DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hivep3 and shn

DIOPT Version :9

Sequence 1:NP_034787.2 Gene:Hivep3 / 16656 MGIID:106589 Length:2348 Species:Mus musculus
Sequence 2:NP_001260883.1 Gene:shn / 36171 FlyBaseID:FBgn0003396 Length:2587 Species:Drosophila melanogaster


Alignment Length:2582 Identity:565/2582 - (21%)
Similarity:899/2582 - (34%) Gaps:880/2582 - (34%)


- Green bases have known domain annotations that are detailed below.


Mouse    24 GEAIQT----SVSSSAPYPGSGTTAPSESATQELLATQPFSGPSQEKTGQQQKPARRPSIEASVH 84
            |:|::|    |.||.:|.|    |.|..:. ..|:..|......|::..|||.|.  ||:..   
  Fly   331 GDAVRTTSLSSNSSLSPPP----TTPLANG-HHLMTQQQSHQQVQQQQQQQQTPP--PSVAI--- 385

Mouse    85 ISQLPQHPLTPAFMSP------GKPEHLLEGSTWQLVDPMRPGPSGS------------------ 125
                  |..:..|::.      |..|.::..|.::.....|...:.|                  
  Fly   386 ------HEFSANFVNSNHVNAIGHEESIISNSGYKAAGRTRTPLANSNSNTNSTSNSNSNHAANA 444

Mouse   126 FVAPGLHPQSQLLPSHASILPPEELPGIP-KVFVPRPSQVSLKPAEEAHKKERKPQKPGKYICQY 189
            .::|....|.|.|..     |....|||| ....|.|:                .:|.|:|:|||
  Fly   445 TLSPASFAQHQQLTQ-----PTTVSPGIPGGAAAPNPA----------------CEKSGRYVCQY 488

Mouse   190 CSRPCAKPSVLQKHIRSHTGERPYPCGPCGFSFKTKSNLYKHRKSHAHRIKA-GL---------A 244
            |:..|||||||:||||:||.||||||..||.:||||||||||.:|.:|..:| ||         .
  Fly   489 CNLICAKPSVLEKHIRAHTNERPYPCDTCGIAFKTKSNLYKHCRSRSHAARARGLEVPADADDGL 553

Mouse   245 SGSSSEMYPPGLEMERIPGEEFEEPTEGESTDSEEETGAAS------------------GPSTDV 291
            |...:|:.....|:....|..:|||....:......:.|.|                  .|:...
  Fly   554 SDQDAELSNSSSELPSRAGSPYEEPINSPTPSPSTLSAAKSAYIQQPPLPTYMQQLPLGSPAAGT 618

Mouse   292 LP--------------------KPKHPLL-SSSLYSSGS------------------HGSSQERC 317
            ||                    ||..|.. ::||||..|                  |..:|::.
  Fly   619 LPPTTADNHHSATAQHRQSIDYKPYKPKFHNASLYSCSSKELQQQQQQLQIQQQQQQHQLAQQKL 683

Mouse   318 SLSQSSTGPSLEDPA---PFAEASSEHPLSHKPEDTHTIKQKLALRLSERKKLIEEQTFLSPGSK 379
            |:..    |.::.|:   |....|::..:.|     |....::.|:|.:::.|:.:|:.|:....
  Fly   684 SIQL----PLVQQPSLAHPTLSPSTQMKMKH-----HINSHQIQLQLQQQQSLLAQQSLLAAMPP 739

Mouse   380 GST----ESGYFSRSESA----------------------EQQVSPPNTNAK---------SYAE 409
            |..    :..|:::..:|                      :||..||...|.         ...:
  Fly   740 GGVYYLGQPSYYNQDTAAAIHQHALAIQQFQIHLAQQQQQQQQQHPPLVKATPPMQQPPSLPPQQ 804

