Protein Alignment PKD1L1 and pkd1l1

DIOPT Version :9

• Sequence 1: XP_016867287.1
• Gene: PKD1L1 / 168507
• HGNCID: 18053
• Length: 2920
• Species: Homo sapiens
• Sequence 2: XP_012820943.2
• Gene: pkd1l1 / 100492056
• XenbaseID: XB-GENE-480146
• Length: 2682
• Species: Xenopus tropicalis
• Alignment Length: 2502
• Identity: 898/2502 - (35%)
• Similarity: 1370/2502 - (54%)
• Gaps: 267/2502 - (10%)

Human   567 SVSVYTNGTVFATDTDITFTAVTKETIPLEFEWYFGEDP-PVRTTSRSIKKRLSIPQWYRVMVKA 630
            :||:.||||.|:|:|:|.|.|||.|:.|:.|.|.||:.. |..|.:..|.|:.|||..|.|:|.|
 Frog    25 TVSIVTNGTFFSTETNIIFKAVTSESGPVHFVWNFGDKSLPESTYNSVISKKYSIPNSYNVIVNA 89

Human   631 SNRMSSVVSEPHVIRVQKKIVANRLTSPSSALVNASVAFECWINFGTDVAYLWDFGDGTVSLGSS 695
            |:.:.:||||.:.|.:|||::.|||.:..|.|:|::|.|||.||.||:::|||:|||.|:..|..
 Frog    90 SSPVGTVVSEVYTIFIQKKVIPNRLIARPSVLINSTVTFECRINSGTNISYLWNFGDETIRFGKI 154

Human   696 SSSHVYSREGEFTVEVLAFNNVSASTLRQQLFIVCEPCQPPLVKNMGPGKVQIWRSQPVRLGVTF 760
            :.:|||.||||:||.|..||||||:.|.:|:|:|.|.|.||.||:|||.|:||.|.:.:.|||||
 Frog   155 TDTHVYMREGEYTVNVSIFNNVSAAFLTKQIFVVRELCLPPPVKHMGPQKIQIRRYEQLCLGVTF 219

Human   761 EAAVFCDISQGLSYTWNLMDSEGLPVSLPAAVDTHRQTLILPSHTLEYGNYTALAKVQIEGSVVY 825
            ||.:.|:|||||.|.|:.:.|.|..|.||..::..:|.:.:|...|||.||||:|:|||.|:|||
 Frog   220 EAEIMCNISQGLHYFWSFVKSNGNSVILPNYINDRKQKITVPGFLLEYENYTAVARVQIVGNVVY 284

Human   826 SNYCVGLEVRAQAPVSVISEGTHLFFSRTTSSPIVLRGTQSFDPDDPGATLRYHWECATAGSPAH 890
            |||.|.|||....|||||:.|||....::|.:...|.|:.|||||.|.|:||:||:|......:.
 Frog   285 SNYTVLLEVLPSDPVSVIAGGTHFLIDKSTVTHFKLDGSASFDPDYPEASLRFHWKCIPVSLYSD 349

Human   891 PCFDSSTAHQLDAAAPTVSFEAQWLSDSYDQFLVMLRVSSGGRNSSETRVFLSPYPDSAFRFVHI 955
            .||:::..:.|......:.|....|::.:||||:.|.||:|.|.|...:..||......||.|.|
 Frog   350 SCFNTAALNPLQTDGSIIHFPTALLNEKFDQFLISLTVSNGNRRSPVAQAVLSISSRPNFRDVQI 414

Human   956 SWVSFKDTFVNWNDELSLQAMCEDCSEIPNLSYSWDLFLVNATEKNRIEVPFCRVVGLLGSLGLG 1020
            ..:..|...||||::.|:|.:|.:|.| ..:||||:|:.:|.||....:.|||.|:.:|||
 Frog   415 ICIECKGYTVNWNEKFSVQVVCTECRE-AEISYSWELYSINTTEVESSDGPFCSVLEILGS---- 474

Human  1021 AISESSQLNLLPTEPGTADPDATTTPFSREPSPVTLGQPATSAPRGTPTEPMTGVYWIPP----- 1080
                                                     |:..|||. |...::..||
 Frog   475 -----------------------------------------SSLFGTPL-PSVEIFTDPPITQII 497

Human  1081 AGDSAVLGEAPEEGSLDLEPGPQSKGS------------LMTG----RSERSQ------------ 1117
            :||........||..|.|:|.|::..|            :.:|    ||:||:
 Frog   498 SGDIFDEHRLTEEAYLRLDPCPKTVPSAPIHGIHGLLEEISSGGRPSRSKRSEYTTALRNISHEQ 562

