLSAGRAEPVLMIDWPKALLGRAVFQGYSSSGITEQTVTIKPYSLSSGETYVLQVSVASKHGLLG 1240
            .|..|||:|.|||||||||:.||||.||::|||....|||||:||||||.||||.||||||.|||
  Rat   821 FLHTGRAKPTLMIDWPKALVSRAVFHGYTTSGIMGPDVTIKPFSLSSGEMYVLQASVASKHVLLG 885

Human  1241 KAQLYLTVNPAPRDMACQVQPHHGLEAHTVFSVFCMSGKPDFHYEFSYQIGNTSKHTLYHGRDTQ 1305
            |||||||||.||:||:|||:||.|:||||:||:|||||||||||||.|:|||.|.||||.|:|||
  Rat   886 KAQLYLTVNQAPQDMSCQVRPHRGMEAHTIFSIFCMSGKPDFHYEFRYRIGNASSHTLYRGQDTQ 950

Human  1306 YYFVLPAGEHLDNYKVMVSTEITDGKGSKVQPCTVVVTVLPRYHGNDCLGEDLYNSSLKNLSTLQ 1370
            |||:||||:..|:|||:||||:|||:|||||||||.||||||||||||..:|||||:|:||||||
  Rat   951 YYFLLPAGDSSDSYKVIVSTEVTDGQGSKVQPCTVEVTVLPRYHGNDCHDKDLYNSTLENLSTLQ 1015

Human  1371 LMGSYTEIRNYITVITRILSRLSKEDK-TASCNQWSRIQDALISSVCRLAFVDQEEMIGSVLMLR 1434
            |:||||||||||.:||.|||||..|.: |:||.|||:|||.||.|.|::.:.|||.|:.|:.:||
  Rat  1016 LVGSYTEIRNYIAMITGILSRLYVESRNTSSCGQWSQIQDVLIFSACKVPYTDQETMMDSIHILR 1080

Human  1435 DLVSFSNKLGFMSAVLILKYTRALLAQGQFSGPFVIDKGVRLELIGLISRVWEVSEQENSKEEVY 1499
            ||:||.|||..|||.||.||.:..|||||.|...::|:.:|:|.|.|||.|||.: :|:.::..|
  Rat  1081 DLISFPNKLSLMSAELIYKYAQMFLAQGQVSRRLLVDEKLRVEFILLISGVWEAA-KEDVRDGYY 1144

Human  1500 RHEEGITVISDLLLGCLSLN-----HVSTGQMEFRTLLHYNLQSSVQSLGSVQVHLPGDLAGHSP 1559
            ..:||:.::||:||.||||:     |:|||||||:||:|.:.|||:|:||.::||||.|:|.|||
  Rat  1145 LQKEGMKIVSDMLLACLSLSPKHQIHISTGQMEFQTLVHRSPQSSIQNLGFIRVHLPNDVALHSP 1209

Human  1560 AGAETQSPCYISQLILFKKNPYPGSQAPGQIGGVVGLNLYTCSSRRPINRQWLRKPVMVEFGEED 1624
            ...|||||||||||..|.|:||.|.|||||:|||:...||:|.|||||.|..|..||.:||||||
  Rat  1210 TQEETQSPCYISQLTFFMKSPYSGEQAPGQLGGVMSPWLYSCKSRRPILRGRLETPVTIEFGEED 1274

Human  1625 GLDNRRNKTTFVLLRDKVNLHQFTELSENPQESLQIEIEFSKPVTRAFPVMLLVRFSEKPTPSDF 1689
            .| :::|...||||||:||:||||.||||.||||||.|||||||.||||::||||||||.|||||
  Rat  1275 HL-HKKNPAMFVLLRDEVNVHQFTGLSENSQESLQIHIEFSKPVIRAFPIILLVRFSEKATPSDF 1338

Human  1690 LVKQIYFWDESIVQIYIPAASQKDASVGYLSLLDADYDRKPPNRYLAKAVNYTVHFQWIRCLFWD 1754
            |:||:|||||..||:|:|||..:.|:|||||||||||||||||:|||.|||||||||||:|:|||
  Rat  1339 LMKQVYFWDEQTVQMYVPAAPWRGANVGYLSLLDADYDRKPPNKYLAGAVNYTVHFQWIQCVFWD 1403

Human  1755 KREWKSERFSPQPGTSPEKVNCSYHRLAAFALLRRKLKASFEVSDISKLQSHPENLLPSIFIMGS 1819
            |.||:||...||||||||||||||||||.|::|||||.|:|:||.:|:.||||.|||||||.:..
  Rat  1404 KTEWRSEGPCPQPGTSPEKVNCSYHRLAPFSVLRRKLNATFQVSSVSEFQSHPHNLLPSIFSVFF 1468

