DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lepr and Dscam1

DIOPT Version :9

Sequence 1:	XP_036019643.1	Gene:	Lepr / 16847	MGIID:	104993	Length:	1163	Species:	Mus musculus
Sequence 2:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster

Alignment Length:	1033	Identity:	189/1033 - (18%)
Similarity:	337/1033 - (32%)	Gaps:	304/1033 - (29%)

- Green bases have known domain annotations that are detailed below.

Mouse    46 DSFLSP--------AGAPNNASALKGASEAIVEAKFNSSGIYVPELSKTVFHCCFGNEQGQNCSA 102
            |.|..|        ...|.....||.:....||    ...::|..:.||       ||....|.|
  Fly   746 DGFPKPQVTWKKAVGDTPGEYKDLKKSDNIRVE----EGTLHVDNIQKT-------NEGYYLCEA 799

Mouse   103 LTDNTEGKTLASVVKASV-------------FRQLGVNWDIECWMKGDLTLFICHMEPLPKNPFK 154
            :  |..|..|::|:..||             ..:.|....::|..||
  Fly   800 I--NGIGSGLSAVIMISVQAPPEFTEKLRNQTARRGEPAVLQCEAKG------------------ 844

Mouse   155 NYDSKVHLLYDLPEVIDDSPLPPLKDSFQTVQCNCSLRGCECHVPVPRAKLNYALLMYLEITSAG 219
              :..:.:|:::    ::..|.|..|:..|::......|....:.:.|.:.:.:.|.....|:|
  Fly   845 --EKPIGILWNM----NNMRLDPKNDNRYTIREEILSTGVMSSLSIKRTERSDSALFTCVATNA- 902

Mouse   220 VSFQSPLMSLQPMLVVKPDPPLGLHMEVTDDGNLKISWDSQTMAPFPL-QYQVKYLENSTIVREA 283
              |.|...|:..::...|:.|..|.:......::::||........|| :|.:::..:.....|.
  Fly   903 --FGSDDASINMIVQEVPEMPYALKVLDKSGRSVQLSWAQPYDGNSPLDRYIIEFKRSRASWSEI 965

Mouse   284 AEIV---SATSLLVDSVLPGSSYEVQVRSKRLDGSGVWSD-----------WSSPQVF------- 327
            ..::   ..|...|..:.|.::|.:::.::...|:...|:           ...||..
  Fly   966 DRVIVPGHTTEAQVQKLSPATTYNIRIVAENAIGTSQSSEAVTIITAEEAPSGKPQNIKVEPVNQ 1030

Mouse   328 TTQDVVYFPPKILTSVGSNASFHCIYKNENQIISSKQIVWWRN-LAEKIPE-----------IQY 380
            ||..|.:.||......|....::..||..|  .:|..:....| :.|:..|           .||
  Fly  1031 TTMRVTWKPPPRTEWNGEILGYYVGYKLSN--TNSSYVFETINFITEEGKEHNLELQNLRVYTQY 1093

Mouse   381 SIVSDRVSKVTFSNLKATRPRGKFTYDAVYCCNEQACHHRYAELYVIDVNINISCETDGYLTKMT 445
            |:|....:|:....|  :....:||                ||........:.:|.|   ||..|
  Fly  1094 SVVIQAFNKIGAGPL--SEEEKQFT----------------AEGTPSQPPSDTACTT---LTSQT 1137

Mouse   446 CR--WSPSTIQSLVG--STVQLRYHRRSLYCPDSPSIHPTSEPKNCVLQRDGFYECVFQPIFLLS 506
            .|  |....::|..|  .|.::.|         :||.....|.|. ..::....:.|...:...:
  Fly  1138 IRVGWVSPPLESANGVIKTYKVVY---------APSDEWYDETKR-HYKKTASSDTVLHGLKKYT 1192

Mouse   507 GYTMWIRINHSLGS--LDSPPTCVLPDSVVKPLPPSNVKAEITVNTGLLKVSWEKPVFPENNL-Q 568
            .|||.:....:.|.  ...|..|.....|  |..|::|||.:..|..:| |||..|..|...: |
  Fly  1193 NYTMQVLATTAGGDGVRSVPIHCQTEPDV--PEAPTDVKALVMGNAAIL-VSWRPPAQPNGIITQ 1254

