DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lama4 and wb

DIOPT Version :9

Sequence 1:NP_034811.2 Gene:Lama4 / 16775 MGIID:109321 Length:1816 Species:Mus musculus
Sequence 2:NP_723870.1 Gene:wb / 43946 FlyBaseID:FBgn0261563 Length:3375 Species:Drosophila melanogaster


Alignment Length:1949 Identity:449/1949 - (23%)
Similarity:782/1949 - (40%) Gaps:450/1949 - (23%)


- Green bases have known domain annotations that are detailed below.


Mouse    71 FFRTLSGECAPCDCNGNSHECLDGSGFCLHCQRNTTGEHCEKCLDGYIGDSIRGTPRFCQPCPCP 135
            |...|.|..|||.|||.|.:|...:|.|.:|:.||.|:||.:|.:|:.||.  .:|..||.||||
  Fly  1659 FIEDLIGRAAPCHCNGRSSDCDRETGVCQNCRGNTGGDHCHQCAEGFYGDP--NSPHGCQACPCP 1721

Mouse   136 LPHLANFAESCYRKNGAVRCICKENYVGPNCERCAPGYYGNPLLI-GSTCKKCDCSGNSDPNLIF 199
            ..: .|||..|...:|.|.|:||..|.|..||||..||:|:|:.. .:||:.|:|..:   .:..
  Fly  1722 ETN-RNFARGCNVWDGEVSCVCKPGYTGRLCERCQAGYFGDPMRYPNTTCQPCNCHPD---GIQT 1782

Mouse   200 EDCDEITGQCRNCLRNTTGFKCERCAPGYYGDARTAKNCAVCNCGGGPCDSVTGECLEEGFEVPT 264
            |.||..||:| .|....||.||::                        |.:.....::.|.::  
  Fly  1783 EGCDVETGRC-YCREGVTGLKCDK------------------------CQAERHHLVDNGCKI-- 1820

Mouse   265 GCDKCVWDLTDDLRLAALSIEESKSGLLSVSSGAAAHRHVTDMNST-IHLLRTRLSERENQY--- 325
             ||.|...|.|.:.|.                |....|.:.:|:.| |.....:|||.|:.|   
  Fly  1821 -CDNCTLLLLDYMELV----------------GNKLRRGMHNMDLTGIPAPYRKLSEYESAYEKW 1868

Mouse   326 ---------TLRKIQINNSENTLRSLLPDVEGLHEKGSQASRKGM-LVEKESMDTIDQATHLVEQ 380
                     |.|::|..:|.:.|:     :|...|.....|||.: .:.|............|.|
  Fly  1869 NGRHWDFSQTKRRLQDYDSADILK-----LEAHAENLKFQSRKAVATIGKREFAIKSMREDAVTQ 1928

Mouse   381 AHN---MRDKIQEINSKMLYYGENQEL--GPEEIAEKLVLAQ------KMLEEIRSR-----QPF 429
            .|:   :|.:|.:..|.:..||::...  .|..:.:.....|      :|::.|||.     :.|
  Fly  1929 QHSVGLLRSEILQTLSDLHGYGKSAHYLSLPTALKQARFYLQAIREHDQMVQGIRSTNDCAWKHF 1993

Mouse   430 LTHRELVDEEADEA--QELLSQAENWQRLHNDTRSLFPVVLEQLDDYNAKLSDLQESINQA---L 489
            .......|...||:  .|:|     |:.| |.|.       .::.|...::..:||..|:|   |
  Fly  1994 YAMGNASDASFDESGRLEML-----WRDL-NQTN-------HRVVDMRLQVDRVQEVENEAEDVL 2045

Mouse   490 DHVRDAEDMNRAITFKQRDHEKQHERVKEQMEVVGASLSMSADSLTIPQLTLEELDEIIKNASGI 554
            :|||   :::..:....::.::.::|:.:.::  ...|......|   :||::.  :|:.|  |.
  Fly  2046 EHVR---NLSIRVGESHQELDELNQRISDHLD--PGYLEQGEGLL---RLTVQR--QIMLN--GH 2098