Human  1820 VILYGFLVAKSRQVDHHEKKKAGYIFLQEASLPGHQLYAVVIDTGFRAPARLTSKVYIVLCGDNG 1884
            ::|||||::||..||.|:||..|.|||:|.:|.||||||||||||||:|||.||||:|||||:||
  Rat  1469 LVLYGFLMSKSSCVDCHKKKDPGCIFLEEEALLGHQLYAVVIDTGFRSPARFTSKVFIVLCGENG 1533

Human  1885 LSETKELSCPEKPLFERNSRHTFILSAPAQLGLLRKIRLWHDSRGPSPGWFISHVMVKELHTGQG 1949
            .||||||.|||||||.||||||||||.|.|||.|:||||||||.|.||.|||||||||||.:||.
  Rat  1534 HSETKELCCPEKPLFGRNSRHTFILSTPHQLGPLQKIRLWHDSSGLSPSWFISHVMVKELCSGQA 1598

Human  1950 WFFPAQCWLSAGRHDGRVERELTCLQGGLGFRKLFYCKFTEYLEDFHVWLSVYSRPSSSRYLHTP 2014
            |||.|||||:..:..|:|..|..||..||.|.||||.||||||||||:|.|:||:|.||.||||.
  Rat  1599 WFFSAQCWLAVSKRGGQVLGEFFCLSHGLSFWKLFYSKFTEYLEDFHIWFSLYSQPPSSNYLHTQ 1663

Human  2015 RLTVSFSLLCVYACLTALVAAGGQEQPHLDVSP---TLGSFRVGLLCTLLASPGAQLLSLLFRLS 2076
            ||.|||.||.||:||||||..||.||..|.|.|   ||.||.:.||||:||.|.|||||||||.|
  Rat  1664 RLAVSFCLLSVYSCLTALVTVGGHEQRPLGVGPTAITLDSFSLALLCTILACPPAQLLSLLFRCS 1728

Human  2077 KE----APGSARVEPHSPLRGGAQTEAPHGPNSWGRIPDAQEPRKQPASAILSGSGRAQRKAASD 2137
            |.    .||..|    ...|.....|......|        |.|......|||||      .||
  Rat  1729 KVWQLCGPGLLR----RSQRASTDFETVASKRS--------EDRSTSGYTILSGS------VAS- 1774

Human  2138 NGTACPAPKLQVHGADHSRTSLMGKSHCCPPHTQ--APSSGLEGLMPQWSRALQPWWSSAVWAIC 2200
                                   |...||.|...  |||||.|.|.||.||....|.||..|||.
  Rat  1775 -----------------------GLLTCCSPSCSFLAPSSGFEELRPQQSRVCLLWSSSVAWAIS 1816

Human  2201 GTASLACSLGTGFLAYRFGQEQCVQWLHLLSLSVVCCIFITQPLMVCLMALGFAWKRRADNHFFT 2265
            |||||||.||||||.|:|...|||.|||||.||:|||..||||||:||.|..|||||:.|:.|||
  Rat  1817 GTASLACGLGTGFLGYKFVPAQCVWWLHLLLLSLVCCALITQPLMICLAASAFAWKRKHDSEFFT 1881

Human  2266 ESLCEATRDLDSELAERSWTRLPFSSSCSIPDCAGEVEK-------------------------- 2304
            |||.:||:.||.||.|||.|.:|.|.....||.|.|.|:
  Rat  1882 ESLQDATKGLDLELEERSRTHIPLSPVSYSPDSAEEAERVSRRRSIQNCSHKDGNSDLSSNLAAL 1946

Human  2305 -----------------------------------VLAARQQARHLRWAHPPSKAQLRGTRQRMR 2334
                                               ||||||:.||||||..||..:.|..|:|:|
  Rat  1947 LEPYSVCVCVCVCVCVCVCVCVCVCEYHGAPLPPQVLAARQRERHLRWAQTPSGPKFRVMRERLR 2011

Human  2335 RESRTRAALRDISMDILMLLLLLCVIYGRFSQDEYSLNQAIRKEFTRNARNCLGGLRNIADWWDW 2399
            ||...:|||||::|..:||||||.:.||||...|||||||||:.|||||.:.||.|.:..|||||
  Rat  2012 RERLMQAALRDVTMHSVMLLLLLFIAYGRFCPGEYSLNQAIRRAFTRNAHHSLGDLSSTEDWWDW 2076

