DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lama2 and NetA

DIOPT Version :9

Sequence 1:	NP_032507.2	Gene:	Lama2 / 16773	MGIID:	99912	Length:	3118	Species:	Mus musculus
Sequence 2:	NP_001285243.1	Gene:	NetA / 32398	FlyBaseID:	FBgn0015773	Length:	726	Species:	Drosophila melanogaster

Alignment Length:	807	Identity:	207/807 - (25%)
Similarity:	322/807 - (39%)	Gaps:	201/807 - (24%)

- Green bases have known domain annotations that are detailed below.

Mouse     9 LLLLLLGTLEGSQTQ-----------RRQ--------SQAHQQRGLFPAVLNLASNALITTNATC 54
            :|||||||...|..|           .:|        ::||:.|...|..:|.|.:|.:..::||
  Fly     5 ILLLLLGTTRFSPIQCISNDVYFKMFSQQAPPEDPCYNKAHEPRACIPDFVNAAYDAPVVASSTC 69

Mouse    55 GEKGPEMYCKLVEHVPGQPVRNPQCRICNQNSSNPYQRHPITNAIDGKN----TWWQSPSIKNGV 115
            |..|.:.||:..:|       ...|..|:.  ::|.:..|..:..|..|    |.|:|..:....
  Fly    70 GSSGAQRYCEYQDH-------ERSCHTCDM--TDPLRSFPARSLTDLNNSNNVTCWRSEPVTGSG 125

Mouse   116 EYHYVTITLDLQQVFQIAYVIVK-AANSPRPGNWILERSLD-DVEYKPWQYHAVTDTECLTLYNI 178
            :  .||:||.|.:.|::.|||:: ..::|||.:.::.:|.| .:.::|:|:.:   ::|..|:.
  Fly   126 D--NVTLTLSLGKKFELTYVILQLCPHAPRPDSMVIYKSTDHGLSWQPFQFFS---SQCRRLFG- 184

Mouse   179 YPRTGPPSYAKDDEVICTSFYSKIHPLENGEIHISLINGRPSAD--DPSPELLEFTSARYIRLRF 241
            .|.........:.|..|:..   ..||.: .|..|.:.||||:.  |.||.|.::.:|..||:.|
  Fly   185 RPARQSTGRHNEHEARCSDV---TRPLVS-RIAFSTLEGRPSSRDLDSSPVLQDWVTATDIRVVF 245

Mouse   242 QRIR--------TLNA----DLMMFAHKDPREIDP------------IVT--RRYYYSVKDISVG 280
            .|::        :|.|    ||....:..|....|            :.|  ...:|::.|.|||
  Fly   246 HRLQRPDPQALLSLEAGGATDLASGKYSVPLANGPAGNNIEANLGGDVATSGSGLHYAISDFSVG 310

Mouse   281 GMCICYGHARACPLDPATNKSRCECEHNTCGESCDRCCPGFHQKPWRAGTFLTKSECEACNCHGK 345
            |.|.|.|||..|..| |:.:..|||.|||.|..|:||.|....:||...|....:||:.|||:..
  Fly   311 GRCKCNGHASKCSTD-ASGQLNCECSHNTAGRDCERCKPFHFDRPWARATAKEANECKECNCNKH 374

Mouse   346 AEECYYDETVASRNLSLNIHGKYIGGGVCINCTHNTAGINCETCVDGFFRPKGVSPNYPRPCQPC 410
            |.:|.:       |:.:....:.:.||||.||.|:|.|.||..|.:||:|.......:.:.|:.|
  Fly   375 ARQCRF-------NMEIFRLSQGVSGGVCQNCRHSTTGRNCHQCKEGFYRDATKPLTHRKVCKAC 432

Mouse   411 HCDPTGSLSEVCVKDEKYAQRGLKPGSCHCKTGFGGVNCDRCVRGY-----HGYPDC--QPCNCS 468
            .|.|.||..::|         ....|.|.||.|..|:.|:||.|||     |..| |  ||....
  Fly   433 DCHPIGSSGKIC---------NSTSGQCPCKDGVTGLTCNRCARGYQQSRSHIAP-CIKQPPRMI 487

