DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GALNTL5 and Pgant9

DIOPT Version :9

Sequence 1:	XP_016867282.1	Gene:	GALNTL5 / 168391	HGNCID:	21725	Length:	496	Species:	Homo sapiens
Sequence 2:	NP_001097342.1	Gene:	Pgant9 / 246627	FlyBaseID:	FBgn0050463	Length:	650	Species:	Drosophila melanogaster

Alignment Length:	424	Identity:	175/424 - (41%)
Similarity:	243/424 - (57%)	Gaps:	41/424 - (9%)

- Green bases have known domain annotations that are detailed below.

Human    91 KSQEPLSAWSPGKKVHQQIIYGSEQIPKPHVIVKRTDEDKAKSMLGTDFN-HTNP-------ELH 147
            |.:..|.|....||..:|        ||     |:..|| :|.::....| ..||       .|.
  Fly   106 KHKADLQAERMRKKAAEQ--------PK-----KKPQED-SKKVIDPPANFEENPGELGKPVRLP 156

Human   148 KEL------------LKYGFNVIISRSLGIEREVPDTRSKMCL-QKHYPARLPTASIVICFYNEE 199
            ||:            .|..||..:|..:.:.|.:||.|...|. :..|...||...::|||:||.
  Fly   157 KEMSDEMKKAVDDGWTKNAFNQYVSDLISVHRTLPDPRDAWCKDEARYLTNLPKTDVIICFHNEA 221

Human   200 CNALFQTMSSVTNLTPHYFLEEIILVDDMSKVDDLKEKLDYHLETFRGKVKIIRNKKREGLIRAR 264
            ...|.:|:.||.:.:|.:.:.:||||||.|.:..||.:|:.:...: .||:|||.:|||||||||
  Fly   222 WTVLLRTVHSVLDRSPEHLIGKIILVDDYSDMPHLKRQLEDYFAAY-PKVQIIRGQKREGLIRAR 285

Human   265 LIGASHASGDVLVFLDSHCEVNRVWLEPLLHAIAKDPKMVVCPLIDVIDDRTLE--YKPSPLVR- 326
            ::||:||...||.:||||||....||||||..||::...||||:||||.|.|||  |:.|..|.
  Fly   286 ILGANHAKSPVLTYLDSHCECTEGWLEPLLDRIARNSTTVVCPVIDVISDETLEYHYRDSGGVNV 350

Human   327 GTFDWNLQFKWDNVFSYEMDGPEGSTKPIRSPAMSGGIFAIRRHYFNEIGQYDKDMDFWGRENLE 391
            |.|||||||.|..|...|......:.:|:.||.|:||:|:|.|.:|:.:|.||...|.||.||||
  Fly   351 GGFDWNLQFSWHPVPERERKRHNSTAEPVYSPTMAGGLFSIDREFFDRLGTYDSGFDIWGGENLE 415

Human   392 LSLRIWMCGGQLFIIPCSRVGHISKKQTG-KPSTIISAMTHNYLRLVHVWLDEYKEQFFLRKPGL 455
            ||.:.|||||.|.|:|||.||||.:|::. |..:.::.:..|.:||..||:||| .|::..:.|.
  Fly   416 LSFKTWMCGGTLEIVPCSHVGHIFRKRSPYKWRSGVNVLKKNSVRLAEVWMDEY-SQYYYHRIGN 479

Human   456 KYVTYGNIRERVELRKRLGCKSFQWYLDNVFPEL 489
            ....:|::.:|.:||..|.||||:|||||::|||
  Fly   480 DKGDWGDVSDRRKLRNDLKCKSFKWYLDNIYPEL 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GALNTL5	XP_016867282.1	GT2	187..437	CDD:224137	121/253 (48%)
GALNTL5	XP_016867282.1	pp-GalNAc-T	190..486	CDD:133004	142/299 (47%)
Pgant9	NP_001097342.1	WcaA	207..>478	CDD:223539	129/272 (47%)
		pp-GalNAc-T	213..510	CDD:133004	142/298 (48%)
		Ricin_B_lectin	521..640	CDD:279046
		RICIN	523..642	CDD:238092
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152463
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D606683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750