Human  2400 SLTTLLDGLYPGGTPSARVPGAQPGALGGKCYLIGSSVIRQLKVFPRHLCKPPRPFSALIEDSIP 2464
            :|:||||||:|...| |...|:|||||||:|:|||.|||:||||.....|..|:|||.|:||.:|
  Rat  2077 TLSTLLDGLHPERMP-ATAWGSQPGALGGQCHLIGPSVIKQLKVSAGTACVAPKPFSELVEDVLP 2140

Human  2465 TCSPEVGGPENPYLIDPENQNVTLNGPGGCGT-REDCVLSLGRTRTEAHTALSRLRASMWIDRST 2528
            ..|         :.:|.||:|||.:.|..||. :|....||||||.|||.||:.||||.|||.||
  Rat  2141 MHS---------HALDLENRNVTPDDPKTCGVKKESYTHSLGRTRHEAHAALTALRASRWIDHST 2196

Human  2529 RAVSVHFTLYNPPTQLFTSVSLRVEILPTGSLVPSSLVESFSIFRSDSALQYHLMLPQLVFLALS 2593
            ||||||||||||||:|||||:|..|.|.|..||.|||:||||||..|||||..|||.:|:||.|:
  Rat  2197 RAVSVHFTLYNPPTRLFTSVTLGAEFLSTRGLVSSSLIESFSIFYRDSALQCLLMLSELLFLVLN 2261

Human  2594 LIHLCVQLYRMMDKGVLSYWRKPRNWLELSVVGVSLTYYAVSGHLVTLAGDVTNQFHRGLCRAFM 2658
            :||||.||:.|..||:||||||||.|||||:|||:|.|.|.||||.|||.::|:|||:||.:.|:
  Rat  2262 MIHLCFQLWEMATKGILSYWRKPRQWLELSMVGVALAYCAASGHLTTLAENITDQFHKGLYQRFV 2326

Human  2659 DLTLMASWNQRARWLRGILLFLFTLKCVYLPGIQNTMASCSSMMRHSLPSIFVAGLVGALMLAAL 2723
            |::||.|||||||.|:||||||:.||||:|....:|||..|:||.| .|.:|...|||||:|||.
  Rat  2327 DISLMVSWNQRARCLQGILLFLWMLKCVHLFSSLSTMAPFSAMMGH-CPGVFSLQLVGALLLAAH 2390

Human  2724 SHLHRFLLSMWVLPPGTFTDAFPGLLFHFPRRSQKDCLLGLSKSDQRAMACYFGILLIVSATLCF 2788
            |||..|||....|..||..:||||||..||.|||||......:||.||:.||:|.|.::.|||.|
  Rat  2391 SHLRWFLLYTSTLSRGTSAEAFPGLLLQFPGRSQKDSQHNHLESDHRAVNCYYGTLFLLLATLGF 2455

Human  2789 GMLRGFLMTLPQKRKSFQSKSFVRLKDVTAYMWEKVLTFLRLETPKLEEAEMVENHNYYLDEFAN 2853
            .|||...:||.|.||||..||.|.||||...||.::||||||||....|.|:..:|.||||||::
  Rat  2456 RMLRATSLTLFQDRKSFHRKSLVTLKDVAVSMWHRLLTFLRLETTTSGETEVTTDHIYYLDEFSS 2520

Human  2854 LLDELLMKINGLSDSLQLPLLEKTSNNTGEARTEESPLVDISSYQAA 2900
            |||||||||:||||||:|.:|||....|.|:||.:||.|.|..||||
  Rat  2521 LLDELLMKIDGLSDSLELSILEKQWRRTVESRTGDSPSVGILEYQAA 2567

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PKD1L1	XP_016867287.1	None
Pkd1l1	XP_038948500.1	PCC	<242..725	CDD:188093	344/482 (71%)
		GPS	1398..1436	CDD:413374	28/37 (76%)
		PLAT_polycystin	1504..1622	CDD:238850	89/117 (76%)
		PKD_channel	2063..2389	CDD:400395	202/336 (60%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83697207
Domainoid	1	1.000	765	1.000	Domainoid score	I2941
eggNOG	0	0.000	Not matched by this tool.
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H51376
Inparanoid	1	1.050	3108	1.000	Inparanoid score	I472
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG50273
OrthoDB	1	1.010	-	-		D10745at32523
OrthoFinder	1	1.000	-	-		FOG0014039
OrthoInspector	1	1.000	-	-		oto130658
orthoMCL	1	0.900	-	-		OOG6_120180
Panther	1	1.100	-	-	LDO	PTHR10877
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X11569
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	15.410