Mouse   555 YAEIDGAKNELQGKLSNLSNLSHDL----VQEATDHAYNLQQEADELSRNLHSSDMNGLVQKALD 615
            ..::||.:..|...|...:....::    :.:|..||.:|...::|.:|....: .|| .:.|:.
  Fly  2099 LNQLDGYRILLNTTLGVKTEQQREVRKHWLPKAEKHASHLLARSNEYARKFQPT-RNG-ARIAML 2161

Mouse   616 ASNVYENIANYVSEANETAELALNITDRIYDAVSGIDTQIIYHKDESDNL------LNQARELQA 674
            ||:.:.||...:::|...:.||   .:|:|:|     .:.:|..|.|..:      |:::::||.
  Fly  2162 ASSAHSNITEAINDARLASILA---KERVYEA-----QRTLYPSDGSSMIERAKHSLHRSKQLQQ 2218

Mouse   675 KA----DSSN--DEAVADTSRRVGGALWRKGALRD---RLNDAVKQLQAAERGDAHQRLGQSKLF 730
            :|    ..||  .:.:....::|.|.   |..:.|   |.|:...|||....|.|.:   |:|..
  Fly  2219 EALKQMHKSNVLKDKLHRQEQQVEGI---KSTIYDSGLRTNNISGQLQGLSDGSARR---QAKDS 2277

Mouse   731 IEEANKT---TAAVQQVTTPMANNLSNWSQNLQTFDSSAYNTAVDSARDAVRNLTEVVPQLLD-Q 791
            :|.|::|   ..|..|....|..::.|...:....:.. :...:..|::.: :||:...:|.: .
  Fly  2278 LEMADRTGEQMRAELQKAKDMQKSIQNMRNSFSNLEPD-WEIKLGMAQENI-SLTQTNLRLANVS 2340

Mouse   792 LRTVEQKRPA---------SNISASIQRIRELIAQTRSVASKIQVSMMFDGQSAVEVHPKVSV-- 845
            |..:||:...         ::::..:|::|:.||:.|..|..|.||:...|...:..:...|.  
  Fly  2341 LSYLEQQAEKEQQVFEVWNNSMAQQLQQLRDQIAKARHAAEAIDVSLESLGPKCIRSYLPASYGL 2405

Mouse   846 ---DDLKAFTSISLYMKPPPKPAEPTGAWVADQFVLYLGSKNAKKEYMGLAIKNDNLVYVYNLGM 907
               :.::...::|.:::..|              :::|.|...:  ::.|.:....:..|:|||.
  Fly  2406 STSNKIRMSFALSNHLESSP--------------LIHLASSEGR--HITLELYKRRVRLVWNLGG 2454

Mouse   908 KDVEI-------LLDSKPVSSWPAYF----------SIVKIERVGKHGKVFLTVPS------LSS 949
            ....:       ..|.|...:|  |.          |:| :.|:..:|:  ||.|:      .:.
  Fly  2455 TTATVTHPMVVHTRDPKYDDAW--YHVEANRTLNLGSLV-VRRMNNYGE--LTPPNPVIITGSTD 2514

Mouse   950 TAEEKF-------IKKGEFAGDDSLLDLTPEDTVFYVGGVPANFKLPASLNLPSYSGCLELATLN 1007
            |...:|       |..|.||..|  |..||                  .||:     .:....::
  Fly  2515 TEHTRFYQSRSDRISLGGFASKD--LQFTP------------------GLNV-----VVHQVEVD 2554

Mouse  1008 NDVISLYNFKHIYNMDPSKSVPCARDKLAFTQSRAAS--YFFDGSSYAVVRDI----TRRGKFG- 1065
            |..:.|:||       .:....|....:...:|.|:|  ..|:|..||.:...    ||:..|. 
  Fly  2555 NKPLGLWNF-------VTSEGSCGGSMVGAKESSASSTARHFNGLGYAQLMKTRPRPTRKNLFSV 2612

Mouse  1066 QVTRFDIEIRTPADNGLVLLMVN--GSMFFSLEMRNGYLHVFYDFGFSNGPVHLEDTLKKAQIND 1128
            |:|     .||..:|.|:.|.|:  .:...|:.:..|.:....|:|..:          |.:||.
  Fly  2613 QMT-----FRTLDENALLFLAVDDKNNRSVSVTLSRGRIMFRIDYGDES----------KLEINT 2662