Mouse   410 IIFGKCGRIGQRTSMLASTSTQPLLPLSSEDKPSLVPLS----VPRTQVIEHITKLITINEAVVD 470
            ::        :..|.::|.:|.|..|..:.:..:....|    |...:|.|||:|||:.|||:|:
  Fly   805 LV--------RANSQISSVATAPATPTPAANLSTFASSSGGKQVNVAKVQEHISKLISQNEAIVE 861

Mouse   471 TSEIDSVKPRRSSLTRRSSVESPKSSLYRDSLSSHGEKTKQEQSLLSLQHPPSSTHPVPLLRSHS 535
            ..||...|.....|:|..|..:..|    ::.|.||                            |
  Fly   862 NKEILLQKKYPKQLSRSRSFNNANS----NNASQHG----------------------------S 894

Mouse   536 MPSAACTISTHHHTFRGSYSFDDHVADPEVPSRNTPVFTSHPRMLKRQPAIELPLGGEYSSEEPG 600
            ..||....::.::|            :.::|.|.|.|..:.....|:|..::             
  Fly   895 NASALHANNSQNNT------------NAQMPERETKVNLAQAIFQKQQHQLQ------------- 934

Mouse   601 PSSKDPTSKPSDEPEPKESDLTKKTKKGFKTKGANYECTICGARYKKRDNYEAHKKYYCSELQIT 665
                          :.::..:|::.::..:.:  ||...|             .::..|.:.|:.
  Fly   935 --------------QQQQQQITQQQQQQLEQQ--NYYTYI-------------QQQQECQQQQLE 970

Mouse   666 KAHSVGAHEVEKTQAEPEPWSQMMHYKLGATLELTPLRKRRKEKSLGDEEEPPAFGSPGPSETAH 730
            ..:.     |.|..|          ||.|..: .||::::        ::.||. .||.|.:|..
  Fly   971 PPNG-----VVKRNA----------YKPGVVM-TTPVKQQ--------QQLPPP-PSPLPMQTMQ 1010

Mouse   731 NRPLGSTKSPAEASKSAPSLEGPTSFQP-------RTPKPGAGSEPGKERRTMS---KEISVIQH 785
            .|     :.||   .....:|.||:..|       ..|||...:.|.....|.|   ...:....
  Fly  1011 YR-----QDPA---TPVTKIEQPTTAVPVMPLNLSAKPKPTLVTVPVSSLSTSSLAPTPTTSTNP 1067

Mouse   786 TSSFEKSDPPEQ------------------PSGLEEDKPPAQFSSPPPAPHGRSAHSLQPRLVRQ 832
            |||.:.:.||.|                  |.|..:|   |.:|.|..|...|||..|  :|...
  Fly  1068 TSSSKTAPPPAQVNNSIIKNLLLNARGLAVPIGEGDD---AVYSCPICASEFRSADDL--KLHNS 1127

Mouse   833 PNIQVPEILVTEEPDRPDTEPEPPPKEPEKTEEFQWPQRSQTLAQLPAEKLPPKKKRLRLAEMAQ 897
            ...|          |...:.|..|...|.::...     |.:|.:|.:. :...|..|.||::|.
  Fly  1128 TYCQ----------DASSSAPMSPASSPFRSNSI-----SLSLPELKSH-MANSKNPLSLAKLAW 1176

Mouse   898 SSGESSFESSVPLSR-----SPSQESSISLSGSSRSASFDREDHGKAEAPGPFSDTRSKTLGSHM 957
            |..::. .||:.|||     :|::.|:::....:            |.||.|...|         
  Fly  1177 SQLKTK-RSSLVLSRLSAAQTPARTSTVTAPTVT------------ASAPAPAVAT--------- 1219

Mouse   958 LTVPSHHPHAREMRRSASEQSPNVPHSSHMTETRSKSFDYGSLSPTGPSLA-VPAAPPPPAAPPE 1021
            :|.||..|            :|.:         .:..|....|...||.|. .|.......:.|.
  Fly  1220 VTAPSSAP------------APQI---------EALRFVDAPLPSPGPLLGKTPLVDYAQQSTPR 1263

