DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lamb1 and LanB1

DIOPT Version :9

Sequence 1:	NP_032508.3	Gene:	Lamb1 / 16777	MGIID:	96743	Length:	1786	Species:	Mus musculus
Sequence 2:	NP_476618.1	Gene:	LanB1 / 34068	FlyBaseID:	FBgn0261800	Length:	1788	Species:	Drosophila melanogaster

Alignment Length:	1822	Identity:	758/1822 - (41%)
Similarity:	1070/1822 - (58%)	Gaps:	167/1822 - (9%)

- Green bases have known domain annotations that are detailed below.

Mouse    27 SYGCAEGSCYPATGDLLIGRAQKLSVTSTCGLHKPEPYCIVSHLQEDKKCFICDSR-----DPYH 86
            ::.|...|||||||:|||||..:|:.:||||||.||.:||:|||| |||||:||:|     |||
  Fly    46 THPCERSSCYPATGNLLIGRENRLTASSTCGLHSPERFCILSHLQ-DKKCFLCDTREETKHDPY- 108

Mouse    87 ETLNPDSHLIENVVTTFAP-NRLKIWWQSENGVENVTIQLDLEAEFHFTHLIMTFKTFRPAAMLI 150
                 .:|.|..::....| ..:..|||||||.||.||||||||||||||||:||.|||||||.|
  Fly   109 -----KNHRIGQIIYKTKPGTNIPTWWQSENGKENATIQLDLEAEFHFTHLIITFTTFRPAAMYI 168

Mouse   151 ERSSDFGKAWGVYRYFAYDCESSFPGISTGPMKKVDDIICDSRYSDIEPSTEGEVIFRALDPAFK 215
            |||.|||:.|.:||||||||:.||||:.| .::.:.|::|.||||::|||..||||||.|.|...
  Fly   169 ERSFDFGQTWHIYRYFAYDCKESFPGVPT-VLENITDVMCTSRYSNVEPSRNGEVIFRVLPPNIN 232

Mouse   216 IEDPYSPRIQNLLKITNLRIKFVKLHTLGDNLLDSRMEIREKYYYAVYDMVVRGNCFCYGHASEC 280
            :.|||:..:||.||:|||||:..|||.|||||||||:|..|||||.:.:|||||:|.||||||:|
  Fly   233 VTDPYAEHVQNQLKMTNLRIQMTKLHKLGDNLLDSRLENEEKYYYGISNMVVRGSCSCYGHASQC 297

Mouse   281 APVDGV-----NEEVEGMVHGHCMCRHNTKGLNCELCMDFYHDLPWRPAEGRNSNACKKCNCNEH 340
            .|:|..     ||  :|||||.|.|.|||||:|||.|.||::||||:||.|:.:||||||.||:|
  Fly   298 LPLDPAFSQADNE--DGMVHGRCECTHNTKGMNCEECEDFFNDLPWKPAFGKKTNACKKCECNDH 360

Mouse   341 SSSCHFDMAVFLATGNVSGGVCDNCQHNTMGRNCEQCKPFYFQHPERDIRDPNLCEPCTCDPAGS 405
            :.|||||.|||.|:|.|||||||||.|||.|::||:|.|::::.||:||....:|:||.|||.||
  Fly   361 AVSCHFDEAVFTASGFVSGGVCDNCLHNTRGQHCEECMPYFYRDPEQDITSERVCQPCDCDPQGS 425

Mouse   406 ENGGICDGYTDFSVGLIAGQCRCKLHVEGERCDVCKEGFYDLSAEDPYGCKSCACNPLGTIPGGN 470
            .:.||||...:...|.:||.|.||..|.|.||:.||:|:::|.:::|.||:.|.||||||: ..:
  Fly   426 SDDGICDSLNELEEGAVAGACHCKAFVTGRRCNQCKDGYWNLQSDNPEGCEPCTCNPLGTL-NNS 489

Mouse   471 PCDSETGYCYCKRLVTGQRCDQCLPQHWGLSNDLDGCRPCDCDLGGALNNSCSEDSGQCSCLPHM 535
            .|...||.|.||:.|||:.|:||:|:.:|||...:||..|:||.||:.:|.|...||||.|.|||
  Fly   490 GCVMRTGECKCKKYVTGKDCNQCMPETYGLSESPEGCSLCNCDAGGSYDNYCDVISGQCRCRPHM 554

