Protein Alignment RNF133 and HRD1

DIOPT Version :9

• Sequence 1: NP_631914.1
• Gene: RNF133 / 168433
• HGNCID: 21154
• Length: 376
• Species: Homo sapiens
• Sequence 2: NP_014630.1
• Gene: HRD1 / 854149
• SGDID: S000005373
• Length: 551
• Species: Saccharomyces cerevisiae
• Alignment Length: 287
• Identity: 58/287 - (20%)
• Similarity: 93/287 - (32%)
• Gaps: 90/287 - (31%)

Human   104 LIERGGCTFTQKIKVATEKGASGVIIYNVPGTGNQVFPMFHQAFEDVVVVMIGNLKGTEIFHLIK 168
            :.|:....||:.:|.|..  .|.:|.:.:|          ....:|||         .:|..|.:
Yeast   269 MYEKAIDVFTRFLKTALH--LSMLIPFRMP----------MMLLKDVV---------WDILALYQ 312

Human   169 KGVLITAVVEVGRKHIIWMNHYLVSFVIVTTATLAYFIFYHIHRLCLARIQNRRWQRLTTDLQNT 233
            .|..:..         ||.|:..:...:||..                          ...|||:
Yeast   313 SGTSLWK---------IWRNNKQLDDTLVTVT--------------------------VEQLQNS 342

Human   234 FGQLQLRVVKEGDEEINPNGDSCVICFER--YKPNDIV--------RILTCKHFFHKNCIDPWIL 288
                      ..|:.|      |:||.:.  :.||...        :.|.|.|..|.:|:..|:.
Yeast   343 ----------ANDDNI------CIICMDELIHSPNQQTWKNKNKKPKRLPCGHILHLSCLKNWME 391

Human   289 PHGTCPICKCDILKVLGIQVVVENGTEPLQVLMSNELPET--LSPSEEETNNEVS--PAGTSDKV 349
            ...|||||:..:....| .||....|....:.....:.::  ::..::...|||.  |..|:...
Yeast   392 RSQTCPICRLPVFDEKG-NVVQTTFTSNSDITTQTTVTDSTGIATDQQGFANEVDLLPTRTTSPD 455

Human   350 IHVEENPTSQNNDIQPHSVVEDVHPSP 376
            |.:.  || ||.|...........|||
Yeast   456 IRIV--PT-QNIDTLAMRTRSTSTPSP 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RNF133	NP_631914.1	PA_GRAIL_like	43..177	CDD:239037	14/72 (19%)
		RING_Ubox	254..302	CDD:327409	16/57 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	327..376		12/52 (23%)
HRD1	NP_014630.1	HRD1	5..551	CDD:227568	58/287 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910