Mouse  1022 RRKCFLV-------RQASLNRPPEAELEAVPKGKQESSEEPAA-----SKPSTKSSVPQISVG-- 1072
            :.:..:|       ||..:...|...::........||::|.:     :..::.:|||::...  
  Fly  1264 KAQDSVVITKMHEDRQFVIEAQPAKRIKTSDLVVASSSQQPTSFNFSFNNQNSSNSVPELQSSKE 1328

Mouse  1073 ------TTQGGPSGGKSQMQDRPPLGSSPPYTEALQVFQPLGTQLPPPASLFSLQQLLPQEQEQS 1131
                  |:.|   |....:.:.|.|.:||         :.:.|.|....|...:...:..|...|
  Fly  1329 ERLRRFTSSG---GSMIPISECPDLDNSP---------KMIRTPLLSGGSFQDVSVKVNNETGSS 1381

Mouse  1132 SEFFPTQAM---AGLLSSPYSMPPLPPSLFQAPPLPLQPTVLHPSQLHLPQLLPHAADIPFQQPP 1193
            |:.....|:   :|||.....     |..||.||:. ..|..:|..|                ||
  Fly  1382 SKERKLMALVSGSGLLGVSSG-----PQHFQFPPIN-SITAFNPLTL----------------PP 1424

Mouse  1194 SFLPMPCPAPSTLSGYFLPLQSQFALQLPGEIESHLPPVKTSLPPLATGPPGPSSSTEYSSDIQL 1258
                        :||              |:..:.:.|:     |...|.|||.|          
  Fly  1425 ------------MSG--------------GDKTTPVTPI-----PHVPGMPGPGS---------- 1448

Mouse  1259 PPVTPQATSPAPTSAPPLALPACPDAMVSLVVPVRIQTHMPSYGSAMYTTLSQILVTQSPGSPAS 1323
              :|||    .|...||               |.::|.                           
  Fly  1449 --LTPQ----MPLLPPP---------------PQQLQL--------------------------- 1465

Mouse  1324 TALTKYEEPSSKSMTVCEADVYEAEPGPSSISKEQNRGYQTPYLRVPERKGTSLSSEGILSLEGC 1388
                                     |.|||..:..||...:|.|                 |.| 
  Fly  1466 -------------------------PIPSSRGRSPNRKQPSPLL-----------------LGG- 1487

Mouse  1389 SSTASGSKRVLSPAGSL-----ELTME--TQQQKRVKEEEASKADEK-----LELVSTCSVVLTS 1441
               .||..:.|||.|.:     |.:.:  |..|::..:..:.:|.:|     |.:.         
  Fly  1488 ---GSGELKALSPFGGVQNVPSEFSRQPPTPAQRQALQWNSKEAPKKAPFNFLRMA--------- 1540

Mouse  1442 TEDRKKTEKPHVGGQGRSRREAETLSSLSSDVSDPKELSPLSHSTLSHGTAPGSEALKEYAQPSS 1506
              |..||.:|.|        ....|.::.|.......|:|| |....:|.||  |.....|..|:
  Fly  1541 --DNVKTTEPEV--------RHFNLENVISGKQQELPLTPL-HVDTPNGNAP--EETSPVASASA 1592

Mouse  1507 KAHRRGLPPMSVKKE----DPKEQTDLPPLAPPSSLPL-SDTSPKPAKLQEGTDSKKVLQ----- 1561
            .|..:.|.|.|:..:    .||....:.|.|  ::||| |..:|:|        ||..:|     
  Fly  1593 SAKSKFLRPTSLPLKPGTFTPKRHHGITPTA--NTLPLISPETPRP--------SKSCVQLYLNG 1647

Mouse  1562 ----FPSLHTTTNVSWCYLNYIKPNHI--QHADRRSSVYAGWCISLYN-PNLPGVSTKAALSLLR 1619
                :..|..:|.:.:|.:|..:|:::  .|   :.|:|:.|.:...| |:..|...|..::|..
  Fly  1648 HAYTYLGLKCSTKMFYCTVNCPQPSYVAGMH---KLSMYSVWQVCEENQPHPLGFKLKQVMALYD 1709

