DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lamb2 and LanB1

DIOPT Version :9

Sequence 1:	NP_032509.2	Gene:	Lamb2 / 16779	MGIID:	99916	Length:	1799	Species:	Mus musculus
Sequence 2:	NP_476618.1	Gene:	LanB1 / 34068	FlyBaseID:	FBgn0261800	Length:	1788	Species:	Drosophila melanogaster

Alignment Length:	1802	Identity:	746/1802 - (41%)
Similarity:	997/1802 - (55%)	Gaps:	112/1802 - (6%)

- Green bases have known domain annotations that are detailed below.

Mouse    45 CSRGSCYPATGDLLVGRADRLTASSTCGLHSPQPYCIVSHLQDEKKCFLCDSRRPFSARDNPNSH 109
            |.|.|||||||:||:||.:|||||||||||||:.:||:||||| |||||||:|.. :..|...:|
  Fly    49 CERSSCYPATGNLLIGRENRLTASSTCGLHSPERFCILSHLQD-KKCFLCDTREE-TKHDPYKNH 111

Mouse   110 RIQNVVTSFAPQRR-TAWWQSENGVPMVTIQLDLEAEFHFTHLIMTFKTFRPAAMLVERSADFGR 173
            ||..::....|... ..|||||||....||||||||||||||||:||.|||||||.:|||.|||:
  Fly   112 RIGQIIYKTKPGTNIPTWWQSENGKENATIQLDLEAEFHFTHLIITFTTFRPAAMYIERSFDFGQ 176

Mouse   174 TWHVYRYFSYDCGADFPGIPLAPPRRWDDVVCESRYSEIEPSTEGEVIYRVLDPAIPIPDPYSSR 238
            |||:||||:|||...|||:|.. .....||:|.||||.:|||..||||:|||.|.|.:.|||:..
  Fly   177 TWHIYRYFAYDCKESFPGVPTV-LENITDVMCTSRYSNVEPSRNGEVIFRVLPPNINVTDPYAEH 240

Mouse   239 IQNLLKITNLRVNLTRLHTLGDNLLDPRREIREKYYYALYELVIRGNCFCYGHASQCAPAPGAPA 303
            :||.||:||||:.:|:||.|||||||.|.|..|||||.:..:|:||:|.||||||||.|...|.:
  Fly   241 VQNQLKMTNLRIQMTKLHKLGDNLLDSRLENEEKYYYGISNMVVRGSCSCYGHASQCLPLDPAFS 305

Mouse   304 HA---EGMVHGACICKHNTRGLNCEQCQDFYQDLPWHPAEDGHTHACRKCECNGHTHSCHFDMAV 365
            .|   :|||||.|.|.|||:|:|||:|:||:.||||.||....|:||:|||||.|..|||||.||
  Fly   306 QADNEDGMVHGRCECTHNTKGMNCEECEDFFNDLPWKPAFGKKTNACKKCECNDHAVSCHFDEAV 370

Mouse   366 YLASGNVSGGVCDGCQHNTAGRHCEFCRPFFYRDPTKDMRDPAVCRPCDCDPMGSQDGGRCDSHD 430
            :.|||.|||||||.|.|||.|:|||.|.|:|||||.:|:....||:||||||.||.|.|.|||.:
  Fly   371 FTASGFVSGGVCDNCLHNTRGQHCEECMPYFYRDPEQDITSERVCQPCDCDPQGSSDDGICDSLN 435

Mouse   431 DPVLGLVSGQCRCKEHVVGTRCQQCRDGFFGLSASDPRGCQRCQCNSRGTVPGSSPCDSSSGTCF 495
            :...|.|:|.|.||..|.|.||.||:||::.|.:.:|.||:.|.||..||: .:|.|...:|.|.
  Fly   436 ELEEGAVAGACHCKAFVTGRRCNQCKDGYWNLQSDNPEGCEPCTCNPLGTL-NNSGCVMRTGECK 499

Mouse   496 CKRLVTGHGCDRCLPGHWGLSHDLLGCRPCDCDVGGALDPQCDEATGQCRCRQHMIGRRCEQVQP 560
            ||:.|||..|::|:|..:|||....||..|:||.||:.|..||..:||||||.||.||.|.|.:.
  Fly   500 CKKYVTGKDCNQCMPETYGLSESPEGCSLCNCDAGGSYDNYCDVISGQCRCRPHMTGRSCSQPKQ 564