Mouse  1129 AKYH------------EISIIYHNDKKMILVVDRRHVKSTDNEKKKIPF------TDIYIGGAPQ 1175
            .|.:            |.|.....:..|:.|.:.|.:.........|..      |..|:||.|.
  Fly  2663 TKKYNVGQWIKIEAAREFSAKRSTENGMLRVNNDRPISGAPTLPVNIHLLPDLSKTVYYLGGVPP 2727

Mouse  1176 EVLQSRTLRAHLP-LDINFRGCMKGFQFQKKDFNLLEQTETLGVGYGCPEDSLISRRAYFNGQSF 1239
            . ..|.|.:|  | .|..|.||||..|...:.::.||.:...||...|  .::|: :|.|:|..:
  Fly  2728 G-FTSGTSKA--PGADNPFLGCMKDVQVNGETYDPLESSSYYGVEPSC--KNMIT-KAGFSGNGY 2786

Mouse  1240 I----ASIQKISFFDGFEGGFNFRTLQPNGLLFYYTSGSDV------------FSISLDNGTVVM 1288
            :    .|::|.|     .....||||||:.||.......::            |||||.:|.:.:
  Fly  2787 LELPSQSLRKRS-----NTALVFRTLQPDCLLLLAAYPPEILGDYDAKDIKGNFSISLVDGQLHV 2846

Mouse  1289 DVKG----IKVMSTDKQYHDGLPHFVVTSISDTRYELVVDKS-----RLRGKNPTKGKAEQTQTT 1344
            .|..    ||:.|...|.:||..|.|....:..:.||:||..     .|.| |||   .......
  Fly  2847 WVNSGRSFIKMSSNSSQMNDGEFHVVHLIKTGRKLELMVDDELQEIRNLNG-NPT---VVSLPRD 2907

Mouse  1345 EKKFYFGG-------SPISPQYANFTGCISNAYFTRLDRDVEVEDFQRYSE-----------KVH 1391
            ....|.||       :|::|.:.|..|.|.:..|.  :|.:...|...::.           .:.
  Fly  2908 AGGLYIGGAPPHESYTPLAPTFVNLEGAIRDVVFN--NRTINFNDALTFANVQIGRNGPLMGSLK 2970

Mouse  1392 TSLYECPIESSPLFLLHKKGKNSSKPKTNKQGEKSKDAPSWDPIGLKFLEQKAPRDSHCHLSSSP 1456
            ..||:..:::.|:.     ||:.:   .:.:|.|...:.|::|                      
  Fly  2971 GGLYDVLLKTEPMI-----GKSFT---ASPEGCKRIGSYSYEP---------------------- 3005

Mouse  1457 RAIEHAYQYGGTANSRQEFEHEQGDFGEKSQFAIRLKTRS--SHGMIFYV--SDQEENDFMTLFL 1517
                :|:::|....|..:.:..:..|.::: |.:....||  .:||::..  |.::...::.|.|
  Fly  3006 ----NAFKFGDDIYSYSQLKLPERHFWQRN-FHLSFDFRSFYPNGMLYLSPGSKEKPKHYVALVL 3065

Mouse  1518 AHGRLVFMFNVGHKKLKIRSQEKYNDGLWHDVIF---------------IREKSSGRLVIDGLRV 1567
            ..|:||.:.. |.::.:::...|.|||.||.|..               ..:|:|.::       
  Fly  3066 KDGQLVLVVR-GRRREELQLTAKLNDGEWHRVTISCHDRKVTMSVEIGRTDQKTSAQM------- 3122

Mouse  1568 LEERLPPSGAAWKIKGPIYLGGV--APGRAVKNVQITSVYSFSGCLGNLQLNG--ASITSASQTF 1628
               :||....|.::   :.:||:  :|.:...::.: .:..|.|||..:.:|.  ..:....:..
  Fly  3123 ---KLPKKIGASQL---LLVGGLPQSPVKVSSDLYV-RLEPFKGCLRRVSINNNTQDLARPGKHS 3180