Mouse  1620 SKQKV------------SKETYTMATAPHPEAGRLVPSNSRKPRMTEVHLPSLVSPE-------S 1665
            |:|::            .|.:|.:..:.     ::|.|.|.....:..:...|.:|.       |
  Fly  1710 SRQRMLGNGSSTAMAGSGKLSYNLVASQ-----QIVSSPSTSSTSSAFYQGPLKTPPTVTIAALS 1769

Mouse  1666 QKDPARVEKEEKQGKAEEGTPTSKRGEPARVKIFEGGYKSNEEYIYVRGRGRGRYVCEECGIRCK 1730
            :.:.|....||.|.|..|   ||..|:|     ..|||:|:|:|.|:||||||||||.|||||||
  Fly  1770 EANVAAKANEEAQAKKLE---TSPSGQP-----LVGGYESHEDYTYIRGRGRGRYVCSECGIRCK 1826

Mouse  1731 KPSMLKKHIRTHTDVRPYVCKHCHFAFKTKGNLTKHMKSKAHSKKCQETGVLEELEAEEGTSDDL 1795
            |||||||||||||||||:.|.||:|:|||||||||||:||.|.|||.|.|:.......:....|:
  Fly  1827 KPSMLKKHIRTHTDVRPFTCSHCNFSFKTKGNLTKHMQSKTHFKKCIELGINPGPMPPDSEFLDV 1891

Mouse  1796 HQDSEGQEGAEA-------VEEHQFSDLEDSDSD-SDLDEDEEEEEEEEESQDELSGPCSEAAPP 1852
            ..|.:.|....|       ..|....|..|::|: ||.||.:..::|.|.::..||...:...|.
  Fly  1892 DMDFDQQSSTSAGGRTSSMAGESDSDDYSDNESESSDTDESKSRQKEHEAARGLLSLSMTPPIPQ 1956

Mouse  1853 CLPPTLQENSSPVEGPQAPDSTSDEVPQGSSISEATHLTASSCSTPSRGTQGLPRLGLAPLEKDM 1917
            .:.|..|...:|:  |.|..:.|    .|||.|:...|..|                        
  Fly  1957 SVSPYPQLQDTPL--PAASPANS----IGSSGSQPKRLVCS------------------------ 1991

Mouse  1918 SSAPSPKATSPRRPWSPSKEAGSRPSLTRKHSLTKNDSSPQQCSPAREAQASVTSTPGPQMGPGR 1982
                   .|||:.|:...|:             .:..|:|::..|.|.. |:..|.|       .
  Fly  1992 -------FTSPKPPFDYQKQ-------------EQYYSNPEESKPKRSV-ANEESAP-------M 2028

Mouse  1983 DLGPHLCGSPRLELSCLTPYPIGREAPAGLERATDTGTPRYSPTRRWSLGQAESPPQTVLPGKWA 2047
            ||     ..||..:..::|.|:.                  .|.......||:.....:.     
  Fly  2029 DL-----TKPRGSILLISPSPVS------------------VPAHDLPKSQAQQMHDVIF----- 2065

Mouse  2048 LAGPCSPSADKSGLGLGPVPRALLQPVPLPHTLLSRSPETCTSAWRKTESRSPSAGPAPLFPRPF 2112
                 ..|.::||               ...||:|.|.:...||..:.:::..:.| ..:..:.:
  Fly  2066 -----GTSGNESG---------------FMKTLISVSDKVRISAEMEEQAKHEAEG-EDVQLQTY 2109

Mouse  2113 SAPHDFHGHLPSRSEENLFSHLPLHSQLLSRAPCPLIPIGGIQMVQARPGAQPTVLPGPCAAWVS 2177
            ...|..|   .::.:::.||...|.:.|.:.|...:.....:....:||......:|......|.
  Fly  2110 IKEHALH---QAKIKQSQFSRSYLINTLYTAASPVMSSSSTLFTANSRPVMSVNEVPSIEVHEVK 2171