Mouse   469 GLGSTN------EDPCVGPCSCKENVEGEDCSRCKSGFFNLQEDNQ----KGCEECFCSGVSNR- 522
            .:..|.      ::|...|.|      |.|    ::|...:...:|    :|..||....||.:
  Fly   488 NMLDTQNTAPEPDEPESSPGS------GGD----RNGAAGMAAQSQYYRTEGGRECGKCRVSTKR 542

Mouse   523 ------CQSSYWTYGNI--QDMRGWYLTDLSGRIRMAPQLDNPDSPQQISISNSEARKSLLDGYY 579
                  |:..|.....:  :|.....::....|..|.|.:.:.:..|   :....||..:...|.
  Fly   543 LNLNKFCKRDYAIMAKVIGRDTSSEAVSREVQRRAMDPDVADYEMDQ---VQPGSARSPITGVYE 604

Mouse   580 WSA---PPPYLGNRLPAVGGQLSFTISYDLEEEEDDTEKILQLMIIFEGNDLRISTAYKEVYLEP 641
            :.|   |.|.     |...|.         |.|..|    ||:..:|:.:....|:....||..|
  Fly   605 FQAADYPNPN-----PNPRGS---------EMERFD----LQIQAVFKRSRPGESSGAGNVYGMP 651

Mouse   642 SEEHIEEVSLKEEAFTIHGTNLPVTRKDFMIVLTNLERVLMQITYN-----LGMDAIFRLSSVNL 701
            :      .:||....|            ::|...:||....:|..|     ||.|:
  Fly   652 N------TTLKRGPMT------------WIIPTKDLECRCPRIRVNRSYLILGRDS--------- 689

Mouse   702 ESAVPYPTDRRIATDVEVCQCPPGYSG 728
                               :.||||.|
  Fly   690 -------------------EAPPGYLG 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lama2	NP_032507.2	Laminin_N	45..281	CDD:278484	66/269 (25%)
		EGF_Lam	283..330	CDD:238012	21/46 (46%)
		Laminin_EGF	410..467	CDD:278482	23/63 (37%)
		Laminin_EGF	465..511	CDD:278482	8/55 (15%)
		Laminin_B	579..707	CDD:278481	26/135 (19%)
		EGF_Lam	752..801	CDD:238012
		EGF_Lam	802..859	CDD:238012
		EGF_Lam	860..912	CDD:238012
		EGF_Lam	913..960	CDD:238012
		EGF_Lam	963..1007	CDD:214543
		EGF_Lam	1009..1054	CDD:238012
		Laminin_EGF	1056..1104	CDD:278482
		Laminin_EGF	1102..1159	CDD:278482
		LamB	1225..1360	CDD:214597
		EGF_Lam	<1375..1403	CDD:238012
		Laminin_EGF	1416..1462	CDD:278482
		Laminin_EGF	1465..1520	CDD:278482
		EGF_Lam	1523..>1560	CDD:238012
		Domain II and I	1570..2140
		Laminin_I	1584..1848	CDD:283627
		SPEC	1682..1881	CDD:295325
		Apolipoprotein	1845..2059	CDD:279749
		Apolipoprotein	2014..2152	CDD:279749
		Laminin_II	2033..2168	CDD:283628
		Laminin_G_1	2170..2310	CDD:278483
		Laminin_G_1	2364..2503	CDD:278483
		LamG	2524..2686	CDD:238058
		Laminin_G_1	2789..2917	CDD:278483
		LamG	2937..3089	CDD:238058
NetA	NP_001285243.1	LamNT	44..280	CDD:214532	66/254 (26%)
		EGF_Lam	312..357	CDD:238012	21/45 (47%)
		EGF_Lam	369..426	CDD:238012	21/63 (33%)
		EGF_Lam	431..479	CDD:238012	20/57 (35%)
		NTR_netrin-1_like	545..723	CDD:239634	41/220 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910