DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lamb2 and LanB1

DIOPT Version :10

Sequence 1:NP_032509.2 Gene:Lamb2 / 16779 MGIID:99916 Length:1799 Species:Mus musculus
Sequence 2:NP_476618.1 Gene:LanB1 / 34068 FlyBaseID:FBgn0261800 Length:1788 Species:Drosophila melanogaster


Alignment Length:1802 Identity:746/1802 - (41%)
Similarity:997/1802 - (55%) Gaps:112/1802 - (6%)


- Green bases have known domain annotations that are detailed below.


Mouse    45 CSRGSCYPATGDLLVGRADRLTASSTCGLHSPQPYCIVSHLQDEKKCFLCDSRRPFSARDNPNSH 109
            |.|.|||||||:||:||.:|||||||||||||:.:||:||||| |||||||:|.. :..|...:|
  Fly    49 CERSSCYPATGNLLIGRENRLTASSTCGLHSPERFCILSHLQD-KKCFLCDTREE-TKHDPYKNH 111

Mouse   110 RIQNVVTSFAPQRR-TAWWQSENGVPMVTIQLDLEAEFHFTHLIMTFKTFRPAAMLVERSADFGR 173
            ||..::....|... ..|||||||....||||||||||||||||:||.|||||||.:|||.|||:
  Fly   112 RIGQIIYKTKPGTNIPTWWQSENGKENATIQLDLEAEFHFTHLIITFTTFRPAAMYIERSFDFGQ 176

Mouse   174 TWHVYRYFSYDCGADFPGIPLAPPRRWDDVVCESRYSEIEPSTEGEVIYRVLDPAIPIPDPYSSR 238
            |||:||||:|||...|||:|.. .....||:|.||||.:|||..||||:|||.|.|.:.|||:..
  Fly   177 TWHIYRYFAYDCKESFPGVPTV-LENITDVMCTSRYSNVEPSRNGEVIFRVLPPNINVTDPYAEH 240

Mouse   239 IQNLLKITNLRVNLTRLHTLGDNLLDPRREIREKYYYALYELVIRGNCFCYGHASQCAPAPGAPA 303
            :||.||:||||:.:|:||.|||||||.|.|..|||||.:..:|:||:|.||||||||.|...|.:
  Fly   241 VQNQLKMTNLRIQMTKLHKLGDNLLDSRLENEEKYYYGISNMVVRGSCSCYGHASQCLPLDPAFS 305

Mouse   304 HA---EGMVHGACICKHNTRGLNCEQCQDFYQDLPWHPAEDGHTHACRKCECNGHTHSCHFDMAV 365
            .|   :|||||.|.|.|||:|:|||:|:||:.||||.||....|:||:|||||.|..|||||.||
  Fly   306 QADNEDGMVHGRCECTHNTKGMNCEECEDFFNDLPWKPAFGKKTNACKKCECNDHAVSCHFDEAV 370

Mouse   366 YLASGNVSGGVCDGCQHNTAGRHCEFCRPFFYRDPTKDMRDPAVCRPCDCDPMGSQDGGRCDSHD 430
            :.|||.|||||||.|.|||.|:|||.|.|:|||||.:|:....||:||||||.||.|.|.|||.:
  Fly   371 FTASGFVSGGVCDNCLHNTRGQHCEECMPYFYRDPEQDITSERVCQPCDCDPQGSSDDGICDSLN 435

Mouse   431 DPVLGLVSGQCRCKEHVVGTRCQQCRDGFFGLSASDPRGCQRCQCNSRGTVPGSSPCDSSSGTCF 495
            :...|.|:|.|.||..|.|.||.||:||::.|.:.:|.||:.|.||..||: .:|.|...:|.|.
  Fly   436 ELEEGAVAGACHCKAFVTGRRCNQCKDGYWNLQSDNPEGCEPCTCNPLGTL-NNSGCVMRTGECK 499