Mouse   536 IGRQCNEVESGYYFTTLDHYIYEAE--------EANLGPGVIVVERQYIQDRIP--SWTGPGFVR 590
            .||.|::.:..|:...|.. ::|||        .|| |...:|.|       .|  |:||.||.|
  Fly   555 TGRSCSQPKQNYFIPLLPE-VHEAEVVDECISYGAN-GNCSLVAE-------TPDGSFTGIGFTR 610

Mouse   591 VPEGAYLEFFIDNIPYSMEYEILIRYEPQLPDHWEKAVITVQRPGKIPASSRCGNTVPDDDNQV- 654
            |||.:.|.|.:.:||.||.|:.:|||:......||.|.||:.||.::.....||.......::.
  Fly   611 VPENSELVFTVGDIPRSMPYDAVIRYQSTSRGDWENAFITLVRPDQVDPEGGCGELAAATSSETR 675

Mouse   655 --VSLSPGSRYVVLPRPVCFEKGMNYTVRLELPQYTASGSDVESPYT--FIDSLVLMPYCKSLDI 715
              .||...||.||....||.|.|..|..|:   .:.....||:||..  .:|||.|:|......|
  Fly   676 IPFSLPDRSRQVVALNEVCLEAGKVYKFRI---YFERKRHDVDSPTATILVDSLTLIPRIDVTPI 737

Mouse   716 FTVGGSGDGEVTNSAWETFQRYRCLENSRSVVKTPMTDV-------CRNIIFSISALIHQTGLAC 773
            |.  ||...::..   :.:::|.|        |:.:.|:       |:|:...:|..:|.....|
  Fly   738 FQ--GSVLADIRK---KDYEKYNC--------KSSLYDMNYKSDPKCQNLDNILSVFVHDGASMC 789

Mouse   774 ECDPQGSLSSVCDPNGGQCQCRPNVVGRTCNRCAPGTFGFGPNGCKPCDCHLQGSASAFCDAITG 838
            .|:|.||||.||:.|||.|||:||||||.|::|||||:||||.|||.|||:..||...:||.|||
  Fly   790 NCNPTGSLSKVCESNGGYCQCKPNVVGRQCDQCAPGTYGFGPEGCKACDCNSIGSKDKYCDLITG 854

Mouse   839 QCHCFQGIYARQCDRCLPGYWGFPSCQPCQCNGHALDCDTVTGECLSCQDYTTGHNCERCLAGYY 903
            ||.|....|.|:|::|.||||.||.|:.|||||||..||.:.|.|:.|||.|||::|:.||.|||
  Fly   855 QCQCVPNTYGRECNQCQPGYWNFPECRVCQCNGHAATCDPIQGTCIDCQDSTTGYSCDSCLDGYY 919

Mouse   904 GDPIIGSGDHCRPCPCPDGPDSGRQFARSCYQDPVTLQLACVCDPGYIGSRCDDCASGFFGNPSD 968
            |:|:.||...||||.||:...||...|..|..|.....:.|.|..||.||||:.||..||||| |
  Fly   920 GNPLFGSEIGCRPCRCPETVASGLAHADGCSLDTRNNNMLCHCQEGYSGSRCEICADNFFGNP-D 983

Mouse   969 FGGSCQPCQCHHNIDTTDPEACDKETGRCLKCLYHTEGDHCQLCQYGYYGDALRQDCRKCVCNYL 1033
            .||:|..|:|.:|:|..|...||::||.||||||.|.||||:||:.|::||||:|:|::|.|::|
  Fly   984 NGGTCSKCECSNNVDLYDTGNCDRQTGACLKCLYQTTGDHCELCKDGFFGDALQQNCQQCECDFL 1048

Mouse  1034 GTVKEHCNGSDCHCDKATGQCSCLPNVIGQNCDRCAPNTWQLASGTGCGPCNCNAAHSFGPSCNE 1098
            ||     |.:..|||:.||||.|||||.|..||:||.|.|::|||.||..|||:...:....||.
  Fly  1049 GT-----NNTIAHCDRFTGQCPCLPNVQGVRCDQCAENHWKIASGEGCESCNCDPIGALHEQCNS 1108

