|
Human 155 NIWKTTSEAALSVVNEKTQAVVNEKTQAPLDCDNSADRIPHKPFIIIARAWSSGGPRFHHRRLCA 219
||..||||..|| ..|.:.|.|.:.|.:.:| ||..|....:.|..
Rat 27 NILNTTSEGRLS--------FTNREPQTPPEWDEATNR-------------SSTSPSSQLQWLRE 70
Human 220 TGTADSTFSALLQ--LQGTTSAAAPCSLKMEASCC-VLRLLCCAEDVATGLLPGTVTMETPTKVA 281
....|.:||...| ||| .|:|||||||.||.|| ..||||..||.|..|| :...|
Rat 71 AEREDGSFSGRQQVDLQG-VSSAAPCSLKKEAFCCNGTRLLCSGEDSANTLL----SFSDP---- 126
Human 282 RPTQTSSQRVPLWPISHFPTSPRSSHGLPPGIPRTPSFTASQSGSEILYPPTQHPPVAILARNSD 346
||||.:|.:.:||....|...|.||||..|:||...:
Rat 127 ----------------------------PPGISQTRNLSASWYHPESSCPLTQHPLGAVLATQPE 163
Human 347 NFMNPVLNCSLEVEARAPPNLGFRVHMASGEALCLMMDFGDSSGVEMRLHNMSEAMAVTAYHQYS 411
|..:....|..|.:|:|||.||.|||.||..||||::||||:.|.||:|..::.|..:|.|:||.
Rat 164 NAGHFATCCFPETDAKAPPALGIRVHAASRTALCLLLDFGDNHGAEMKLSTVTGAATMTGYYQYR 228
Human 412 KGIFFHLLHFQLDMSTYKEAETQNTTLNVYLCQSENSCLEDSDPSNLGYELISAFVTKGVYMLKA 476
|:|||.||.
Rat 229 --------------------------------------------------------TEGVYKLKV 237
Human 477 VIYNEFHGTEVELGPYYVEIGHEAVSAFMNSSSVHEDEVLVFADSQVNQKSTVVIHHFPSIPSYN 541
|: ::.||.:.||||||::|||..||.||||||:|.:|.|.||:|...|:.|||:|.|.|:.|||
Rat 238 VV-SDCHGADEELGPYYMDIGHGNVSVFMNSSSIHNNESLAFANSLPQQEGTVVVHCFSSVSSYN 301
Human 542 VSFISQTQVGDSQAWHSMTVWYKMQSVSVYTNGTVFATDTDITFTAVTKETIPLEFEWYFGEDPP 606
|||:|||:||.||||..:||.|.||||||||||||||.||:|||.|||:||:||||.|||||:||
Rat 302 VSFMSQTRVGSSQAWSGVTVGYTMQSVSVYTNGTVFAADTNITFVAVTEETVPLEFTWYFGENPP 366
Human 607 VRTTSRSIKKRLSIPQWYRVMVKASNRMSSVVSEPHVIRVQKKIVANRLTSPSSALVNASVAFEC 671
|.||||||::||||||||||||||::||.|||||||:|||||:|:||||.|.:||||||:|:|||
Rat 367 VTTTSRSIRRRLSIPQWYRVMVKATSRMGSVVSEPHLIRVQKRILANRLVSTASALVNANVSFEC 431
Human 672 WINFGTDVAYLWDFGDGTVSLGSSSSSHVYSREGEFTVEVLAFNNVSASTLRQQLFIVCEPCQPP 736
.:||||||||||:||||::.||||||.|||.||||||||||||||:|::|||:|:|||.||||||
Rat 432 RLNFGTDVAYLWNFGDGSIELGSSSSGHVYDREGEFTVEVLAFNNISSATLRKQIFIVQEPCQPP 496
Human 737 LVKNMGPGKVQIWRSQPVRLGVTFEAAVFCDISQGLSYTWNLMDSEGLPVSLPAAVDTHRQTLIL 801
.||||||.|||||||||:|||||||||:.|:|||||||||:.:.:|...|:|||||:|||||::|
Rat 497 PVKNMGPAKVQIWRSQPLRLGVTFEAAIICNISQGLSYTWSFVGAEATAVTLPAAVNTHRQTIML 561
Human 802 PSHTLEYGNYTALAKVQIEGSVVYSNYCVGLEVRAQAPVSVISEGTHLFFSRTTSSPIVLRGTQS 866
||:|||.|||||:|||||:||:||||||||:||||:|||||||||||:|.|:.||:.|:|.|:||
Rat 562 PSYTLECGNYTAVAKVQIKGSMVYSNYCVGVEVRARAPVSVISEGTHIFLSKATSTSIILSGSQS 626
Human 867 FDPDDPGATLRYHWECATAGSPAHPCFDSSTAHQLDAAAPTVSFEAQWLSDSYDQFLVMLRVSSG 931
:|||:|||.|||||.|..|.||..||||.||::|:|..||.:||.|:|||:..|||||.|.|||.
