DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RNF133 and H10E21.5

DIOPT Version :9

Sequence 1:	NP_631914.1	Gene:	RNF133 / 168433	HGNCID:	21154	Length:	376	Species:	Homo sapiens
Sequence 2:	NP_497129.1	Gene:	H10E21.5 / 175169	WormBaseID:	WBGene00019185	Length:	473	Species:	Caenorhabditis elegans

Alignment Length:	163	Identity:	51/163 - (31%)
Similarity:	88/163 - (53%)	Gaps:	10/163 - (6%)

- Green bases have known domain annotations that are detailed below.

Human   192 VSFVIVTTATLAYFIFYHIHRLCLARIQNRRWQRLTTDLQNTFGQLQLRVVKEG-DEEINPNGDS 255
            :||:|:...:||:.:||::.|...|..::|..:||....:....::....:..| .:|:.   ..
Worm   165 ISFIILMVISLAWLVFYYVQRFRYAHAKDRLQRRLFNAARKALTRIPTMTITPGMTQELQ---SD 226

Human   256 CVICFERYKPNDIVRILTCKHFFHKNCIDPWILPHGTCPICKCDILKVLGIQVVVENGTE-PLQV 319
            |.:|.:.|:..|::|:|.|||.:||:|||||:|.|.|||:||.||||..|....:.|..: |...
Worm   227 CAVCLDPYQLQDVIRLLPCKHIYHKSCIDPWLLEHRTCPMCKNDILKHFGYWNDIRNDIQMPTNS 291

Human   320 L-MSNELPETLSPSEEE----TNNEVSPAGTSD 347
            . ::::....|...|:|    :.:.:||...||
Worm   292 RGIADDFTIRLELGEQEHQAPSADVISPEANSD 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RNF133	NP_631914.1	PA_GRAIL_like	43..177	CDD:239037
		RING_Ubox	254..302	CDD:327409	25/47 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	327..376		7/25 (28%)
H10E21.5	NP_497129.1	HRD1	<150..325	CDD:227568	51/163 (31%)
H10E21.5	NP_497129.1	RING-H2_GRAIL	226..273	CDD:319582	25/46 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm15229
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22765
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X295
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.970