Mouse   561 GYFRPFLDHLTWEAEAAQGQGLEVVERLVTN---------RETP--SWTGPGFVRLREGQEVEFL 614
            .||.|.|.    |...|     |||:..::.         .|||  |:||.||.|:.|..|:.|.
  Fly   565 NYFIPLLP----EVHEA-----EVVDECISYGANGNCSLVAETPDGSFTGIGFTRVPENSELVFT 620

Mouse   615 VTSLPRAMDYDLLLRWEPQVPEQWAELELMVQRPGPVSAHSPCGHV---LPKDDRIQGMLHPNTR 676
            |..:||:|.||.::|::......|....:.:.||..|.....||.:   ...:.||...|...:|
  Fly   621 VGDIPRSMPYDAVIRYQSTSRGDWENAFITLVRPDQVDPEGGCGELAAATSSETRIPFSLPDRSR 685

Mouse   677 FLVFPRPVCLEPGISYKLKLKLIGTGGRAQPETSYSGLLIDSLVLQPHVLVLEMFSGGDAAALER 741
            .:|....||||.|..||.::..  ...|...::..:.:|:|||.|.|.:.|..:|.|...|.: |
  Fly   686 QVVALNEVCLEAGKVYKFRIYF--ERKRHDVDSPTATILVDSLTLIPRIDVTPIFQGSVLADI-R 747

Mouse   742 RTTFERYRCHEEGLMPSKAPLSETCAPLLISVSALIYNGALPCQCDPQGSLSSECSPHGGQCRCK 806
            :..:|:|.| :..|..........|..|...:|..:::||..|.|:|.||||..|..:||.|:||
  Fly   748 KKDYEKYNC-KSSLYDMNYKSDPKCQNLDNILSVFVHDGASMCNCNPTGSLSKVCESNGGYCQCK 811

Mouse   807 PGVVGRRCDVCATGYYGFGPAGCQACQCSPDGALSALCEGTSGQCPCRPGAFGLRCDHCQRGQWG 871
            |.||||:||.||.|.|||||.||:||.|:..|:....|:..:|||.|.|..:|..|:.||.|.|.
  Fly   812 PNVVGRQCDQCAPGTYGFGPEGCKACDCNSIGSKDKYCDLITGQCQCVPNTYGRECNQCQPGYWN 876

Mouse   872 FPNCRPCVCNGRADECDTHTGACLGCRDYTGGEHCERCIAGFHGDPRLPYGGQ--CRPCPCPEGP 934
            ||.||.|.|||.|..||...|.|:.|:|.|.|..|:.|:.|::|:|.  :|.:  ||||.|||..
  Fly   877 FPECRVCQCNGHAATCDPIQGTCIDCQDSTTGYSCDSCLDGYYGNPL--FGSEIGCRPCRCPETV 939

Mouse   935 GSQRHFATSCHRDGYSQQIVCQCREGYTGLRCEACAPGHFGDPSKPGGRCQLCECSGNIDPMDPD 999
            .|....|..|..|..:..::|.|:|||:|.|||.||...||:|.. ||.|..||||.|:|..|..
  Fly   940 ASGLAHADGCSLDTRNNNMLCHCQEGYSGSRCEICADNFFGNPDN-GGTCSKCECSNNVDLYDTG 1003

Mouse  1000 ACDPHTGQCLRCLHNTEGPHCGYCKPGFHGQAARQSCHRCTCNLLGTDPRRCPSTDLCHCDPSTG 1064
            .||..||.||:||:.|.|.||..||.||.|.|.:|:|.:|.|:.|||      :..:.|||..||
  Fly  1004 NCDRQTGACLKCLYQTTGDHCELCKDGFFGDALQQNCQQCECDFLGT------NNTIAHCDRFTG 1062

