DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lamc2 and NetA

DIOPT Version :9

Sequence 1:	NP_032511.3	Gene:	Lamc2 / 16782	MGIID:	99913	Length:	1193	Species:	Mus musculus
Sequence 2:	NP_001285243.1	Gene:	NetA / 32398	FlyBaseID:	FBgn0015773	Length:	726	Species:	Drosophila melanogaster

Alignment Length:	410	Identity:	106/410 - (25%)
Similarity:	156/410 - (38%)	Gaps:	100/410 - (24%)

- Green bases have known domain annotations that are detailed below.

Mouse    28 CDCNGKSRQCVFDQELHRQTGSGFRCLNCNDNTAGVHCERCREGFYRHRDR----------DRCL 82
            |.|||.:.:|..|       .||.....|:.||||..||||:.   .|.||          :.|.
  Fly   313 CKCNGHASKCSTD-------ASGQLNCECSHNTAGRDCERCKP---FHFDRPWARATAKEANECK 367

Mouse    83 PCNCHSKG----------SLSAGCDNSGQCR-CKPGVTGQRCDRCQPGFHMLTDAGCTRDQGQLD 136
            .|||:...          .||.|. :.|.|: |:...||:.|.:|:.||:  .||.......::.
  Fly   368 ECNCNKHARQCRFNMEIFRLSQGV-SGGVCQNCRHSTTGRNCHQCKEGFY--RDATKPLTHRKVC 429

Mouse   137 SKCDCDPAGISGP-CD--SGRCVCKPAVTGERCDRCRPGYYHLDRANPEGCTQCFCYGHSASCHA 198
            ..|||.|.|.||. |:  ||:|.||..|||..|:||..||..             ...|.|.|..
  Fly   430 KACDCHPIGSSGKICNSTSGQCPCKDGVTGLTCNRCARGYQQ-------------SRSHIAPCIK 481

Mouse   199 SADFSVHKI-TSTFSQDVDGWKAV-----QRNGAPAKLHWSQRHR-----------------DVF 240
            .....::.: |...:.:.|..::.     .||||......||.:|                 ::.
  Fly   482 QPPRMINMLDTQNTAPEPDEPESSPGSGGDRNGAAGMAAQSQYYRTEGGRECGKCRVSTKRLNLN 546

Mouse   241 SSARRSDPVYFVAPAKFLGNQQVSYGQSLSFDYRVDRGGRQPSAYDVILEGAGLQIRAPLMAPGK 305
            ...:|.    :...||.:|....|...|    ..|.|....|...|..::    |::     ||
  Fly   547 KFCKRD----YAIMAKVIGRDTSSEAVS----REVQRRAMDPDVADYEMD----QVQ-----PG- 593

Mouse   306 TLPCGITKTYTFRLNEHPSSHWSPQLSYFEYRRLLRNLTALLIRATYGEYSTGYIDNVTLVSARP 370
            :....||..|.|:..::|:.:.:|:.|  |..|....:.|:..|:..|| |:| ..||..:....
  Fly   594 SARSPITGVYEFQAADYPNPNPNPRGS--EMERFDLQIQAVFKRSRPGE-SSG-AGNVYGMPNTT 654

Mouse   371 VSGAPAPWV-----ERCVCP 385
            :...|..|:     ..|.||
  Fly   655 LKRGPMTWIIPTKDLECRCP 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lamc2	NP_032511.3	Laminin_EGF	28..86	CDD:365839	22/67 (33%)
		EGF_Lam	83..127	CDD:238012	16/54 (30%)
		Laminin_EGF	139..184	CDD:365839	21/47 (45%)
		Laminin_B	245..370	CDD:383018	30/124 (24%)
		EGF_Lam	461..509	CDD:238012
		Laminin_EGF	517..564	CDD:365839
		EGF_Lam	572..>604	CDD:238012
		Cell attachment site. /evidence=ECO:0000255	586..588
		SMC_prok_B	<614..1192	CDD:274008
NetA	NP_001285243.1	LamNT	44..280	CDD:214532
		EGF_Lam	312..357	CDD:238012	20/53 (38%)
		EGF_Lam	369..426	CDD:238012	17/59 (29%)
		EGF_Lam	431..479	CDD:238012	23/60 (38%)
		NTR_netrin-1_like	545..723	CDD:239634	35/152 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000