Protein Alignment DFFB and Drep4

DIOPT Version :10

• Sequence 1: NP_001269598.1
• Gene: DFFB / 1677
• HGNCID: 2773
• Length: 362
• Species: Homo sapiens
• Sequence 2: NP_609631.1
• Gene: Drep4 / 34734
• FlyBaseID: FBgn0028406
• Length: 450
• Species: Drosophila melanogaster
• Alignment Length: 423
• Identity: 108/423 - (25%)
• Similarity: 171/423 - (40%)
• Gaps: 138/423 - (32%)

Human    17 RKFGVAGRSCQEVLRKGCLRFQLPERGSRLCLYEDGTELTED-YFPSVPDNAELVLLTLG----- 75
            ||:|:...|.:.::.|...:|.|.|  ..|.|..||.|:::| |..|:|  |:.:.:..|
  Fly    59 RKYGIGANSLEMLIAKAKSKFPLLE--PHLYLASDGFEVSDDEYLKSLP--AQTLFIVSGPDAVI 119

Human    76 QAWQGCEWQGLWRMCLLLDRHLLFVPLVADVSDIRRFLSAFHEPQVGLIQAAQQLLCDEQAPQR- 139
            ......|::.:.:...||.        |||:         |::             ..||.|::
  Fly   120 TTDADFEFEKMRQQSPLLK--------VADI---------FYD-------------FIEQHPEKF 154

Human   140 QRLLADLLHNVSQNIAAET------RAEDPPWFEGLESRFQSKSGYLRYSCESRIRSYLREVSSY 198
            :|::.:..|...:.:...:      :||...||.|.|.||.||...:....::|:|.|.
  Fly   155 RRMITEYEHQKQRRVLDNSKTHLSLKAEHVEWFTGGEERFHSKEEAMATRAQTRVRGYY------ 213

Human   199 PSTVGAEAQEEFLR------------VLGSMCQRLRSM----QYNGSYFDRGAK----------- 236
                 .:|:||..|            |:.|:.::.|.:    .:....|||..|
  Fly   214 -----YKAKEELTRNPLYRQNAKARQVINSVLEKFRYLLIGCDFFSMMFDRNCKQKHEFLKQHLG 273

Human   237 ------------------------------GGSRLCTPEGWFSCQGPF--DMDSCLSRHSINPYS 269
                                          ..:.||:..|.|.|||.:  :.:||..:|:||||:
  Fly   274 DEETDAGRIPSKRLRQVIREYTKENCILDEWSTSLCSDLGDFYCQGSYSENGNSCSKQHTINPYA 338

Human   270 NRESRILFSTWNLDHIIEKKRTIIPTLVEAIKE-----------QDGREVD---WEYFYGLLFTS 320
            :||:.|||..|||||.||..|||:|.||..::|           ...:.||   .|||.. :|:.
  Fly   339 SRENLILFQVWNLDHQIELCRTILPALVANVEELVSHPQTKCSIHKKQVVDISVLEYFLE-IFSL 402

Human   321 ENLKLVHIVCHKK------TTHKLNCDPSRIYK 347
            :||||||||||:|      :..:|.|.....|:
  Fly   403 KNLKLVHIVCHEKAQRSNRSNGRLLCSDCHEYR 435

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DFFB	NP_001269598.1	CIDE_N_CAD	4..80	CDD:119368	19/68 (28%)
		DFF40	124..347	CDD:462717	81/308 (26%)
Drep4	NP_609631.1	CIDE_N	46..121	CDD:119367	19/65 (29%)
		DFF40	151..435	CDD:462717	79/295 (27%)