DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Krt6b and LamC

DIOPT Version :9

Sequence 1:	NP_034799.2	Gene:	Krt6b / 16688	MGIID:	1333768	Length:	554	Species:	Mus musculus
Sequence 2:	NP_001260974.1	Gene:	LamC / 36615	FlyBaseID:	FBgn0010397	Length:	640	Species:	Drosophila melanogaster

Alignment Length:	443	Identity:	117/443 - (26%)
Similarity:	202/443 - (45%)	Gaps:	83/443 - (18%)

- Green bases have known domain annotations that are detailed below.

Mouse   149 RTEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWALLQEQGTKTVRQ---NLEPMFEQYISNL 210
            |.:|:|:::.||::.|.:||::|.||.:|..|..:..|.|:    ||.:   ||:.::|:.::..
  Fly    43 RQQEKEELQHLNDRLACYIDRMRNLENENSRLTQELNLAQD----TVNRETSNLKAVYEKELAAA 103

Mouse   211 RRQLDSIIGERGRLDSELRNMQDTVEDYKSKYEDEINKRTKAEN--------------------- 254
            |:.||....|:.:|:.:::.:.:..:|.|.:.:.:..:.|.|||
  Fly   104 RKLLDETAKEKAKLEIDIKRLWEENDDLKPRLDKKTKEATVAENNARLYENRYNEVNGKYNQSLA 168

Mouse   255 ---------------------EFVTVKKDVDAAYMTKVELQAKADSLADEINFLRVIYEAEL--- 295
                                 :...::|.::|..:.:|:|:.:..||.:|:.|...::..||
  Fly   169 DRKKFEDQAKELALENERLRRQLDDLRKQLEAETLARVDLENQNQSLREELAFKDQVHTQELTET 233

Mouse   296 -SQMQTHISDTSVVLSMDNNRSLDLDSIIAEVKAQYEDIAQRSRAEAESWYQTKYEELQVTAGRH 359
             |:.|..||:....||  ......|...:.|::.|||...:.:|.|.|..|..:.:.|:..|.|.
  Fly   234 RSRRQIEISEIDGRLS--RQYEAKLQQSLQELRDQYEGQMRINREEIELLYDNEIQNLKAAANRA 296

Mouse   360 GDDLRNTKQEIAEINRMIQRLRSEIDHVKKQCANLQAAIADAEQRGEMALKDARGKLEGLEDALQ 424
            ........:|:..:...|..|.:::.:::...|.|.|.|.:.|...:...:.....:..||..||
  Fly   297 AQGSALATEEVRLMRTKIDGLNAKLQNLEDTNAGLNARIRELENLLDTERQRHNQYIASLEAELQ 361

Mouse   425 KAKQEMARLLKEYQELMNVKLALDVEIATYRKLLEGEECRLNGEGVGPVNISVVQSTVSSGYGSA 489
            :.:.|||..|:|||.||::|::||:|||.|.|||.|||.|||.|..|       :.|..||..|.
  Fly   362 RMRDEMAHQLQEYQGLMDIKVSLDLEIAAYDKLLCGEERRLNIESPG-------RPTTDSGISSN 419

Mouse   490 GGASSSLGLGGSSSYSYGSSHGLGGGFSAGSGRAI-GGGLSSSGGLS-SSTIK 540
            |                  || |....|:.|||.. .|..|::.|:| ||.:|
  Fly   420 G------------------SH-LTASASSRSGRVTPSGRRSATPGISGSSAVK 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Krt6b	NP_034799.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Keratin_2_head	15..148	CDD:292825
		Filament	151..464	CDD:278467	92/361 (25%)
		Coil 1A	152..187		12/34 (35%)
		Linker 1	188..206		6/20 (30%)
		Coil 1B	207..298		22/136 (16%)
		Linker 12	299..322		6/22 (27%)
		Coil 2	323..461		42/137 (31%)
		DUF883	377..>437	CDD:295076	15/59 (25%)
		Tail	462..554		25/81 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	528..554		6/14 (43%)
LamC	NP_001260974.1	Filament	45..401	CDD:278467	92/361 (25%)
		ATP-synt_B	<67..>142	CDD:304375	18/78 (23%)
		MreC	<178..>224	CDD:302802	8/45 (18%)
		LTD	473..574	CDD:279300
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910