DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DHX15 and Dhx15

DIOPT Version :9

Sequence 1:	NP_001349.2	Gene:	DHX15 / 1665	HGNCID:	2738	Length:	795	Species:	Homo sapiens
Sequence 2:	NP_001260766.1	Gene:	Dhx15 / 35654	FlyBaseID:	FBgn0033160	Length:	729	Species:	Drosophila melanogaster

Alignment Length:	794	Identity:	568/794 - (71%)
Similarity:	649/794 - (81%)	Gaps:	67/794 - (8%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSKRHRLDLGEDYPSGKKRAGTDGKDRDRDRDREDRSKDRDRERDRGDREREREKEKEKELRAST 65
            |||| |:::||.|.|..|                                ::.|........|:.
  Fly     1 MSKR-RIEVGETYGSKAK--------------------------------KDPEASSSSAAAAAG 32

Human    66 NAMLISAGLPPLKASHSAHSTHSAHSTHSTHSAHSTHAGHAGHTSLPQCINPFTNLPHTPRYYDI 130
            ....|..|..|.|.                                |..:||.||.|::.||.::
  Fly    33 TVAQILGGFVPNKQ--------------------------------PPTMNPLTNTPYSQRYQNL 65

Human   131 LKKRLQLPVWEYKDRFTDILVRHQSFVLVGETGSGKTTQIPQWCVEYMRSLPGPKRGVACTQPRR 195
            .|||:.|||:||:..|..:|..||..|||||||||||||||||||::  ::...::||:||||||
  Fly    66 YKKRIALPVFEYQADFMRLLSLHQCIVLVGETGSGKTTQIPQWCVDF--AVSKGRKGVSCTQPRR 128

Human   196 VAAMSVAQRVADEMDVMLGQEVGYSIRFEDCSSAKTILKYMTDGMLLREAMNDPLLERYGVIILD 260
            ||||||||||::||||.||:||||||||||||:|||:||||||||||||||:||:|::|.||:||
  Fly   129 VAAMSVAQRVSEEMDVKLGEEVGYSIRFEDCSTAKTLLKYMTDGMLLREAMSDPMLDQYQVILLD 193

Human   261 EAHERTLATDILMGVLKEVVRQRSDLKVIVMSATLDAGKFQIYFDNCPLLTIPGRTHPVEIFYTP 325
            |||||||||||||||||||:|||||||::||||||||||||.||||.||:.:|||||||||||||
  Fly   194 EAHERTLATDILMGVLKEVIRQRSDLKLVVMSATLDAGKFQQYFDNAPLMKVPGRTHPVEIFYTP 258

Human   326 EPERDYLEAAIRTVIQIHMCEEEEGDLLLFLTGQEEIDEACKRIKREVDDLGPEVGDIKIIPLYS 390
            ||||||||||||||||||||||.|||:|:||||||||:|||||||||:|:||.|:|::|.|||||
  Fly   259 EPERDYLEAAIRTVIQIHMCEEIEGDILMFLTGQEEIEEACKRIKREIDNLGSEIGELKCIPLYS 323

Human   391 TLPPQQQQRIFEPPPPKKQNGAIGRKVVVSTNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVES 455
            ||||..|||||||.||...||||||||||||||||||||||||||||||||||||||||||||||
  Fly   324 TLPPNLQQRIFEPAPPPNANGAIGRKVVVSTNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVES 388

Human   456 LLVTAISKASAQQRAGRAGRTRPGKCFRLYTEKAYKTEMQDNTYPEILRSNLGSVVLQLKKLGID 520
            |||:.|||||||||:|||||||||||||||||||:|.||||||||||||||||:|||||||||||
  Fly   389 LLVSPISKASAQQRSGRAGRTRPGKCFRLYTEKAFKNEMQDNTYPEILRSNLGTVVLQLKKLGID 453

Human   521 DLVHFDFMDPPAPETLMRALELLNYLAALNDDGDLTELGSMMAEFPLDPQLAKMVIASCDYNCSN 585
            |||||||||||||||||||||||||||||:|||:||:||::|:|||||||||||:||||.:||||
  Fly   454 DLVHFDFMDPPAPETLMRALELLNYLAALDDDGNLTDLGAVMSEFPLDPQLAKMLIASCQHNCSN 518

Human   586 EVLSITAMLSVPQCFVRPTEAKKAADEAKMRFAHIDGDHLTLLNVYHAFKQNHESVQWCYDNFIN 650
            |:||||||||||||||||.||||||||||||||||||||||||||||||||:.|...|||:||||
  Fly   519 EILSITAMLSVPQCFVRPNEAKKAADEAKMRFAHIDGDHLTLLNVYHAFKQSSEDPNWCYENFIN 583

Human   651 YRSLMSADNVRQQLSRIMDRFNLPRRSTDFTSRDYYINIRKALVTGYFMQVAHLERTGHYLTVKD 715
            :|||.|||||||||:||||||||.|.||:|||:|||:|||||||.|:|||||||||||:|||:||
  Fly   584 FRSLKSADNVRQQLARIMDRFNLRRTSTEFTSKDYYVNIRKALVQGFFMQVAHLERTGYYLTIKD 648

Human   716 NQVVQLHPSTVLDHKPEWVLYNEFVLTTKNYIRTCTDIKPEWLVKIAPQYYDMSNFPQCEAKRQL 780
            ||.|||||||.|||||:||:||||||||||||||.||:|||||..:||||||::|||||||||||
  Fly   649 NQNVQLHPSTCLDHKPDWVIYNEFVLTTKNYIRTVTDVKPEWLCCLAPQYYDLNNFPQCEAKRQL 713

Human   781 DRIIAKLQSKEYSQ 794
            :.:..:|::|:|.:
  Fly   714 ELLQQRLETKQYQK 727

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DHX15	NP_001349.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..108		16/106 (15%)
		HrpA	124..763	CDD:224557	526/638 (82%)
		DEAH box	260..263		2/2 (100%)
Dhx15	NP_001260766.1	Motor_domain	50..>102	CDD:277568	28/51 (55%)
		DEXDc	67..255	CDD:214692	144/189 (76%)
		DEXDc	91..228	CDD:238005	110/138 (80%)
		HELICc	315..408	CDD:197757	80/92 (87%)
		HA2	478..561	CDD:214852	71/82 (87%)
		OB_NTP_bind	595..698	CDD:285018	83/102 (81%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160229
Domainoid	1	1.000	240	1.000	Domainoid score	I2270
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1040
Inparanoid	1	1.050	1140	1.000	Inparanoid score	I214
Isobase	1	0.950	-	0	Normalized mean entropy	S173
OMA	1	1.010	-	-		QHG53574
OrthoDB	1	1.010	-	-		D113216at33208
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	1	1.000	-	-		oto89583
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	1	1.100	-	-	LDO	PTHR18934
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R312
SonicParanoid	1	1.000	-	-		X141
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750