Mouse   496 CKRLVTGHGCDRCLPGHWGLSHDLLGCRPCDCDVGGALDPQCDEATGQCRCRQHMIGRRCEQVQP 560
            ||:.|||..|::|:|..:|||....||..|:||.||:.|..||..:||||||.||.||.|.|.:.
  Fly   500 CKKYVTGKDCNQCMPETYGLSESPEGCSLCNCDAGGSYDNYCDVISGQCRCRPHMTGRSCSQPKQ 564

Mouse   561 GYFRPFLDHLTWEAEAAQGQGLEVVERLVTN---------RETP--SWTGPGFVRLREGQEVEFL 614
            .||.|.|.    |...|     |||:..::.         .|||  |:||.||.|:.|..|:.|.
  Fly   565 NYFIPLLP----EVHEA-----EVVDECISYGANGNCSLVAETPDGSFTGIGFTRVPENSELVFT 620

Mouse   615 VTSLPRAMDYDLLLRWEPQVPEQWAELELMVQRPGPVSAHSPCGHV---LPKDDRIQGMLHPNTR 676
            |..:||:|.||.::|::......|....:.:.||..|.....||.:   ...:.||...|...:|
  Fly   621 VGDIPRSMPYDAVIRYQSTSRGDWENAFITLVRPDQVDPEGGCGELAAATSSETRIPFSLPDRSR 685

Mouse   677 FLVFPRPVCLEPGISYKLKLKLIGTGGRAQPETSYSGLLIDSLVLQPHVLVLEMFSGGDAAALER 741
            .:|....||||.|..||.::..  ...|...::..:.:|:|||.|.|.:.|..:|.|...|.: |
  Fly   686 QVVALNEVCLEAGKVYKFRIYF--ERKRHDVDSPTATILVDSLTLIPRIDVTPIFQGSVLADI-R 747

Mouse   742 RTTFERYRCHEEGLMPSKAPLSETCAPLLISVSALIYNGALPCQCDPQGSLSSECSPHGGQCRCK 806
            :..:|:|.| :..|..........|..|...:|..:::||..|.|:|.||||..|..:||.|:||
  Fly   748 KKDYEKYNC-KSSLYDMNYKSDPKCQNLDNILSVFVHDGASMCNCNPTGSLSKVCESNGGYCQCK 811

Mouse   807 PGVVGRRCDVCATGYYGFGPAGCQACQCSPDGALSALCEGTSGQCPCRPGAFGLRCDHCQRGQWG 871
            |.||||:||.||.|.|||||.||:||.|:..|:....|:..:|||.|.|..:|..|:.||.|.|.
  Fly   812 PNVVGRQCDQCAPGTYGFGPEGCKACDCNSIGSKDKYCDLITGQCQCVPNTYGRECNQCQPGYWN 876

Mouse   872 FPNCRPCVCNGRADECDTHTGACLGCRDYTGGEHCERCIAGFHGDPRLPYGGQ--CRPCPCPEGP 934
            ||.||.|.|||.|..||...|.|:.|:|.|.|..|:.|:.|::|:|.  :|.:  ||||.|||..
  Fly   877 FPECRVCQCNGHAATCDPIQGTCIDCQDSTTGYSCDSCLDGYYGNPL--FGSEIGCRPCRCPETV 939

Mouse   935 GSQRHFATSCHRDGYSQQIVCQCREGYTGLRCEACAPGHFGDPSKPGGRCQLCECSGNIDPMDPD 999
            .|....|..|..|..:..::|.|:|||:|.|||.||...||:|.. ||.|..||||.|:|..|..
  Fly   940 ASGLAHADGCSLDTRNNNMLCHCQEGYSGSRCEICADNFFGNPDN-GGTCSKCECSNNVDLYDTG 1003

Mouse  1000 ACDPHTGQCLRCLHNTEGPHCGYCKPGFHGQAARQSCHRCTCNLLGTDPRRCPSTDLCHCDPSTG 1064
            .||..||.||:||:.|.|.||..||.||.|.|.:|:|.:|.|:.|||      :..:.|||..||
  Fly  1004 NCDRQTGACLKCLYQTTGDHCELCKDGFFGDALQQNCQQCECDFLGT------NNTIAHCDRFTG 1062