Rat 627 YDPDNPGAALRYHWTCTAASSPIWPCFDDSTSYQMDTQAPAISFPAKWLSECCDQFLVTLTVSSS 691
Human 932 GRNSSETRVFLSPYPDSAFRFVHISWVSFKDTFVNWNDELSLQAMCEDCSEIPNLSYSWDLFLVN 996
|||||:...|||..||.||||:|:|||:|:|..||||:|:||:|:||||.::.:|:|||||||||
Rat 692 GRNSSQALTFLSTRPDLAFRFIHVSWVNFRDISVNWNEEVSLRAVCEDCGDVSDLTYSWDLFLVN 756
Human 997 ATEKNRIEVPFCRVVGLLGSLGLGAISESSQLNLLPTEPGTADPDATTTPFSREPSPVTLGQPAT 1061
|||||.:|...|..:.|:|.: ..||
Rat 757 ATEKNAVEGKSCYSILLIGKV---------------------------------HGPV------- 781
Human 1062 SAPRGTPTEPMTGVYWIPPAGDSAVLGEAPEEGSLDLEPGPQSKGSLMTGRSERSQPTHSPDPHL 1126
|..|.|.| :.|||...|...::.:||....|.|.|..|..
Rat 782 -AGSGEPME---------------------DYGSLSPAPSSLAEEALMMSDPEGSWPFPSSS--- 821
Human 1127 SDFEAYYSDIQEAIPSGGRQPAKDTSFPGSGPSLSAEESPGDGDNLVDPSLSAGRAEPVLMIDWP 1191
:.|:...::.||| |.|||||||...||||:.|.|..|||:|.||||||
Rat 822 TAFDGISANFQEA-----------------GSSLSAEESASYGDNLLGPFLHTGRAKPTLMIDWP 869
Human 1192 KALLGRAVFQGYSSSGITEQTVTIKPYSLSSGETYVLQVSVASKHGLLGKAQLYLTVNPAPRDMA 1256
|||:.||||.||::|||....|||||:||||||.||||.||||||.||||||||||||.||:||:
Rat 870 KALVSRAVFHGYTTSGIMGPDVTIKPFSLSSGEMYVLQASVASKHVLLGKAQLYLTVNQAPQDMS 934
Human 1257 CQVQPHHGLEAHTVFSVFCMSGKPDFHYEFSYQIGNTSKHTLYHGRDTQYYFVLPAGEHLDNYKV 1321
|||:||.|:||||:||:|||||||||||||.|:|||.|.||||.|:||||||:||||:..|:|||
Rat 935 CQVRPHRGMEAHTIFSIFCMSGKPDFHYEFRYRIGNASSHTLYRGQDTQYYFLLPAGDSSDSYKV 999
Human 1322 MVSTEITDGKGSKVQPCTVVVTVLPRYHGNDCLGEDLYNSSLKNLSTLQLMGSYTEIRNYITVIT 1386
:||||:|||:|||||||||.||||||||||||..:|||||:|:|||||||:||||||||||.:||
Rat 1000 IVSTEVTDGQGSKVQPCTVEVTVLPRYHGNDCHDKDLYNSTLENLSTLQLVGSYTEIRNYIAMIT 1064
Human 1387 RILSRLSKEDK-TASCNQWSRIQDALISSVCRLAFVDQEEMIGSVLMLRDLVSFSNKLGFMSAVL 1450
.|||||..|.: |:||.|||:|||.||.|.|::.:.|||.|:.|:.:||||:||.|||..|||.|
Rat 1065 GILSRLYVESRNTSSCGQWSQIQDVLIFSACKVPYTDQETMMDSIHILRDLISFPNKLSLMSAEL 1129
Human 1451 ILKYTRALLAQGQFSGPFVIDKGVRLELIGLISRVWEVSEQENSKEEVYRHEEGITVISDLLLGC 1515
|.||.:..|||||.|...::|:.:|:|.|.|||.|||.: :|:.::..|..:||:.::||:||.|
Rat 1130 IYKYAQMFLAQGQVSRRLLVDEKLRVEFILLISGVWEAA-KEDVRDGYYLQKEGMKIVSDMLLAC 1193
Human 1516 LSLN-----HVSTGQMEFRTLLHYNLQSSVQSLGSVQVHLPGDLAGHSPAGAETQSPCYISQLIL 1575
|||: |:|||||||:||:|.:.|||:|:||.::||||.|:|.|||...|||||||||||..