Mouse   569 FQIRYGLSGKEIQWKTHEV------FDA-----------------------KSKSASLLVSDLCA 604
            :.:.....|.|.:.||.:|      |:|                       :|||...:.||
  Fly  1255 YTVYSKAEGAETETKTQKVPHYQMSFEATELEKNKPYEFWVTASTTIGEGQQSKSIVAMPSD--- 1316

Mouse   605 VYVVQVRCRRLDGLGYWSNWSSPAYTLVMDVKVPMRG-----PEFWRKMDG-DVTKKER-----N 658
              .|..:....|        .:...|...|.|:|...     ||...|:.| :.:..:|     :
  Fly  1317 --QVPAKIASFD--------DTFTATFKEDAKMPCLAVGAPQPEITWKIKGVEFSANDRMRVLPD 1371

Mouse   659 VTLLWKPLTKNDS---LCSVRRYVVKHRTAHN--------------------------------- 687
            .:||.|.:.:.|:   .|.....:.|....|.
  Fly  1372 GSLLIKSVNRQDAGDYSCHAENSIAKDSITHKLIVLAPPQSPHVTLSATTTDALTVKLKPHEGDT 1436

Mouse   688 --------------GTW-SEDV---GNRTNLTFLWTEPAHTVTVLAVNSLGASLVNFNLTFSWPM 734
                          |.| :.:|   ..:.|:..|.....:.|.....|::||...:..|......
  Fly  1437 APLHGYTLHYKPEFGEWETSEVSVDSQKHNIEGLLCGSRYQVYATGFNNIGAGEASDILNTRTKG 1501

Mouse   735 SKVSAVESLSAYPLSSSCVILSWTLSPD-DYSLLYLVIEWKILNEDDGMKWLRIPSNVKKFYIHD 798
            .|....|......:||:.|.|.:....| ...:.:.|:|.|   :.|.::|.:|.:|||.   .:
  Fly  1502 QKPKLPEKPRFIEVSSNSVSLHFKAWKDGGCPMSHFVVESK---KRDQIEWNQISNNVKP---DN 1560

Mouse   799 NFIPIE----------------------KYQFSLYPV-------FMEGVGKPKI-----INGFTK 829
            |::.::                      :|.|:...|       ..:|.|...:     :..:..
  Fly  1561 NYVVLDLEPATWYNLRITAHNSAGFTVAEYDFATLTVTGGTIAPLDDGSGHGNVHTRIRLPAWMP 1625

Mouse   830 DAIDKQQNDAGLYVIVPIIISSCVLLLGTLLI----SHQR-------MKKLFWDDVPN 876
            :.:|       |..:||:|.:..|:.:|..::    |.:|       .|.:::|.|.|
  Fly  1626 EWLD-------LNFMVPLIATVVVVAVGICVVCVALSRRRADDMRGGQKDVYYDVVYN 1676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lepr	XP_036019643.1	ObR_Ig	127..232	CDD:408372	16/104 (15%)
		FN3	237..329	CDD:238020	17/113 (15%)
		Lep_receptor_Ig	328..419	CDD:399379	21/102 (21%)
		ObR_Ig	430..532	CDD:408372	22/107 (21%)
		FN3	536..626	CDD:238020	27/119 (23%)
		FN3	738..819	CDD:214495	20/110 (18%)
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845
		IG	57..133	CDD:214652
		IG_like	267..343	CDD:214653
		Ig	269..340	CDD:143165
		IG_like	353..425	CDD:214653
		IGc2	361..413	CDD:197706
		I-set	433..527	CDD:254352
		IGc2	446..517	CDD:197706
		I-set	533..618	CDD:254352
		IGc2	544..607	CDD:197706
		Ig	641..714	CDD:143165
		IGc2	735..804	CDD:197706	16/70 (23%)
		I-set	819..914	CDD:254352	17/121 (14%)
		Ig	833..921	CDD:299845	18/114 (16%)
		FN3	918..1011	CDD:238020	15/92 (16%)
		FN3	1018..1116	CDD:238020	21/101 (21%)
		FN3	1124..1217	CDD:238020	22/105 (21%)
		FN3	1222..1312	CDD:238020	23/90 (26%)
		Ig	1339..1406	CDD:299845	13/66 (20%)
		FN3	1409..1499	CDD:238020	10/89 (11%)
		FN3	1504..1584	CDD:238020	16/85 (19%)
		Dscam_C	1890..2008	CDD:289151
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910