Mouse  1099 FTGQCQCMPGFGGRTCSECQELFWGDPDVECRACDCDPRGIETPQCDQSTGQCVCVEGVEGPRCD 1163
            :||||||.||||||.|::||..:||:|:.:|:.|:||..|....|||:.||.|||.||:.|.:|:
  Fly  1109 YTGQCQCKPGFGGRACNQCQAHYWGNPNEKCQPCECDQFGAADFQCDRETGNCVCHEGIGGYKCN 1173

Mouse  1164 KCTRGYSGVFPDCTPCHQCFALWDAIIGELTNRTHKFLEKAKALKISGVIGPYRETVDSVEKKVN 1228
            :|.|||.|.||.|:||.:||..||.|:..|.:.|...:.:||.:|..|..|.|......::||:.
  Fly  1174 ECARGYIGQFPHCSPCGECFNNWDLILSALEDATTATILRAKEIKQVGATGAYTSEFSELDKKLQ 1238

Mouse  1229 EIKDILAQSPAAEPLKNIGILFEEAEKL---TKDVTE-------KMAQVEVKLTDTASQSNSTAG 1283
            .|:::         |:|..:...:.|||   |:.:.:       ::::.|..|.|..:..:.:..
  Fly  1239 HIRNL---------LQNTSVSLVDIEKLDYETQSLRDQLQASHGRLSETEQNLDDIYNSLSLSGV 1294

Mouse  1284 ELGALQAEAESLDKTVKELAEQLEFIKNSDIQGALDSITK--YFQMS----LEAEKRVNASTTDP 1342
            ||.:||..:..:.:..|||.|....::.|:|:||| ::|:  |.::|    |:.|....||.||.
  Fly  1295 ELESLQNHSRLVQQLSKELKENGIQLQESNIEGAL-NLTRHAYERVSNLSTLKDEANELASNTDR 1358

Mouse  1343 NSTVEQSALTRDRVEDLMLERESPFKEQQEEQA---RLLDELAGKLQSL--DLSAVAQMTCGTPP 1402
            |.         .|||:|    .:..:.:.::.|   :|:::...:|.||  .:..:....|| .|
  Fly  1359 NC---------KRVENL----SNKIQAEADDLANNNKLIEDYRAELTSLTSQIPELNNQVCG-KP 1409

Mouse  1403 GADCSESECGGPNCRTDEGEKKCGGPGCGGLVTVAHSA---WQKAMDFDRDVLSALA----EVEQ 1460
            |..| :|.|||..|    |.       |||.::..|.|   .::|:...:|..:|:.    :.:|
  Fly  1410 GDPC-DSLCGGAGC----GH-------CGGFLSCEHGAKTHSEEALKVAKDAETAITSKKDQADQ 1462

Mouse  1461 LSKMVSEAKVRADEAKQNA-------QDVLLKTNATKEKVDKSNEDLRNLIKQIRNFLTEDSADL 1518
            ..:.:::||:.|.||.:.|       :..|.:|||..:..:       ||...:.||....:|..
  Fly  1463 TIRALTQAKLNASEAYEKAKRGFEQSERYLNQTNANIKLAE-------NLFIALNNFQENKTASP 1520

Mouse  1519 DSIEAVANEVLKMEMPSTPQQLQNLTEDIRERVETLSQVEVILQQSAADIARAELLLEEAKRASK 1583
            ...:.:|.:.|.:::...|::::.|.:.|...|.:|..||.|:.::..|:.|...|...|....:
  Fly  1521 SESKELAQKTLDLDLKLEPEEIETLGDQINRAVSSLKNVEAIIYRTKPDLDRVNNLQSIANATKE 1585

Mouse  1584 SATDVKVTADMVKEALEEAEKAQVAAEKAIKQADEDIQGTQNLLTSIESETAASEETLTNASQRI 1648
            .|..:..:|:.|.|:|..|:::|..|:.||:||:.:|:.....|..|:.||.::|....|.:|::
  Fly  1586 KADKILDSANSVVESLAAADESQGKAKDAIQQANSNIELAGQDLEKIDEETYSAEAPANNTAQQV 1650

