Protein Alignment DHX15 and mle

DIOPT Version :10

• Sequence 1: NP_001349.2
• Gene: DHX15 / 1665
• HGNCID: 2738
• Length: 795
• Species: Homo sapiens
• Sequence 2: NP_476641.1
• Gene: mle / 35523
• FlyBaseID: FBgn0002774
• Length: 1293
• Species: Drosophila melanogaster
• Alignment Length: 678
• Identity: 199/678 - (29%)
• Similarity: 330/678 - (48%)
• Gaps: 93/678 - (13%)

Human   127 YYDILKKRLQLPVWEYKDRFTDILVRHQSFVLVGETGSGKTTQIPQWCV-EYMRSLPGPKRGVAC 190
            |...|:.|.:||:...:......:..:...::.|.||.||||||.|:.: :|:.|..|....:..
  Fly   374 YRQFLEFREKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYICSGQGGYANIYV 438

Human   191 TQPRRVAAMSVAQRVADEMDVMLGQEVGYSIRFEDCSSAK--TILKYMTDGMLLREAMNDPLLER 253
            |||||::|:|||:|||.|....||..||||:|||......  .|| :.|.|:|||:.  :..|..
  Fly   439 TQPRRISAISVAERVARERCEQLGDTVGYSVRFESVFPRPYGAIL-FCTVGVLLRKL--EAGLRG 500

Human   254 YGVIILDEAHERTLATDILMGVLKEVVRQRSDLKVIVMSATLDAGKFQIYFDNCPLLTIPGRTHP 318
            ...||:||.|||.:.:|.|:.:|:::|....||.||:||||:|..||..||..||:|.:|||..|
  Fly   501 VSHIIVDEIHERDVNSDFLLVILRDMVDTYPDLHVILMSATIDTTKFSKYFGICPVLEVPGRAFP 565

Human   319 VEIF----------YTPEPE----------------RDYLEAAI------------RTVIQIHMC 345
            |:.|          :.|..|                .|..||.|            :|...:.|.
  Fly   566 VQQFFLEDIIQMTDFVPSAESRRKRKEVEDEEQLLSEDKDEAEINYNKVCEDKYSQKTRNAMAML 630

Human   346 EEEE-------------------GDLLLFLTGQEEIDEACKRIKREVDDLGPEVGDIKIIPLYST 391
            .|.:                   |.:|:||.|...|....|.::.  .::..:....:|:|.:|.
  Fly   631 SESDVSFELLEALLMHIKSKNIPGAILVFLPGWNLIFALMKFLQN--TNIFGDTSQYQILPCHSQ 693

Human   392 LPPQQQQRIFEPPPPKKQNGAIGRKVVVSTNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESL 456
            :|..:|:::|||.|    .|.  .|:::||||||||:|||.:|||||...|:.|::.....:.|.
  Fly   694 IPRDEQRKVFEPVP----EGV--TKIILSTNIAETSITIDDIVFVIDICKARMKLFTSHNNLTSY 752

Human   457 LVTAISKASAQQRAGRAGRTRPGKCFRLYTEKAYKTEMQDNTYPEILRSNLGSVVLQLKKLGIDD 521
            .....||.:.:||.|||||.|||.||.|.:...::. ::||..||:.|:.|..:.|.:|.|.:..
  Fly   753 ATVWASKTNLEQRKGRAGRVRPGFCFTLCSRARFQA-LEDNLTPEMFRTPLHEMALTIKLLRLGS 816

Human   522 LVHF--DFMDPPAPETLMRALELLNYLAALNDDGDLTELGSMMAEFPLDPQLAKMVIASCDYNCS 584
            :.||  ..::||..:.::.|..||..:..|:.:.:||.||.::|..|::|:|.||::....:.|:
  Fly   817 IHHFLSKALEPPPVDAVIEAEVLLREMRCLDANDELTPLGRLLARLPIEPRLGKMMVLGAVFGCA 881

Human   585 NEVLSITAMLS--VPQCFVRPTEAKKAADEAKMRFAHIDGDHLTLLNVYHAFKQNHESVQWCYDN 647
             ::::|.|..|  ..:.|......::.|:..|........||:.::.....:::..:..:.....
  Fly   882 -DLMAIMASYSSTFSEVFSLDIGQRRLANHQKALSGTKCSDHVAMIVASQMWRREKQRGEHMEAR 945

Human   648 FINYRSL-MSADNV----RQQLSRIMDRFNLPRR---STDFTSR----DYYINIRKALV-TGYFM 699
            |.:::.| ||..||    :|||..::.:...|..   |.:...|    |..:::..||: .|.:.
  Fly   946 FCDWKGLQMSTMNVIWDAKQQLLDLLQQAGFPEECMISHEVDERIDGDDPVLDVSLALLCLGLYP 1010

Human   700 QV-AHLERTGHYLTVKDNQVVQLHPSTV 726
            .: .|.|:  ..:...:::...||.::|
  Fly  1011 NICVHKEK--RKVLTTESKAALLHKTSV 1036

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DHX15	NP_001349.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..108
		HrpA	136..>763	CDD:441249	196/669 (29%)
		DEAH box	260..263		2/2 (100%)
mle	NP_476641.1	DSRM_DHX9_rpt1	2..70	CDD:380683
		DSRM_DHX9_rpt2	167..241	CDD:380684
		DEXHc_DHX9	326..559	CDD:350730	75/187 (40%)
		HrpA	378..>889	CDD:441249	170/523 (33%)
		OB_NTP_bind	1002..1079	CDD:400182	8/37 (22%)