Rat 1194 LSLSPKHQIHISTGQMEFQTLVHRSPQSSIQNLGFIRVHLPNDVALHSPTQEETQSPCYISQLTF 1258
Human 1576 FKKNPYPGSQAPGQIGGVVGLNLYTCSSRRPINRQWLRKPVMVEFGEEDGLDNRRNKTTFVLLRD 1640
|.|:||.|.|||||:|||:...||:|.|||||.|..|..||.:||||||.| :::|...||||||
Rat 1259 FMKSPYSGEQAPGQLGGVMSPWLYSCKSRRPILRGRLETPVTIEFGEEDHL-HKKNPAMFVLLRD 1322
Human 1641 KVNLHQFTELSENPQESLQIEIEFSKPVTRAFPVMLLVRFSEKPTPSDFLVKQIYFWDESIVQIY 1705
:||:||||.||||.||||||.|||||||.||||::||||||||.||||||:||:|||||..||:|
Rat 1323 EVNVHQFTGLSENSQESLQIHIEFSKPVIRAFPIILLVRFSEKATPSDFLMKQVYFWDEQTVQMY 1387
Human 1706 IPAASQKDASVGYLSLLDADYDRKPPNRYLAKAVNYTVHFQWIRCLFWDKREWKSERFSPQPGTS 1770
:|||..:.|:|||||||||||||||||:|||.|||||||||||:|:||||.||:||...||||||
Rat 1388 VPAAPWRGANVGYLSLLDADYDRKPPNKYLAGAVNYTVHFQWIQCVFWDKTEWRSEGPCPQPGTS 1452
Human 1771 PEKVNCSYHRLAAFALLRRKLKASFEVSDISKLQSHPENLLPSIFIMGSVILYGFLVAKSRQVDH 1835
||||||||||||.|::|||||.|:|:||.:|:.||||.|||||||.:..::|||||::||..||.
Rat 1453 PEKVNCSYHRLAPFSVLRRKLNATFQVSSVSEFQSHPHNLLPSIFSVFFLVLYGFLMSKSSCVDC 1517
Human 1836 HEKKKAGYIFLQEASLPGHQLYAVVIDTGFRAPARLTSKVYIVLCGDNGLSETKELSCPEKPLFE 1900
|:||..|.|||:|.:|.||||||||||||||:|||.||||:|||||:||.||||||.|||||||.
Rat 1518 HKKKDPGCIFLEEEALLGHQLYAVVIDTGFRSPARFTSKVFIVLCGENGHSETKELCCPEKPLFG 1582
Human 1901 RNSRHTFILSAPAQLGLLRKIRLWHDSRGPSPGWFISHVMVKELHTGQGWFFPAQCWLSAGRHDG 1965
||||||||||.|.|||.|:||||||||.|.||.|||||||||||.:||.|||.|||||:..:..|
Rat 1583 RNSRHTFILSTPHQLGPLQKIRLWHDSSGLSPSWFISHVMVKELCSGQAWFFSAQCWLAVSKRGG 1647
Human 1966 RVERELTCLQGGLGFRKLFYCKFTEYLEDFHVWLSVYSRPSSSRYLHTPRLTVSFSLLCVYACLT 2030
:|..|..||..||.|.||||.||||||||||:|.|:||:|.||.||||.||.|||.||.||:|||
Rat 1648 QVLGEFFCLSHGLSFWKLFYSKFTEYLEDFHIWFSLYSQPPSSNYLHTQRLAVSFCLLSVYSCLT 1712
Human 2031 ALVAAGGQEQPHLDVSP---TLGSFRVGLLCTLLASPGAQLLSLLFRLSKEAPGSARVEPHSPLR 2092
|||..||.||..|.|.| ||.||.:.||||:||.|.|||||||||.||.. |:
Rat 1713 ALVTVGGHEQRPLGVGPTAITLDSFSLALLCTILACPPAQLLSLLFRCSKWT-----------LQ 1766
Human 2093 GGAQTEAPHGPNSWGRIPDAQEPRKQPASAILSGSGRAQRKAASDNGTACPAPKLQVHGADHSRT 2157
..:.| :|..:.........|.|.:|.|:.:|.|..||::
Rat 1767 SNSLT-------AWSCLEATSIGPMHPISDLLPGTDQAWRMTASNS------------------- 1805
Human 2158 SLMGKSHCCPPHTQAPSSGLEGLMPQWSRALQPWWSSAVWAICGTASLACSLGTGFLAYRFGQEQ 2222
|||||.|.|.||.||....|.||..|||.|||||||.||||||.|:|...|
Rat 1806 --------------APSSGFEELRPQQSRVCLLWSSSVAWAISGTASLACGLGTGFLGYKFVPAQ 1856
Human 2223 CVQWLHLLSLSVVCCIFITQPLMVCLMALGFAWKRRADNHFFTESLCEATRDLDSELAERSWTRL 2287
||.|||||.||:|||..||||||:||.|..|||||:.|:.||||||.:||:.||.||.|||.|.:
Rat 1857 CVWWLHLLLLSLVCCALITQPLMICLAASAFAWKRKHDSEFFTESLQDATKGLDLELEERSRTHI 1921
Human 2288 PFSSSCSIPDCAGEVEKVLAARQQARHLRWAHPPSKAQLRGTRQRMRRESRTRAALRDISMDILM 2352
|.|.....||.|.|.|:||||||:.||||||..||..:.|..|:|:|||...:|||||::|..:|
Rat 1922 PLSPVSYSPDSAEEAERVLAARQRERHLRWAQTPSGPKFRVMRERLRRERLMQAALRDVTMHSVM 1986
Human 2353 LLLLLCVIYGRFSQDEYSLNQAIRKEFTRNARNCLGGLRNIADWWDWSLTTLLDGLYPGGTPSAR 2417
|||||.:.||||...|||||||||:.|||||.:.||.|.:..|||||:|:||||||:|...| |.
