DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lef1 and Sox15

DIOPT Version :9

Sequence 1:	NP_001365988.1	Gene:	Lef1 / 16842	MGIID:	96770	Length:	412	Species:	Mus musculus
Sequence 2:	NP_523739.2	Gene:	Sox15 / 36575	FlyBaseID:	FBgn0005613	Length:	784	Species:	Drosophila melanogaster

Alignment Length:	364	Identity:	83/364 - (22%)
Similarity:	146/364 - (40%)	Gaps:	96/364 - (26%)

- Green bases have known domain annotations that are detailed below.

Mouse    78 QEPYH----DKAREHPDEGKHPDGGLYNKGPSYSSYSGYI----MMPNMNSDP---YMSNGS--L 129
            :.|:|    ..::::|...:.|:.. ::.|..|..:.||:    :|...|||.   ::..||  .
  Fly     8 EHPHHLLTNYNSKKYPHVSRTPEYS-HSTGSDYPEHGGYLTDGRLMHESNSDAGIYHVRQGSEHS 71

Mouse   130 SPPIPRTSNKVPVVQPSHAVHPLTPLITYSDEHFSPGSHPSHIPSDVNSKQGMSRHPPAPEIPTF 194
            ||     |...|.:|.|          .|.:||.:.....:|..|          |.|.|.:.:.
  Fly    72 SP-----SLHSPAIQSS----------GYENEHLNEAVLAAHSHS----------HSPMPMVSSA 111

Mouse   195 YPLSPGGVGQITPPIGWQGQPV---YPITGGFRQPYPSSLSGDTSMSRFSHH----MIPGPPGPH 252
            |      ||..|.    .|..:   .|:.||         .|::.:::|..|    |:.|..|..
  Fly   112 Y------VGGGTA----SGSLINSNIPLLGG---------GGNSVLNKFLSHPHAGMVGGGTGQM 157

Mouse   253 TTGIPHPAIVTPQV----------------KQEHPHTDSDLMHVKPQHEQRKEQEPKRPHIKKPL 301
            .....|..|....:                .:.|....:||.: :|...|.|..:..|  |::|:
  Fly   158 EDCTSHSPIEAASMWSYDYKGDLCAPNCGYLERHKPLPADLKY-RPGGTQSKSAKESR--IRRPM 219

Mouse   302 NAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSA 366
            ||||::.|..|..:..|.....:|.::::||::|.:|:.:::..|.|.|.:.|.:||..:|.:..
  Fly   220 NAFMVWAKIERKKLADENPDLHNADLSKMLGKKWRSLTPQDRRPYVEEAERLRVIHMTEHPNYKY 284

Mouse   367 RDNYGKKKKRKREKLQESTSGGKRSSFPTCKAKAATPGP 405
            |     .::||:.||:....|||..|       .::|.|
  Fly   285 R-----PRRRKQSKLRAMQPGGKEQS-------ESSPNP 311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lef1	NP_001365988.1	CTNNB1_binding	1..211	CDD:400583	32/145 (22%)
		CTNNB1-binding	1..60
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	59..102		4/27 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	164..191		5/26 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	266..296		7/45 (16%)
		SOX-TCF_HMG-box	296..367	CDD:238684	21/70 (30%)
Sox15	NP_523739.2	SOX-TCF_HMG-box	214..285	CDD:238684	22/72 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000