Mouse  2178 GFSGGGSDLTGAREAQERSRWSPTESPSASVSPVAKVSKFTLSSELEEERTGRGPGRPPDWEPHR 2242
                       ..||.|..|.:|.::|         |....::.|..||        |...|||.
  Fly  2172 -----------TPEAIESPRSAPEQAP---------VILAQIAQEENEE--------PNIAEPHN 2208

Mouse  2243 AEAPPGPMGTHSPCSPQLPQGHQVAPSWRGLLGSPH-------TLANLKASSFPPLDRSSSMDCL 2300
            |         :.|.:.|.|..::    :.|:||:|.       |..::..::..|:..||     
  Fly  2209 A---------NLPAAVQQPDVNE----FTGVLGNPTAPPTSSVTATSVSTTTAAPVAPSS----- 2255

Mouse  2301 AETSTYSPPRSRNL--------SGEPRTRQGSPELL--GRGELRTPL 2337
              |:..:.|..|.:        |..|.::.|..:.:  |||....|:
  Fly  2256 --TANSTQPAQRTVIVGEDGFKSSTPTSKSGDLQHVSYGRGVPPAPI 2300

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hivep3NP_034787.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..105 22/90 (24%)
ZAS1 185..235 36/49 (73%)
C2H2 Zn finger 187..207 CDD:275368 15/19 (79%)
zf-H2C2_2 200..224 CDD:404364 16/23 (70%)
No DNA binding activity or transactivation activity, but complete prevention of TRAF-dependent NF-Kappa-B activation, associates with TRAF2 and JUN 204..1055 202/1000 (20%)
C2H2 Zn finger 215..235 CDD:275368 13/19 (68%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 239..401 43/257 (17%)
Acidic 1 257..280 5/22 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 475..532 8/56 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 561..628 7/66 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 692..1098 96/459 (21%)
PHA03247 <733..1278 CDD:223021 121/601 (20%)
Acidic 2 844..865 4/20 (20%)
Nuclear localization signal. /evidence=ECO:0000255 885..891 1/5 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1229..1274 11/44 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1386..1427 11/47 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1441..1555 31/118 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1654..1694 12/46 (26%)
ZAS2 1720..1772 44/51 (86%)
zf-C2H2 1720..1742 CDD:395048 20/21 (95%)
C2H2 Zn finger 1722..1742 CDD:275370 18/19 (95%)
zf-H2C2_2 1734..1759 CDD:404364 19/24 (79%)
ZnF_U1 1745..1778 CDD:197732 24/32 (75%)
C2H2 Zn finger 1750..1768 CDD:275370 14/17 (82%)
Acidic 3 1783..1841 14/65 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1786..1990 43/211 (20%)
PHA03247 <1845..2315 CDD:223021 84/484 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2009..2038 3/28 (11%)
5 X 4 AA tandem repeats of [ST]-P-X-[RK] 2053..2148 17/94 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2184..2265 18/80 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2284..2348 13/64 (20%)
shnNP_001260883.1 C2H2 Zn finger 486..506 CDD:275368 15/19 (79%)
zf-H2C2_2 499..523 CDD:290200 16/23 (70%)
C2H2 Zn finger 514..536 CDD:275368 14/21 (67%)
zf-C2H2 1816..1838 CDD:278523 20/21 (95%)
C2H2 Zn finger 1818..1838 CDD:275370 18/19 (95%)
zf-H2C2_2 1830..1855 CDD:290200 19/24 (79%)
zf-C2H2 1844..1868 CDD:278523 17/23 (74%)
C2H2 Zn finger 1846..1868 CDD:275370 17/21 (81%)
zf-C2H2 2307..2328 CDD:278523
C2H2 Zn finger 2308..2328 CDD:275368
zf-C2H2_jaz 2333..2359 CDD:288983
C2H2 Zn finger 2336..2358 CDD:275368
C2H2 Zn finger 2381..2403 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 147 1.000 Domainoid score I4485
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 361 1.000 Inparanoid score I2181
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm43626
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR45944
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3898
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
77.140

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