Rat 1987 LLLLLFIAYGRFCPGEYSLNQAIRRAFTRNAHHSLGDLSSTEDWWDWTLSTLLDGLHPERMP-AT 2050
Human 2418 VPGAQPGALGGKCYLIGSSVIRQLKVFPRHLCKPPRPFSALIEDSIPTCSPEVGGPENPYLIDPE 2482
..|:|||||||:|:|||.|||:||||.....|..|:|||.|:||.:|..| :.:|.|
Rat 2051 AWGSQPGALGGQCHLIGPSVIKQLKVSAGTACVAPKPFSELVEDVLPMHS---------HALDLE 2106
Human 2483 NQNVTLNGPGGCGT-REDCVLSLGRTRTEAHTALSRLRASMWIDRSTRAVSVHFTLYNPPTQLFT 2546
|:|||.:.|..||. :|....||||||.|||.||:.||||.|||.||||||||||||||||:|||
Rat 2107 NRNVTPDDPKTCGVKKESYTHSLGRTRHEAHAALTALRASRWIDHSTRAVSVHFTLYNPPTRLFT 2171
Human 2547 SVSLRVEILPTGSLVPSSLVESFSIFRSDSALQYHLMLPQLVFLALSLIHLCVQLYRMMDKGVLS 2611
||:|..|.|.|..||.|||:||||||..|||||..|||.:|:||.|::||||.||:.|..||:||
Rat 2172 SVTLGAEFLSTRGLVSSSLIESFSIFYRDSALQCLLMLSELLFLVLNMIHLCFQLWEMATKGILS 2236
Human 2612 YWRKPRNWLELSVVGVSLTYYAVSGHLVTLAGDVTNQFHRGLCRAFMDLTLMASWNQRARWLRGI 2676
||||||.|||||:|||:|.|.|.||||.|||.::|:|||:||.:.|:|::||.|||||||.|:||
Rat 2237 YWRKPRQWLELSMVGVALAYCAASGHLTTLAENITDQFHKGLYQRFVDISLMVSWNQRARCLQGI 2301
Human 2677 LLFLFTLKCVYLPGIQNTMASCSSMMRHSLPSIFVAGLVGALMLAALSHLHRFLLSMWVLPPGTF 2741
||||:.||||:|....:|||..|:||.| .|.:|...|||||:|||.|||..|||....|..||.
Rat 2302 LLFLWMLKCVHLFSSLSTMAPFSAMMGH-CPGVFSLQLVGALLLAAHSHLRWFLLYTSTLSRGTS 2365
Human 2742 TDAFPGLLFHFPRRSQKDCLLGLSKSDQRAMACYFGILLIVSATLCFGMLRGFLMTLPQKRKSFQ 2806
.:||||||..||.|||||......:||.||:.||:|.|.::.|||.|.|||...:||.|.||||.
Rat 2366 AEAFPGLLLQFPGRSQKDSQHNHLESDHRAVNCYYGTLFLLLATLGFRMLRATSLTLFQDRKSFH 2430
Human 2807 SKSFVRLKDVTAYMWEKVLTFLRLETPKLEEAEMVENHNYYLDEFANLLDELLMKINGLSDSLQL 2871
.||.|.||||...||.::||||||||....|.|:..:|.||||||::|||||||||:||||||:|
Rat 2431 RKSLVTLKDVAVSMWHRLLTFLRLETTTSGETEVTTDHIYYLDEFSSLLDELLMKIDGLSDSLEL 2495
Human 2872 PLLEKTSNNTGEARTEESPLVDISSYQAA 2900
.:|||....|.|:||.:||.|.|..||||
Rat 2496 SILEKQWRRTVESRTGDSPSVGILEYQAA 2524
| 