Human  1118 -------------------------------PTHSPDPHLSDFEAYYSDIQEAIPSGGRQPAKDT 1151
                                           |||      ||.|.:...|||.....|.:| :|.
 Frog   563 SGEQTNFNGTYSGFLIGGGEGGADLFNLTEVPTH------SDLEVHCIGIQEGKKGSGGRP-EDP 620

Human  1152 SFPGSGPSLSAEESPGDGDNLVDPSLSAGRAEPVLMIDWPKALLGRAVFQGYSSSGITEQTVTIK 1216
            .....|.:...|.....||.:::||.:|..:....|:||....:.::.|:|:.::.::.|.:|.|
 Frog   621 EGERYGSTRPHENEDQKGDEILNPSKAAAVSPVTSMLDWKTQQISKSTFRGFVTTDLSSQVLTFK 685

Human  1217 PYSLSSGETYVLQVSVASKHGLLGKAQLYLTVNP-APRDMACQVQPHHGLEAHTVFSVFCMSGKP 1280
            |:||..|:.|:|.||:||:...:||:|||.|||. ||| |.|||||:.|:|.:||||:||.|||.
 Frog   686 PFSLKPGKMYMLDVSLASRGNEIGKSQLYFTVNEMAPR-MTCQVQPNEGMELYTVFSIFCTSGKE 749

Human  1281 DFHYEFSYQIGNTS-KHTLYHGRDTQYYFVLPAGEHLDNYKVMVSTEITDGKGSKVQPCTVVVTV 1344
            |.:|:||||:|..| :..||.|||.||||.||||:..|.|:|.:.|:||:..||:.:||.|.|||
 Frog   750 DLYYDFSYQVGRRSARKKLYEGRDIQYYFNLPAGDQTDGYQVTLFTQITNMYGSQTKPCPVNVTV 814

Human  1345 LPRYHGN---DCLGEDLYNSSLKNLSTLQLMGSYTEIRNYITVITRILSRLSKEDKTASCNQWSR 1406
            .|.:..|   |.:.|.||:..|||||.|.||.::.|||||||::|.:|::|..|:........|:
 Frog   815 WPSFGKNTSTDFIAEQLYHHGLKNLSVLLLMENHIEIRNYITLLTVVLNKLYSEETKTPFELQSK 879

Human  1407 IQDALISSVCRLAFVDQEEMIGSVLMLRDLVSFSNKLGFMSAVLILKYTRALLAQGQFS---GPF 1468
            |::||||::|.::|.|::|....|.||.||::::.::...||:|::..|:.:|.:...|   ...
 Frog   880 IRNALISALCSMSFQDEDEFDEIVSMLIDLLNYTKQVTAKSAILVVNATKKILKRSVDSEDHSRI 944

Human  1469 VIDKGVRLELIGLISRVWEVSEQENSKEEVYRHEEGITVISDLLLGCLSLNH-----VSTGQMEF 1528
            .:.:....:::.|||...|||...|.:..:..  :|:.:||||:|..::.|.     :||..::|
 Frog   945 YLQRNSVEKIVSLISYSMEVSIGYNERNFIVL--DGMNIISDLMLEYIAFNKKQHLGLSTNLIDF 1007

Human  1529 RTLLHYNLQSSVQSLGSVQVHLPGDLAGHSPAGAETQ--SPCYISQLILFKKNPYPGSQAPGQI- 1590
            :|..|..||:|:|::||.:|:||...:.|    .||:  :.||||||:.||||||..::...|:
 Frog  1008 QTSTHMMLQNSIQTIGSTKVYLPQLQSSH----LETKLSNRCYISQLVYFKKNPYLWAEISSQLQ 1068

Human  1591 GGVVGLNLYTCSSRRPINRQWLRKPVMVEFGEEDGLDNRRNKTTFVLLRDKVNLHQFTELSENPQ 1655
            |...|::|:.||:::.||.:.:..|||:||..:...|...||..|.|..||||.|:|..:|.|..
 Frog  1069 GEFAGVSLFNCSNKKKINAREIAAPVMMEFDMKRNHDLELNKNLFSLYWDKVNFHRFHTVSVNRD 1133

Human  1656 ESLQIEIEFSKPVTRAFPVMLLVRFSEKPTPSDFLVKQIYFWDESIVQIYIPAASQKDASVGYLS 1720
            |:|.|.:.||:|..|||||:||||:|:||..|.|.:|:||.|:.:.|||:|||.|.||....||:
 Frog  1134 EALLITVTFSRPNLRAFPVLLLVRYSDKPNTSHFNIKEIYTWEGNSVQIFIPAHSIKDGDNPYLA 1198

