DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RNF133 and gol

DIOPT Version :9

Sequence 1:	NP_631914.1	Gene:	RNF133 / 168433	HGNCID:	21154	Length:	376	Species:	Homo sapiens
Sequence 2:	NP_001163300.1	Gene:	gol / 38006	FlyBaseID:	FBgn0004919	Length:	601	Species:	Drosophila melanogaster

Alignment Length:	289	Identity:	87/289 - (30%)
Similarity:	141/289 - (48%)	Gaps:	59/289 - (20%)

- Green bases have known domain annotations that are detailed below.

Human    79 EGKIQN------------------ACNPNTIFSRSKY-------SETWLALIERGGCTFTQKIKV 118
            |||:.|                  ||.|   :.|...       .|||:||:.||.|||.:|:|.
  Fly    97 EGKVLNVTGRLIHITATDNFSDDYACTP---YIRGTLGAPIPDKGETWIALVRRGRCTFEEKVKH 158

Human   119 ATEKGASGVIIYNVPGTGNQVFPMFHQAFED-----VVVVMIGNLKGTEIFHLIKKGVLITAVVE 178
            ..::.|:||||||    ..||..:.....:.     ..|:...|: |.::...:.||..:|..:.
  Fly   159 VYQQNAAGVIIYN----DKQVMQLEKMQIKGKTRNIAAVITYQNI-GQDLSLTLDKGYNVTISII 218

Human   179 VGRK-----------HIIWMNHYLVSFVIVTTATLAYFIFYHIHRLCLARIQNRRWQRLTTDLQN 232
            .||:           .:::::   :||:::...:|.:.|||:|.|....:.::::.:.|.:..:.
  Fly   219 EGRRGVRTISSLNRTSVLFVS---ISFIVLMIISLVWLIFYYIQRFRYMQAKDQQSRNLCSVTKK 280

Human   233 TFGQLQLRVVKEGDEEINPNGDSCVICFERYKPNDIVRILTCKHFFHKNCIDPWILPHGTCPICK 297
            ...::..:..|..||: :.:.|.|.||.|.|||.|.:|||.|||.|||||||||::.|.|||:||
  Fly   281 AIMKIPTKTGKFSDEK-DLDSDCCAICIEAYKPTDTIRILPCKHEFHKNCIDPWLIEHRTCPMCK 344

Human   298 CDILKVLGI------QVVVENGTEPLQVL 320
            .|:||..|.      :.::|...:|.|.|
  Fly   345 LDVLKFYGYVFLGSEESILEYQPDPPQGL 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RNF133	NP_631914.1	PA_GRAIL_like	43..177	CDD:239037	35/127 (28%)
		RING_Ubox	254..302	CDD:327409	31/47 (66%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	327..376
gol	NP_001163300.1	PA_GRAIL_like	73..217	CDD:239037	35/127 (28%)
		UPF0233	226..>258	CDD:299753	6/34 (18%)
		zf-RING_2	301..344	CDD:290367	28/42 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22765
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X295
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.980