Mouse  1065 QCPCLPHVQGLNCDHCAPNFWNFTSGRGCQPCACHPSRARGPTCNEFTGQCHCHAGFGGRTCSEC 1129
            ||||||:|||:.||.||.|.|...||.||:.|.|.|..|....||.:||||.|..|||||.|::|
  Fly  1063 QCPCLPNVQGVRCDQCAENHWKIASGEGCESCNCDPIGALHEQCNSYTGQCQCKPGFGGRACNQC 1127

Mouse  1130 QELYWGDPGLQCRACDCDPRGIDKPQCHRSTGHCSCRPGVSGVRCDQCARGFSGVFPACHPCHAC 1194
            |..|||:|..:|:.|:||..|....||.|.||:|.|..|:.|.:|::||||:.|.||.|.||..|
  Fly  1128 QAHYWGNPNEKCQPCECDQFGAADFQCDRETGNCVCHEGIGGYKCNECARGYIGQFPHCSPCGEC 1192

Mouse  1195 FGDWDRVVQDLAARTRRLEQWAQELQQTGVLGAFESSFLNMQGKLGMVQAIMSARNASAASTAKL 1259
            |.:||.::..|...|......|:|::|.|..||:.|.|..:..||..::.::...:.|.....||
  Fly  1193 FNNWDLILSALEDATTATILRAKEIKQVGATGAYTSEFSELDKKLQHIRNLLQNTSVSLVDIEKL 1257

Mouse  1260 VEATEGLRHEIGKTTERLTQLEAELTAVQDENFNANHALSGLERDGLALNLTL-RQLDQHLE--- 1320
            ...|:.||.::..:..||::.|..|    |:.:| :.:|||:|.:.|..:..| :||.:.|:
  Fly  1258 DYETQSLRDQLQASHGRLSETEQNL----DDIYN-SLSLSGVELESLQNHSRLVQQLSKELKENG 1317

Mouse  1321 -ILKHSNFLGAYDSIRHAHSQSTEAERRANASTF--AVPSPVSNSADTRRRTEVLMGAQKENFNR 1382
             .|:.||..||.:..|||:      ||.:|.||.  ......||:....:|.|.|  :.|.....
  Fly  1318 IQLQESNIEGALNLTRHAY------ERVSNLSTLKDEANELASNTDRNCKRVENL--SNKIQAEA 1374

Mouse  1383 QHLANQQALGRLSAHAHTLSLTG----INELVCGAPGDAPCATSPCGGAGCRDEDGQPRCGG-LG 1442
            ..|||...|.. ...|...|||.    :|..|||.||| || .|.||||||      ..||| |.
  Fly  1375 DDLANNNKLIE-DYRAELTSLTSQIPELNNQVCGKPGD-PC-DSLCGGAGC------GHCGGFLS 1430

Mouse  1443 CSGAAATADLALGRARHTQAELQRALVEGGGILSR---VSETRRQAEEAQQRAQAALDKANASRG 1504
            |...|.|         |::..|:.|......|.|:   ..:|.|...:|:..|..|.:|  |.||
  Fly  1431 CEHGAKT---------HSEEALKVAKDAETAITSKKDQADQTIRALTQAKLNASEAYEK--AKRG 1484

Mouse  1505 QVEQANQELRELIQNVK----------DFLSQEGADPDSIEMVATRVLDISIPASPEQIQRLASE 1559
             .||:.:.|.:...|:|          :|...:.|.|...:.:|.:.||:.:...||:|:.|..:
  Fly  1485 -FEQSERYLNQTNANIKLAENLFIALNNFQENKTASPSESKELAQKTLDLDLKLEPEEIETLGDQ 1548

Mouse  1560 IAERVRSLADVDTILAHTMGDVRRAEQLLQDAHRARSRAEGERQKAETVQAALEEAQRAQGAAQG 1624
            |...|.||.:|:.|:..|..|:.|...|...|:..:.:|:.....|.:|..:|..|..:||.|:.
  Fly  1549 INRAVSSLKNVEAIIYRTKPDLDRVNNLQSIANATKEKADKILDSANSVVESLAAADESQGKAKD 1613

