Protein Alignment DCP2 and DCP2

DIOPT Version :10

• Sequence 1: NP_689837.2
• Gene: DCP2 / 167227
• HGNCID: 24452
• Length: 420
• Species: Homo sapiens
• Sequence 2: NP_001246776.1
• Gene: DCP2 / 39722
• FlyBaseID: FBgn0036534
• Length: 792
• Species: Drosophila melanogaster
• Alignment Length: 444
• Identity: 164/444 - (36%)
• Similarity: 224/444 - (50%)
• Gaps: 82/444 - (18%)

Human     4 KRVEIPGSVLDDLCSRFILHIPSEERDNAIRVCFQIELAHWFYLDFYMQNTPG------------ 56
            ::.:||..:||||.||||:::|..|.:|.||:||||||||||||||:.....|
  Fly   205 EKSKIPSDILDDLASRFIINVPDMELNNLIRMCFQIELAHWFYLDFFCAPESGEDGETPKCVQRK 269

Human    57 LPQCGIRDFAKAVFSHCPFLLPQGEDVEKVLDEWKEYKMGVPTYGAIILDETLENVLLVQGYLAK 121
            ||..||:.||..:|.|.|||......|:::|||||.||:.|||||||::.|...:.||||.|.|:
  Fly   270 LPSVGIKQFAMQLFQHIPFLNKHFGTVDQILDEWKNYKLSVPTYGAILVSEDHNHCLLVQSYFAR 334

Human   122 SGWGFPKGKVNKEEAPHDCAAREVFEETGFDIKDYICKDDYIELRINDQLARLYIIPGIPKDTKF 186
            :.|||||||:|:.|.|..||.|||:|||||||.|.|..:||||..||.|..|||::..||.||:|
  Fly   335 NSWGFPKGKINENEDPAHCATREVYEETGFDITDLIDANDYIEAFINYQYTRLYVVRNIPMDTQF 399

Human   187 NPKTRREIRNIEWFSIEKLPCHRNDMTPKSKLGLAPNKFFMAIPFIRPLRDWLSRRFGDSSDSDN 251
            .|:||.||:..:||.|:.||.::||...|:|||...|.|||.:||::.|:.|::.|.........
  Fly   400 APRTRNEIKCCDWFRIDALPVNKNDAISKAKLGKTSNSFFMIMPFVKRLKKWVNDRKAGIEPRRR 464

Human   252 GFSSTGS-TPAKPTVE----KLSRTKFRHSQQLFPDGSPGDQWVKHRQPLQQKPYNNHSEMSDL- 310
            .||...| ..|.||..    |...|..|:..|              ||        .|..|.||
  Fly   465 KFSGQQSPKAASPTNMNGNCKKDVTGVRNESQ--------------RQ--------RHKSMGDLD 507

Human   311 ------LKGKN------------------QSM---RGNGRKQYQDS---PNQKKRTNGLQPAKQQ 345
                  |.||.                  .||   ..||::..|::   .||...|....|....
  Fly   508 GVKLNNLNGKGTVGTGAGSAASASATAAINSMNICNSNGKRNKQNAAAGSNQATPTTIATPMTSN 572

Human   346 NSL----MKCEKKLHPRKLQDNFETDA--------VYDLPSSSEDQLLEHAEGQ 387
            .::    :..:::|...:.|::.:..|        .:||....:.|.|:.|:.|
  Fly   573 GAVVGGTVSSKRQLFHSQSQNDAQQSASNEKQIVSSFDLIRKEKQQQLKAAKAQ 626

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DCP2	NP_689837.2	DCP2	12..93	CDD:428265	45/92 (49%)
		NUDIX_Dcp2p_Nudt20	97..246	CDD:467540	78/148 (53%)
		Nudix box	129..150		12/20 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	246..266		6/20 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	313..344		11/54 (20%)
DCP2	NP_001246776.1	DCP2	212..306	CDD:428265	54/105 (51%)
		NUDIX_Dcp2p_Nudt20	310..458	CDD:467540	72/147 (49%)