Protein Alignment L1cam and klg

DIOPT Version :10

• Sequence 1: NP_032504.3
• Gene: L1cam / 16728
• MGIID: 96721
• Length: 1259
• Species: Mus musculus
• Sequence 2: NP_524454.2
• Gene: klg / 42707
• FlyBaseID: FBgn0017590
• Length: 545
• Species: Drosophila melanogaster
• Alignment Length: 487
• Identity: 117/487 - (24%)
• Similarity: 189/487 - (38%)
• Gaps: 96/487 - (19%)

Mouse   316 SLGSARHAYY----VTVEAA----------------------------PYWLQKPQSHLYGPGET 348
            |||...||:.    ..||||                            |.:|.:..::....|:|
  Fly    53 SLGWLLHAHAGSGGFAVEAAISNRGSNSRSMSNVQQSAVAASTLTATLPRFLSRGHTYRAVVGDT 117

Mouse   349 ARLDCQVQGRPQPEITWRINGMSMET-----VNKDQKYRIEQG-SLILSNVQPSDTMVTQCEARN 407
            ..|.|||:......:.|| .|.::.|     |.:|::.|:..| :|.:|:::|.|.....|:..:
  Fly   118 LVLPCQVENLGNFVLLWR-RGTNVLTASNIMVTRDERVRLIDGYNLEISDLEPQDAGDYVCQISD 181

Mouse   408 QHGLLLANAYIYVVQL----PARILTKDNQTYMAVEGSTAYLLCKAFGAPVPSVQWLDEEG---- 464
            :    :....::.|::    ..|.:....| ..|.:|....|.||..|.||||:.|..:.|
  Fly   182 K----INRDQVHTVEILVPPSVRAIPTSGQ-LQARKGGPITLECKGSGNPVPSIYWTKKSGANKS 241

Mouse   465 TTVLQDERFFPYANGTLSIRDLQANDTGRYFCQAANDQNN-VTILANLQVKEATQITQGPRSAIE 528
            |..:.|       ...|::..|:....|.|.|.|.|...: ||:...|.|.....| |..:|.|.
  Fly   242 TARIGD-------GPILTLEKLERQQAGVYQCTADNGVGDPVTVDMRLDVLYPPDI-QVEKSWIH 298

Mouse   529 K-KGARVTFTCQASFDPSLQASITWRGDGRDLQERGDSDKYFI----EDGKLVIQSLDYSDQGNY 588
            . :|......|....||  .|:::|..:...:|   .:|:..:    ....|.|:.:...|.|||
  Fly   299 SGEGFEAKLVCIVFADP--VATVSWYQNSFPIQ---STDRRIMATRANRHMLTIRHIQQEDFGNY 358

Mouse   589 SCVASTELDEVESRAQLLVVGSPGPVPHLELSDRHLLKQSQVHLSWSPAEDHNSPIEKYDIEFED 653
            ||||...|.  .||..:.:.|.||....  .|.:........:|:|.  .|...|:|:..:.:..
  Fly   359 SCVADNSLG--RSRKYMELSGRPGAAEF--YSPKWGRSPDSYNLTWK--IDSYPPLEEVRLLYRR 417

Mouse   654 KEM-----APEKWFSLGKVPGNQ---------TSTTLK-LSPYVHYTFRVTAINKYGPGEPSPVS 703
            .:|     .|.:|......|.::         .|.|:| |.|..:|...|.|.|:||..|.|.:.
  Fly   418 VQMNETYQQPGRWHDFILTPEHRPASEPLTHIMSYTIKNLHPGGYYEAIVQAKNRYGWNEVSDIF 482

Mouse   704 ETVV---TPEAAPEKNPVDVRGEGNETNNMVI 732
            :.||   :.:..||...| |....:.:|:..|
  Fly   483 QFVVATNSQDIGPEDAEV-VASSKSRSNSASI 513

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
L1cam	NP_032504.3	IgI_L1-CAM_like	35..130	CDD:409396
		Ig strand A	35..39	CDD:409396
		Ig strand A'	44..48	CDD:409396
		Ig strand B	53..60	CDD:409396
		Ig strand C	66..71	CDD:409396
		Ig strand C'	74..76	CDD:409396
		Ig strand D	83..86	CDD:409396
		Ig strand E	93..97	CDD:409396
		Ig strand F	109..117	CDD:409396
		Ig strand G	120..130	CDD:409396
		Ig	139..229	CDD:472250
		Ig strand B	153..157	CDD:409353
		Ig strand C	167..171	CDD:409353
		Ig strand E	190..194	CDD:409353
		Ig strand F	205..210	CDD:409353
		Ig strand G	221..224	CDD:409353
		Ig3_L1-CAM	247..329	CDD:409460	5/16 (31%)
		Ig strand B	259..263	CDD:409460
		Ig strand C	272..276	CDD:409460
		Ig strand E	294..298	CDD:409460
		Ig strand F	308..313	CDD:409460
		Ig strand G	321..324	CDD:409460	1/2 (50%)
		Ig	333..421	CDD:472250	20/93 (22%)
		Ig strand B	349..353	CDD:409353	1/3 (33%)
		Ig strand C	362..366	CDD:409353	0/3 (0%)
		Ig strand E	386..390	CDD:409353	2/4 (50%)
		Ig strand F	400..405	CDD:409353	1/4 (25%)
		Ig strand G	413..416	CDD:409353	0/2 (0%)
		Ig	427..513	CDD:472250	25/90 (28%)
		Ig strand B	443..447	CDD:409353	1/3 (33%)
		Ig strand C	456..460	CDD:409353	1/3 (33%)
		Ig strand E	479..483	CDD:409353	1/3 (33%)
		Ig strand F	493..498	CDD:409353	2/4 (50%)
		Ig strand G	506..509	CDD:409353	1/2 (50%)
		Ig	515..611	CDD:472250	26/100 (26%)
		Ig strand B	534..538	CDD:409353	0/3 (0%)
		Ig strand C	549..553	CDD:409353	0/3 (0%)
		Cell attachment site. /evidence=ECO:0000255	553..555		0/1 (0%)
		Cell attachment site. /evidence=ECO:0000255	562..564		0/1 (0%)
		Ig strand E	573..577	CDD:409353	1/3 (33%)
		Ig strand F	587..592	CDD:409353	4/4 (100%)
		Ig strand G	600..603	CDD:409353	1/2 (50%)
		FN3	611..708	CDD:238020	27/114 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	697..724		8/29 (28%)
		fn3	717..798	CDD:394996	4/16 (25%)
		fn3	824..906	CDD:394996
		FN3	917..1002	CDD:238020
		Bravo_FIGEY	1146..1235	CDD:464016
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1182..1209
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1228..1259
klg	NP_524454.2	IG_like	109..195	CDD:214653	20/90 (22%)
		Ig strand B	118..122	CDD:409353	1/3 (33%)
		Ig strand C	131..135	CDD:409353	0/3 (0%)
		Ig strand E	160..164	CDD:409353	1/3 (33%)
		Ig strand F	174..179	CDD:409353	1/4 (25%)
		Ig strand G	188..191	CDD:409353	0/2 (0%)
		Ig_3	196..270	CDD:464046	22/81 (27%)
		Ig_3	287..364	CDD:464046	22/82 (27%)
		FN3	392..486	CDD:238020	22/95 (23%)