Human  1721 LLDADYDRKPPNRYLAKAVNYTVHFQWIRCLFWD-KREWKSERFSPQPGTSPEKVNCSYHRLAAF 1784
            ::||||:|:|.|:||:|.:|||:..||.:||:|| .::|.||...||.||....:.||...|..:
 Frog  1199 IMDADYNRQPRNKYLSKMINYTLETQWTKCLYWDYYKQWNSESCFPQKGTLSTNIICSCKHLGIY 1263

Human  1785 ALLRRKLKASFEVSDISKLQSHPENLLPSIFIMGSVILYGFLVAKSRQVDHHEKKKAGYIFLQEA 1849
            ..||..:..|....:||:.....:|::|..|::.:|.:|..|....:..|.||:||.|.:|||:.
 Frog  1264 TYLRSPVNTSINTEEISQYLLTTKNVIPCTFVLLTVFVYTLLAIYYKFKDRHEEKKNGVVFLQDN 1328

Human  1850 SLPGHQLYAVVIDTGFRAPARLTSKVYIVLCGDNGLSETKELSCPEKPLFERNSRHTFILSAPAQ 1914
            |...||.:|:|:|.|.|:..:.|:|||:||.|::|:|||:||..|:|||||:|||..|::|....
 Frog  1329 SPNDHQHFAIVVDVGLRSRPKSTAKVYVVLHGEDGVSETRELYFPDKPLFEKNSRQAFVMSVSES 1393

Human  1915 LGLLRKIRLWHDSRGPSPGWFISHVMVKELHTGQGWFFPAQCWLSAGRHDGRVERELTCLQGGLG 1979
            ||.:.||.:||::.|.||..::||::||:|.:|..:||.|:|||:....||:||||||....||.
 Frog  1394 LGPIWKIHIWHNNSGYSPSLYLSHIIVKDLQSGHSYFFLAECWLAMDEGDGKVERELTSAVHGLE 1458

Human  1980 FRKLFYCKFTEYLEDFHVWLSVYSRPSSSRYLHTPRLTVSFSLLCVYACLTALVAAGGQEQ---P 2041
            |:||||||.||.|||.|:|.|::||||.|.:.:|.|:||...||..|..|.:::....:||   .
 Frog  1459 FKKLFYCKLTELLEDLHLWGSLFSRPSYSCFTYTQRITVCLVLLLGYMFLNSVLIHWEEEQHSFE 1523

Human  2042 H--LDVSPTLGSFRVGLLCTLLASPGAQLLSLLFRLSKEAPGSARVEPHSPLRGGAQTEAPHGPN 2104
            |  |||||.  |...|...||...|.|.|:|||||.|::...|.        .|..:.:.|...|
 Frog  1524 HGLLDVSPV--SMISGFQSTLALYPLAALISLLFRFSEKKLTSD--------SGEEKLKVPIQTN 1578

Human  2105 SWGRIPDAQEP----------------------RKQ-------PASAILSGSGRAQRKAASDNGT 2140
            |.|...::..|                      :|:       |:...::.|.|:::
 Frog  1579 SSGDHRNSLSPSDTMFESNLTWQHFQYWAYDAWKKKYERDYFTPSIHSVNCSKRSKK-------- 1635

Human  2141 ACPAPKLQVHGADHSRTSLMGKSHC----CPPHTQAPSSGLEGLMPQWSRALQPWWSSAVWAICG 2201
            ..|:|.:|........:..:.:.:|    |...::.| :|...|.....:.|..|.....|..|.
 Frog  1636 GSPSPTIQSSSGFEDCSQHLAQKNCSHSSCDTCSEFP-TGHRSLFGNQYKVLPQWCIYLAWCFCA 1699

Human  2202 TASLACSLGTGFLAYRFGQEQCVQWLHLLSLSVVCCIFITQPLMVCLMALGFAWKRRADNHFFTE 2266
            ..|:.|:.||..:.:.||..:|:.|.|.:..||:.|.|:.||..:.::|....|:::.....|.|
 Frog  1700 VISIVCAAGTTLIGFSFGPTKCILWAHSVFFSVIFCTFVVQPSTIFIIAFFMTWRKKEIIDLFAE 1764

Human  2267 SLCEATRDLDSELAERSWTRLPFSSSCSIP---DCAGEVEKVLAARQQARHLRWAHPPSKAQLRG 2328
            ::||||:....|.:  ::.::....||  |   |.:.:.||:||||::||:||.|.|||.:||:.
 Frog  1765 TVCEATKYFQRETS--TFEQISTLHSC--PNDLDISTDFEKILAARKRARYLRLARPPSPSQLKV 1825

Human  2329 TRQRMRRESRTRAALRDISMDILMLLLLLCVIYGRFSQDEYSLNQAIRKEFTRNARNCLGGLRNI 2393
            .:.::|:::.|....|:..|..:|:|:.|.:..|:.|.|:|.||||:|.||||:|:.....:|..
 Frog  1826 VKDKIRKKTTTEKTFRECFMHGIMILIFLFITLGKCSNDDYLLNQAVRNEFTRHAKQSFKNIRTE 1890