Mouse  1629 SVTPCFEGPMETGTYFSTEGGYVVLDESFNIGLKFEIAFEVRPRSSSGTLVHGHSVNG-EYLNVH 1692
            :|..||. .:|.|:||..: .|.:..::||:|...::..|.|....||.|:.....|| ..|::.
  Fly  3181 NVGQCFP-TVERGSYFPGD-AYAIYKKNFNVGKYLDLETEFRTSELSGILLSVSDPNGFPALSLE 3243

Mouse  1693 MRNGQVIVKV---NNGVRDFSTSVTPKQNLCDGRWHRITVIRDSNVVQLDVDS--EVNHVVGPLN 1752
            :.||.:|...   |.......:|:..|..|||.:||.|:.:.|...:.|.:|.  .|..|....|
  Fly  3244 LHNGNIIFSCDPGNGAPMRVESSLPTKYALCDNKWHNISALYDGEQIVLRIDQLPAVISVGNQGN 3308

Mouse  1753 PKPVDHREPVFVGGVPESLLTPRLAPSKPFTGCIRHFVI-----------DSRPVSFSKAALVS 1805
            ...|..|.|:::||:|||..:..|...:.|.|||||..|           |.|.|..|: .|||
  Fly  3309 AGKVQTRSPLYIGGLPESAPSGSLISRENFKGCIRHVSIRNERRDWIEMEDLRNVLLSE-CLVS 3371

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lama4NP_034811.2 EGF_Lam 81..130 CDD:238012 20/48 (42%)
EGF_Lam 131..185 CDD:238012 24/54 (44%)
EGF_Lam 187..238 CDD:238012 13/50 (26%)
Domain II and I 256..825 134/635 (21%)
Laminin_I 289..547 CDD:283627 59/292 (20%)
ApoLp-III_like 610..787 CDD:304399 43/194 (22%)
Cell attachment site. /evidence=ECO:0000255 717..719 0/1 (0%)
Laminin_II 727..854 CDD:283628 26/144 (18%)
LamG 853..1008 CDD:214598 32/184 (17%)
LamG 1044..1202 CDD:238058 45/185 (24%)
LamG 1232..1371 CDD:238058 46/170 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1409..1433 5/23 (22%)
LamG 1482..1617 CDD:238058 32/155 (21%)
LamG 1641..1792 CDD:238058 49/167 (29%)
wbNP_723870.1 Laminin_N 164..396 CDD:278484
EGF_Lam 401..450 CDD:238012
TNFRSF <407..507 CDD:304602
EGF_Lam 505..552 CDD:238012
Laminin_EGF 550..597 CDD:278482
Laminin_B 660..798 CDD:278481
EGF_Lam 851..900 CDD:238012
Laminin_EGF <943..971 CDD:278482
VSP 953..1414 CDD:146106
Laminin_EGF 974..1018 CDD:278482
EGF_Lam 1017..1065 CDD:238012
Laminin_EGF 1065..>1105 CDD:278482
EGF_Lam 1150..1197 CDD:238012
Laminin_EGF 1199..1247 CDD:278482
EGF_Lam 1247..1292 CDD:238012
Laminin_EGF 1294..1342 CDD:278482
Laminin_EGF 1340..1392 CDD:278482
Laminin_B 1486..1611 CDD:278481
EGF_Lam 1669..1716 CDD:238012 20/48 (42%)
Laminin_EGF 1718..1767 CDD:278482 23/49 (47%)
EGF_Lam 1772..1819 CDD:238012 15/74 (20%)
CrfC <1933..2267 CDD:223771 79/371 (21%)
Laminin_II 2277..2400 CDD:283628 24/124 (19%)
LamG 2399..>2492 CDD:304605 16/111 (14%)
Laminin_G_2 2616..2755 CDD:280389 36/151 (24%)
Laminin_G_2 2804..2944 CDD:280389 41/145 (28%)
Laminin_G_2 3038..3169 CDD:280389 31/145 (21%)
LamG 3192..3347 CDD:238058 48/155 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1836
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100395
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
43.670

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