Mouse  1625 AIWGAVVDTQNTEQTLQRVQERMAGAEKSLNSAGERARQLDALLEALKLKRAGNSLAASTAEETA 1689
            ||..|..:.:...|.|:::.|....||...|:..::..:|...::.|:.....|...|....:.|
  Fly  1614 AIQQANSNIELAGQDLEKIDEETYSAEAPANNTAQQVEKLAKKVQKLQNNIMKNDRDAKEITKEA 1678

Mouse  1690 GSAQ---SRAREAEKQLREQVGDQYQTVRALAERKAEGVLAAQARAEQLRDEARDLLQAAQDKLQ 1751
            ||.:   .|||.....|:.......||:...|.|...    |:.||:||...|..|......||:
  Fly  1679 GSVKLEAMRARGEANNLQSATSATNQTLTDRASRSEN----ARERAKQLLQRASKLTVDTNAKLK 1739

Mouse  1752 RLQELEGTYEENERALEGKAAQLDGLEARMRSVLQAINLQVQIYNTC 1798
            .|.:|:..|....:.|....|::..|...:...|..|..:...|..|
  Fly  1740 DLNDLQTVYLNKNQQLLRLQAEIGPLNKELNEHLIHIKERGSHYRQC 1786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lamb2	NP_032509.2	Laminin_N	64..284	CDD:365840	133/220 (60%)
		EGF_Lam	286..338	CDD:238012	33/54 (61%)
		EGF_Lam	350..402	CDD:238012	37/51 (73%)
		Laminin_EGF	413..470	CDD:365839	28/56 (50%)
		EGF_Lam	472..523	CDD:238012	21/50 (42%)
		EGF_Lam	524..565	CDD:238012	22/40 (55%)
		Laminin_EGF	784..832	CDD:365839	30/47 (64%)
		Laminin_EGF	832..880	CDD:365839	20/47 (43%)
		EGF_Lam	877..922	CDD:238012	18/44 (41%)
		EGF_Lam	927..985	CDD:238012	25/57 (44%)
		Laminin_EGF	987..>1029	CDD:365839	23/41 (56%)
		Laminin_EGF	1039..1093	CDD:365839	27/53 (51%)
		Laminin_EGF	1096..1144	CDD:365839	24/47 (51%)
		Laminin_EGF	1144..1191	CDD:365839	22/46 (48%)
		Domain II	1191..1410		66/229 (29%)
		Smc	<1257..1789	CDD:224117	158/559 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1339..1365		7/27 (26%)
		Domain alpha	1411..1443		18/32 (56%)
		Domain I	1444..1799		93/371 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1679..1701		7/24 (29%)
LanB1	NP_476618.1	Laminin_N	63..286	CDD:278484	135/225 (60%)
		EGF_Lam	287..343	CDD:238012	33/55 (60%)
		Laminin_EGF	355..415	CDD:278482	38/59 (64%)
		Laminin_EGF	418..475	CDD:278482	28/56 (50%)
		EGF_Lam	477..526	CDD:238012	20/49 (41%)
		EGF_Lam	529..567	CDD:214543	20/37 (54%)
		EGF_Lam	789..834	CDD:214543	28/44 (64%)
		Laminin_EGF	837..885	CDD:278482	20/47 (43%)
		Laminin_EGF	883..930	CDD:278482	19/48 (40%)
		Laminin_EGF	933..988	CDD:278482	24/55 (44%)
		Laminin_EGF	991..1043	CDD:278482	27/51 (53%)
		Laminin_EGF	1043..1091	CDD:278482	27/53 (51%)
		Laminin_EGF	1094..1142	CDD:278482	24/47 (51%)
		Laminin_EGF	1142..1190	CDD:278482	23/47 (49%)
		COG6	1212..>1398	CDD:303003	58/199 (29%)
		TelA	1439..1782	CDD:226371	88/349 (25%)
		ApoLp-III_like	1545..1702	CDD:304399	40/156 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	304	1.000	Domainoid score	I1373
eggNOG	1	0.900	-	-		E1_KOG0994
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1723
Inparanoid	1	1.050	1458	1.000	Inparanoid score	I113
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49316
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002726
OrthoInspector	1	1.000	-	-		otm43243
orthoMCL	1	0.900	-	-		OOG6_100925
Panther	1	1.100	-	-	O	PTHR10574
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3531
SonicParanoid	1	1.000	-	-		X1817
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.860