Human  2394 ADWWDWSLTTLLDGLYPGGTPSARVPGAQPGALGGKCYLIGSSVIRQLKVFPRHLCKPPRPFSAL 2458
            .|||:||...||||||.....:.....::.|.:|||.:|||:.:|::..:.....|......|::
 Frog  1891 DDWWNWSFNVLLDGLYWNKMYNITSAKSKTGPIGGKFFLIGTPIIQKFSLENSSACVTYSFISSI 1955

Human  2459 IEDSIPTCSPEVGGPENPYLIDPENQNVTLNGPGGCGTREDCVLSLGRTRTEAHTALSRLRASMW 2523
            | .|....:.:...|:....::..::....||...|......|::|||:||||::||.|:::..|
 Frog  1956 I-SSYNQANDKPKEPDTENHLEVRDKMHHRNGKVHCYKGRKSVINLGRSRTEAYSALLRIQSQQW 2019

Human  2524 IDRSTRAVSVHFTLYNPPTQLFTSVSLRVEILPTGSLVPSSLVESFSIFRSDSALQYHLMLPQLV 2588
            |:.||.|:.|.||||||||.:||.|.|::|...:|.::.|||:|||.|:...:.|.|..|..:|:
 Frog  2020 INHSTTALHVLFTLYNPPTNVFTVVLLQMEFPASGGVITSSLIESFKIYHIATLLDYITMALKLL 2084

Human  2589 FLALSLIHLCVQLYRMMDKGVLSYWRKPRNWLELSVVGVSLTYYAVSGHLVTLAGDVTNQFHRGL 2653
            ||.|.|:|.|.||..|:..|:.:||::|.||:||.::..||.|||...:...|..|:.::..:..
 Frog  2085 FLGLILLHSCFQLGVMIQTGIRNYWQEPWNWIELGIIASSLCYYACITYTFLLTMDMIDRLQKVF 2149

Human  2654 CRAFMDLTLMASWNQRARWLRGILLFLFTLKCVYLPGIQNTMASCSSMMRHSLPSI---FVAGLV 2715
            .|.|:|.:::|:|.:..|.|.||:.||..:|.:.|..|...||.|.:::..|..|:   .::|::
 Frog  2150 FRIFIDCSILAAWEKWNRSLHGIIFFLMVIKFIKLFRIYKVMAPCLTVLHLSSSSMAFTMISGII 2214

Human  2716 GALMLAALSHLHRFLLSMWVLPPGTFTDAFPGLLFHFPR--RSQKDCLLGL-------------- 2764
            .:|..::|.|:.....|                 |||..  ||.....:.|
 Frog  2215 FSLAFSSLGHVIVLFNS-----------------FHFSNMIRSLHMLFMNLLGVGDRRLFSFLHL 2262

Human  2765 -SKSDQRAMACYFGILLIVSATLCFGMLRGFLMTLPQK-RKSFQSKSFVRLKDVTAYMWEKVLTF 2827
             :||......|.:.:|.:....|..||:||.|.::.:. .|..::|..:.|.||.::..|||.:.
 Frog  2263 RTKSVPLPATCVYVVLFLFITILWTGMIRGILTSIMKNTSKIHRNKQLITLTDVASHAKEKVYSV 2327

Human  2828 LRLETPKLEEAEMVENHNYYLDEFANLLDELLMKINGLSDSLQLPLLEKTSNNTGEARTEESPLV 2892
            ...:..|..:......:|:||:||.:|:||||.::|.:|:||...|..|.     ...|||
 Frog  2328 FGRQRMKSTDTTTFPRNNFYLEEFEDLIDELLFRLNAISNSLHHSLPAKL-----HCYTEE---- 2383

Human  2893 DISSYQAAEENTTLSGLSL--YEP---ADIKD 2919
                   |||.:.|...|:  ::|   :|:|:
 Frog  2384 -------AEEVSQLESHSVCCFKPPQESDLKN 2408

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PKD1L1	XP_016867287.1	None
pkd1l1	XP_012820943.2	PCC	<36..448	CDD:188093	188/412 (46%)
		REJ	<671..841	CDD:366875	87/170 (51%)
		PLAT	1334..1453	CDD:412108	59/118 (50%)
		PKD_channel	1891..2250	CDD:400395	123/376 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	371	1.000	Domainoid score	I6761
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H51376
Inparanoid	1	1.050	1503	1.000	Inparanoid score	I1391
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10745at32523
OrthoFinder	1	1.000	-	-		FOG0014039
OrthoInspector	1	1.000	-	-		oto149287
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11569
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.970