Mouse  1065 QCPCLPHVQGLNCDHCAPNFWNFTSGRGCQPCACHPSRARGPTCNEFTGQCHCHAGFGGRTCSEC 1129
            ||||||:|||:.||.||.|.|...||.||:.|.|.|..|....||.:||||.|..|||||.|::|
  Fly  1063 QCPCLPNVQGVRCDQCAENHWKIASGEGCESCNCDPIGALHEQCNSYTGQCQCKPGFGGRACNQC 1127

Mouse  1130 QELYWGDPGLQCRACDCDPRGIDKPQCHRSTGHCSCRPGVSGVRCDQCARGFSGVFPACHPCHAC 1194
            |..|||:|..:|:.|:||..|....||.|.||:|.|..|:.|.:|::||||:.|.||.|.||..|
  Fly  1128 QAHYWGNPNEKCQPCECDQFGAADFQCDRETGNCVCHEGIGGYKCNECARGYIGQFPHCSPCGEC 1192

Mouse  1195 FGDWDRVVQDLAARTRRLEQWAQELQQTGVLGAFESSFLNMQGKLGMVQAIMSARNASAASTAKL 1259
            |.:||.::..|...|......|:|::|.|..||:.|.|..:..||..::.::...:.|.....||
  Fly  1193 FNNWDLILSALEDATTATILRAKEIKQVGATGAYTSEFSELDKKLQHIRNLLQNTSVSLVDIEKL 1257

Mouse  1260 VEATEGLRHEIGKTTERLTQLEAELTAVQDENFNANHALSGLERDGLALNLTL-RQLDQHLE--- 1320
            ...|:.||.::..:..||::.|..|    |:.:| :.:|||:|.:.|..:..| :||.:.|:   
  Fly  1258 DYETQSLRDQLQASHGRLSETEQNL----DDIYN-SLSLSGVELESLQNHSRLVQQLSKELKENG 1317

Mouse  1321 -ILKHSNFLGAYDSIRHAHSQSTEAERRANASTF--AVPSPVSNSADTRRRTEVLMGAQKENFNR 1382
             .|:.||..||.:..|||:      ||.:|.||.  ......||:....:|.|.|  :.|.....
  Fly  1318 IQLQESNIEGALNLTRHAY------ERVSNLSTLKDEANELASNTDRNCKRVENL--SNKIQAEA 1374

Mouse  1383 QHLANQQALGRLSAHAHTLSLTG----INELVCGAPGDAPCATSPCGGAGCRDEDGQPRCGG-LG 1442
            ..|||...|.. ...|...|||.    :|..|||.||| || .|.||||||      ..||| |.
  Fly  1375 DDLANNNKLIE-DYRAELTSLTSQIPELNNQVCGKPGD-PC-DSLCGGAGC------GHCGGFLS 1430

Mouse  1443 CSGAAATADLALGRARHTQAELQRALVEGGGILSR---VSETRRQAEEAQQRAQAALDKANASRG 1504
            |...|.|         |::..|:.|......|.|:   ..:|.|...:|:..|..|.:|  |.||
  Fly  1431 CEHGAKT---------HSEEALKVAKDAETAITSKKDQADQTIRALTQAKLNASEAYEK--AKRG 1484

Mouse  1505 QVEQANQELRELIQNVK----------DFLSQEGADPDSIEMVATRVLDISIPASPEQIQRLASE 1559
             .||:.:.|.:...|:|          :|...:.|.|...:.:|.:.||:.:...||:|:.|..:
  Fly  1485 -FEQSERYLNQTNANIKLAENLFIALNNFQENKTASPSESKELAQKTLDLDLKLEPEEIETLGDQ 1548

Mouse  1560 IAERVRSLADVDTILAHTMGDVRRAEQLLQDAHRARSRAEGERQKAETVQAALEEAQRAQGAAQG 1624
            |...|.||.:|:.|:..|..|:.|...|...|:..:.:|:.....|.:|..:|..|..:||.|:.
  Fly  1549 INRAVSSLKNVEAIIYRTKPDLDRVNNLQSIANATKEKADKILDSANSVVESLAAADESQGKAKD 1613