Mouse  1649 SKLERNVEELKRKAAQNSGEAEYIEKVVYSVKQNADDVKKTLDGE---LDEKYKKVESLIAQKTE 1710
            .||.:.|::|:....:|..:|:.|.|...|||..|...:    ||   |..........:..:..
  Fly  1651 EKLAKKVQKLQNNIMKNDRDAKEITKEAGSVKLEAMRAR----GEANNLQSATSATNQTLTDRAS 1711

Mouse  1711 ESADARRKAELLQNEAKTLLAQANSKLQLLEDLERKYEDNQKYLEDKAQELVRLEGEVRSLLKDI 1775
            .|.:||.:|:.|...|..|....|:||:.|.||:..|       .:|.|:|:||:.|:..|.|::
  Fly  1712 RSENARERAKQLLQRASKLTVDTNAKLKDLNDLQTVY-------LNKNQQLLRLQAEIGPLNKEL 1769

Mouse  1776 SE 1777
            :|
  Fly  1770 NE 1771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lamb1	NP_032508.3	Laminin_N	44..269	CDD:365840	137/230 (60%)
		EGF_Lam	271..323	CDD:238012	34/56 (61%)
		EGF_Lam	335..387	CDD:238012	32/51 (63%)
		Laminin_EGF	398..455	CDD:365839	25/56 (45%)
		Laminin_EGF	458..512	CDD:365839	26/53 (49%)
		EGF_Lam	509..>548	CDD:238012	18/38 (47%)
		EGF_Lam	773..818	CDD:214543	31/44 (70%)
		Laminin_EGF	821..869	CDD:365839	25/47 (53%)
		EGF_Lam	866..911	CDD:238012	26/44 (59%)
		Laminin_EGF	917..973	CDD:365839	26/55 (47%)
		Laminin_EGF	976..1025	CDD:365839	28/48 (58%)
		Laminin_EGF	1028..1082	CDD:365839	29/53 (55%)
		Laminin_EGF	1084..1132	CDD:365839	24/47 (51%)
		Laminin_EGF	1132..>1171	CDD:365839	20/38 (53%)
		Domain II	1179..1397		58/238 (24%)
		SCP-1	<1201..1667	CDD:114219	124/500 (25%)
		Domain alpha	1398..1430		11/31 (35%)
		Domain I	1431..1786		95/364 (26%)
		SMC_prok_B	1456..>1776	CDD:274008	87/333 (26%)
LanB1	NP_476618.1	Laminin_N	63..286	CDD:278484	137/230 (60%)
		EGF_Lam	287..343	CDD:238012	34/57 (60%)
		Laminin_EGF	355..415	CDD:278482	35/59 (59%)
		Laminin_EGF	418..475	CDD:278482	25/56 (45%)
		EGF_Lam	477..526	CDD:238012	23/49 (47%)
		EGF_Lam	529..567	CDD:214543	18/37 (49%)
		EGF_Lam	789..834	CDD:214543	31/44 (70%)
		Laminin_EGF	837..885	CDD:278482	25/47 (53%)
		Laminin_EGF	883..930	CDD:278482	27/46 (59%)
		Laminin_EGF	933..988	CDD:278482	26/55 (47%)
		Laminin_EGF	991..1043	CDD:278482	29/51 (57%)
		Laminin_EGF	1043..1091	CDD:278482	28/52 (54%)
		Laminin_EGF	1094..1142	CDD:278482	24/47 (51%)
		Laminin_EGF	1142..1190	CDD:278482	25/47 (53%)
		COG6	1212..>1398	CDD:303003	50/208 (24%)
		TelA	1439..1782	CDD:226371	91/351 (26%)
		ApoLp-III_like	1545..1702	CDD:304399	46/160 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	304	1.000	Domainoid score	I1373
eggNOG	1	0.900	-	-		E1_KOG0994
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1458	1.000	Inparanoid score	I113
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49316
OrthoDB	1	1.010	-	-		D42471at33208
OrthoFinder	1	1.000	-	-		FOG0002726
OrthoInspector	1	1.000	-	-		otm43243
orthoMCL	1	0.900	-	-		OOG6_100925
Panther	1	1.100	-	-	O	PTHR10574
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3531
SonicParanoid	1	1.000	-	-		X1817
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.870