Mouse  1625 AIWGAVVDTQNTEQTLQRVQERMAGAEKSLNSAGERARQLDALLEALKLKRAGNSLAASTAEETA 1689
            ||..|..:.:...|.|:::.|....||...|:..::..:|...::.|:.....|...|....:.|
  Fly  1614 AIQQANSNIELAGQDLEKIDEETYSAEAPANNTAQQVEKLAKKVQKLQNNIMKNDRDAKEITKEA 1678

Mouse  1690 GSAQ---SRAREAEKQLREQVGDQYQTVRALAERKAEGVLAAQARAEQLRDEARDLLQAAQDKLQ 1751
            ||.:   .|||.....|:.......||:...|.|...    |:.||:||...|..|......||:
  Fly  1679 GSVKLEAMRARGEANNLQSATSATNQTLTDRASRSEN----ARERAKQLLQRASKLTVDTNAKLK 1739

Mouse  1752 RLQELEGTYEENERALEGKAAQLDGLEARMRSVLQAINLQVQIYNTC 1798
            .|.:|:..|....:.|....|::..|...:...|..|..:...|..|
  Fly  1740 DLNDLQTVYLNKNQQLLRLQAEIGPLNKELNEHLIHIKERGSHYRQC 1786

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lamb2NP_032509.2 Laminin_N 50..284 CDD:459653 143/234 (61%)
EGF_Lam 286..338 CDD:238012 33/54 (61%)
Laminin_EGF 350..401 CDD:395007 36/50 (72%)
Laminin_EGF 413..470 CDD:395007 28/56 (50%)
Laminin_EGF 473..527 CDD:395007 23/53 (43%)
EGF_Lam 524..565 CDD:238012 22/40 (55%)
EGF_Lam 784..829 CDD:214543 28/44 (64%)
Laminin_EGF 832..880 CDD:395007 20/47 (43%)
Laminin_EGF 878..925 CDD:395007 19/48 (40%)
EGF_Lam 927..985 CDD:238012 25/57 (44%)
Laminin_EGF 987..>1029 CDD:395007 23/41 (56%)
Laminin_EGF 1039..1093 CDD:395007 27/53 (51%)
Laminin_EGF 1096..1144 CDD:395007 24/47 (51%)
Laminin_EGF 1144..1191 CDD:395007 22/46 (48%)
Domain II 1191..1410 66/229 (29%)
SMC_prok_B <1204..1571 CDD:274008 116/391 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1339..1365 7/27 (26%)
Domain alpha 1411..1443 18/32 (56%)
Domain I 1444..1799 93/371 (25%)
Smc <1446..>1787 CDD:440809 90/356 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1679..1701 7/24 (29%)
cc_LAMB2_C 1728..1799 CDD:411970 19/71 (27%)
LanB1NP_476618.1 Laminin_N 54..286 CDD:459653 143/234 (61%)
EGF_Lam 287..343 CDD:238012 33/55 (60%)
Laminin_EGF 355..415 CDD:395007 38/59 (64%)
Laminin_EGF 418..475 CDD:395007 28/56 (50%)
EGF_Lam 477..526 CDD:238012 20/49 (41%)
EGF_Lam 529..567 CDD:214543 20/37 (54%)
EGF_Lam 789..834 CDD:214543 28/44 (64%)
Laminin_EGF 837..885 CDD:395007 20/47 (43%)
Laminin_EGF 883..930 CDD:395007 19/48 (40%)
Laminin_EGF 933..988 CDD:395007 24/55 (44%)
Laminin_EGF 991..1035 CDD:395007 24/43 (56%)
Laminin_EGF 1043..1091 CDD:395007 27/53 (51%)
Laminin_EGF 1094..1142 CDD:395007 24/47 (51%)
Laminin_EGF 1142..1190 CDD:395007 23/47 (49%)
Mplasa_alph_rch 1228..>1771 CDD:275316 162/580 (28%)
cc_DmLAMB1-like_C 1717..1786 CDD:411973 17/68 (25%)

Return to query results.
Submit another query.